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Recombinant Human CDNF (Carrier-free)
  • Recombinant Human CDNF (Carrier-free)

Recombinant Human CDNF (Carrier-free)

Cat No. Size Price Quantity
21-7099-U005 5 µg $76.00
21-7099-U025 25 µg $175.00
21-7099-U100 100 µg $585.00
21-7099-U500 500 µg $1,795.00

Description

Cerebral Dopamine Neurotrophic Factor (CDNF), also known as ARMETL1, is a novel secreted protein that exhibits strong trophic activity on dopaminergic neurons, comparable to that of GDNF. It is structurally similar to MANF. This conserved neurotrophic factor promotes the survival, growth and function of dopaminergic neurons. Besides neurons, it is widely expressed in brain regions including cerebral cortex, cerebellum and hippocampus.
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Cerebral Dopamine Neurotrophic Factor (CDNF), also known as ARMETL1, is a novel secreted protein that exhibits strong trophic activity on dopaminergic neurons, comparable to that of GDNF. It is structurally similar to MANF. This conserved neurotrophic factor promotes the survival, growth and function of dopaminergic neurons. Besides neurons, it is widely expressed in brain regions including cerebral cortex, cerebellum and hippocampus.
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Product Details

Name Recombinant Human CDNF (Carrier-free)
Cat. No. 21-7099
Alternative Names Cerebral dopamine neurotrophic factor, Conserved dopamine neurotrophic factor, ARMETL1, arginine-rich, mutated in early stage tumors-like 1
Amino Acid Sequence MQEAGGRPGA DCEVCKEFLN RFYKSLIDRG VNFSLDTIEK ELISFCLDTK GKENRLCYYL GATKDAATKI LSEVTRPMSV HMPAMKICEK LKKLDSQICE LKYEKTLDLA SVDLRKMRVA ELKQILHSWG EECRACAEKT DYVNLIQELA PKYAATHPKT EL
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity The expected ED50 is 15-25 μg/ml, as determined by the ability to stimulate the proliferation of rat C6 cells.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant Human CDNF is comprised of 162 amino acids that result in an 18.5 kDa protein.
Protein Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Human
Research Areas Neurobiology, Stem Cells, Differentiation
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.