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Validated reagents. Trusted by your peers

Check out what researchers around the world are doing with reagents from Tonbo Biosciences. Our flow and In Vivo Ready antibodies, buffers, and recombinant proteins are being cited in top immunology journals. We provide quality, validated reagents to support your immunology workflow - now you can read about them in a growing selection of peer reviewed articles.

Featured Citation

Generation of knock-in primary human T cells using Cas9 ribonucleoproteins

T-cell genome engineering holds great promise for cancer immunotherapies and cell-based therapies for HIV, primary immune deficiencies, and autoimmune diseases, but genetic manipulation of human T cells has been inefficient. We achieved efficient genome editing by delivering Cas9 protein pre-assembled with guide RNAs. These active Cas9 ribonucleoproteins (RNPs) enabled successful Cas9-mediated homology-directed repair in primary human T cells. Cas9 RNPs provide a programmable tool to replace specific nucleotide sequences in the genome of mature immune cells—a longstanding goal in the field. These studies establish Cas9 RNP technology for diverse experimental and therapeutic genome engineering applications in primary human T cells.

Products cited: APC CD25 (BC96), PE CD127 (R34-34), violetFluor™ CD45RA (HI100), FITC CD45RO (UCHL1)

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Anti-Human Antibodies:

CD3 (OKT3) 

 

Kamakura D, Asano R, Kawai H, Yasunaga M. Mechanism of action of a T cell-dependent bispecific antibody as a breakthrough immunotherapy against refractory colorectal cancer with an oncogenic mutation. Cancer Immunol Immunother. 2020;10.1007/s00262-020-02667-9. doi:10.1007/s00262-020-02667-9.

» View on PubMed

Brincks E. L., Adams J., Wang L., Turner B., Marcinowicz A., Ke J., Essmann M., Mautino L. M., Allen C. Van, Kumar S., Vahanian N., Link C., Mautino M. R. et al Indoximod opposes the immunosuppressive effects mediated by IDO and TDO via modulation of AhR function and activation of mTORC1. Oncotarget. 2020; 11: 2438-2461.

View on Oncotarget

The Tat Protein of HIV-1 Prevents the Loss of HSV-Specific Memory Adaptive Responses and Favors the Control of Viral Reactivation.  Francesco Nicoli, Eleonora Gallerani, Mariaconcetta Sicurella, Salvatore Pacifico, Aurelio Cafaro, Barbara Ensoli, Peggy Marconi, Antonella Caputo, and Riccardo Gavioli. Vaccines (Basel). 2020 Jun 4;8(2):E274. doi: 10.3390/vaccines8020274.

» View on PubMed

Sánchez-Villanueva JA, Rodríguez-Jorge O, Ramírez-Pliego O, et al. Contribution of ROS and metabolic status to neonatal and adult CD8+ T cell activation. PLoS One. 2019;14(12):e0226388. Published 2019 Dec 16. doi:10.1371/journal.pone.0226388.

» View on PubMed

Morimoto S, Fujiki F, Kondo K, et al. Establishment of a novel platform cell line for efficient and precise evaluation of T cell receptor functional avidity. Oncotarget. 2018;9(75):34132-34141. Published 2018 Sep 25. doi:10.18632/oncotarget.26139.

» View on PubMed

Sun CW, Wu LC, Knopick PL, Bradley DS, Townes T and Terman DS. 2017. Sickle Cells Produce Functional Immune Modulators and Cytotoxics. Am J Hematol. doi: 10.1002/ajh.24836.

» View on PubMed

Poujol F, Monneret G, Friggeri A, Rimmele T, Malcus C, Poitevin-Later F, Pachot A, Lepape A, Textoris J and Venet F. 2014. Flow cytometric evaluation of lymphocyte transformation test based on 5-ethynyl-2'deoxyuridine incorporation as a clinical alternative to tritiated thymidine uptake measurement. J Immunol Methods. 415: 71-79.

» View on PubMed

He Q, Zhang H, Wang Y, Ting HH, Yu W, Cao X and Ge W. 2014. Purified anti-CD3 x anti-HER2 bispecific antibody potentiates cytokine-induced killer cells of poor spontaneous cytotoxicity against breast cancer cells. Cell Biosci. 4(1): 70.

» View on PubMed

Khan SQ, Guo L, Cimbaluk D, Elshabrawy H, Faridi MH, Jolly M, George JF, Agarwal A and Gupta V. 2014. A Small Molecule β2 Integrin Agonist Improves Chronic Kidney Allograft Survival by Reducing Leukocyte Recruitment and Accompanying Vasculopathy. Front Med (Lausanne). 1:45.

» View on PubMed

Bachanova V, Frankel AE, Cao Q, Lewis D, Grzywacz B, Verneris MR, Ustun C, Lazaryan A, McClune B, Warlick ED, Kantarjian H, Weisdorf DJ, Miller JS, Vallera DA. 2015. Phase I Study of a Bispecific Ligand-Directed Toxin Targeting CD22 and CD19 (DT2219) for Refractory B-cell Malignancies. Clin Cancer Res. 21(6): 1267-1272.

» View on PubMed

Miles B, Miller SM, Folkvord JM, Kimball A, Chamanian M, Meditz AL, Arends T, McCarter MD, Levy DN, Rakasz EG, Skinner PJ and Connick E. 2015. Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection. Nat Commun. doi: 10.1038/ncomms9608.

» View on PubMed

Chen KH, Wada M, Firor AE, Pinz KG, Jares A, Liu H, Salman H, Golightly M, Lan F, Jiang X and Ma Y. 2016. Novel anti-CD3 chimeric antigen receptor targeting of aggressive. DOI:10.18632/oncotarget.11019

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Galindo-Albarran AO, Lopez-Portales OH, Gutierrez-Reyna DY, Rodriguez-Jorge O, Sanchez-Villanueva JA, Ramirez-Pliego O, Bergon A, Loriod B, Holota H, Imbert J, Hernandez-mendoza A, Ferrier P, Carrillo-de Santa Pau E, Valencia A, Spicuglia S and Santana MA. 2016. CD8+ T Cells from Human Neonates Are Biased toward an Innate Immune Response. Cell Rep. doi: 10.1016/j.celrep.2016.10.056

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CD11c (3.9)

Johnson LE, Olson BM and McNeel DG. 2017. Pretreatment antigen-specific immunity and regulation - association with subsequent immune response to anti-tumor DNA vaccination. J Immunother Cancer. doi: 10.1186/s40425-017-0260-3.

» View on PubMed

Visvabharathy L and Freitag NE. 2017. Propofol sedation exacerbates kidney pathology and dissemination of bacteria during Staphylococcus aureus bloodstream infections.Infect Immun. doi: 10.1128/IAI.00097-17

» View on PubMed

CD3ɛ (Hit3a)

Yamamura K, Uruno T, Shiraishi A, Tanaka Y, Ushijima M, Nakahara T, Watanabe M, Kido-Nakahara M, Tsuge I, Furue M and Fukui Y. 2017. The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction. Nat. Commun. doi:10.1038/ncomms13946

» View on PubMed

CD3 (SK7)

Chaganty BKR, Lu Y, Qiu S, Somanchi SS, Lee DA and Fan Z. 2015. Trastuzumab upregulates expression of HLA-ABC and T cell costimulatory molecules through engagement of natural killer cells and stimulation of IFN-γ secretion. OncoImmunology. DOI: 10.1080/2162402X.2015.1100790

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CD3 (UCHT1)

 

Roth TL, Li PJ, Blaeschke F, Nies JF, Apathy R, Mowery C, Yu R, Nguyen MLT, Lee Y, Truong A, Hiatt J, Wu D, Nguyen DN, Goodman D, Bluestone JA, Ye CJ, Roybal K, Shifrut E, Marson A. Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies. Cell. 2020 Apr 15. pii: S0092-8674(20)30332-9. doi: 10.1016/j.cell.2020.03.039.

» View on ScienceDirect

Molly OhainleI, Kyusik Kim, Sevnur Komurlu Keceli, Abby Felton, Ed Campbell, Jeremy LubanI, Michael. Emerman. TRIM34 restricts HIV-1 and SIV capsids in a TRIM5α-dependent manner. PLoS Pathog. 2020 Apr 13;16(4):e1008507. doi: 10.1371/journal.ppat.1008507.

» View on PubMed

Hultquist JF, Hiatt J, Schumann K, et al. CRISPR-Cas9 genome engineering of primary CD4+ T cells for the interrogation of HIV-host factor interactions. Nat Protoc. 2019;14(1):1-27. doi:10.1038/s41596-018-0069-7.

» View on PubMed

Rupp LJ, Schumann K, Roybal KT, Gate RE, Ye CJ, Lim WA and Marson A. 2017. CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells. Sci Rep. doi: 10.1038/s41598-017-00462-8

» View on PubMed

Miles B, Miller SM, Folkvord JM, Kimball A, Chamanian M, Meditz AL, Arends T, McCarter MD, Levy DN, Rakasz EG, Skinner PJ and Connick E. 2015. Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection. Nat Commun. doi: 10.1038/ncomms9608.

» View on PubMed

Chi S, Weiss A and Wang H. 2015. A CRISPR-based Toolbox For Studying T Cell Signal Transduction. BioMed Res Int. DOI:10.1155/2016/5052369

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Locci M, Wu JE, Arumemi F, Mikulski Z, Dahlberg C, Miller AT and Crotty S. 2016. Activin A Programs the Differentiation of Human TFH Cells. Nature Immunology. doi:10.1038/ni.3494

» View on PubMed

Hultquist JF, Schumann K, Woo JM, Manganaro L, McGregor MJ, Doudna J, Simon V, Krogan NJ and Marson A. 2016. A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells. Cell Rep. doi: 10.1016/j.celrep.2016.09.080.

» View on PubMed

Chen D, Ireland SJ, Remington G, Alvarez E, Racke MK, Greenberg B, Frohman EM and Monson NL. 2016. CD40 Mediated NF-kB Activation in B Cells Is Increased in Multiple Sclerosis and Modulated by Therapeutics. J. Immunol. doi:10.4049/jimmunol.1600782

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CD4 (RPA-T4)

Zhang AH, Yoon J, Kim YC, Scott DW. Targeting Antigen-Specific B Cells Using Antigen-Expressing Transduced Regulatory T Cells. J Immunol. 2018;201(5):1434-1441. doi:10.4049/jimmunol.1701800.

» View on Journal of Immunology

Ryotokuji K, Nakajima T, Ishimaru K, Ozaki-Shimada A, Kihara K, Namiki Y and Otani S. 2015. Effect of Stress-Free Therapy on immune system: Induction of Interleukin 10 expression in lymphocytes through activation of CD19(+) CD24(hi) CD38(hi) regulatory B Cells. Laser Therapy. 24(3): 179-188.

