Customer Service: (855) 848-6626 | 8:00 a.m - 4:30 p.m. PST | Save 35% on Ghost Dyes™

Recombinant Human E-selectin (Carrier-free)
  • Recombinant Human E-selectin (Carrier-free)

Recombinant Human E-selectin (Carrier-free)

Cat No. Size Price Quantity
21-7178-U010 10 µg $76.00
21-7178-U050 50 µg $179.00
21-7178-U100 100 µg $280.00
21-7178-U500 500 µg $859.00

Description

E-selectin (CD62E) is a member of the calcium-dependent selectin family. E-selectin, a cell adhesion surface glycoprotein, is also known as endothelial-leukocyte adhesion molecule-1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2). E-selectin is expressed on cytokine activated endothelial cells playing a critical role in inflammation. E-selectin recognizes and binds to sialylated carbohydrates present on the surface proteins expressed by neutrophils, monocytes, eosinophils, memory-effector T-like lymphocytes, and natural killer cells. Macrophage release of cytokines induces the over-expression of E-selectin on endothelial cells of nearby blood vessels. Along with other selectins, E-selectin recruits circulating leukocytes to the site of inflammation. E-selectin is associated with metastatic dissemination of tumor cells by facilitating their escape from the location of the primary tumor. Recombinant Human E-selectin comprises the extracellular signaling domain of the E-selectin protein.
View More
E-selectin (CD62E) is a member of the calcium-dependent selectin family. E-selectin, a cell adhesion surface glycoprotein, is also known as endothelial-leukocyte adhesion molecule-1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2). E-selectin is expressed on cytokine activated endothelial cells playing a critical role in inflammation. E-selectin recognizes and binds to sialylated carbohydrates present on the surface proteins expressed by neutrophils, monocytes, eosinophils, memory-effector T-like lymphocytes, and natural killer cells. Macrophage release of cytokines induces the over-expression of E-selectin on endothelial cells of nearby blood vessels. Along with other selectins, E-selectin recruits circulating leukocytes to the site of inflammation. E-selectin is associated with metastatic dissemination of tumor cells by facilitating their escape from the location of the primary tumor. Recombinant Human E-selectin comprises the extracellular signaling domain of the E-selectin protein.
Hide

Product Details

Name Recombinant Human E-selectin (Carrier-free)
Cat. No. 21-7178
Alternative Names Endothelial leukocyte adhesion molecule 1 (ELAM1), CD62E, SELE
Amino Acid Sequence WSYNTSTEAM TYDEASAYCQ QRYTHLVAIQ NKEEIEYLNS ILSYSPSYYW IGIRKVNNVW VWVGTQKPLT EEAKNWAPGE PNNRQKDEDC VEIYIKREKD VGMWNDERCS KKKLALCYTA ACTNTSCSGH GECVETINNY TCKCDPGFSG LKCEQIVNCT ALESPEHGSL VCSHPLGNFS YNSSCSISCD RGYLPSSMET MQCMSSGEWS APIPACNVVE CDAVTNPANG FV
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity Measured by its ability to support adhesion of U937 cells, a human hystiocytic lymphoma cell line.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant Human E-selectin is a 58.6 kDa protein containing 535 amino acid residues, corresponding to the extracellular portion of the full length protein. The 58.6 kDa protein migrates under reducing conditions at an apparent molecular weight of approx
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 95
Source CHO cells
Reactivity Human
Research Areas Angiogensis & Cardiovascular, Chemotaxis, Inflammation
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.