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Recombinant Human Chemerin (Carrier-free)
  • Recombinant Human Chemerin (Carrier-free)

Recombinant Human Chemerin (Carrier-free)

Cat No. Size Price Quantity
21-7145-U005 5 µg $76.00
21-7145-U025 25 µg $175.00
21-7145-U100 100 µg $585.00
21-7145-U500 500 µg $1,750.00

Description

Chemerin, an adipokine and member of the Cystatin superfamily, is highly expressed in white adipose tissue. It is a ligand for the GPCR ChemR23 (CMKLR1, DEZ) and it acts as a chemoattractant for cells expressing this receptor. Chemerin is a secreted protein that, after cleavage by serine protease, becomes an active protein that can be found in plasma and serum. Studies show bioactive chemerin generation occurs during the early stages of inflammation, implicating a role as a bridge between ≥ ≥ ≥ innate and adaptive immunity.
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Chemerin, an adipokine and member of the Cystatin superfamily, is highly expressed in white adipose tissue. It is a ligand for the GPCR ChemR23 (CMKLR1, DEZ) and it acts as a chemoattractant for cells expressing this receptor. Chemerin is a secreted protein that, after cleavage by serine protease, becomes an active protein that can be found in plasma and serum. Studies show bioactive chemerin generation occurs during the early stages of inflammation, implicating a role as a bridge between ≥ ≥ ≥ innate and adaptive immunity.
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Product Details

Name Recombinant Human Chemerin (Carrier-free)
Cat. No. 21-7145
Alternative Names RARRES2, Retinoic Acid Receptor Responder Protein 2, Zarotene-induced Gene 2 (TIG2)
Amino Acid Sequence ELTEAQRRGL QVALEEFHKH PPVQWAFQET SVESAVDTPF PAGIFVRLEF KLQQTSCRKR DWKKPECKVR PNGRKRKCLA CIKLGSEDKV LGRLVHCPIE TQVLREAEEH QETQCLRVQR AGEDPHSFYF PGQFA
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity Within a concentration range of 1.0-100.0 ng/ml, the ability to chemoattract human immature dendritic cells is determined.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant Human Chemerin consists of 135 amino acids, resulting in a 15.6 kDa protein.
Protein Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Human
Research Areas Immune System, Chemotaxis, Diabetes, Lipid Metabolism
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.