Customer Service: (855) 848-6626 | 8:00 a.m - 4:30 p.m. PST | FREE mini stocking with orders all month

Human peripheral blood lymphocytes were stained with APC Anti-Human CD45 (20-0459) and 5 uL (0.25 ug) PE Anti-Human CD34 (50-0349) (right panel) or 0.25 ug PE Mouse IgG1 isotype control (left panel).
  • Human peripheral blood lymphocytes were stained with APC Anti-Human CD45 (20-0459) and 5 uL (0.25 ug) PE Anti-Human CD34 (50-0349) (right panel) or 0.25 ug PE Mouse IgG1 isotype control (left panel).

PE Anti-Human CD34 (4H11)

Cat No. Size Price Quantity
50-0349-T025 25 tests $95.00
50-0349-T100 100 tests $229.00

Description

The 4H11 monoclonal antibody reacts with human CD34, a single pass transmembrane protein with a molecular weight of 105-120 kDa. CD34 is heavily glycosylated with an N-terminal mucin domain. Although the function of CD34 is not defined, the intracellular domain of CD34 is a target for phosphorylation by activated protein kinase C, suggesting a possible role in signal transduction. CD34 is expressed on hematopoietic progenitor cells, some populations of mesenchymal stem cells, and vascular endothelium. Various epitopes of CD34 have been defined based on their differential sensitivity to enzymatic cleavage. By these criteria, the 4H11 antibody belongs to class III, indicating that it reacts with a protein epitope. Additionally, CD34 may also function as an adhesion molecule with a role in mediating attachment of stem cells to bone marrow extracellular matrix, stromal cells, or other bone marrow components.

View More

The 4H11 monoclonal antibody reacts with human CD34, a single pass transmembrane protein with a molecular weight of 105-120 kDa. CD34 is heavily glycosylated with an N-terminal mucin domain. Although the function of CD34 is not defined, the intracellular domain of CD34 is a target for phosphorylation by activated protein kinase C, suggesting a possible role in signal transduction. CD34 is expressed on hematopoietic progenitor cells, some populations of mesenchymal stem cells, and vascular endothelium. Various epitopes of CD34 have been defined based on their differential sensitivity to enzymatic cleavage. By these criteria, the 4H11 antibody belongs to class III, indicating that it reacts with a protein epitope. Additionally, CD34 may also function as an adhesion molecule with a role in mediating attachment of stem cells to bone marrow extracellular matrix, stromal cells, or other bone marrow components.

Hide

Product Details

Name PE Anti-Human CD34 (4H11)
Cat. No. 50-0349
Alternative Names
Gene ID
Clone 4H11
Isotype Mouse IgG1, k
Reactivity Human
Cross Reactivity
Format PE
Application Flow Cytometry
Citations* Loken MR, Shah VO, Hollander Z, Civin CI. 1988. Pathol Immunopathol Res. 1988. 7(5):357-570. Berenson RJ, Andrews RG, Bensinger WI, Kalamasz D, Knitter G, Buckner CD, Bernstein ID. 1988. J Clin Invest. Mar;81(3):951-955. Knapp W, Dorken B, Rieber EP, et al, ed. 1989. Leucocyte Typing IV. New York: Oxford University Press. Egeland T, Tjonnfjord G, Steen R, Gaudernack G, Thorsby E. 1993. Transplant Proc. 25(1):1261-1263.
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.