Recombinant Human GDF-15/MIC-1 (CHO derived) (Carrier-free)
  • Recombinant Human GDF-15/MIC-1 (CHO derived) (Carrier-free)

Recombinant Human GDF-15/MIC-1 (CHO derived) (Carrier-free)

Cat No. Size Price Quantity
21-9224-U005 5 µg $70.00
21-9224-U020 20 µg $180.00
21-9224-U100 100 µg $800.00
21-9224-U250 250 µg $1,750.00
21-9224-U500 500 µg $3,050.00
21-9224-M001 1 mg $4,900.00
Lead time: 2-3 business days

Description

Growth/differentiation factor-15 (GDF-15), also named macrophage inhibitory cytokine-1 (MIC-1), is a member of the transforming growth factor β superfamily, whose members play an important role during prenatal development and postnatal growth, and the remodeling and maintenance of a variety of tissues and organs. GDF-15 is expressed predominantly in the placenta and, to a much lesser extent, in various other tissues. GDF-15 has become an emerging marker of early heart disease and has the potential as being used as a molecule for screening patients for early heart failure. Recombinant Human GDF-15/MIC-1 is a disulfide-linked homodimeric protein consisting of two 112 amino acid polypeptide chains.  The calculated molecular weight of Recombinant Human GDF-15/MIC-1 is 24.6 kDa.
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Growth/differentiation factor-15 (GDF-15), also named macrophage inhibitory cytokine-1 (MIC-1), is a member of the transforming growth factor β superfamily, whose members play an important role during prenatal development and postnatal growth, and the remodeling and maintenance of a variety of tissues and organs. GDF-15 is expressed predominantly in the placenta and, to a much lesser extent, in various other tissues. GDF-15 has become an emerging marker of early heart disease and has the potential as being used as a molecule for screening patients for early heart failure. Recombinant Human GDF-15/MIC-1 is a disulfide-linked homodimeric protein consisting of two 112 amino acid polypeptide chains.  The calculated molecular weight of Recombinant Human GDF-15/MIC-1 is 24.6 kDa.
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Product Details

Name Recombinant Human GDF-15/MIC-1 (CHO derived) (Carrier-free)
Cat. No. 21-9224
Alternative Names Growth/Differentiation Factor-15, MIC-1, Macrophage Inhibitory Cytokine 1, Placental TGFβ, Prostate Differentiation Factor (PDF), PLAB, NRG-1
Amino Acid Sequence ARNGDHCPLG PGRCCRLHTV RASLEDLGWA DWVLSPREVQ VTMCIGACPS QFRAANMHAQ IKTSLHRLKP DTVPAPCCVP ASYNPMVLIQ KTDTGVSLQT YDDLLAKDCH CI
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity Determined by its ability to inhibit alkaline phosphatase activity in differentiating MC3T3/E1 osteoblastcells. The expected ED50 for this effect is 75-200 ng/ml.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass 24.6 kDa
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 95
Source CHO
Reactivity Human
Research Areas Cell Culture, Stem Cells & Differentiation, TGF-β Superfamily
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.