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Recombinant Human BD-5 (Carrier-Free)
  • Recombinant Human BD-5 (Carrier-Free)

Recombinant Human BD-5 (Carrier-Free)

Cat No. Size Price Quantity
21-9175-U005 5 µg $80.00
21-9175-U020 20 µg $195.00
21-9175-U100 100 µg $600.00
21-9175-U500 500 µg $1,800.00

Description

Defensins (? and ?) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The ?-defensins are distinguished from the ?-defensins by the pairing of their three disulfide bonds. To date, six human ?-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6. ?-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells. The ?-defensin proteins are expressed as the C-terminal portion of precursors, and are released by proteolytic cleavage of a signal sequence and, in some cases, a propeptide sequence. ?-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds.
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Defensins (? and ?) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The ?-defensins are distinguished from the ?-defensins by the pairing of their three disulfide bonds. To date, six human ?-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6. ?-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells. The ?-defensin proteins are expressed as the C-terminal portion of precursors, and are released by proteolytic cleavage of a signal sequence and, in some cases, a propeptide sequence. ?-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds.
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Product Details

Name Recombinant Human BD-5 (Carrier-Free)
Cat. No. 21-9175
Alternative Names BD5, DEFB5, DEFB105a, Beta-Defensin 5
Amino Acid Sequence GLDFSQPFPS GEFAVCESCK LGRGKCRKEC LENEKPDGNC RLNFLCCRQR I
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity Data not available at this time.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant Human BD-5 is a 57.8 kDa protein containing 51 amino acid residues.
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Human
Research Areas Immune System, Chemotaxis
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.