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Recombinant Human 4-1BB Ligand (Carrier-free)
  • Recombinant Human 4-1BB Ligand (Carrier-free)

Recombinant Human 4-1BB Ligand (Carrier-free)

Cat No. Size Price Quantity
21-7135-U005 5 µg $76.00
21-7135-U020 20 µg $190.00
21-7135-U100 100 µg $555.00
21-7135-U500 500 µg $1,750.00

Description

4-1BB Ligand, also known as TNFSF9, is a type II surface glycoprotein expressed on activated T-cells and antigen presenting cells (APCs). As a member of the TNF-α superfamily, it functions in promoting CD4+ and CD8+ T cell cytokine production. 4-1BB/4-1BBL signaling also enhances cell proliferation and T cell effector function. A recent study shows that 4-1BBL expressed on T cells can restrict effector T cell development under tolerogenic conditions.
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4-1BB Ligand, also known as TNFSF9, is a type II surface glycoprotein expressed on activated T-cells and antigen presenting cells (APCs). As a member of the TNF-α superfamily, it functions in promoting CD4+ and CD8+ T cell cytokine production. 4-1BB/4-1BBL signaling also enhances cell proliferation and T cell effector function. A recent study shows that 4-1BBL expressed on T cells can restrict effector T cell development under tolerogenic conditions.
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Product Details

Name Recombinant Human 4-1BB Ligand (Carrier-free)
Cat. No. 21-7135
Alternative Names CD137L, TNFSF9, 4-1BBL, tumor necrosis factor ligand superfamily member 9
Amino Acid Sequence MREGPELSPD DPAGLLDLRQ GMFAQLVAQN VLLIDGPLSW YSDPGLAGVS LTGGLSYKED TKELVVAKAG VYYVFFQLEL RRVVAGEGSG SVSLALHLQP LRSAAGAAAL ALTVDLPPAS SEARNSAFGF QGRLLHLSAG QRLGVHLHTE ARARHAWQLT QGATVLGLFR VTPEIPAGLP SPRSE
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity The ED50 of ≥ 5-10 ng/ml is determined by measuring dose-dependent stimulation of human IL-8 in PBMC. Results may vary due to differences between ≥ ≥ ≥ PBMC donors.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant Human 4-1BB Ligand consists of 185 amino acids resulting in a 19.5 kDa protein.
Protein Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Human
Research Areas TNF-α Superfamily, Apoptosis, Angiogenesis & Cardiovascular, Immune System, Transplantation
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.