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Recombinant Human EPO (Carrier-free)

Cat No. Size Price Quantity
21-8992-U010 10 µg $175.00
21-8992-U050 50 µg $475.00

Description

Erythropoietin (EPO) is a secreted, glycosylated growth factor that plays an important role in erythropoiesis, where it is the major regulator for stimulating proliferation and differentiation of erythroid progenitor cells. EPO induces the final maturation of partially differentiated erythroid cells and the production of red cell-specific proteins, such as hemoglobin. The protein is found in the plasma, and physiological levels of EPO in adult mammals are maintained primarily by the kidneys, whereas levels in fetal or neonatal mammals are maintained by the liver. EPO may also exert various non-hematopoietic activities, including neuroprotective activity from damage and initiation of repair.
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Erythropoietin (EPO) is a secreted, glycosylated growth factor that plays an important role in erythropoiesis, where it is the major regulator for stimulating proliferation and differentiation of erythroid progenitor cells. EPO induces the final maturation of partially differentiated erythroid cells and the production of red cell-specific proteins, such as hemoglobin. The protein is found in the plasma, and physiological levels of EPO in adult mammals are maintained primarily by the kidneys, whereas levels in fetal or neonatal mammals are maintained by the liver. EPO may also exert various non-hematopoietic activities, including neuroprotective activity from damage and initiation of repair.
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Product Details

Name Recombinant Human EPO (Carrier-free)
Cat. No. 21-8992
Alternative Names Erythropoietin, Epoetin
Amino Acid Sequence APPRLICDSR VLERYLLEAK EAENITTGCA EHCSLNENIT VPDTKVNFYA WKRMEVGQQA VEVWQGLALL SEAVLRGQAL LVNSSQPWEP LQLHVDKAVS GLRSLTTLLR ALGAQKEAIS PPDAASAAPL RTITADTFRK LFRVYSNFLR GKLKLYTGEA CRTGDR
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity Determined by a cell proliferation assay using TF-1 cells. The expected ED50 for this effect is 0.8-1.0 ng/ml.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass This recombinant human EPO contains 166 amino acid residues and has a calculated molecular weight of approximately 18.4 kDa. As a result of glycosylation, Recombinant Human EPO migrates with an apparent molecular mass of 37.0 kDa by SDS-PAGE gel, under re
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 90
Source CHO cells
Reactivity Human
Research Areas Angiogenesis/Cardiovascular; Proliferation; Neurobiology; Stem Cells & Differentiation
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.