Recombinant Human Growth Hormone (Carrier-free)
| Cat No. | Size | Price | Quantity | |
|---|---|---|---|---|
| 21-7147-U010 | 10 µg | $69.00 | ||
| 21-7147-U050 | 50 µg | $169.00 | ||
| 21-7147-U100 | 100 µg | $205.00 | ||
| 21-7147-U500 | 500 µg | $455.00 |
Technical Data Sheet
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Growth Hormone (GH), also known as somatotropin, is a secreted protein that is best known for stimulating the growth and differentiation of bone, cartilage and muscle. It stimulates the production of IGF-1, involved in the regulation of growth and metabolism. GH also can act on B cells, T cells, NK cells, macrophages and neutrophils to exert immunomodulatory actions directly or indirectly through IGF-1. Its varied functions are associated with binding to its receptor, which is present on a wide array of cell types. GH is synthesized by somatotropes in the anterior pituitary and is stored in secretory granules. Release into circulation is tightly regulated by hypothalamic hormones and other signals.
Growth Hormone (GH), also known as somatotropin, is a secreted protein that is best known for stimulating the growth and differentiation of bone, cartilage and muscle. It stimulates the production of IGF-1, involved in the regulation of growth and metabolism. GH also can act on B cells, T cells, NK cells, macrophages and neutrophils to exert immunomodulatory actions directly or indirectly through IGF-1. Its varied functions are associated with binding to its receptor, which is present on a wide array of cell types. GH is synthesized by somatotropes in the anterior pituitary and is stored in secretory granules. Release into circulation is tightly regulated by hypothalamic hormones and other signals.
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Product Details
| Name | Recombinant Human Growth Hormone (Carrier-free) |
|---|---|
| Cat. No. | 21-7147 |
| Alternative Names | GH1, GH, Somatotrophin, GH-N, Pituitary Growth Hormone, HGH |
| Amino Acid Sequence | MFPTIPLSRL FDNAMLRAHR LHQLAFDTYQ EFEEAYIPKE QKYSFLQNPQ TSLCFSESIP TPSNREETQQ KSNLELLRIS LLLIQSWLEP VQFLRSVFAN SLVYGASDSN VYDLLKDLEE GIQTLMGRLE DGSPRTGQIF KQTYSKFDTN SHNDDALLKN YGLLYCFRKD MDKVETFLRI VQCRSVEGSC GF |
| Authenticity | Verified by N-terminal and Mass Spectrometry analyses (when applicable). |
| Bioactivity | The expected ED50 of ≤ 0.05 ng/ml is determined by its ability to stimulate the proliferation of Nb2-11 cells in rat, and corresponds to a specific activity of ≥ 2 x 107 units/mg. |
| Endotoxin Level | Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg). |
| Molecular Mass | Recombinant Human Growth Hormone is a non-glycosylated polypeptide consisting of 192 amino acids and has a molecular weight of ≥ 22.3 kDa. |
| Protein Content | Verified by UV Spectroscopy and/or SDS-PAGE gel. |
| Purity (%) | 98 |
| Source | E. coli |
| Reactivity | Human |
| Research Areas | Proliferation, Immune System, Bone and Cartilage, Chemotaxis, Wound Healing, AIDS/HIV, Cell Culture |
| Reconstitution | See Certificate of Analysis (COA) for lot specific reconstitution information. |
| Application | Bioassay |
Application Key:
FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy
*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.