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Recombinant Human Heregulin beta-1 (Carrier-free)
  • Recombinant Human Heregulin beta-1 (Carrier-free)

Recombinant Human Heregulin beta-1 (Carrier-free)

Cat No. Size Price Quantity
21-7062-U010 10 µg $76.00
21-7062-U050 50 µg $199.00
21-7062-U100 100 µg $295.00
21-7062-U500 500 µg $859.00

Description

Heregulin-1/Neuregulin (HRG1/NRG1) is one of four members of the Heregulin/Neuregulin family of cytokine growth factors that play important roles during development of the nervous system and the heart. A shared EGF-like domain interacts with ErbB3 and ErbB4 members of the ErbB family of receptors. Alternative splicing in the EGF-like domain of NRG1 results in ? and beta isoforms. Heregulin beta-1 is a secreted protein that acts to modulate cell growth and differentiation. The HRG1-beta isoform displays neuroprotective properties and participates in development, survival, and metabolism in neuron and glial cells.
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Heregulin-1/Neuregulin (HRG1/NRG1) is one of four members of the Heregulin/Neuregulin family of cytokine growth factors that play important roles during development of the nervous system and the heart. A shared EGF-like domain interacts with ErbB3 and ErbB4 members of the ErbB family of receptors. Alternative splicing in the EGF-like domain of NRG1 results in ? and beta isoforms. Heregulin beta-1 is a secreted protein that acts to modulate cell growth and differentiation. The HRG1-beta isoform displays neuroprotective properties and participates in development, survival, and metabolism in neuron and glial cells.
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Product Details

Name Recombinant Human Heregulin beta-1 (Carrier-free)
Cat. No. 21-7062
Alternative Names Neuregulin 1 (NRG1-beta1), Neu differentiation factor (rat)
Amino Acid Sequence SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity The ED50 was determined by the dose-dependent stimulation of the proliferation of human MCF-7 cells is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant human Heregulin beta-1 (HRG1-beta1) is a 7.5 kDa polypeptide consisting of only the EGF domain of Heregulin beta-1 (65 amino acid residues).
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Human
Research Areas Angiogenesis/Cardiovascular; Apoptosis; Cancer; Proliferation; Stem Cells & Differentiation; Neurobiology
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.