PE Anti-Mouse CD11a (M17/4)
| Cat No. | Size | Price | Quantity | |
|---|---|---|---|---|
| 50-0111-U025 | 25 µg | $42.00 | ||
| 50-0111-U100 | 100 µg | $119.00 |
Technical Data Sheet
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The M17/4 monoclonal antibody reacts with mouse CD11a, an 180kD glycoprotein that is also known as integrin alpha L (ITGAL). CD11a associates non-covalently with CD18 (integrein beta 2) to form the lymphocyte function associated antigen-1 (LFA-1) heterodimer. CD11a is expressed on the cell surface of all leukocytes. LFA-1 plays a critical role in intercellular adhesion that is mediated through interactions with its ligands, ICAM-1 (CD54), ICAM-2 (CD102), and ICAM-3 (CD50). LFA-1 also functions in lymphocyte costimulatory signaling. On resting cells, LFA-1 exists in a low-affinity conformation that is rapidly induced to the high-affinity conformation following cell stimulation.
The M17/4 monoclonal antibody reacts with mouse CD11a, an 180kD glycoprotein that is also known as integrin alpha L (ITGAL). CD11a associates non-covalently with CD18 (integrein beta 2) to form the lymphocyte function associated antigen-1 (LFA-1) heterodimer. CD11a is expressed on the cell surface of all leukocytes. LFA-1 plays a critical role in intercellular adhesion that is mediated through interactions with its ligands, ICAM-1 (CD54), ICAM-2 (CD102), and ICAM-3 (CD50). LFA-1 also functions in lymphocyte costimulatory signaling. On resting cells, LFA-1 exists in a low-affinity conformation that is rapidly induced to the high-affinity conformation following cell stimulation.
Product Details
| Name | PE Anti-Mouse CD11a (M17/4) |
|---|---|
| Cat. No. | 50-0111 |
| Alternative Names | alpha L integrin α. CD11 antigen-like family member A. integrin αalpha-L. leukocyte adhesion glycoprotein LFA-1 alpha chain. leukocyte function-associated molecule 1 alpha chain. lymphocyte antigen 15. lymphocyte function associated antigen 1, alpha polypeptide |
| Gene ID | 16408 |
| Clone | M17/4 |
| Isotype | Rat IgG2a, kappa |
| Reactivity | Mouse |
| Cross Reactivity | |
| Format | PE |
| Application | Flow Cytometry |
| Citations* |
FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy
*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.