» View on J-STAGE

Dillon, SM, Lee EJ, Donovan AM, Guo K, Harper MS, Frank DN, McCarter MD, Santiago ML, and Wilson CC. 2016. Enhancement of HIV-1 infection and intestinal CD4+ T cell depletion ex vivo by gut microbes altered during chronic HIV-1 infection. Retrovirology. DOI 10.1186/s12977-016-0237-1

» View on PubMed

Arnold N, Girke T, Sureshchandra S and Messaoudi I. 2016. Acute simian varicella infection causes robust and sustained changes in gene expression in the sensory ganglia. J. Virol. doi: 10.1128/JVI.01272-16

» View on PubMed

Viisanen T, Ihantola E, Nanto-Salonen K, Hyoty H, Nurminen N, Selvenius J, Juutilainen A, Moilanen L, Pihlajamaki J, Veijola R, Toppari J, Knip M, Ilonen J and Kinnunen T. 2016. Circulating CXCR5+PD-1+ICOS+ Follicular T Helper Cells Are Increased Close to the Diagnosis of Type 1 Diabetes in Children with Multiple Autoantibodies. Diabetes. DOI: 10.2337/db16-0714

» View on ADA

Chen D, Ireland SJ, Remington G, Alvarez E, Racke MK, Greenberg B, Frohman EM and Monson NL. 2016. CD40 Mediated NF-kB Activation in B Cells Is Increased in Multiple Sclerosis and Modulated by Therapeutics. J. Immunol. doi:10.4049/jimmunol.1600782

» View on Journal of Immunology

Rudloff I, Cho SX, Lao JC, Ngo D, McKenzie M, Nold-Petry CA and Nold MF. 2016. Monocytes and dendritic cells are the primary sources of interleukin 37 in human immune cells. J. Leukoc. Biol. doi:10.1189/jlb.3MA0616-287R

» View on PubMed

CD4 (OKT4)

 

Woolsey C, Jankeel A, Matassov D, et al. Immune correlates of postexposure vaccine protection against Marburg virus. Sci Rep. 2020;10(1):3071. Published 2020 Feb 20. doi:10.1038/s41598-020-59976-3.

 » View on Nature

Scharer CD, Bally AP, Gandham B and Boss JM. 2017. Cutting Edge: Chromatin Accessibility Programs CD8 T Cell Memory. J Immunol. doi: 10.4049/jimmunol.1602086

» View on PubMed

Visvabharathy L and Freitag NE. 2017. Propofol sedation exacerbates kidney pathology and dissemination of bacteria during Staphylococcus aureus bloodstream infections.Infect Immun. doi: 10.1128/IAI.00097-17

» View on PubMed

Versteeg K, Menicucci AR, Woolsey C, Mire CE, Geisbert JB, Cross RW, Agans KN, Jeske D, Messaoudi I and Geisbert TW. 2017. Infection with the Makona variant results in a delayed and distinct host immune response compared to previous Ebola virus variants. Sci Rep. doi: 10.1038/s41598-017-09963-y.

» View on PubMed

CD19 (SJ25C1)

Sato Y, Kato H, Ebina-Shibuya R, Itoh-Nakadai A, Okuyama R and Igarashi K. 2017. Bach2 Controls Homeostasis of Eosinophils by Restricting the Type-2 Helper Function of T Cells. Tohoku J Exp Med. doi: 10.1620/tjem.241.175

» View on PubMed

IL-4 (MP4-25D2)

Visvabharathy L and Freitag NE. 2017. Propofol sedation exacerbates kidney pathology and dissemination of bacteria during Staphylococcus aureus bloodstream infections.Infect Immun. doi: 10.1128/IAI.00097-17

» View on PubMed

CD14 (61D3)

 

Martín-Nalda A, Fortuny C, Rey L, et al. Severe Autoinflammatory Manifestations and Antibody Deficiency Due to Novel Hypermorphic PLCG2 Mutations [published online ahead of print, 2020 Jul 15]. J Clin Immunol. 2020;10.1007/s10875-020-00794-7. doi:10.1007/s10875-020-00794-7.

» View on PubMed

Roa, J.A., Sarkar, D., Zanaty, M. et al. Preliminary results in the analysis of the immune response after aneurysmal subarachnoid hemorrhage. Sci Rep 10, 11809 (2020). https://doi.org/10.1038/s41598-020-68861-y.

» View on Nature 

Malhotra S, Costa C, Eixarch H, Keller CW, Amman L, Martínez-Banaclocha H, Midaglia L, Sarró E, Machín-Díaz I, Villar LM, Triviño JC, Oliver-Martos B, Parladé LN, Calvo-Barreiro L, Matesanz F, Vandenbroeck K, Urcelay E, Martínez-Ginés ML, Tejeda-Velarde A, Fissolo N, Castilló J, Sanchez A, Robertson AAB, Clemente D, Prinz M, Pelegrin P, Lünemann JD, Espejo C, Montalban X, Comabella M. NLRP3 inflammasome as prognostic factor and therapeutic target in primary progressive multiple sclerosis patients. Brain. 2020 Apr 13. pii: awaa084. doi: 10.1093/brain/awaa084.

» View on PubMed

Burel JG, Pomaznoy M, Lindestam Arlehamn CS, et al. Circulating T cell-monocyte complexes are markers of immune perturbations. Elife. 2019;8:e46045. Published 2019 Jun 25.

» View on PubMed

Sato Y, Kato H, Ebina-Shibuya R, Itoh-Nakadai A, Okuyama R and Igarashi K. 2017. Bach2 Controls Homeostasis of Eosinophils by Restricting the Type-2 Helper Function of T Cells. Tohoku J Exp Med. doi: 10.1620/tjem.241.175

» View on PubMed

Moghaddas F, Llamas R, De Nardo D, Martinez-Banaclocha H, Martinez-Garcia JJ, Mesa-Del-Castillo P, Baker PJ, Gargallo V, Mensa-Vilaro A, Canna S, Wicks IP, Pelegrin P, Arostegui JI and Masters SL. 2017. A novel Pyrin-Associated Autoinflammation with Neutrophilic Dermatosis mutation further defines 14-3-3 binding of pyrin and distinction to Familial Mediterranean Fever. Ann Rheum Dis. 2. doi: 10.1136/annrheumdis-2017-211473.

» View on PubMed

CD8 (SK1)

 

Muneyoshi FutamiI, Keisuke Suzuki, Satomi Kato, Saori Ohmae, Yoshio Tahara, Masanori Nojima, Yoichi Imai, Takayuki Mimura, Yoshihiro Watanabe, Arinobu Tojo.  The novel multi-cytokine inhibitor TO-207 specifically inhibits pro-inflammatory cytokine secretion in monocytes without affecting the killing ability of CAR T cells. PLoS One. 2020 Apr 22;15(4):e0231896. doi: 10.1371/journal.pone.0231896.

» View on PubMed

Scharer CD, Bally AP, Gandham B and Boss JM. 2017. Cutting Edge: Chromatin Accessibility Programs CD8 T Cell Memory. J Immunol. doi: 10.4049/jimmunol.1602086

» View on PubMed

Sato Y, Kato H, Ebina-Shibuya R, Itoh-Nakadai A, Okuyama R and Igarashi K. 2017. Bach2 Controls Homeostasis of Eosinophils by Restricting the Type-2 Helper Function of T Cells. Tohoku J Exp Med. doi: 10.1620/tjem.241.175

» View on PubMed

CD56 (NCAM) (MY31)

Bennit HF, Gonda A, Oppegard L, Chi D, Khan S and Wall N. 2017. Uptake of lymphoma-derived exosomes by peripheral blood leukocytes. Blood and Lymphatic Cancer: Targets and Therapy 7:9-23.

» View on PubMed

Chen KH, Wada M, Firor AE, Pinz KG, Jares A, Liu H, Salman H, Golightly M, Lan F, Jiang X and Ma Y. 2016. Novel anti-CD3 chimeric antigen receptor targeting of aggressive. DOI:10.18632/oncotarget.11019

» View on PubMed

CD5 (UCHT2)

Chen KH, Wada M, Firor AE, Pinz KG, Jares A, Liu H, Salman H, Golightly M, Lan F, Jiang X and Ma Y. 2016. Novel anti-CD3 chimeric antigen receptor targeting of aggressive T cell malignancies. Oncotarget. DOI: 10.18632/oncotarget.11019

» View on PubMed

CD11b (M1/70)

 

Roa, J.A., Sarkar, D., Zanaty, M. et al. Preliminary results in the analysis of the immune response after aneurysmal subarachnoid hemorrhage. Sci Rep 10, 11809 (2020). https://doi.org/10.1038/s41598-020-68861-y.

» View on Nature 

Kamata T, So TY, Ahmed Q, et al. Fibroblast-Derived STC-1 Modulates Tumor-Associated Macrophages and Lung Adenocarcinoma Development. Cell Rep. 2020;31(12):107802. doi:10.1016/j.celrep.2020.107802.

» View on ScienceDirect

Komura N, Mabuchi S, Shimura K, et al. The role of myeloid-derived suppressor cells in increasing cancer stem-like cells and promoting PD-L1 expression in epithelial ovarian cancer. 2020 Jun 19. Cancer Immunol Immunother. 2020;10.1007/s00262-020-02628-2. doi:10.1007/s00262-020-02628-2.

» View on PubMed

Julie E. Stark, Amy M. OpokaID, Lin Fei, Huaiyu Zang, Stella M. Davies, Hector R. Wong, Matthew N. Alder. Longitudinal characterization of olfactomedin-4 expressing neutrophils in pediatric patients undergoing bone marrow transplantation. PLoS One. 2020 May 29;15(5):e0233738. doi: 10.1371/journal.pone.0233738. eCollection 2020.

» View on PubMed

Markman, J.L., Porritt, R.A., Wakita, D. et al. Loss of testosterone impairs anti-tumor neutrophil function. Nat Commun 11, 1613 (2020). https://doi.org/10.1038/s41467-020-15397-4.

» View on Nature Communications

Shindo R, Katagiri T, Komazawa-Sakon S, et al. Regenerating islet-derived protein (Reg)3β plays a crucial role in attenuation of ileitis and colitis in mice. Biochem Biophys Rep. 2020;21:100738. Published 2020 Feb 7. doi:10.1016/j.bbrep.2020.100738.

» View on PubMed

Udden SN, Kwak YT, Godfrey V, et al. NLRP12 suppresses hepatocellular carcinoma via downregulation of cJun N-terminal kinase activation in the hepatocyte. Elife. 2019;8:e40396. Published 2019 Apr 16. doi:10.7554/eLife.40396.

» View on PubMed

Andersen TK, Huszthy PC, Gopalakrishnan RP, et al. Enhanced germinal center reaction by targeting vaccine antigen to major histocompatibility complex class II molecules. NPJ Vaccines. 2019;4:9. Published 2019 Feb 11. doi:10.1038/s41541-019-0101-0.

» View on PubMed

Kim IS, Gao Y, Welte T, et al. Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms. Nat Cell Biol. 2019;21(9):1113-1126. doi:10.1038/s41556-019-0373-7.

» View on PubMed

Guo M, Price MJ, Patterson DG, et al. EZH2 Represses the B Cell Transcriptional Program and Regulates Antibody-Secreting Cell Metabolism and Antibody Production. J Immunol. 2018;200(3):1039-1052. doi:10.4049/jimmunol.1701470.

» View on PubMed

Bahnan W, Boucher JC, Gayle P, et al. The eIF2α Kinase Heme-Regulated Inhibitor Protects the Host from Infection by Regulating Intracellular Pathogen Trafficking. Infect Immun. 2018;86(3):e00707-17. Published 2018 Feb 20. doi:10.1128/IAI.00707-17.

» View on PubMed

Kuroda H, Mabuchi S, Kozasa K, Yokoi E, Matsumoto Y, Komura N, Kawano M, Hashimoto K, Sawada K and Kimura T. 2017. PM01183 inhibits myeloid-derived suppressor cells in vitro and in vivo. Immunotherapy. doi: 10.2217/imt-2017-0046.

