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Human peripheral blood monocytes were stained with 5 uL (0.125 ug) PE Anti-Human CD38 (50-0388) (solid line) or 0.125 ug PE Mouse IgG1 isotype control (dashed line).
  • Human peripheral blood monocytes were stained with 5 uL (0.125 ug) PE Anti-Human CD38 (50-0388) (solid line) or 0.125 ug PE Mouse IgG1 isotype control (dashed line).
  • PE Anti-Human CD38 (HB7)

PE Anti-Human CD38 (HB7)

Cat No. Size Price Quantity
50-0388-T025 25 tests $75.00
50-0388-T100 100 tests $205.00
50-0388-T500 500 tests $920.00

Description

The HB7 antibody is specific for human CD38, a 45 kDa type II transmembrane glycoprotein expressed on thymocytes, plasma cells, and monocytes as well as other non-hematopoietic cells. T and B lymphocyte expression is discontinuous and varies based on differentiation state – present on immature cells, low on intermediate stages, and high on activated mature cells. It is found on most CD34+ cells, but not on pluripotent stem cells. CD38 is an ectoenzyme that functions to catalyze the synthesis and hydrolysis of cyclic ADP-ribose and is involved in cell signaling, regulating cell adhesion, and activation. Additionally, CD38 has been shown to be a prognostic marker for some leukemias and other diseases.

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The HB7 antibody is specific for human CD38, a 45 kDa type II transmembrane glycoprotein expressed on thymocytes, plasma cells, and monocytes as well as other non-hematopoietic cells. T and B lymphocyte expression is discontinuous and varies based on differentiation state – present on immature cells, low on intermediate stages, and high on activated mature cells. It is found on most CD34+ cells, but not on pluripotent stem cells. CD38 is an ectoenzyme that functions to catalyze the synthesis and hydrolysis of cyclic ADP-ribose and is involved in cell signaling, regulating cell adhesion, and activation. Additionally, CD38 has been shown to be a prognostic marker for some leukemias and other diseases.

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Product Details

Name PE Anti-Human CD38 (HB7)
Cat. No. 50-0388
Alternative Names T10, ADP-ribosyl cyclase, cyclic ADP ribose hydrolase
Gene ID 952
Clone HB7
Isotype Mouse IgG1, kappa
Reactivity Human
Cross Reactivity
Format PE
Application Flow Cytometry
Citations*

Tedder TF, Clement LT and Cooper MD. 1984. Tissue Antigens. 24(3): 140-149. (Flow cytometry)

Jackson DG and Bell JI. 1990. J Immunol. 144(7): 2811-2815.

Mahta K, Shahid U and Malavasi F. 1996. FASEB J. 10(12): 1408-1417.

Ferrero E and Malavasi F. 1999. J Leukoc Biol. 65(2): 151-161.

Llinas L, Lazaro A, de Saolrt J, Matesanz-Isabel J, Sintes J and Engel P. 2011. Immunol Lett. 134(2): 113-121. (Flow cytometry)

Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.