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Recombinant Human Furin (Carrier-free)
  • Recombinant Human Furin (Carrier-free)

Recombinant Human Furin (Carrier-free)

Cat No. Size Price Quantity
21-7106-U002 2 µg $76.00
21-7106-U010 10 µg $179.00
21-7106-U100 100 µg $925.00
21-7106-U500 500 µg $2,750.00

Description

Furin is a member of the subtilisin-like proprotein convertase (PC) family, a part of the subtilisin superfamily of serine proteases. It is a type I membrane bound calcium-dependent protease and is expressed in tissues including liver, gut, brain and neuroendocrine. It is localized in the Golgi apparatus and functions to cleave various proproteins with a specific recognition sequence into their mature forms. Substrates are involved in various secretory pathways and include proalbumin, membrane type-1 matrix metalloproteinase, von Willebrand factor and proparathyroid hormone.
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Furin is a member of the subtilisin-like proprotein convertase (PC) family, a part of the subtilisin superfamily of serine proteases. It is a type I membrane bound calcium-dependent protease and is expressed in tissues including liver, gut, brain and neuroendocrine. It is localized in the Golgi apparatus and functions to cleave various proproteins with a specific recognition sequence into their mature forms. Substrates are involved in various secretory pathways and include proalbumin, membrane type-1 matrix metalloproteinase, von Willebrand factor and proparathyroid hormone.
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Product Details

Name Recombinant Human Furin (Carrier-free)
Cat. No. 21-7106
Alternative Names FUR, PACE, paired basic amino acid cleaving enzyme, PCSK3, PCSK3furin, proprotein convertase subtilisin/kexin type 3, FURdibasic processing enzyme, SPC1
Amino Acid Sequence DLNVKAAWAQ GYTGHGIVVS ILDDGIEKNH PDLAGNYDPG ASFDVNDQDP DPQPRYTQMN DNRHGTRCAG EVAAVANNGV CGVGVAYNAR IGGVRMLDGE VTDAVEARSL GLNPNHIHIY SASWGPEDDG KTVDGPARLA EEAFFRGVSQ GRGGLGSIFV WASGNGGREH DSCNCDGYTN SIYTLSISSA TQFGNVPWYS EACSSTLATT YSSGNQNEKQ IVTTDLRQKC TE
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity Activity is determined by measuring the ability to cleave Boc-Arg-Val-Arg-Arg-AMC (Bachem Catalog# I-1645.0025), a fluorogenic peptide substrate.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant Human Furin corresponds to residues 131 through 715 of the Furin precursor, plus a C-terminal His-tag, resulting in a 63.9 kDa protein.
Protein Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 95
Source Hi-5 insect cells
Reactivity Human
Research Areas Cancer, Neurobiology
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.