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C57Bl/6 T cells, enriched from total splenocytes, were stimulated with PMA and ionomycin for 6 hours and stained with 0.25 ug Biotin Anti-Mouse CD154 (30-1541) (solid line) or 0.25 ug Biotin Armenian Hamster IgG isotype control (dashed line), followed by
  • C57Bl/6 T cells, enriched from total splenocytes, were stimulated with PMA and ionomycin for 6 hours and stained with 0.25 ug Biotin Anti-Mouse CD154 (30-1541) (solid line) or 0.25 ug Biotin Armenian Hamster IgG isotype control (dashed line), followed by

Biotin Anti-Mouse CD154 (MR1)

Cat No. Size Price Quantity
30-1541-U025 25 µg $31.00
30-1541-U100 100 µg $94.00

Description

The MR1 antibody is specific for mouse CD154, a 39 kD glycoprotein that is primarily expressed on activated T cells. CD154 (CD40 ligand, gp39) binds to CD40 expressed on antigen presenting cells and mediates important costimulatory functions between ≥ ≥ ≥ these cells. Signals generated via cognate interactions between ≥ ≥ ≥ CD154-CD40 on activated T and B cells are required for T-dependent B cell responses. The MR1 antibody is reported to block interaction of CD154 with CD40.

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The MR1 antibody is specific for mouse CD154, a 39 kD glycoprotein that is primarily expressed on activated T cells. CD154 (CD40 ligand, gp39) binds to CD40 expressed on antigen presenting cells and mediates important costimulatory functions between ≥ ≥ ≥ these cells. Signals generated via cognate interactions between ≥ ≥ ≥ CD154-CD40 on activated T and B cells are required for T-dependent B cell responses. The MR1 antibody is reported to block interaction of CD154 with CD40.

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Product Details

Name Biotin Anti-Mouse CD154 (MR1)
Cat. No. 30-1541
Alternative Names CD40L, TRAP, Ly-62, TNF-αSF5
Gene ID 21947
Clone MR1
Isotype Armenian Hamster IgG
Reactivity Mouse
Cross Reactivity
Format Biotin
Application Flow Cytometry
Citations*

Noelle RJ, Roy M, Shepherd DM, Stamenkovic I, Ledbetter JA, Aruffo A. 1992. Proc Natl Acad Sci U S A. 89(14):6550-6554.

Foy TM, Laman JD, Ledbetter JA, Aruffo A, Claassen E, Noelle RJ. 1994. J Exp Med. 180(1):157-163.

Laman JD, Claassen E, Noelle RJ. 1996. Crit Rev Immunol. 16(1):59-108.

Grewal IS, Flavell RA. 1998. Annu Rev Immunol. 16:111-35.

Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.