» View on PubMed

Frederick DR, Goggins JA, Sabbagh LM, Freytag LC, Clements JD and McLachlan JB. 2017. Adjuvant selection regulates gut migration and phenotypic diversity of antigen-specific CD4+ T cells following parenteral immunization. Mucosal Immunol. doi: 10.1038/mi.2017.70.

» View on PubMed

Johnson LE, Olson BM and McNeel DG. 2017. Pretreatment antigen-specific immunity and regulation - association with subsequent immune response to anti-tumor DNA vaccination. J Immunother Cancer. doi: 10.1186/s40425-017-0260-3.

» View on PubMed

Shiokawa A, Kotaki R, Takano T, Nakajima-Adachi H and Hachimura S. 2017. Mesenteric lymph node CD11b- CD103+ PD-L1High dendritic cells highly induce regulatory T cells. Immunology. doi: 10.1111/imm.12747

» View on PubMed

Kishimoto Y, Asakawa S, Sato T, Takano T, Nakajyo T, Mizuno N, Segawa R, Yoshikawa T, Hiratsuka M, Yanai K, Ohtsu H and Hirasawa N. 2017. Induced histamine regulates Ni elution from an implanted Ni wire in mice by downregulating neutrophil migration. Exp Dermatol. doi: 10.1111/exd.13315.

» View on PubMed

Mgbemena VE, Signer RA, Wijayatunge R, Laxson T, Morrison SJ, Ross TS. 2017. Distinct Brca1 Mutations Differentially Reduce Hematopoietic Stem Cell Function. Cell Rep. DOI: 10.1016/j.celrep.2016.12.075

» View on PubMed

Trott DW, Henson GD, Ho MHT, Allison SA, Lesniewski LA and Donato AJ. 2016. Age-related arterial immune cell infiltration in mice is attenuated by caloric restriction or voluntary exercise. Exp. Gerontol. DOI: 10.1016/j.exger.2016.12.016

» View on PubMed

Hastings AK, Erickson JJ, Schuster JE, Boyd KL, Tollefson SJ, Johnson M, Gilchuk P, Joyce S and Williams JV. 2015. Role of type I interferon signaling in human metapneumovirus pathogenesis and control of viral replication. J Virol. 89(8): 4405-4420.

» View on PubMed

Kawano M, Mabuchi S, Matsumoto Y, Sasano T, Takahashi R, Kuroda H, Kozasa K, Hashimoto K, Isobe A, Sawada K, Hamasaki T, Morii E and Kimura T. 2015. The significance of G-CSF expression and myeloid-derived suppressor cells in the chemoresistance of uterine cervical cancer. Sci Rep. 5:18217 doi:10.1038/srep18217.

» View on PubMed

Molina-Sanchez P, Chevre R, Rius C, Fuster JJ and Andres V. 2015. Loss of p27 phosphorylation at Ser10 accelerates early atherogenesis by promoting leukocyte recruitment via RhoA/ROCK. J Mol Cell Cardiol. 84: 84-94.

» View on PubMed

O'Sullivan TE, Johnson LR, Kang HH, Sun JC. 2015. BNIP3- and BNIP3L-Mediated Mitophagy Promotes the Generation of Natural Killer Cell Memory. Immunity. 43: 331-342.

» View on PubMed

Manz BN, Tan YX, Courtney A, Rutaganira F, Palmer E, Shokat KM and Weiss A. 2015. Small molecule inhibition of Csk alters affinity recognition by T cells. Elife. doi: 10.7554/eLife.08088.

» View on PubMed

Come C, Cvrljevic A, Khan MM, Treise I, Adler T, Aguilar-Pimental JA, Au-Yeung B, Sittig E, Laajala TD, Chen Y, Oeder S, Calzada-Wack J, Horsch M, Aittokallio T, Busch DH, Ollert MW, Neff F, Beckers J, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Chen Z, Lahesmaa R, and Westermarck J. 2016. CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection. PLoS ONE 11(4):e0152996. doi:10.1371/journal.pone.0152996

» View on PubMed

Spanier JA, Frederick DR, Taylor JJ, Heffernan JR, Kotov DI, Martinox T, Osum KC, Ruggiero JL, Rust BJ, Landry SJ, Jenkins MK, McLachlan JB, and Fife BT. 2016. Efficient Generation of Monoclonal Antibodies Against Peptide in the Context of MHCII Using Magnetic Enrichment. Nature Communications. doi:10.1038/ncomms11804

» View on PubMed

Sato T, Kishimoto Y, Asakawa S, Mizuno N, Hiratsuka M and Hirasawa N. 2016. Involvement of COX-2 in nickel elution from a wire implanted subcutaneously in mice. Toxicology. Volumes 363–364, 1 July 2016, Pages 37–45

» View on PubMed

Gilchuk P, Hill TM, Guy C, McMaster SR, Boyd KL, Rabacal WA, Lu P, Shyr Y, Kohlmeier JE, Sebzda E, Green DR and Joyce S.2016. A Distinct Lung-Interstitium-Resident Memory CD8+ T Cell Subset Confers Enhanced Protection to Lower Respiratory Tract Infection. Cell Reports. DOI: 10.1016/j.celrep.2016.07.037

» View on PubMed

Barwick BG, Scharer CD, Bally APR and Boss JM. 2016. Plasma Cell Differentiation is Coupled to Division-Dependent DNA Hypomethylation and Gene Regulation. Nat Immunol. 17(10):1216-25

» View on PubMed

Taylor RA, Chang CF, Goods BA, Hammond MD, Mac Grory B, Ai Y, Steinschneider AF, Renfroe SC, Askenase MH, McCullough LD, Kasner SE, Mullen MT, Hafler DA, Love JC, Sansing LH. 2016. TGF-β1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage. J. Clin. Invest. doi:10.1172/JCI88647

» View on PubMed

Dill R and Walker AM. 2016. Role of Prolactin in Promotion of Immune Cell Migration into the Mammary Gland. J. Mammary Gland Biol. Neoplasia. doi: 10.1007/s10911-016-9369-0

» View on PubMed

Huo M, Huang Y, Qu D, Zhang H, Wong WT, Chawla A, Huang Y and Tian XY. 2016. Myeloid Bmal1 deletion increases monocyte recruitment and worsens atherosclerosis. FASEB J. doi:10.1096/fj.201601030R

» View on PubMed


CD19 (HIB19)

Roa, J.A., Sarkar, D., Zanaty, M. et al. Preliminary results in the analysis of the immune response after aneurysmal subarachnoid hemorrhage. Sci Rep 10, 11809 (2020). https://doi.org/10.1038/s41598-020-68861-y.

» View on Nature 

Diaz-Flores E, Comeaux EQ, Kim KL, et al. Bcl-2 Is a Therapeutic Target for Hypodiploid B-Lineage Acute Lymphoblastic Leukemia. Cancer Res. 2019;79(9):2339-2351. doi:10.1158/0008-5472.CAN-18-0236.

» View on PubMed

Bustos-Moran E, Blas-Rus N, Martin-Cofreces N and Sanchez-Madrid F. 2017. Microtubule associated protein-4 (MAP4) controls nanovesicle dynamics and T cell activation. J Cell Sci. doi: 10.1242/jcs.199042

» View on PubMed

Yoshia Y, Ogata A, Kang S, Ebina K, Shi K, Nojima S, Kimura T, Ito D, et al. 2015. Semaphorin 4D contributes to rheumatoid arthritis by inducing inflammatory cytokine production: Pathogenic and therapeutic implications. Arthritis Rheumatol. 67(6): 1481-1490.

» View on PubMed

Ryotokuji K, Nakajima T, Ishimaru K, Ozaki-Shimada A, Kihara K, Namiki Y and Otani S. 2015. Effect of Stress-Free Therapy on immune system: Induction of Interleukin 10 expression in lymphocytes through activation of CD19(+) CD24(hi) CD38(hi) regulatory B Cells. Laser Therapy. 24(3): 179-188.

» View on J-STAGE

Price AA, Tedesco D, Prasad MR, Workowski KA, Walker CM, Suthar MS, Honegger JR and Grakoui A. 2016. Prolonged Activation of Innate Antiviral Gene Signature After Childbirth is Determined by IFNL3 Genotype. Proc Natl Acad Sci USA doi: 10.1073/pnas.1602319113

» View on PubMed

» View on PubMed CD20 (2H7)

Kevin C. Osum, Adam L. Burrack, Tijana Martinov, Nathanael L. Sahli, Jason S. Mitchell, Christopher G. Tucker, Kristen E. Pauken, Klearchos Papas, Balamurugan Appakalai, Justin A. Spanier, & Brian T. Fife. Interferon-gamma drives programmed death-ligand 1 expression on islet β cells to limit T cell function during autoimmune diabetes. Sci Rep. 2018 May 29;8(1):8295. doi: 10.1038/s41598-018-26471-9

» View on PubMed

CD27 (O323)

 

Versteeg K, Menicucci AR, Woolsey C, Mire CE, Geisbert JB, Cross RW, Agans KN, Jeske D, Messaoudi I and Geisbert TW. 2017. Infection with the Makona variant results in a delayed and distinct host immune response compared to previous Ebola virus variants. Sci Rep. doi: 10.1038/s41598-017-09963-y.

» View on PubMed

Wilson RM, Marshall NE, Jeske DR, Purnell JQ, Thornburg K and Messaoudi I. 2015. Maternal Obesity alters immune cell frequencies and responses in umbilical cord blood samples. Pediatr Allergy Immunol. 26(4): 344-351.

» View on PubMed

Cantisan S, Paez-Vega A, Perez-Romero P, Montejo M, Cordero E, Gracia-Ahufinger I, Martin-Gandul C, Maruri N, Aguado R, Solana R and Torre-Cisneros J. 2016. Prevention Strategies Differentially Modulate the Impact of Cytomegalovirus Replication on CD8+ T-cell Differentiation in High-Risk Solid Organ Transplant Patients. Antiviral Research. doi:10.1016/j.antiviral.2016.06.012

» View

CD44 (IM7)

Iida Y, Yoshikawa R, Murata A, et al. Local injection of CCL19-expressing mesenchymal stem cells augments the therapeutic efficacy of anti-PD-L1 antibody by promoting infiltration of immune cells. J Immunother Cancer. 2020;8(2):e000582. doi:10.1136/jitc-2020-000582.

» View on PubMed

Kiatpakdee B, Sato K, Otsuka Y, Arashiki N, Chen Y, Tsumita T, Otsu W, Yamamoto A, Kawata R, Yamazaki J, Sugimoto Y, Takada K, Mohandas N, Inaba M. Cholesterol-binding protein TSPO2 coordinates maturation and proliferation of terminally differentiating erythroblasts. J Biol Chem. 2020 May 1. pii: jbc.RA119.011679. doi: 10.1074/jbc.RA119.011679.

» View on PubMed

Atif SM, Mack DG, McKee AS, et al. Protective role of B cells in sterile particulate-induced lung injury. JCI Insight. 2019;5(12):e125494. Published 2019 May 16. doi:10.1172/jci.insight.125494.

» View on PubMed

Govindarajan S, Gaublomme D, Van der Cruyssen R, et al. Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha. Nat Commun. 2018;9(1):5340. Published 2018 Dec 17. doi:10.1038/s41467-018-07758-x.

