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Human PBMC were stimulated for 3 days with PHA and stained with 5 uL (1 ug) APC Anti-Human CD279 (20-2797) (solid line) or 1 ug APC Mouse IgG1 isotype control (dashed line).
  • Human PBMC were stimulated for 3 days with PHA and stained with 5 uL (1 ug) APC Anti-Human CD279 (20-2797) (solid line) or 1 ug APC Mouse IgG1 isotype control (dashed line).

APC Anti-Human CD279 (PD-1) (J110)

Cat No. Size Price Quantity
20-2797-T025 25 tests $120.00
20-2797-T100 100 tests $255.00

Description

The J110 antibody is specific for human CD279, also known as programmed death-1 (PD-1). PD-1 is a 55 kDa glycoprotein member of the Ig superfamily and is expressed on activated T cells, B cells, and myeloid cells. PD-L1 (B7-H1) and PD-L2 (B7-DC) are ligands for CD279 and belong to the B7 gene family. PD-1 is an immune checkpoint and interaction with its ligands results in inhibition of T cell proliferation and cytokine secretion.

 

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The J110 antibody is specific for human CD279, also known as programmed death-1 (PD-1). PD-1 is a 55 kDa glycoprotein member of the Ig superfamily and is expressed on activated T cells, B cells, and myeloid cells. PD-L1 (B7-H1) and PD-L2 (B7-DC) are ligands for CD279 and belong to the B7 gene family. PD-1 is an immune checkpoint and interaction with its ligands results in inhibition of T cell proliferation and cytokine secretion.

 

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Product Details

Name APC Anti-Human CD279 (PD-1) (J110)
Cat. No. 20-2797
Alternative Names CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, hSLE1
Gene ID 5133
Clone J110
Isotype Mouse IgG1
Reactivity Human
Cross Reactivity
Format APC
Application Flow Cytometry
Citations*

Freeman GJ, Long AJ, Iwai Y, et al. 2000. J Exp Med. 192:1027-1034.

 

Latchman Y, Wood CR, Chernova T, et al. 2001. Nat Immunol. 2(3):261-268.

 

Bennett F, Luxenberg D, Ling V, et al. 2003. J Immunol. 170(2):711-718.

 

Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.