Recombinant Human APRIL (Carrier-free)
| Cat No. | Size | Price | Quantity | |
|---|---|---|---|---|
| 21-8124-U002 | 2 µg | $58.00 | ||
| 21-8124-U010 | 10 µg | $147.00 |
Technical Data Sheet
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APRIL, an acronym for a proliferation inducing ligand is a TNF-α superfamily molecule. APRIL is expressed in myeloid cells, monocytes, and macrophages and appears to be involved in tumor cell regulation. It is highly expressed in certain transformed cell lines, certain colon carcinomas, and lymphoid tissues. APRIL enhances tumor cell proliferation. APRIL competes with BAFF for two common receptors, TACI and BCMA, and also binds proteoglycans. Like BAFF, APRIL also appears to have anti-apoptotic effects, enhances B cell and plasma cell survival and maintenance and shares other common effects.
APRIL, an acronym for a proliferation inducing ligand is a TNF-α superfamily molecule. APRIL is expressed in myeloid cells, monocytes, and macrophages and appears to be involved in tumor cell regulation. It is highly expressed in certain transformed cell lines, certain colon carcinomas, and lymphoid tissues. APRIL enhances tumor cell proliferation. APRIL competes with BAFF for two common receptors, TACI and BCMA, and also binds proteoglycans. Like BAFF, APRIL also appears to have anti-apoptotic effects, enhances B cell and plasma cell survival and maintenance and shares other common effects.
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Product Details
| Name | Recombinant Human APRIL (Carrier-free) |
|---|---|
| Cat. No. | 21-8124 |
| Alternative Names | |
| Amino Acid Sequence | AVLTQKQKKQ HSVLHLVPIN ATSKDDSDVT EVMWQPALRR GRGLQAQGYG VRIQDAGVYL LYSQVLFQDV TFTMGQVVSR EGQGRQETLF RCIRSMPSHP DRAYNSCYSA GVFHLHQGDI LSVIIPRARA KLNLSPHGTF LGFVKL |
| Authenticity | Verified by N-terminal and Mass Spectrometry analyses (when applicable). |
| Bioactivity | Measured by its ability to induce cell death in Jurkat cells. |
| Endotoxin Level | Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg). |
| Molecular Mass | This recombinant protein is 146 amino acid residues with a molecular weight of 16.3 kDa. |
| Protein Content | Content Verified by UV Spectroscopy and/or SDS-PAGE gel. |
| Purity (%) | 95 |
| Source | Hi-5 Insect cells |
| Reactivity | Human |
| Research Areas | Apoptosis; Cancer; Immune System; TNF-α Superfamily |
| Reconstitution | See Certificate of Analysis (COA) for lot specific reconstitution information. |
| Application | Bioassay |
Application Key:
FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy
*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.