» View on Nature Communications

Scharer CD, Bally AP, Gandham B and Boss JM. 2017. Cutting Edge: Chromatin Accessibility Programs CD8 T Cell Memory. J Immunol. doi: 10.4049/jimmunol.1602086

» View on PubMed

Zander RA, Guthmiller JJ, Graham AC, Pope RL, Burke BE, Carr DJ and Butler NS. 2016. Type I Interferons Induce T Regulatory 1 Responses and Restrict Humoral Immunity during Experimental Malaria. PLOS Pathogens. DOI:10.1371/journal.ppat.1005945

» View on PubMed

Nakamachi T, Sugiyama K, Watanabe J, Imai N, Kagami N, Hori M, Arata S and Shioda S. 2014. Comparison of Expression and Proliferative Effect of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) and its Receptors on Human Astrocytoma Cell Lines J Mol Neurosci. 54(3): 388-394.

» View on PubMed

Schwerk A, Altshuler J, Roch M, Gossen M, Winter C, Berg J, Kurtz A, Akyuz L and Steiner B. 2015. Adipose-derived human mesenchymal stem cells induce long-term neurogenic and anti-inflammatory effects and improve cognitive but not motor performance in a rat model of Parkinson's disease. Regen Med. 10(4): 431-445.

» View on PubMed

CD45 (HI30)

 

A CX3CR1 Reporter hESC Line Facilitates Integrative Analysis of In-Vitro-Derived Microglia and Improved Microglia Identity Upon Neuron-Glia Co-culture. Alexandra GrubmanTeresa H Vandekolk, Jan Schröder, Guizhi Sun, Jessica Hatwell-Humble, Jonathan Chan, Minna Oksanen, Sarka Lehtonen, Cameron Hunt, Jari E Koistinaho, Susan K Nilsson, John M Haynes, Colin W Pouton, Jose M Polo. Stem Cell Reports. 2020 May 11;S2213-6711(20)30147-8. doi: 10.1016/j.stemcr.2020.04.007. 

» View on PubMed

Markman, J.L., Porritt, R.A., Wakita, D. et al. Loss of testosterone impairs anti-tumor neutrophil function. Nat Commun 11, 1613 (2020). https://doi.org/10.1038/s41467-020-153.

» View on Nature Communications

Burel JG, Pomaznoy M, Lindestam Arlehamn CS, et al. Circulating T cell-monocyte complexes are markers of immune perturbations. Elife. 2019;8:e46045. Published 2019 Jun 25.

» View on PubMed

Bachanova V, Frankel AE, Cao Q, Lewis D, Grzywacz B, Verneris MR, Ustun C, Lazaryan A, McClune B, Warlick ED, Kantarjian H, Weisdorf DJ, Miller JS, Vallera DA. 2015. Phase I Study of a Bispecific Ligand-Directed Toxin Targeting CD22 and CD19 (DT2219) for Refractory B-cell Malignancies. Clin Cancer Res. 21(6): 1267-1272.

» View on PubMed

Ogata Y, Mabuchi Y, Yoshida M, Suto EG, Suzuki N, Muneta T, Sekiya I and Akazawa C. 2015. Purified Human Synovium Mesenchymal Stem Cells as a Good Resource for Cartilage Regeneration. PLoS One. 10.1371/journal.pone.0129096.

» View on PubMed

Mei HE, Leipold MD and Maecker HT. 2015. Platinum-conjugated antibodies for application in mass cytometry. Cytometry A. DOI: 10.1002/cyto.a.22778.

» View on PubMed

Shen Z, Rodriguez-Garcia M, Patel MV, Barr FD and Wire CR. 2016. Menopausal Status Influences the Expression of Programmed Death (PD)-1 and its Ligand PD-L1 on Immune Cells from the Human Female Reproductive Tract. American Journal of Reproductive Immunology. DOI: 10.1111/aji.12532

» View on PubMed

Rodriguez-Garcia M, Shen Z, Barr FD, Boesch AW, Ackerman ME, Kappes JC, Ochsenbauer C and Wira CR. 2016. Dendritic cells from the human female reproductive tract rapidly capture and respond to HIV. Dartmouth. Immunol. doi:10.1038/mi.2016.72 199

» View on PubMed

CD127 (R34-34)

Kyoizumi S, Kubo Y, Kajimura J, Yoshida K, Hayashi T, Nakachi K, Young LF, Moore MA, van den Brink MR and Kusunoki Y. 2014. Linkage between Dendritic and T Cell Commitments in Human Circulating Hematopoietic Progenitors. J Immunol. 192(12): 5749-5760.

» View on PubMed

CD8a (RPA-T8)

 

Zhang AH, Yoon J, Kim YC, Scott DW. Targeting Antigen-Specific B Cells Using Antigen-Expressing Transduced Regulatory T Cells. J Immunol. 2018;201(5):1434-1441. doi:10.4049/jimmunol.1701800.

» View on Journal of Immunology

Morimoto S, Fujiki F, Kondo K, et al. Establishment of a novel platform cell line for efficient and precise evaluation of T cell receptor functional avidity. Oncotarget. 2018;9(75):34132-34141. Published 2018 Sep 25. doi:10.18632/oncotarget.26139.

» View on PubMed

Ryotokuji K, Nakajima T, Ishimaru K, Ozaki-Shimada A, Kihara K, Namiki Y and Otani S. 2015. Effect of Stress-Free Therapy on immune system: Induction of Interleukin 10 expression in lymphocytes through activation of CD19(+) CD24(hi) CD38(hi) regulatory B Cells. Laser Therapy. 24(3): 179-188.

» View

Dillon, SM, Lee EJ, Donovan AM, Guo K, Harper MS, Frank DN, McCarter MD, Santiago ML, and Wilson CC. 2016. Enhancement of HIV-1 infection and intestinal CD4+ T cell depletion ex vivo by gut microbes altered during chronic HIV-1 infection. Retrovirology. DOI 10.1186/s12977-016-0237-1

» View on PubMed

CD28 (CD28.2)

 

Brincks E. L., Adams J., Wang L., Turner B., Marcinowicz A., Ke J., Essmann M., Mautino L. M., Allen C. Van, Kumar S., Vahanian N., Link C., Mautino M. R. et al Indoximod opposes the immunosuppressive effects mediated by IDO and TDO via modulation of AhR function and activation of mTORC1. Oncotarget. 2020; 11: 2438-2461.

View on Oncotarget

Molly OhainleI, Kyusik Kim, Sevnur Komurlu Keceli, Abby Felton, Ed Campbell, Jeremy LubanI, Michael. Emerman. TRIM34 restricts HIV-1 and SIV capsids in a TRIM5α-dependent manner. PLoS Pathog. 2020 Apr 13;16(4):e1008507. doi: 10.1371/journal.ppat.1008507

» View on PubMed

Hultquist JF, Hiatt J, Schumann K, et al. CRISPR-Cas9 genome engineering of primary CD4+ T cells for the interrogation of HIV-host factor interactions. Nat Protoc. 2019;14(1):1-27. doi:10.1038/s41596-018-0069-7.

» View on PubMed

Nau GJ, Horzempa J, O'Dee D, et al. A predicted Francisella tularensis DXD-motif glycosyltransferase blocks immune activation. Virulence. 2019;10(1):643-656. doi:10.1080/21505594.2019.1631662.

» View on PubMed

Sánchez-Villanueva JA, Rodríguez-Jorge O, Ramírez-Pliego O, et al. Contribution of ROS and metabolic status to neonatal and adult CD8+ T cell activation. PLoS One. 2019;14(12):e0226388. Published 2019 Dec 16. doi:10.1371/journal.pone.0226388.

» View on PubMed

Versteeg K, Menicucci AR, Woolsey C, Mire CE, Geisbert JB, Cross RW, Agans KN, Jeske D, Messaoudi I and Geisbert TW. 2017. Infection with the Makona variant results in a delayed and distinct host immune response compared to previous Ebola virus variants. Sci Rep. doi: 10.1038/s41598-017-09963-y.

» View on PubMed

 Rupp LJ, Schumann K, Roybal KT, Gate RE, Ye CJ, Lim WA and Marson A. 2017. CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells. Sci Rep. doi: 10.1038/s41598-017-00462-8

» View on PubMed

Chi S, Weiss A and Wang H. 2015. A CRISPR-based Toolbox For Studying T Cell Signal Transduction. BioMed Res Int. DOI:10.1155/2016/5052369

» View

Miles B, Miller SM, Folkvord JM, Kimball A, Chamanian M, Meditz AL, Arends T, McCarter MD, Levy DN, Rakasz EG, Skinner PJ and Connick E. 2015. Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection. Nat Commun. doi: 10.1038/ncomms9608.

» View on PubMed

Hultquist JF, Schumann K, Woo JM, Manganaro L, McGregor MJ, Doudna J, Simon V, Krogan NJ and Marson A. 2016. A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells. Cell Rep. doi: 10.1016/j.celrep.2016.09.080.

» View on PubMed

Galindo-Albarran AO, Lopez-Portales OH, Gutierrez-Reyna DY, Rodriguez-Jorge O, Sanchez-Villanueva JA, Ramirez-Pliego O, Bergon A, Loriod B, Holota H, Imbert J, Hernandez-mendoza A, Ferrier P, Carrillo-de Santa Pau E, Valencia A, Spicuglia S and Santana MA. 2016. CD8+ T Cells from Human Neonates Are Biased toward an Innate Immune Response. Cell Rep. doi: 10.1016/j.celrep.2016.10.056

» View

Park RJ, Wang T, Koundakjian D, Hultquist JF, Lamothe-Molina P, Monel B, Schumann K, Yu H,Krupzcak KM, Garcia-Beltran W, Piechocka-Trocha A, Krogan NJ, Marson A, Sabatini DM, Lander ES, Hacohen N and Walker BD. 2016. A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors. Nature Genet. doi:10.1038/ng.3741

» View on PubMed

CD45RA (HI100)

 

Dejene M. Tufa, Tyler Shank, Ashley M. Yingst, George Devon Trahan, Seonhui Shim, Jessica Lake, Renee Woods, Kenneth Jones & Michael R. Verneris. Prolactin Acts on Myeloid Progenitors to Modulate SMAD7 Expression and Enhance Hematopoietic Stem Cell Differentiation into the NK Cell Lineage.  Sci Rep. 2020 Apr 14;10(1):6335. doi: 10.1038/s41598-020-63346-4

» View on Nature

Tomellini E, Fares I, Lehnertz B, et al. Integrin-α3 Is a Functional Marker of Ex Vivo Expanded Human Long-Term Hematopoietic Stem Cells. Cell Rep. 2019;28(4):1063-1073.e5. doi:10.1016/j.celrep.2019.06.084.

» View on PubMed

Zhang AH, Yoon J, Kim YC, Scott DW. Targeting Antigen-Specific B Cells Using Antigen-Expressing Transduced Regulatory T Cells. J Immunol. 2018;201(5):1434-1441. doi:10.4049/jimmunol.1701800.

» View on Journal of Immunology

Kyoizumi S, Kubo Y, Kajimura J, Yoshida K, Hayashi T, Nakachi K, Moore MA, van den Brink MRM and Kusunoki Y. 2017. Fate Decision Between Group 3 Innate Lymphoid and Conventional NK Cell Lineages by Notch Signaling in Human Circulating Hematopoietic Progenitors. J Immunol. doi: 10.4049/jimmunol.1601711.

