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Recombinant Human ANGPTL3 (Carrier-free)
  • Recombinant Human ANGPTL3 (Carrier-free)

Recombinant Human ANGPTL3 (Carrier-free)

Cat No. Size Price Quantity
21-7169-U010 10 µg $76.00
21-7169-U050 50 µg $179.00
21-7169-U100 100 µg $280.00
21-7169-U500 500 µg $859.00
Lead time: 2-3 business days

Description

ANGPTL3 (Angiopoietin-Like Protein 3) is a secreted glycoprotein structurally related to the angiopoietin family of growth factors, but does not bind the angiopoietin-specific receptors Tie-2 or Tie-1. ANGPTL3 is expressed primarily in the liver during early liver development and throughout adulthood. It is found in full-length, C-terminal (fibrinogen-like) and N-terminal (coiled) formats in plasma. It is a lipoprotein lipase (LPL) inhibitor, promoting an increase in circulating triglyceride levels. ANGPTL3 also plays a role in angiogenesis, with the fibrinogen-like domain binding to integrin αalpha V, beta 3 and inducing adhesion and migration of endothelial cells.
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ANGPTL3 (Angiopoietin-Like Protein 3) is a secreted glycoprotein structurally related to the angiopoietin family of growth factors, but does not bind the angiopoietin-specific receptors Tie-2 or Tie-1. ANGPTL3 is expressed primarily in the liver during early liver development and throughout adulthood. It is found in full-length, C-terminal (fibrinogen-like) and N-terminal (coiled) formats in plasma. It is a lipoprotein lipase (LPL) inhibitor, promoting an increase in circulating triglyceride levels. ANGPTL3 also plays a role in angiogenesis, with the fibrinogen-like domain binding to integrin αalpha V, beta 3 and inducing adhesion and migration of endothelial cells.
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Product Details

Name Recombinant Human ANGPTL3 (Carrier-free)
Cat. No. 21-7169
Alternative Names Angiopoietin-Like Protein 3, ANGPT5, Ang-5, Angiopoietin-5, FHBL2, ANL3
Amino Acid Sequence SRIDQDNSSF DSLSPEPKSR FAMLDDVKIL ANGLLQLGHG LKDFVHKTKG QINDIFQKLN IFDQSFYDLS LQTSEIKEEE KELRRTTYKL QVKNEEVKNM SLELNSKLES LLEEKILLQQ KVKYLEEQLT NLIQNQPETP EHPEVTSLKT FVEKQDNSIK DLLQTVEDQY KQLNQQHSQI KEIENQLRRT SIQEPTEISL SSKPRAPRTT PFLQLNEIRN VKHDGIPAEC TT
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity The ability to bind recombinant integrin αalpha V, beta 3 is measured through a functional ELISA.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant Human ANGPTL3 contains a C-terminal His-tag and is comprised of 452 amino acids. It migrates at approximately 62 kDa by SDS-PAGE.
Protein Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source CHO cells
Reactivity Human
Research Areas Diabetes, Angiogensis & Cardiovascular, Lipid Metabolism
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.