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Recombinant Human Endostatin (Carrier-free)
  • Recombinant Human Endostatin (Carrier-free)

Recombinant Human Endostatin (Carrier-free)

Cat No. Size Price Quantity
21-7182-U020 20 µg $76.00
21-7182-U100 100 µg $179.00
21-7182-U500 500 µg $635.00
21-7182-M001 1 mg $1,035.00

Description

Endostatin is a C-terminal proteolytic fragment of collagen XVIII ?1 (Col 18) that is localized in the vascular basement membrane of almost all epithelia and endothelia.Expressed in multiple organs, its highest levels of expression are in liver, lung and kidney. Endostatin is known to inhibit proliferation, migration, and tubule formation of endothelial cells and is an endogenous inhibitor of angiogenesis. Since tumor growth and metastasis relies on angiogenesis to provide blood supply, Endostatin is inhibitory for a wide variety of primary and metastatic tumors.
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Endostatin is a C-terminal proteolytic fragment of collagen XVIII ?1 (Col 18) that is localized in the vascular basement membrane of almost all epithelia and endothelia.Expressed in multiple organs, its highest levels of expression are in liver, lung and kidney. Endostatin is known to inhibit proliferation, migration, and tubule formation of endothelial cells and is an endogenous inhibitor of angiogenesis. Since tumor growth and metastasis relies on angiogenesis to provide blood supply, Endostatin is inhibitory for a wide variety of primary and metastatic tumors.
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Product Details

Name Recombinant Human Endostatin (Carrier-free)
Cat. No. 21-7182
Alternative Names COL18A1
Amino Acid Sequence MHSHRDFQPV LHLVALNSPL SGGMRGIRGA DFQCFQQARA VGLAGTFRAF LSSRLQDLYS IVRRADRAAV PIVNLKDELL FPSWEALFSG SEGPLKPGAR IFSFDGKDVL RHPTWPQKSV WHGSDPNGRR LTESYCETWR TEAPSATGQA SSLLGGRLLG QSAASCHHAY IVLCIENSFM TASK
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity Measured by its ability to inhibit HUVEC migration.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant Human Endostatin is a 20.2 kDa protein consisting of 184 amino acid residues.
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E.coli
Reactivity Human
Research Areas Angiogenesis & Cardiovascular
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.