» View on PubMed

Caër C, Rouault C, Le Roy T, Poitou C, Aron-Wisnewsky J, Torcivia A, Bichet JC, Clément K, Guerre-Millo M, and André S. 2017. Immune cell-derived cytokines contribute to obesity-related inflammation, fibrogenesis and metabolic deregulation in human adipose tissue. Sci Rep. doi: 10.1038/s41598-017-02660-w.

» View on PubMed

Ryotokuji K, Nakajima T, Ishimaru K, Ozaki-Shimada A, Kihara K, Namiki Y and Otani S. 2015. Effect of Stress-Free Therapy on immune system: Induction of Interleukin 10 expression in lymphocytes through activation of CD19(+) CD24(hi) CD38(hi) regulatory B Cells. Laser Therapy. 24(3): 179-188.

» View

Viisanen T, Ihantola E, Nanto-Salonen K, Hyoty H, Nurminen N, Selvenius J, Juutilainen A, Moilanen L, Pihlajamaki J, Veijola R, Toppari J, Knip M, Ilonen J and Kinnunen T. 2016. Circulating CXCR5+PD-1+ICOS+ Follicular T Helper Cells Are Increased Close to the Diagnosis of Type 1 Diabetes in Children with Multiple Autoantibodies. Diabetes. DOI: 10.2337/db16-0714

» View

CD45R (B220) (RA3-6B2)

 

Jonathan J Pinney, Fátima Rivera-Escalera, Charles C Chu, Hannah E Whitehead, Karl VanDerMeid, Ashley M Nelson, Michelle C Barbeau, Clive S Zent, Michael R Elliott; Macrophage hypophagia as a mechanism of innate immune exhaustion in mAb-induced cell clearance. Blood.2020005571. doi: https://doi.org/10.1182/blood.2020005571.

» View on PubMed

Noviski M, Mueller JL, Satterthwaite A, Garrett-Sinha LA, Brombacher F, Zikherman J. IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate. Elife. 2018;7:e35074. Published 2018 Mar 9. doi:10.7554/eLife.35074.

» View on PubMed

Guo M, Price MJ, Patterson DG, et al. EZH2 Represses the B Cell Transcriptional Program and Regulates Antibody-Secreting Cell Metabolism and Antibody Production. J Immunol. 2018;200(3):1039-1052. doi:10.4049/jimmunol.1701470.

» View on PubMed

Scharer CD, Barwick BG, Guo M, Bally APR, Boss JM. Plasma cell differentiation is controlled by multiple cell division-coupled epigenetic programs. Nat Commun. 2018;9(1):1698. Published 2018 Apr 27. doi:10.1038/s41467-018-04125-8.

» View on PubMed

Ganuza M, Hall T, Finkelstein D, Chabot A, Kang G and McKinney-Freeman S. (2017) Lifelong haematopoiesis is established by hundreds of precursors throughout mammalian ontogeny. Nat Cell Biol. DOI: 10.1038/ncb3607

» View on PubMed

CD161 (HP-3G10)

Roa, J.A., Sarkar, D., Zanaty, M. et al. Preliminary results in the analysis of the immune response after aneurysmal subarachnoid hemorrhage. Sci Rep 10, 11809 (2020). https://doi.org/10.1038/s41598-020-68861-y.

» View on Nature 

Ryotokuji K, Nakajima T, Ishimaru K, Ozaki-Shimada A, Kihara K, Namiki Y and Otani S. 2015. Effect of Stress-Free Therapy on immune system: Induction of Interleukin 10 expression in lymphocytes through activation of CD19(+) CD24(hi) CD38(hi) regulatory B Cells. Laser Therapy. 24(3): 179-188.

» View on J-STAGE

CD25 (BC96)

Zhang AH, Yoon J, Kim YC, Scott DW. Targeting Antigen-Specific B Cells Using Antigen-Expressing Transduced Regulatory T Cells. J Immunol. 2018;201(5):1434-1441. doi:10.4049/jimmunol.1701800.

» View on Journal of Immunology

Kyoizumi S, Kubo Y, Kajimura J, Yoshida K, Hayashi T, Nakachi K, Moore MA, van den Brink MRM and Kusunoki Y. 2017. Fate Decision Between Group 3 Innate Lymphoid and Conventional NK Cell Lineages by Notch Signaling in Human Circulating Hematopoietic Progenitors. J Immunol. doi: 10.4049/jimmunol.1601711.

» View on PubMed

Ryotokuji K, Nakajima T, Ishimaru K, Ozaki-Shimada A, Kihara K, Namiki Y and Otani S. 2015. Effect of Stress-Free Therapy on immune system: Induction of Interleukin 10 expression in lymphocytes through activation of CD19(+) CD24(hi) CD38(hi) regulatory B Cells. Laser Therapy. 24(3): 179-188.

» View

Miles B, Miller SM, Folkvord JM, Kimball A, Chamanian M, Meditz AL, Arends T, McCarter MD, Levy DN, Rakasz EG, Skinner PJ and Connick E. 2015. Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection. Nat Commun. doi: 10.1038/ncomms9608.

» View on PubMed

Cheng H, Gaddis DE, Wu R, McSkimming C, Haynes LD, Taylor AM, McNamara CA, Sorci-Thomas M and Hedrick CC. 2016. Loss of ABCG1 Influences Regulatory T Cell Differentiation and Atherosclerosis. J. Clin. Invest. doi:10.1172/JCI83136.

» View on PubMed

CD45RO (UCHL1)

 

Justin T GibsonKatlyn E Norris, Gal Wald, Claire M Buchta Rosean, Lewis J Thomas, Shannon K Boi, Laura A Bertrand, Megan Bing, Jennifer B Gordetsky, Jessy Deshane, Peng Li James A Brown, Kenneth G Nepple, Lyse A Norian. Obesity induces limited changes to systemic and local immune profiles in treatment-naive human clear cell renal cell carcinoma. PLoS One. 2020 May 29;15(5):e0233795. doi: 10.1371/journal.pone.0233795. eCollection 2020.

» View on PubMed

Galindo-Albarran AO, Lopez-Portales OH, Gutierrez-Reyna DY, Rodriguez-Jorge O, Sanchez-Villanueva JA, Ramirez-Pliego O, Bergon A, Loriod B, Holota H, Imbert J, Hernandez-mendoza A, Ferrier P, Carrillo-de Santa Pau E, Valencia A, Spicuglia S and Santana MA. 2016. CD8+ T Cells from Human Neonates Are Biased toward an Innate Immune Response. Cell Rep. doi: 10.1016/j.celrep.2016.10.056

» View

CD11b (ICRF44)

 

Markman, J.L., Porritt, R.A., Wakita, D. et al. Loss of testosterone impairs anti-tumor neutrophil function. Nat Commun 11, 1613 (2020). https://doi.org/10.1038/s41467-020-153.

» View on Nature Communications

Kevin C. Osum, Adam L. Burrack, Tijana Martinov, Nathanael L. Sahli, Jason S. Mitchell, Christopher G. Tucker, Kristen E. Pauken, Klearchos Papas, Balamurugan Appakalai, Justin A. Spanier, & Brian T. Fife. Interferon-gamma drives programmed death-ligand 1 expression on islet β cells to limit T cell function during autoimmune diabetes. Sci Rep. 2018 May 29;8(1):8295. doi: 10.1038/s41598-018-26471-9.

» View on PubMed

Rodriguez-Garcia M, Shen Z, Barr FD, Boesch AW, Ackerman ME, Kappes JC, Ochsenbauer C and Wira CR. 2016. Dendritic cells from the human female reproductive tract rapidly capture and respond to HIV. Mucosal. Immunol. doi:10.1038/mi.2016.72 199.

» View on PubMed

 

 HLA-DR (L243) 

 

Markman, J.L., Porritt, R.A., Wakita, D. et al. Loss of testosterone impairs anti-tumor neutrophil function. Nat Commun 11, 1613 (2020). https://doi.org/10.1038/s41467-020-15397-4.

» View on Nature Communications

Clones not Specified

Roa, J.A., Sarkar, D., Zanaty, M. et al. Preliminary results in the analysis of the immune response after aneurysmal subarachnoid hemorrhage. Sci Rep 10, 11809 (2020). https://doi.org/10.1038/s41598-020-68861-y.

» View on Nature 

Dishon S, Cohen SJ, Cohen IR and Nussbaum G. 2017. Inhibition of Myeloid Differentiation Factor 88 Reduces Human and Mouse T-Cell Interleukin-17 and IFNγ Production and Ameliorates Experimental Autoimmune Encephalomyelitis Induced in Mice. Front Immunol. doi: 10.3389/fimmu.2017.00615

» View on PubMed

Chu HH, Chan SW, Gosling JP, Blanchard N, Tsitsiklis A, Lythe G, Shastri N, Molina-París C and Robey EA. 2016. Continuous Effector CD8(+) T Cell Production in a Controlled Persistent Infection Is Sustained by a Proliferative Intermediate Population. Immunity. doi: 10.1016/j.immuni.2016.06.013.

» View on PubMed

Kobayashi E, Kishi H, Ozawa T, Horii M, Hamana H, Nagai T and Muraguchi A. 2014. Retroviral vectors for homologous recombination provide efficient cloning and expression in mammalian cells. Biochem Biophys Res Commun. 444(3): 319-324.

» View on PubMed

Steiner S, Daniel C, Fischer A, Atreya I, Hirschmann S, Waldner M, Neumann H, Neurath M, Atreya R and Weigmann B. 2014. Cyclosporine A Regulates Pro-Inflammatory Cytokine Production in Ulcerative Colitis. Arch Immunol Ther Exp (Warsz). 63(1): 53-63.

» View on PubMed

Abraham S, Choi JG, Ye C, Manjunath N and Shankar P. 2014. IL-10 exacerbates xenogeneic GVHD by inducing massive human T cell expansion. Clin Immunol. 156(1): 58-64.

» View on PubMed

Clarke EV, Weist BM, Walsh CM and Tenner AJ. 2015. Complement protein C1q bound to apoptotic cells suppresses human macrophage and dendritic cell-mediated Th17 and Th1 T cell subset proliferation. J Leukoc Biol. 97(1): 147-160.

» View on PubMed

Harper MS, Guo K, Gibbert K, Lee EJ, Dillon SM, Barrett BS, McCarter MD, Hasenkrug KJ, Dittmer U, Wilson CC and Santiago ML. 2015. Interferon-α Subtypes in an Ex Vivo Model of Acute HIV-1 Infection: Expression, Potency and Effector Mechanisms. PLoS Pathog. doi: 10.1371/journal.ppat.1005254.

» View on PubMed




Buffers:

Brefeldin A Solution

 

Lam LKM, Watson AM, Ryman KD, Klimstra WB. Gamma-interferon exerts a critical early restriction on replication and dissemination of yellow fever virus vaccine strain 17D-204. NPJ Vaccines. 2018;3:5. Published 2018 Jan 23. doi:10.1038/s41541-017-0039-z.

