Customer Service: (855) 848-6626 | 8:00 a.m - 4:30 p.m. PST | Receive a Free Mask with Orders over $300

Recombinant Human ICAM-1 (Carrier-free)
  • Recombinant Human ICAM-1 (Carrier-free)

Recombinant Human ICAM-1 (Carrier-free)

Cat No. Size Price Quantity
21-7064-U010 10 µg $76.00
21-7064-U050 50 µg $209.00
21-7064-U100 100 µg $280.00
21-7064-U500 500 µg $859.00

Description

Intercellular adhesion molecule 1 (ICAM-1), also known as CD54, is a member of the immunoglobulin (Ig) superfamily and binds the leukocyte integrin αs LFA-1 and Mac-1, and functions as the major receptor for human rhinovirus. LFA-1 is found on all T cells and interaction with ICAM-1 has been shown to stimulate various T cell activation and differentiation activities. ICAM-1 is expressed at low levels on the surface of leukocytes, endothelial cells, macrophages, and lymphocytes but is activated by LPS and cytokines such as IFN-gamma, TNF-alpha and IL-1beta. The primary function of ICAM-1 is to provide adhesion between ≥ ≥ ≥ endothelial cells and leukocytes after stress or injury.
View More
Intercellular adhesion molecule 1 (ICAM-1), also known as CD54, is a member of the immunoglobulin (Ig) superfamily and binds the leukocyte integrin αs LFA-1 and Mac-1, and functions as the major receptor for human rhinovirus. LFA-1 is found on all T cells and interaction with ICAM-1 has been shown to stimulate various T cell activation and differentiation activities. ICAM-1 is expressed at low levels on the surface of leukocytes, endothelial cells, macrophages, and lymphocytes but is activated by LPS and cytokines such as IFN-gamma, TNF-alpha and IL-1beta. The primary function of ICAM-1 is to provide adhesion between ≥ ≥ ≥ endothelial cells and leukocytes after stress or injury.
Hide

Product Details

Name Recombinant Human ICAM-1 (Carrier-free)
Cat. No. 21-7064
Alternative Names Intercellular adhesion molecule 1, major group rhinovirus receptor, CD54 antigen
Amino Acid Sequence QTSVSPSKVI LPRGGSVLVT CSTSCDQPKL LGIETPLPKK ELLLPGNNRK VYELSNVQED SQPMCYSNCP DGQSTAKTFL TVYWTPERVE LAPLPSWQPV GKNLTLRCQV EGGAPRANLT VVLLRGEKEL KREPAVGEPA EVTTTVLVRR DHHGANFSCR TELDLRPQGL ELFENTSAPY QLQTFVLPAT PPQLVSPRVL EVDTQGTVVC SLDGLFPVSE AQVHLALGDQ RL
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity ICAM-1 supported the adhesion of more than 50% PMA-stimulated HSB2 cells to plates coated at 25 µg/ml ICAM-1 concentration.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant human ICAM-1 is a 49.5 kDa glycoprotein comprising the extracellular domain (453 amino acid residues) of ICAM-1. Monomeric glycosylated ICAM-1 migrates at an apparent molecular weight of approximately 72.0-80.0 kDa by SDS-PAGE analysis under r
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source CHO cells
Reactivity Human
Research Areas Angiogenesis/Cardiovascular; Inflammation; Allergy; Transplantation
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.