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Recombinant Human IGF-Binding Protein 2 (Insect Der.) (Carrier-Free)
  • Recombinant Human IGF-Binding Protein 2 (Insect Der.) (Carrier-Free)

Recombinant Human IGF-Binding Protein 2 (Insect Der.) (Carrier-Free)

Cat No. Size Price Quantity
21-9192-U005 5 µg $80.00
21-9192-U020 20 µg $195.00
21-9192-U100 100 µg $850.00
21-9192-U500 500 µg $3,120.00

Description

IGF-BPs controls the distribution, function and activity of ≥≥IGFs in various cell tissues and body fluids. Currently, there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP2 is a cysteine-rich, secreted protein produced by bone cells, and is most abundant in the brain. IGF-BP2 has been shown to inhibit IGF-II action in human breast and ovarian carcinoma cells.
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IGF-BPs controls the distribution, function and activity of ≥≥IGFs in various cell tissues and body fluids. Currently, there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP2 is a cysteine-rich, secreted protein produced by bone cells, and is most abundant in the brain. IGF-BP2 has been shown to inhibit IGF-II action in human breast and ovarian carcinoma cells.
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Product Details

Name Recombinant Human IGF-Binding Protein 2 (Insect Der.) (Carrier-Free)
Cat. No. 21-9192
Alternative Names Insulin-like Growth Factor-Binding Protein 2, IBP-2
Amino Acid Sequence EVLFRCPPCT PERLAACGPP PVAPPAAVAA VAGGARMPCA ELVREPGCGC CSVCARLEGE ACQVYTPRCG QGLRCYPHPG SELPLQALVM GEGTCEKRRD AEYGASPEQV ADNGDDHSEG GLVENHVDST MNMLGGGGSA GRKPLKSGMK ELAVFREKVT EQHRQMGKGG KHHLGLEEPK KLRPPPARTP CQQELDQVLE RISTMRLPDE RGPLEHLYSL HIPNCDKHGL YN
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity Determined by its ability to inhibit IGF-I induced proliferation of FDC-P1 cells.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant Human IGF-BP2 is a 31.5 kDa protein consisting of ≥ 289 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain.
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source (BTI-Tn-5B1-4) Hi-5 Insect cells
Reactivity Human
Research Areas Proliferation, Apoptosis, Cancer, Diabetes/Weight Regulation
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.