View on PubMed

Cell Stimulation Cocktail (500X)

Brincks E. L., Adams J., Wang L., Turner B., Marcinowicz A., Ke J., Essmann M., Mautino L. M., Allen C. Van, Kumar S., Vahanian N., Link C., Mautino M. R. et al Indoximod opposes the immunosuppressive effects mediated by IDO and TDO via modulation of AhR function and activation of mTORC1. Oncotarget. 2020; 11: 2438-2461.

View on Oncotarget

Cordoro KM, Hitraya-Low M, Taravati K, Sandoval PM, Kim E, Sugarman J, Pauli ML, Liao W and Rosenblum MD. 2017. Skin-infiltrating, interleukin-22-producing T cells differentiate pediatric psoriasis from adult psoriasis. J Am Acad Dermatol. doi: 10.1016/j.jaad.2017.05.017.

» View on PubMed

Flow Cytometry Perm Buffer (10X), TNB-1213

 

Kotov JA, Kotov DI, Linehan JL, Bardwell VJ, Gearhart MD, Jenkins MK. BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors. J Exp Med. 2019;216(6):1450-1464. doi:10.1084/jem.20182376.

» View on PubMed

Colombo E, Tentorio P, Musio S, Rajewsky K, Pedotti R, Casola S and Farina C. 2014. Skewed B cell differentiation affects lymphoid organogenesis but not T cell-mediated autoimmunity. Clin Exp Immunol. 176(1): 58-65.

» View on PubMed

Khan TN, Mooster JL, Kilgore AM, Osborn JF, and Nolz JC. 2016. Local Antigen in Nonlymphoid Tissue Promotes Resident Memory CD8+ T Cell Formation During Viral Infection. The Journal of Experimental Medicine. doi: 10.1084/jem.20151855

» View on PubMed

Ashley SL, Pretto CD, Stier MT, Kadiyala P, Castro-Jorge L, Hsu TH, Doherty R, Carnahan KE, Castro MG, Lowenstein PD and Spindler KR. 2017. Matrix Metalloproteinase Activity in Infections by an Encephalitic Virus, Mouse Adenovirus Type 1. J. Virol. doi: 10.1128/JVI.01412-16

» View on PubMed

Kevin C. Osum, Adam L. Burrack, Tijana Martinov, Nathanael L. Sahli, Jason S. Mitchell, Christopher G. Tucker, Kristen E. Pauken, Klearchos Papas, Balamurugan Appakalai, Justin A. Spanier, & Brian T. Fife. Interferon-gamma drives programmed death-ligand 1 expression on islet β cells to limit T cell function during autoimmune diabetes. Sci Rep. 2018 May 29;8(1):8295. doi: 10.1038/s41598-018-26471-9

» View on PubMed

Lesteberg K, Orange J and Makedonas G. 2017. Recycling endosomes in human cytotoxic T lymphocytes constitute an auxiliary intracellular trafficking pathway for newly synthesized perforin. Immunol Res. doi: 10.1007/s12026-017-8945-8.

» View on PubMed

Foxp3 / Transcription Factor Staining Buffer Kit, TNB-0607

 

Long Y, Zhao X, Liu C, Xia C, Liu C. Activated inducible co-stimulator-positive (ICOS+ ) programmed death 1-positive (PD-1+ ) Tfh cells indicate disease activity and severity in ulcerative colitis patients [published online ahead of print, 2020 Jul 4]. Clin Exp Immunol. 2020;10.1111/cei.13485. doi:10.1111/cei.13485.

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J. Michael Stolley, Timothy S. Johnston, Andrew G. Soerens, Lalit K. Beura, Pamela C. Rosato, Vineet Joag, Sathi P. Wijeyesinghe, Ryan A. Langlois, Kevin C. Osum, Jason S. Mitchell, David Masopust; Retrograde migration supplies resident memory T cells to lung-draining LN after influenza infection. J Exp Med3 June 2020; 217 (8): e20192197. doi: https://doi.org/10.1084/jem.20192197.

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IL-6 Deficiency Exacerbates Allergic Asthma and Abrogates the Protective Effect of Allergic Inflammation against Streptococcus pneumoniae Pathogenesis. Taylor Schmit, Sumit Ghosh, Ram Kumar Mathur, Tyler Barnhardt, Ganesh Ambigapathy, Min Wu, Colin Combs, M. Nadeem Khan. The Journal of Immunology June 15, 2020, ji1900755; DOI: 10.4049/jimmunol.1900755.

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Correlation of the levels of DNA-binding inhibitor Id3 and regulatory T cells with SLE disease severity. ChenLiu. SenYu. RongJin. YanLong. SongsongLu. YingSong. XiuyuanSun. Xiao-HongSun. YuZhang. J Autoimmun2020 Jun 11;102498.  doi: 10.1016/j.jaut.2020.102498. 

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Franco da Cunha F, Andrade-Oliveira V, Candido de Almeida D, Borges da Silva T, Naffah de Souza Breda C, Costa Cruz M, Faquim-Mauro EL, Antonio Cenedeze M, Ioshie Hiyane M, Pacheco-Silva A, Aparecida Cavinato R, Torrecilhas AC, Olsen Saraiva Câmara N. Extracellular Vesicles isolated from Mesenchymal Stromal Cells Modulate CD4+ T Lymphocytes Toward a Regulatory Profile. Cells. 2020 Apr 23;9(4). pii: E1059. doi: 10.3390/cells9041059Extracellular Vesicles isolated from Mesenchymal Stromal Cells Modulate CD4+ T Lymphocytes Toward a Regulatory Profile. Cells. 2020 Apr 23;9(4). pii: E1059. doi: 10.3390/cells9041059

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Woolsey C, Jankeel A, Matassov D, et al. Immune correlates of postexposure vaccine protection against Marburg virus. Sci Rep. 2020;10(1):3071. Published 2020 Feb 20. doi:10.1038/s41598-020-59976-3.

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Adami AJ, Bracken SJ, Guernsey LA, et al. Early-life antibiotics attenuate regulatory T cell generation and increase the severity of murine house dust mite-induced asthma. Pediatr Res. 2018;84(3):426-434. doi:10.1038/s41390-018-0031-y.

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Manrique-Rincón AJ, Beraldo CM, Toscaro JM and Bajgelman MC. 2017. Exploring Synergy in Combinations of Tumor-Derived Vaccines That Harbor 4-1BBL, OX40L, and GM-CSF. Front Immunol. doi: 10.3389/fimmu.2017.01150.

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Li YY, Pearson JA, Chao C, Peng J, Zhang X, Zhou Z, Liu Y, Wong FS and Wen L. 2017. Nucleotide-binding oligomerization domain-containing protein 2 (Nod2) modulates T1DM susceptibility by gut microbiota. J Autoimmun. doi: 10.1016/j.jaut.2017.05.007.

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Bowen JR, Quicke KM, Maddur MS, O'Neal JT, McDonald CE, Fedorova NB, Puri V, Shabman RS, Pulendran B and Suthar MS. 2017. Zika Virus Antagonizes Type I Interferon Responses during Infection of Human Dendritic Cells. PLoS Pathog. doi: 10.1371/journal.ppat.1006164

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Yanagita T, Murata Y, Tanaka D2, Motegi SI, Arai E, Daniwijaya EW, Hazama D, Washio K, Saito Y, Kotani T, Ohnishi H, Oldenborg PA, Garcia NV, Miyasaka M, Ishikawa O, Kanai Y, Komori T and Matozaki T. 2017. Anti-SIRPα antibodies as a potential new tool for cancer immunotherapy. JCI Insight. DOI: 10.1172/jci.insight.89140

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Guthmiller JJ, Graham AC, Zander RA, Pope RL and Butler NS. 2017. Cutting Edge: IL-10 Is Essential for the Generation of Germinal Center B Cell Responses and Anti-Plasmodium Humoral Immunity. DOI:10.4049/jimmunol.1601762

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Cruz LO, Hashemifar SS, Wu CJ, Cho S, Nguyen DT. Lin LL, Khan AA and Lu LF. 2017. Excessive expression of miR-27 impairs Treg-mediated immunological tolerance. J. Clin. Invest. doi:10.1172/JCI88415

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Lambracht-Washington D and Rosenberg RN. 2014. A non-inflammatory immune response in aged DNA Aβ42 immunized mice supports its safety for possible use as immunotherapy in AD patients. doi:10.1016/j.neurobiolaging.2014.12.011

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Karo JM, Schatz DG and Sun JC. 2014. The RAG Recombinase Dictates Functional Heterogeneity and Cellular Fitness in Natural Killer Cells. Cell. 159(1): 94-107.

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Yasuoka T, Kuwahara M, Yamada T, Maruyama S, Suzuki J, Taniguchi M, Yasukawa M, and Yamashita M. 2016. The Transcriptional Repressor Gfi1 Plays a Criticol Role in the Development of NKT1- and NKT2- Type iNKT Cells. PLOS One. doi:10.1371/journal.pone.0157395

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Kuwahara M, Ise W, Ochi M, Suzuki J, Kometani K, Saho M, Izumoto M, Matsumoto A, Takemori N, Takemori A, Shinoda K, Nakayama T, Ohara O, Yasukawa M, Sawasaki T, Kurosaki T and Yamashita M. 2016. Bach2–Batf Interactions Control Th2-type Immune Response by Regulating the IL-4 Amplification Loop. Nat. Commun. doi:10.1038/ncomms12596

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Kalokhe AS, Ibegbu CC, Kaur SP, Amara RR, Kelley ME, Rio C and Stephenson R. 2016. Initimate Partner Violence is Associated with Increased CD4+ T-Cell Activation Among HIV-Negative High-Risk Women. Pathog. Immun. doi: 10.20411/pai.v1i1.120

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Adam L. Burrack, Ellen J. Spartz, Jackson F. Raynor, Iris Wang, Margaret Olson, Ingunn M. Stromnes. Combination PD-1 and PD-L1 Blockade Promotes Durable Neoantigen-Specific T Cell-Mediated Immunity in Pancreatic Ductal Adenocarcinoma. Cell Rep. 2019 Aug 20;28(8):2140-2155.e6. doi: 10.1016/j.celrep.2019.07.059

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Laura S. Angelo, Lynn H. Bimler, Rana Nikzad, Kevin Aviles-Padilla, and Silke Paust. CXCR6+ NK Cells in Human Fetal Liver and Spleen Possess Unique Phenotypic and Functional Capabilities. Front Immunol. 2019 Mar 19;10:469. doi: 10.3389/fimmu.2019.00469

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Foxp3/Transcription Factor Fix/Perm Concentrate (4X), TNB-1020

Li X, Li Z, Hou D, Zhao Y, Wang C and Li X. 2016. The bovine endometrial epithelial cells promote the differentiation of trophoblast stem-like cells to binucleate trophoblast cells. Cytotechnology. DOI: 10.1007/s10616-016-9994-x

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RBC Lysis Buffer

 

Jennifer S. Chen, Jessica D.S. Grassmann, Uthaman Gowthaman, Sam J. Olyha, Tregony Simoneau, M. Cecilia Berin, Stephanie C. Eisenbarth, Adam Williams. Flow cytometric identification of Tfh13 cells in mouse and human. Journal of Allergy and Clinical Immunology, 2020.  https://doi.org/10.1016/j.jaci.2020.04.063.

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Jackson LP, Tjoa BA, Mellert H, Pestano GA. Development of a TCR beta repertoire assay for profiling liquid biopsies from NSCLC donors. Cancer Drug Resist 2020;3. http://dx.doi.org/10.20517/cdr.2020.07.

