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In Vivo Ready™ Anti-Human CD178 (Fas ligand) (NOK-1)
  • In Vivo Ready™ Anti-Human CD178 (Fas ligand) (NOK-1)

In Vivo Ready™ Anti-Human CD178 (Fas ligand) (NOK-1)

Cat No. Size Price Quantity
40-9919-U100 100 µg $104.00

Description

The NOK-1 antibody reacts with human CD178 (Fas ligand) in both membrane bound and soluble forms. Fas ligand is a 40 kDa transmembrane glycoprotein, a member of the TNF-α family, and is expressed by activated T and NK cells, neutrophils, and monocytes. Interactions between ≥ ≥ ≥ CD178 (Fas ligand) and CD95 (Fas) induce a program of apoptosis and play a key role in immune regulation and homeostasis. The extracellular domain of human CD178 can be cleaved from the surface by matrix metalloproteinases (MMPs) resulting in a 26 kDa soluble protein.

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The NOK-1 antibody reacts with human CD178 (Fas ligand) in both membrane bound and soluble forms. Fas ligand is a 40 kDa transmembrane glycoprotein, a member of the TNF-α family, and is expressed by activated T and NK cells, neutrophils, and monocytes. Interactions between ≥ ≥ ≥ CD178 (Fas ligand) and CD95 (Fas) induce a program of apoptosis and play a key role in immune regulation and homeostasis. The extracellular domain of human CD178 can be cleaved from the surface by matrix metalloproteinases (MMPs) resulting in a 26 kDa soluble protein.

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Product Details

Name In Vivo Ready™ Anti-Human CD178 (Fas ligand) (NOK-1)
Cat. No. 40-9919
Alternative Names CD95L, Fas ligand, FasL
Gene ID 356
Clone NOK-1
Isotype Mouse IgG1, kappa
Reactivity
Cross Reactivity
Format In Vivo Ready™
Application Flow Cytometry, Functional Assays
Citations*

Tanaka M, Suda T, Takahashi T, and Nagata S. 1995. EMBO J. 14(6):1129-1135.

Kayagaki N, Kawasaki A, Ebata T, Ohmoto H, Ikeda S, Inoue S, Yoshino K, Okumura K, and Yagita H. 1995. J Exp Med. 182(6):1777-1783.

Suda T, Hashimoto H, Tanaka M, Ochi T, Nagata S. 1997. J Exp Med. 186(12):2045-2050.

Ehrenschwender M, Wajant H. 2009. Adv Exp Med Biol. 647:64-93.

Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.