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Recombinant Human IGF-Binding Protein 4 (Insect Der.) (Carrier-Free)
  • Recombinant Human IGF-Binding Protein 4 (Insect Der.) (Carrier-Free)

Recombinant Human IGF-Binding Protein 4 (Insect Der.) (Carrier-Free)

Cat No. Size Price Quantity
21-9191-U005 5 µg $80.00
21-9191-U020 20 µg $195.00
21-9191-U100 100 µg $850.00
21-9191-U500 500 µg $3,120.00

Description

IGF-BPs control the distribution, function and activity of ≥≥IGFs in various cell tissues and body fluids. IGF-BP4 is the major IGF-BP produced by osteoblasts, and is found in the epidermis, ovarian follicles, and other tissues. IGF-BP4 inhibits the activity of ≥≥IGF-I and IGF-II by binding in a manner that results in the formation of complexes with reduced ability to signal through cell surface IGF receptors.
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IGF-BPs control the distribution, function and activity of ≥≥IGFs in various cell tissues and body fluids. IGF-BP4 is the major IGF-BP produced by osteoblasts, and is found in the epidermis, ovarian follicles, and other tissues. IGF-BP4 inhibits the activity of ≥≥IGF-I and IGF-II by binding in a manner that results in the formation of complexes with reduced ability to signal through cell surface IGF receptors.
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Product Details

Name Recombinant Human IGF-Binding Protein 4 (Insect Der.) (Carrier-Free)
Cat. No. 21-9191
Alternative Names Insulin-like Growth Factor-Binding Protein 4, IBP-4, HT29-IGF-BP, colon cancer cell growth inhibitor
Amino Acid Sequence DEAIHCPPCS EEKLARCRPP VGCEELVREP GCGCCATCAL GLGMPCGVYT PRCGSGLRCY PPRGVEKPLH TLMHGQGVCM ELAEIEAIQE SLQPSDKDEG DHPNNSFSPC SAHDRRCLQK HFAKIRDRST SGGKMKVNGA PREDARPVPQ GSCQSELHRA LERLAASQSR THEDLYIIPI PNCDRNGNFH PKQCHPALDG QRGKCWCVDR KTGVKLPGGL EPKGELDCHQ LA
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity Determined by its ability to inhibit IGF-I induced proliferation of FDC-P1 cells.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant Human IGF-BP4 is a 25.7 kDa protein consisting of ≥ 237 amino acid residues including, the IGF-BP domain and thyroglobulin type-I domain.
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 95
Source (BTI-Tn-5B1-4) Hi-5 Insect cells
Reactivity Human
Research Areas Proliferation, Apoptosis, Cancer, Diabetes/Weight Regulation
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.