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Kim IS, Gao Y, Welte T, et al. Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms. Nat Cell Biol. 2019;21(9):1113-1126. doi:10.1038/s41556-019-0373-7.

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Viability Dyes:

7-AAD

 

Takahashi D, Hoshina N, Kabumoto Y, et al. Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells. EBioMedicine. 2020;58:102913. doi:10.1016/j.ebiom.2020.102913.

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Jonathan J Pinney, Fátima Rivera-Escalera, Charles C Chu, Hannah E Whitehead, Karl VanDerMeid, Ashley M Nelson, Michelle C Barbeau, Clive S Zent, Michael R Elliott; Macrophage hypophagia as a mechanism of innate immune exhaustion in mAb-induced cell clearance. Blood.2020005571. doi: https://doi.org/10.1182/blood.2020005571.

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Homann S, Hofmann C, Gorin AM, Nguyen HCX, Huynh D, Hamid P, Maithel N, Yacoubian V, Mu W, Kossyvakis A, Sen Roy S, Yang OO and Kelesidis T. 2017. A novel rapid and reproducible flow cytometric method for optimization of transfection efficiency in cells. PLoS One. doi: 10.1371/journal.pone.0182941.

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Koshy Cherian A, Parikh V, Wu Q, Mao-Draayer Y, Wang Q, Blakely RD and Sarter M. 2017. Hemicholinium-3 sensitive choline transport in human T lymphocytes: Evidence for use as a proxy for brain choline transporter (CHT) capacity. Neurochem Int. doi: 10.1016/j.neuint.2017.05.022.

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Kamachi F, Isshiki T, Harada N, Akiba H and Miyake S. 2015. ICOS promotes group 2 innate lymphoid cell activation in lungs. Biochem Biophys Res Commun. doi: 10.1016/j.bbrc.2015.06.005.

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Huang B, Faucette AN, Pawlitz MD, Pei B, Goyert JW, Zhou JZ, El-Hage NG, Deng J, Lin J, Yao F, Dewar III RS, Jassal JS, Sandberg ML, Dai J, Cols M, Shen C, Polin LA, Nichols RA, Jones TB, Bluth MH, Puder KS, Gonik B, Nayak NR, Puscheck E, Wei WZ, Cerutti A, Colonna M and Chen K. 2016. Interleukin-33-induced expression of PIBF1 by decidual B cells protects against preterm labor. Nat. Med. doi:10.1038/nm.4244

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CFSE

 

Domínguez-Romero AN, Martínez-Cortés F, Munguía ME, Odales J, Gevorkian G, Manoutcharian K. Generation of multiepitope cancer vaccines based on large combinatorial libraries of survivin-derived mutant epitopes [published online ahead of print, 2020 Jul 3]. Immunology. 2020;10.1111/imm.13233. doi:10.1111/imm.13233.

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Brincks E. L., Adams J., Wang L., Turner B., Marcinowicz A., Ke J., Essmann M., Mautino L. M., Allen C. Van, Kumar S., Vahanian N., Link C., Mautino M. R. et al Indoximod opposes the immunosuppressive effects mediated by IDO and TDO via modulation of AhR function and activation of mTORC1. Oncotarget. 2020; 11: 2438-2461.

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Rana PS, Mudrak NJ, Lopez R, Lynn M, Kershner L and Model MA. 2017. Phase separation in necrotic cells. Biochem Biophys Res Commun. doi: 10.1016/j.bbrc.2017.08.123.

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Murphy S, Patrick K, Thoner T, Edwards RW and Gubbels Bupp MR. 2016. T cell up-regulation of CD127 is associated with reductions in the homeostatic set point of the peripheral Tcell pool during malnourishment. Biochemistry and Biophysics Reports. doi:10.1016/j.bbrep.2016.06.006

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Barwick BG, Scharer CD, Bally APR and Boss JM. 2016. Plasma Cell Differentiation is Coupled to Division-Dependent DNA Hypomethylation and Gene Regulation. Nat Immunol. 17(10):1216-25

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Ghost Dye™ Fixable Viability Dyes

 

Tucker CG, Mitchell JS, Martinov T, et al. Adoptive T Cell Therapy with IL-12-Preconditioned Low-Avidity T Cells Prevents Exhaustion and Results in Enhanced T Cell Activation, Enhanced Tumor Clearance, and Decreased Risk for Autoimmunity. J Immunol. 2020;ji2000007. doi:10.4049/jimmunol.2000007.

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Majumder, Aditi & Suknuntha, Kran & Bennin, David & Klemm, Lucas & Brok-Volchanskaya, Vera & Huttenlocher, Anna & Slukvin, Igor. (2020). Generation of Human Neutrophils from Induced Pluripotent Stem Cells in Chemically Defined Conditions Using ETV2 Modified mRNA. STAR Protocols. 100075. 10.1016/j.xpro.2020.100075.

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Symonds AL, Zheng W, Miao T, et al. Egr2 and 3 control inflammation, but maintain homeostasis, of PD-1high memory phenotype CD4 T cells. Life Sci Alliance. 2020;3(9):e202000766. Published 2020 Jul 24. doi:10.26508/lsa.202000766.

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Poholek CH, Raphael I, Wu D, et al. Noncanonical STAT3 activity sustains pathogenic Th17 proliferation and cytokine response to antigen. J Exp Med. 2020;217(10):e20191761. doi:10.1084/jem.20191761.

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Nagayama M, Yano T, Atarashi K, et al. TH1 cell-inducing Escherichia coli strain identified from the small intestinal mucosa of patients with Crohn's disease [published online ahead of print, 2020 Jul 20]. Gut Microbes. 2020;1-14. doi:10.1080/19490976.2020.1788898.

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Jennifer S. Chen, Jessica D.S. Grassmann, Uthaman Gowthaman, Sam J. Olyha, Tregony Simoneau, M. Cecilia Berin, Stephanie C. Eisenbarth, Adam Williams. Flow cytometric identification of Tfh13 cells in mouse and human. Journal of Allergy and Clinical Immunology, 2020.  https://doi.org/10.1016/j.jaci.2020.04.063.

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Zhou W, Zhang J, Toki S, et al. COX Inhibition Increases Alternaria-Induced Pulmonary Group 2 Innate Lymphoid Cell Responses and IL-33 Release in Mice [published online ahead of print, 2020 Jul 20]. J Immunol. 2020;ji1901544. doi:10.4049/jimmunol.1901544.

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Clark PA, Sriramaneni RN, Jin WJ, et al.  In situ vaccination at a peripheral tumor site augments response against melanoma brain metastases. Journal for ImmunoTherapy of Cancer 2020;8:e000809. doi: 10.1136/jitc-2020-000809.

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Terranova-Barberio, M., Pawlowska, N., Dhawan, M. et al. Exhausted T cell signature predicts immunotherapy response in ER-positive breast cancer. Nat Commun 11, 3584 (2020). https://doi.org/10.1038/s41467-020-17414-y.

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Zhao Z, Zhang G, Sun Y, Winoto A. Necroptotic-susceptible dendritic cells exhibit enhanced antitumor activities in mice [published online ahead of print, 2020 Jul 14]. Immun Inflamm Dis. 2020;10.1002/iid3.330. doi:10.1002/iid3.330.

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Stearoyl-CoA desaturase mediated monounsaturated fatty acid availability supports humoral immunity. Xian Zhou, Xingxing Zhu, Chaofan Li, Yanfeng Li, Zhenqing Ye, Virginia ShapiroJohn A. Copland III, Taro Hitosugi, David Bernlohr, Jie Sun, Hu Zeng. bioRxiv 2020.04.22.028613; doi: https://doi.org/10.1101/2020.04.22.028613.

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Wormsbaecher C, Hindman AR, Avendano A, et al. In utero estrogenic endocrine disruption alters the stroma to increase extracellular matrix density and mammary gland stiffness. Breast Cancer Res. 2020;22(1):41. Published 2020 May 5. doi:10.1186/s13058-020-01275-w.

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Hong-Xia ZhouRun-Feng LiYi-Feng Wang, et al. Total alkaloids from Alstonia scholaris inhibit influenza A virus replication and lung immunopathology by regulating the innate immune response.  ScienceDirect.  June 29 2020. https://doi.org/10.1016/j.phymed.2020.153272.

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Marcovecchio, Paola M et al. Frontline Science: Kindlin-3 is essential for patrolling and phagocytosis functions of nonclassical monocytes during metastatic cancer surveillance. Journal of leukocyte biology vol. 107,6 (2020): 883-892. doi:10.1002/JLB.4HI0420-098R.

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Mahuron KM, Moreau JM, Glasgow JE, et al. Layilin augments integrin activation to promote antitumor immunity. J Exp Med. 2020;217(9):e20192080. doi:10.1084/jem.20192080.

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Pham GS, Gusson Shimoura C, Chaudhari S, Kulp DV, Mathis KW. Chronic unilateral cervical vagotomy reduces renal inflammation, blood pressure, and renal injury in a mouse model of lupus. 2020 Jun 15. Am J Physiol Renal Physiol. 2020;10.1152/ajprenal.00201.2020. doi:10.1152/ajprenal.00201.2020.

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Logsdon, A.F., Schindler, A.G., Meabon, J.S. et al. Nitric oxide synthase mediates cerebellar dysfunction in mice exposed to repetitive blast-induced mild traumatic brain injury. Sci Rep 10, 9420 (2020). https://doi.org/10.1038/s41598-020-66113-7.

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Irini EvnouchidouPascal Chappert, Samira Benadda, Andres Zucchetti, Mirjana Weimershaus, Marcelle Bens, Vivien Caillens, Despoina Koumantou, Sophie Lotersztajn, Peter van Endert, Jean Davoust, Pierre Guermonprez, Claire Hivroz, David A Gross, Loredana Saveanu. IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses. Nat Commun. 2020 Jun 2;11(1):2779. doi: 10.1038/s41467-020-16471-7.

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Marcia de Almeida Monteiro Melo Ferraz, Mayako Fujihara, Jennifer Beth NagashimaMichael James NoonanMiho Inoue-MurayamaNucharin Songsasen. Follicular Extracellular Vesicles Enhance Meiotic Resumption of Domestic Cat Vitrified Oocytes. Sci Rep2020 May 25;10(1):8619. doi: 10.1038/s41598-020-65497-w.

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Follicular extracellular vesicles enhance meiotic resumption of domestic cat vitrified oocytes. Marcia de Almeida Monteiro Melo FerrazMayako FujiharaJennifer Beth NagashimaMichael James NoonanMiho Inoue-MurayamaNucharin Songsasen. Sci Rep. 2020 May 25;10(1):8619. doi: 10.1038/s41598-020-65497-w.

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Zhichao Fan, Zbigniew Mikulski, Sara McArdle, Prithu Sundd, Klaus Ley. Super-STORM: Molecular Modeling to Achieve Single-molecule Localization with STORM Microscopy. ScienceDirect. 2020 June 3: https://doi.org/10.1016/j.xpro.2019.100012.

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Human Adipose-Derived Mesenchymal Stem Cells for Acute and Sub-Acute TBI. Katherine A RuppertKarthik S PrabhakaraNaama E Toledano-FurmanSanjna UdthaAustin Q ArceneauxHyeonggeun ParkAn DaoCharles S CoxScott D Olson.  PLoS One 2020 May 26;15(5):e0233263. doi: 10.1371/journal.pone.0233263. eCollection 2020.

