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Recombinant Human Activin B (Carrier-free)
  • Recombinant Human Activin B (Carrier-free)

Recombinant Human Activin B (Carrier-free)

Cat No. Size Price Quantity
21-7094-U001 1 µg $69.00
21-7094-U005 5 µg $175.00
21-7094-U100 100 µg $1,800.00
21-7094-U500 500 µg $5,600.00

Description

Activin B is a TGF-beta family member that exerts a wide array of biological activities including regulation of cell proliferation and differentiation, apoptosis and metabolism. Activins exist as homodimers or heterodimers of the four mammalian beta-subunit isoforms. Activin B is a homodimer of the beta-B subunit. Activin protein complexes are closely related to inhibins, which consist of one of the beta-subunits paired with a unique alpha-subunit. Activin B binds the ActRII receptor, which then associates with ActRI to initiate signaling. Activins and inhibins are expressed by various cell types and mediate opposing biological effects.
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Activin B is a TGF-beta family member that exerts a wide array of biological activities including regulation of cell proliferation and differentiation, apoptosis and metabolism. Activins exist as homodimers or heterodimers of the four mammalian beta-subunit isoforms. Activin B is a homodimer of the beta-B subunit. Activin protein complexes are closely related to inhibins, which consist of one of the beta-subunits paired with a unique alpha-subunit. Activin B binds the ActRII receptor, which then associates with ActRI to initiate signaling. Activins and inhibins are expressed by various cell types and mediate opposing biological effects.
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Product Details

Name Recombinant Human Activin B (Carrier-free)
Cat. No. 21-7094
Alternative Names Activin beta-B, Inhibin beta-2
Amino Acid Sequence GLECDGRTNL CCRQQFFIDF RLIGWNDWII APTGYYGNYC EGSCPAYLAG VPGSASSFHT AVVNQYRMRG LNPGTVNSCC IPTKLSTMSM LYFDDEYNIV KRDVPNMIVE ECGCA
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity A specific activity of ≥ 5 x 105 units/mg corresponds to an ED50 of ≥ 2.0 ng/ml. This was determined by its ability to inhibit the proliferation of murine MPC-11 cells.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Human Activin B is a homodimer consisting of two beta-B subunits, each containing 115 amino acid residues. It has a molecular weight of ≥ 25.6 kDa.
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 95
Source (BTI-Tn-5B1-4) Hi-5 Insect cells
Reactivity Human
Research Areas Apoptosis, Neurobiology, Stem Cells, Differentiation, TGF-beta Superfamily
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.