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Recombinant Human EGF-L7 (Carrier-free)
  • Recombinant Human EGF-L7 (Carrier-free)

Recombinant Human EGF-L7 (Carrier-free)

Cat No. Size Price Quantity
21-7181-U002 2 µg $76.00
21-7181-U010 10 µg $175.00
21-7181-U100 100 µg $585.00
21-7181-U500 500 µg $1,750.00

Description

EGF-L7 also known as VE-Statin (vascular endothelia cell statin) is a secreted glycoprotein belonging to the family of EGF-like domain-containing proteins. EGF-L7 is a multi-domain protein containing two EGF-like domains and one EMI domain. Almost exclusively expressed in endothelial cells, it is commonly used as an early marker of embryonic endothelial cells. In adult endothelial cells, although downregulated, it is still detectable in blood vessels of lung, heart and kidney. EGF-L7’s primary function is to promote normal development of the vascular system, particularly tubulogenesis. An up-regulation of EGF-L7 is observed in endothelial cells during vascular remodeling tissues, such as regenerating endothelium of the artery and atherosclerotic plaques. EGF-L7 interacts with Notch receptors and overexpression has be shown to inhibit the Notch pathway in HUVEC and neural stem cells. In HCAEC (human coronary artery endothelial cells), EGF-L7 inhibits hypoxia/re-oxygenation, ICAM-1 expression, NF-κB nuclear translocation and decrease of I?B? expression. Additionally, EGF-L7 can chemoattract endothelial cells and bind to the extracellular matrix. Overexpression of EGF-L7 is generally correlated with increased metastasis and a poor prognosis in growing tumors.
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EGF-L7 also known as VE-Statin (vascular endothelia cell statin) is a secreted glycoprotein belonging to the family of EGF-like domain-containing proteins. EGF-L7 is a multi-domain protein containing two EGF-like domains and one EMI domain. Almost exclusively expressed in endothelial cells, it is commonly used as an early marker of embryonic endothelial cells. In adult endothelial cells, although downregulated, it is still detectable in blood vessels of lung, heart and kidney. EGF-L7’s primary function is to promote normal development of the vascular system, particularly tubulogenesis. An up-regulation of EGF-L7 is observed in endothelial cells during vascular remodeling tissues, such as regenerating endothelium of the artery and atherosclerotic plaques. EGF-L7 interacts with Notch receptors and overexpression has be shown to inhibit the Notch pathway in HUVEC and neural stem cells. In HCAEC (human coronary artery endothelial cells), EGF-L7 inhibits hypoxia/re-oxygenation, ICAM-1 expression, NF-κB nuclear translocation and decrease of I?B? expression. Additionally, EGF-L7 can chemoattract endothelial cells and bind to the extracellular matrix. Overexpression of EGF-L7 is generally correlated with increased metastasis and a poor prognosis in growing tumors.
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Product Details

Name Recombinant Human EGF-L7 (Carrier-free)
Cat. No. 21-7181
Alternative Names Epidermal growth factor-like protein 7, MEGF7, Multiple EGF-like domains protein 7, NOTCH4-like protein, VE-statin, Zneu1
Amino Acid Sequence MYRPGRRVCA VRAHGDPVSE SFVQRVYQPF LTTCDGHRAC STYRTIYRTA YRRSPGLAPA RPRYACCPGW KRTSGLPGAC GAAICQPPCR NGGSCVQPGR CRCPAGWRGD TCQSDVDECS ARRGGCPQRC VNTAGSYWCQ CWEGHSLSAD GTLCVPKGGP PRVAPNPTGV DSAMKEEVQR LQSRVDLLEE KLQLVLAPLH SLASQALEHG LPDPGSLLVH SFQQLGRIDS LS
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity Data Not Available.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant Human EGF-L7 is a 27.4 kDa protein containing 251 amino acid residues.
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E.coli
Reactivity Human
Research Areas Angiogenesis & Cardiovascular, Cancer, Chemotaxis, Inflammation, Stem Cells & Differentiation
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.