APC Anti-Human CD34 (4H11)
| Cat No. | Size | Price | Quantity | |
|---|---|---|---|---|
| 20-0349-T025 | 25 tests | $94.00 | ||
| 20-0349-T100 | 100 tests | $235.00 |
Technical Data Sheet
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The 4H11 monoclonal antibody reacts with human CD34, a single pass transmembrane protein with a molecular weight of 105-120 kDa. CD34 is heavily glycosylated with an N-terminal mucin domain. Although the function of CD34 is not defined, the intracellular domain of CD34 is a target for phosphorylation by activated protein kinase C, suggesting a possible role in signal transduction. CD34 is expressed on hematopoietic progenitor cells, some populations of mesenchymal stem cells, and vascular endothelium. The epitope of CD34 recognized by the 4H11 antibody is assigned to the class III epitopes. Additionally, CD34 may also function as an adhesion molecule with a role in mediating attachment of stem cells to bone marrow extracellular matrix, stromal cells, or other bone marrow components.
The 4H11 monoclonal antibody reacts with human CD34, a single pass transmembrane protein with a molecular weight of 105-120 kDa. CD34 is heavily glycosylated with an N-terminal mucin domain. Although the function of CD34 is not defined, the intracellular domain of CD34 is a target for phosphorylation by activated protein kinase C, suggesting a possible role in signal transduction. CD34 is expressed on hematopoietic progenitor cells, some populations of mesenchymal stem cells, and vascular endothelium. The epitope of CD34 recognized by the 4H11 antibody is assigned to the class III epitopes. Additionally, CD34 may also function as an adhesion molecule with a role in mediating attachment of stem cells to bone marrow extracellular matrix, stromal cells, or other bone marrow components.
Product Details
| Name | APC Anti-Human CD34 (4H11) |
|---|---|
| Cat. No. | 20-0349 |
| Alternative Names | |
| Gene ID | |
| Clone | 4H11 |
| Isotype | Mouse IgG1 k |
| Reactivity | Human |
| Cross Reactivity | |
| Format | APC |
| Application | Flow Cytometry |
| Citations* | Loken MR, Shah VO, Hollander Z, Civin CI. 1988. Pathol Immunopathol Res. 1988. 7(5):357-570. Berenson RJ, Andrews RG, Bensinger WI, Kalamasz D, Knitter G, Buckner CD, Bernstein ID. 1988. J Clin Invest. Mar;81(3):951-955. Knapp W, Dorken B, Rieber EP, et al, ed. 1989. Leucocyte Typing IV. New York: Oxford University Press. Egeland T, Tjonnfjord G, Steen R, Gaudernack G, Thorsby E. 1993. Transplant Proc. 25(1):1261-1263. |
FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy
*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.