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C57Bl/6 splenocytes were stained with 0.25 ug PE Anti-Mouse CD40 (50-8050) (solid line) or 0.25 ug PE Rat IgG2a isotype control (dashed line).
  • C57Bl/6 splenocytes were stained with 0.25 ug PE Anti-Mouse CD40 (50-8050) (solid line) or 0.25 ug PE Rat IgG2a isotype control (dashed line).

PE Anti-Mouse CD40 (FGK45)

Cat No. Size Price Quantity
50-8050-U025 25 µg $65.00
50-8050-U100 100 µg $215.00

Description

The FGK45 antibody reacts with mouse CD40, a 40-50 kDa glycoprotein member of the tumor necrosis factor receptor (TNFR) family. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells, and macrophages. The interaction of CD40 and its ligand CD154, expressed on activated T cells, plays an essential role in mediating a broad range of immune and inflammatory responses including T cell dependent immunoglobulin class switching, germinal center formation, and the development of memory B cells.

The FGK45 clone is reported to be functionally useful for both in vitro and in vivo activation of CD40 expressing antigen presenting cells.

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The FGK45 antibody reacts with mouse CD40, a 40-50 kDa glycoprotein member of the tumor necrosis factor receptor (TNFR) family. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells, and macrophages. The interaction of CD40 and its ligand CD154, expressed on activated T cells, plays an essential role in mediating a broad range of immune and inflammatory responses including T cell dependent immunoglobulin class switching, germinal center formation, and the development of memory B cells.

The FGK45 clone is reported to be functionally useful for both in vitro and in vivo activation of CD40 expressing antigen presenting cells.

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Product Details

Name PE Anti-Mouse CD40 (FGK45)
Cat. No. 50-8050
Alternative Names Bp50, gp39, HIGM1, IGM, IMD3, T-BAM, TRAP, TNFRSF5, p50, FGK4.5
Gene ID 21939
Clone FGK45
Isotype Rat IgG2a
Reactivity Mouse
Cross Reactivity
Format PE
Application Flow Cytometry
Citations*

Shepherd DM, Kerkvliet NI. 1999. J Immunol. Sep 1;163(5):2470-2477.

Mauri C, Mars LT, Londei M. 2000. Nat Med. Jun;6(6):673-679.

Hellings PW, Kasran A, Bullens D, Overbergh L, Mathieu C, Heremans H, Matthys P, Boon L, Jorissen M, Ceuppens JL. 2006. J Immunol. Oct 15;177(8):5138-5144.

Bartholdy C, Kauffmann SO, Christensen JP, Thomsen AR. 2007. J Immunol. Feb 1;178(3):1662-1670.

Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.