Recombinant Human C1 Inhibitor (Carrier-free)
| Cat No. | Size | Price | Quantity | |
|---|---|---|---|---|
| 21-7138-U050 | 50 µg | $76.00 | ||
| 21-7138-U200 | 200 µg | $175.00 | ||
| 21-7138-U500 | 500 µg | $455.00 | ||
| 21-7138-M001 | 1 mg | $800.00 |
Lead time: 2-3 business days
Technical Data Sheet
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C1 Inhibitor, a highly glycosylated protein, is a serine protease inhibitor belonging to the serpin superfamily. It regulates the immune complement system by acting as a protease inhibitor within the C1 complex, binding the C1r and C1s proteases. It also inhibits the contact system proteases Kallikrein and factor XIIa. C1 inhibitor deficiency results in hereditary angioedema (HAE), and for certain types of the disease C1 inhibitor concentrate may be used therapeutically.
C1 Inhibitor, a highly glycosylated protein, is a serine protease inhibitor belonging to the serpin superfamily. It regulates the immune complement system by acting as a protease inhibitor within the C1 complex, binding the C1r and C1s proteases. It also inhibits the contact system proteases Kallikrein and factor XIIa. C1 inhibitor deficiency results in hereditary angioedema (HAE), and for certain types of the disease C1 inhibitor concentrate may be used therapeutically.
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Product Details
| Name | Recombinant Human C1 Inhibitor (Carrier-free) |
|---|---|
| Cat. No. | 21-7138 |
| Alternative Names | serpin peptidase inhibitor clade G, serpin G1, C1IN, HEA1, HAE2, C1INH |
| Amino Acid Sequence | VEPILEVSSL PTTNSTTNSA TKITANTTDE PTTQPTTEPT TQPTIQPTQP TTQLPTDSPT QPTTGSFCPG PVTLCSDLES HSTEAVLGDA LVDFSLKLYH AFSAMKKVET NMAFSPFSIA SLLTQVLLGA GENTKTNLES ILSYPKDFTC VHQALKGFTT KGVTSVSQIF HSPDLAIRDT FVNASRTLYS SSPRVLSNNS DANLELINTW VAKNTNNKIS RLLDSLPSDT RL |
| Authenticity | Verified by N-terminal and Mass Spectrometry analyses (when applicable). |
| Bioactivity | Expected IC50 is ? 2.6 nM and is measured by its ability to inhibit recombinant human complement component C1a cleavage of the N Carbobenzyloxy-Lys-ThioBenzyl ester (Z-K-SBzl) substrate. |
| Endotoxin Level | Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg). |
| Molecular Mass | Recombinant Human C1 Inhibitor corresponds to amino acids 56 – 500 of the C1 inhibitor precursor, resulting in a molecular weight of 49.4 kDa. It retains functionality, based on its ability to inhibit the C1 complex. Due to glycoslyation, it migrates at 8 |
| Protein Content | Verified by UV Spectroscopy and/or SDS-PAGE gel. |
| Purity (%) | 95 |
| Source | CHO cells |
| Reactivity | Human |
| Research Areas | Apoptosis, Inflammation, Immune System |
| Reconstitution | See Certificate of Analysis (COA) for lot specific reconstitution information. |
| Application | Bioassay |
Application Key:
FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy
*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.