Recombinant Human IGF-Binding Protein 2 (Insect Der.) (Carrier-Free)
| Cat No. | Size | Price | Quantity | |
|---|---|---|---|---|
| 21-9192-U005 | 5 µg | $80.00 | ||
| 21-9192-U020 | 20 µg | $195.00 | ||
| 21-9192-U100 | 100 µg | $850.00 | ||
| 21-9192-U500 | 500 µg | $3,120.00 |
Technical Data Sheet
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IGF-BPs controls the distribution, function and activity of ≥≥IGFs in various cell tissues and body fluids. Currently, there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP2 is a cysteine-rich, secreted protein produced by bone cells, and is most abundant in the brain. IGF-BP2 has been shown to inhibit IGF-II action in human breast and ovarian carcinoma cells.
IGF-BPs controls the distribution, function and activity of ≥≥IGFs in various cell tissues and body fluids. Currently, there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP2 is a cysteine-rich, secreted protein produced by bone cells, and is most abundant in the brain. IGF-BP2 has been shown to inhibit IGF-II action in human breast and ovarian carcinoma cells.
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Product Details
| Name | Recombinant Human IGF-Binding Protein 2 (Insect Der.) (Carrier-Free) |
|---|---|
| Cat. No. | 21-9192 |
| Alternative Names | Insulin-like Growth Factor-Binding Protein 2, IBP-2 |
| Amino Acid Sequence | EVLFRCPPCT PERLAACGPP PVAPPAAVAA VAGGARMPCA ELVREPGCGC CSVCARLEGE ACQVYTPRCG QGLRCYPHPG SELPLQALVM GEGTCEKRRD AEYGASPEQV ADNGDDHSEG GLVENHVDST MNMLGGGGSA GRKPLKSGMK ELAVFREKVT EQHRQMGKGG KHHLGLEEPK KLRPPPARTP CQQELDQVLE RISTMRLPDE RGPLEHLYSL HIPNCDKHGL YN |
| Authenticity | Verified by N-terminal and Mass Spectrometry analyses (when applicable). |
| Bioactivity | Determined by its ability to inhibit IGF-I induced proliferation of FDC-P1 cells. |
| Endotoxin Level | Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg). |
| Molecular Mass | Recombinant Human IGF-BP2 is a 31.5 kDa protein consisting of ≥ 289 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain. |
| Protein Content | Content Verified by UV Spectroscopy and/or SDS-PAGE gel. |
| Purity (%) | 98 |
| Source | (BTI-Tn-5B1-4) Hi-5 Insect cells |
| Reactivity | Human |
| Research Areas | Proliferation, Apoptosis, Cancer, Diabetes/Weight Regulation |
| Reconstitution | See Certificate of Analysis (COA) for lot specific reconstitution information. |
| Application | Bioassay |
Application Key:
FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy
*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.