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Recombinant Human EGFR (Carrier-free)
  • Recombinant Human EGFR (Carrier-free)

Recombinant Human EGFR (Carrier-free)

Cat No. Size Price Quantity
21-7103-U002 2 µg $69.00
21-7103-U010 10 µg $175.00
21-7103-U100 100 µg $765.00
21-7103-U500 500 µg $2,295.00

Description

The EGF Receptor (EGFR) is one of the four members of the EGFR subfamily of receptor tyrosine kinases. It is a transmembrane glycoprotein expressed on the cell surface and is a receptor for EGF and at least six other structurally related ligands including amphiregulin, betacellulin and TGF-alpha. Binding of EGFR to one of these ligands induces receptor dimerization and tyrosine autophosphorylation, leading to cell proliferation. It is involved in regulation of other functions including differentiation, survival, motility and apoptosis. EGFR has been found to be overexpressed in many tumors.
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The EGF Receptor (EGFR) is one of the four members of the EGFR subfamily of receptor tyrosine kinases. It is a transmembrane glycoprotein expressed on the cell surface and is a receptor for EGF and at least six other structurally related ligands including amphiregulin, betacellulin and TGF-alpha. Binding of EGFR to one of these ligands induces receptor dimerization and tyrosine autophosphorylation, leading to cell proliferation. It is involved in regulation of other functions including differentiation, survival, motility and apoptosis. EGFR has been found to be overexpressed in many tumors.
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Product Details

Name Recombinant Human EGFR (Carrier-free)
Cat. No. 21-7103
Alternative Names Epidermal Growth Factor Receptor, ErbB1, Receptor Tyrosine Protein Kinase ErbB1, HER-1, mENA
Amino Acid Sequence LEEKKVCQGT SNKLTQLGTF EDHFLSLQRM FNNCEVVLGN LEITYVQRNY DLSFLKTIQE VAGYVLIALN TVERIPLENL QIIRGNMYYE NSYALAVLSN YDANKTGLKE LPMRNLQEIL HGAVRFSNNP ALCNVESIQW RDIVSSDFLS NMSMDFQNHL GSCQKCDPSC PNGSCWGAGE ENCQKLTKII CAQQCSGRCR GKSPSDCCHN QCAAGCTGPR ESDCLVCRKF RD
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity Testing in progress.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant soluble Human EGFR comprises the extracellular domain of EGFR and is 621 amino acids in length. Under reducing conditions it migrates at approximately 97.5 kDa by SDS-PAGE analysis.
Protein Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 95
Source CHO cells
Reactivity Human
Research Areas Angiogenesis & Cardiovascular, Cancer, Differentiation,? Inflammation, Neurobiology, Stem Cells, Wound Healing
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.