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Human peripheral blood lymphocytes were stained with 5 uL (0.25 ug) APC Anti-Human CD49d (20-0499) (solid line) or 0.25 ug APC Mouse IgG1 isotype control (dashed line).
  • Human peripheral blood lymphocytes were stained with 5 uL (0.25 ug) APC Anti-Human CD49d (20-0499) (solid line) or 0.25 ug APC Mouse IgG1 isotype control (dashed line).

APC Anti-Human CD49d (Integrin alpha 4) (9F10)

Cat No. Size Price Quantity
20-0499-T025 25 tests $109.00
20-0499-T100 100 tests $249.00

Description

The 9F10 monoclonal antibody reacts with human CD49d, a 150kD integral membrane protein that is also known as integrin αalpha4 (ITGA4). Together with integrin αbeta1 (CD29), CD49d forms the VLA-4 heterodimer that serves as a receptor for fibronectin and VCAM-1. VLA-4 is widely expressed on lymphocytes, monocytes, thymocytes, and NK cells. CD49d can also dimerize with integrin αbeta7 to form a receptor that binds the mucosal vascular addressin molecule, MAdCAM-1. CD49d is involved in cellular adhesion to other cells as well as extracellular matrix.

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The 9F10 monoclonal antibody reacts with human CD49d, a 150kD integral membrane protein that is also known as integrin αalpha4 (ITGA4). Together with integrin αbeta1 (CD29), CD49d forms the VLA-4 heterodimer that serves as a receptor for fibronectin and VCAM-1. VLA-4 is widely expressed on lymphocytes, monocytes, thymocytes, and NK cells. CD49d can also dimerize with integrin αbeta7 to form a receptor that binds the mucosal vascular addressin molecule, MAdCAM-1. CD49d is involved in cellular adhesion to other cells as well as extracellular matrix.

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Product Details

Name APC Anti-Human CD49d (integrin αalpha 4) (9F10)
Cat. No. 20-0499
Alternative Names VLA-4 ? chain, ?4 integrin α, integrin α?4 chain, ITGA4
Gene ID
Clone 9F10
Isotype Mouse IgG1, kappa
Reactivity Human
Cross Reactivity
Format APC
Application Flow Cytometry
Citations* Hemler ME, Huang C, Takada Y, Schwarz L, Strominger JL, Clabby ML. 1987. J Biol Chem. 262(24):11478-11485. Hemler ME. 1990. Annu Rev Immunol. 8:365-400. Berlin C, Berg EL, Briskin MJ, et al. 1993. Cell. 74(1):185-195. Nevers T, Salvador AM, Velazquez F, Ngwenyama N, Carrillo-Salinas FJ, Aronovitz M, Blanton RM, Alcaide P. 2017. J Exp Med. Nov 6;214(11):3311-3329. Savino W, Pinto-Mariz F, Mouly V. 2018. Methods Mol Biol. 1687:219-227.
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.