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In Vivo Ready™ Anti-Human CD16 (3G8)
  • In Vivo Ready™ Anti-Human CD16 (3G8)

In Vivo Ready™ Anti-Human CD16 (3G8)

Cat No. Size Price Quantity
40-0166-U100 100 µg $85.00
40-0166-U500 500 µg $255.00

Description

The 3G8 monoclonal antibody reacts with the 50-65kD transmembrane form of human CD16 (FCGR3A). CD16 is the low affinity IgG receptor III and is expressed on NK cells and macrophages. CD16 participates in signal transduction and mediates antibody-dependent cellular cytotoxicity (ADCC) by natural killer (NK) cells. The second form of CD16 (FCGR3B) is a glycosyl-phosphatidylinositol (GPI) linked molecule expressed exclusively on neutrophils.

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The 3G8 monoclonal antibody reacts with the 50-65kD transmembrane form of human CD16 (FCGR3A). CD16 is the low affinity IgG receptor III and is expressed on NK cells and macrophages. CD16 participates in signal transduction and mediates antibody-dependent cellular cytotoxicity (ADCC) by natural killer (NK) cells. The second form of CD16 (FCGR3B) is a glycosyl-phosphatidylinositol (GPI) linked molecule expressed exclusively on neutrophils.

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Product Details

Name In Vivo Ready™ Anti-Human CD16 (3G8)
Cat. No. 40-0166
Alternative Names Cd16, FcγRIII
Gene ID
Clone 3G8
Isotype Mouse IgG1, k
Reactivity Human
Cross Reactivity
Format In Vivo Ready™
Application Functional Assays
Citations* Fleit HB, Wright SD, Unkeless JC. 1982. Proc Natl Acad Sci U S A. May;79(10):3275-3279. Windebank KP, Abraham RT, Powis G, Olsen RA, Barna TJ, Leibson PJ. 1988. J Immunol. Dec 1;141(11):3951-3957. Fleit HB. 1991. Clin Immunol Immunopathol. May;59(2):222-235. Wirthmueller U, Kurosaki T, Murakami MS, Ravetch JV. 1992. J Exp Med. May 1;175(5):1381-1390.
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.