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C57Bl/6 splenocytes were stained with 0.25 ug PE Anti-Mouse CD11a (50-0111) (solid line) or 0.25 ug PE Rat IgG2a isotype control (dashed line).
  • C57Bl/6 splenocytes were stained with 0.25 ug PE Anti-Mouse CD11a (50-0111) (solid line) or 0.25 ug PE Rat IgG2a isotype control (dashed line).

PE Anti-Mouse CD11a (M17/4)

Cat No. Size Price Quantity
50-0111-U025 25 µg $42.00
50-0111-U100 100 µg $119.00

Description

The M17/4 monoclonal antibody reacts with mouse CD11a, an 180kD glycoprotein that is also known as integrin alpha L (ITGAL). CD11a associates non-covalently with CD18 (integrein beta 2) to form the lymphocyte function associated antigen-1 (LFA-1) heterodimer. CD11a is expressed on the cell surface of all leukocytes. LFA-1 plays a critical role in intercellular adhesion that is mediated through interactions with its ligands, ICAM-1 (CD54), ICAM-2 (CD102), and ICAM-3 (CD50). LFA-1 also functions in lymphocyte costimulatory signaling. On resting cells, LFA-1 exists in a low-affinity conformation that is rapidly induced to the high-affinity conformation following cell stimulation.

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The M17/4 monoclonal antibody reacts with mouse CD11a, an 180kD glycoprotein that is also known as integrin alpha L (ITGAL). CD11a associates non-covalently with CD18 (integrein beta 2) to form the lymphocyte function associated antigen-1 (LFA-1) heterodimer. CD11a is expressed on the cell surface of all leukocytes. LFA-1 plays a critical role in intercellular adhesion that is mediated through interactions with its ligands, ICAM-1 (CD54), ICAM-2 (CD102), and ICAM-3 (CD50). LFA-1 also functions in lymphocyte costimulatory signaling. On resting cells, LFA-1 exists in a low-affinity conformation that is rapidly induced to the high-affinity conformation following cell stimulation.

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Product Details

Name PE Anti-Mouse CD11a (M17/4)
Cat. No. 50-0111
Alternative Names alpha L integrin α. CD11 antigen-like family member A. integrin αalpha-L. leukocyte adhesion glycoprotein LFA-1 alpha chain. leukocyte function-associated molecule 1 alpha chain. lymphocyte antigen 15. lymphocyte function associated antigen 1, alpha polypeptide
Gene ID 16408
Clone M17/4
Isotype Rat IgG2a, kappa
Reactivity Mouse
Cross Reactivity
Format PE
Application Flow Cytometry
Citations*
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.