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Andrea PennatiEmily A Nylen, Ian D Duncan, Jacques Galipeau . Regulatory B Cells Normalize CNS Myeloid Cell Content in a Mouse Model of Multiple Sclerosis and Promote Oligodendrogenesis and Remyelination. J Neuroscience. 2020 May 19;JN-RM-2840-19. doi: 10.1523/JNEUROSCI.2840-19.2020. 

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Nadia S. Kurd, Zhaoren He, Tiani L. Louis, J. Justin Milner, Kyla D. Omilusik, Wenhao Jin, Matthew S. Tsai, Christella E. Widjaja, Jad N. Kanbar, Jocelyn G. Olvera, Tiffani Tysl, Lauren K. Quezada, Brigid S. Boland, Wendy J. Huang, Cornelis Murre, Ananda W. Goldrath, Gene W. Yeo, John T. Chang. Early precursors and molecular determinants of tissue-resident memory CD8+ T lymphocytes revealed by single-cell RNA sequencing. Sci Immunol 2020 May 15;5(47):eaaz6894. doi: 10.1126/sciimmunol.aaz6894.

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Caplan HW, Prabhakara KS, Kumar A, Toledano-Furman NE, Martin C, Carrillo L, Moreno NF, Bordt AS, Olson SD, Cox CS Jr. Human cord blood-derived regulatory T-cell therapy modulates the central and peripheral immune response after traumatic brain injury. Stem Cells Transl Med. 2020 May 7:e12706. doi: 10.1002/sctm.19-0444.

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Giri J, Galipeau J. Mesenchymal stromal cell therapeutic potency is dependent upon viability, route of delivery, and immune match. Blood Adv. 2020 May 12;4(9):1987-1997. doi: 10.1182/bloodadvances.2020001711.

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Alexander J Neuwelt, Abigail K Kimball, Amber M Johnson, Benjamin W Arnold, Bonnie L Bullock, Rachael E Kaspar, Emily K Kleczko, Jeff W Kwak, Meng-Han Wu, Lynn E Heasley, Robert C Doebele, Howard Y Li,Raphael A Nemenoff, Eric T Clambey. Cancer cell-intrinsic expression of MHC II in lung cancer cell lines is actively restricted by MEK/ERK signaling and epigenetic mechanisms.  J Immunother Cancer. 2020 Apr;8(1). pii: e000441. doi: 10.1136/jitc-2019-000441.

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Roth TL, Li PJ, Blaeschke F, Nies JF, Apathy R, Mowery C, Yu R, Nguyen MLT, Lee Y, Truong A, Hiatt J, Wu D, Nguyen DN, Goodman D, Bluestone JA, Ye CJ, Roybal K, Shifrut E, Marson A. Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies. Cell. 2020 Apr 15. pii: S0092-8674(20)30332-9. doi: 10.1016/j.cell.2020.03.039.

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Alkhani A, Levy CS, Tsui M, Rosenberg KA, Polovina K, Mattis AN, Mack M, Van Dyken S, Wang BM, Maher JJ, Nijagal A. Ly6cLo non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic inflammation. Sci Rep. 2020 Apr 28;10(1):7165. doi: 10.1038/s41598-020-64158-2.

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Martinov T, Swanson LA, Breed ER, Tucker CG, Dwyer AJ, Johnson JK, Mitchell JS, Sahli NL, Wilson JC, Singh LM, Hogquist KA, Spanier JA, Fife BT. Programmed Death-1 Restrains the Germinal Center in Type 1 Diabetes. J Immunol. 2019 Aug 15;203(4):844-852. doi: 10.4049/jimmunol.1801535

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Derek W. Trobaugh, Chengqun Sun, Matthew D. Dunn, Douglas S. Reed, William B. Klimstra. Rational design of a live-attenuated eastern equine encephalitis virus vaccine through informed mutation of virulence determinants. PLoS Pathog. 2019 Feb 11;15(2):e1007584. doi: 10.1371/journal.ppat.1007584

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Rita Kansal, Noah Richardson, Indira Neeli, Saleem Khawaja, Damian Chamberlain, Marium Ghani, Qurat-ul-ain Ghani, Louisa Balazs, Sarka Beranova-Giorgianni, Francesco Giorgianni, James N. Kochenderfer, Tony Marion, Lorraine M. Albritton, Marko Radic. Sustained B cell depletion by CD19-targeted CAR T cells is a highly effective treatment for murine lupus. Sci Transl Med. 2019 Mar 6;11(482). pii: eaav1648. doi: 10.1126/scitranslmed.aav1648

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Jessica K. Fiege, Ian A. Stone, Elizabeth J. Fay, Matthew W. Markman, Sathi Wijeyesinghe, Marissa G. Macchietto, Steven Shen, David Masopust and Ryan A. Langlois. The Impact of TCR Signal Strength on Resident Memory T Cell Formation during Influenza Virus Infection. J Immunol. 2019 Aug 15;203(4):936-945. doi: 10.4049/jimmunol.1900093

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Jessica K. Fiege, Ian A. Stone, Rebekah E. Dumm, Barbara M. Waring, Brian T. FifeI, Judith Agudo, Brian D. Brown, Nicholas S. Heaton, Ryan A. Langlois. Long-term surviving influenza infected cells evade CD8+ T cell mediated clearance. PLoS Pathog. 2019 Sep 26;15(9):e1008077. doi: 10.1371/journal.ppat.1008077

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Sarika Saraswati, Stephanie M.W. Marrow, Lester A. Watch1 & Pampee P. Young. Identification of a pro-angiogenic functional role for FSP1-positive fibroblast subtype in wound healing. Nat Commun. 2019 Jul 9;10(1):3027. doi: 10.1038/s41467-019-10965-9

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Matthew A. Huggins, Frances V. Sjaastad, Mark Pierson, Tamara A. Kucaba, Whitney Swanson, Christopher Staley, Alexa R. Weingarden, Isaac J. Jensen, Derek B. Danahy, Vladimir P. Badovinac, Stephen C. Jameson, Vaiva Vezys, David Masopust, Alexander Khoruts, Thomas S. Griffith, and Sara E. Hamilton. Microbial Exposure Enhances Immunity to Pathogens Recognized by TLR2 but Increases Susceptibility to Cytokine Storm through TLR4 Sensitization. Cell Rep. 2019 Aug 13;28(7):1729-1743.e5. doi: 10.1016/j.celrep.2019.07.028

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Scharer CD, Barwick BG, Guo M, Bally APR, Boss JM. Plasma cell differentiation is controlled by multiple cell division-coupled epigenetic programs. Nat Commun. 2018;9(1):1698. Published 2018 Apr 27. doi:10.1038/s41467-018-04125-8.

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Guo M, Price MJ, Patterson DG, et al. EZH2 Represses the B Cell Transcriptional Program and Regulates Antibody-Secreting Cell Metabolism and Antibody Production. J Immunol. 2018;200(3):1039-1052. doi:10.4049/jimmunol.1701470.

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Wang H, Hogquist KA. CCR7 defines a precursor for murine iNKT cells in thymus and periphery. Elife. 2018;7:e34793. Published 2018 Aug 13. doi:10.7554/eLife.34793.

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Uzodinma U. Uche, Ann R. Piccirillo, Shunsuke Kataoka, Stephanie J. Grebinoski, Louise M. D’Cruz, and Lawrence P. Kane. PIK3IP1/TrIP restricts activation of T cells through inhibition of PI3K/Akt. J Exp Med. 2018 Dec 3;215(12):3165-3179. doi: 10.1084/jem.20172018

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Avery L, Filderman J, Szymczak-Workman AL, Kane LP4. Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2455-2460. doi: 10.1073/pnas.1712107115

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Manan M. Mehta, Samuel E. Weinberg, Elizabeth M. Steinert, Krishan Chhiba, Carlos Alberto Martinez, Peng Gao, Harris R. Perlman, Paul Bryce, Nissim Hay, and Navdeep S. Chandel. Hexokinase 2 is dispensable for T cell-dependent immunity. Cancer Metab. 2018 Aug 17;6:10. doi: 10.1186/s40170-018-0184-5

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Pushpak Bhattacharjee & Peter A. Keyel. Cholesterol-dependent cytolysins impair pro-inflammatory macrophage responses. Sci Rep. 2018 Apr 4;8(1):6458. doi: 10.1038/s41598-018-24955-2

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Mande P, Zirak B, Ko WC, Taravati K, Bride KL, Brodeur TY, Deng A, Dresser K, Jiang Z, Ettinger R, Fitzgerald KA, Rosenblum MD, Harris JE, Marshak-Rothstein A. Fas ligand promotes an inducible TLR-dependent model of cutaneous lupus-like inflammation. J Clin Invest. 2018 Jul 2;128(7):2966-2978. doi: 10.1172/JCI98219

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Adam L. Burrack, Ellen J. Spartz, Jackson F. Raynor, Iris Wang, Margaret Olson, Ingunn M. Stromnes. Combination PD-1 and PD-L1 Blockade Promotes Durable Neoantigen-Specific T Cell-Mediated Immunity in Pancreatic Ductal Adenocarcinoma. Cell Rep. 2019 Aug 20;28(8):2140-2155.e6. doi: 10.1016/j.celrep.2019.07.059

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Kevin C. Osum, Adam L. Burrack, Tijana Martinov, Nathanael L. Sahli, Jason S. Mitchell, Christopher G. Tucker, Kristen E. Pauken, Klearchos Papas, Balamurugan Appakalai, Justin A. Spanier, & Brian T. Fife. Interferon-gamma drives programmed death-ligand 1 expression on islet β cells to limit T cell function during autoimmune diabetes. Sci Rep. 2018 May 29;8(1):8295. doi: 10.1038/s41598-018-26471-9

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Das S, Raundhal M, Chen J, Oriss TB, Huff R, Williams JV, Ray A and Ray P. 2017. Respiratory syncytial virus infection of newborn CX3CR1-deficent mice induces a pathogenic pulmonary innate immune response. JCI Insight. doi: 10.1172/jci.insight.94605.

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Werner LR, Kler JS, Gressett MM, Riegert M, Werner LK, Heinze CM, Kern JG, Abbariki M, Erbe AK, Patel RB, Sriramaneni RN, Harari PM and Morris ZS. 2017. Transcriptional-mediated effects of radiation on the expression of immune susceptibility markers in melanoma. Radiother Oncol. doi: 10.1016/j.radonc.2017.08.016.

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England CG, Jiang D, Ehlerding EB, Rekoske BT, Ellison PA, Hernandez R, Barnhart TE, McNeel DG, Huang P and Cai W. 2017. 89Zr-labeled nivolumab for imaging of T-cell infiltration in a humanized murine model of lung cancer. Eur J Nucl Med Mol Imaging. doi: 10.1007/s00259-017-3803-4.

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Johnson LE, Olson BM and McNeel DG. 2017. Pretreatment antigen-specific immunity and regulation - association with subsequent immune response to anti-tumor DNA vaccination. J Immunother Cancer. doi: 10.1186/s40425-017-0260-3.

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Barros SM, Avila LA, Whitaker SK, Wilkinson KE, Sukthankar P, Beltrão EIC and Tomich JM. 2017. Branched Amphipathic Peptide Capsules: Different Ratios of the Two Constituent Peptides Direct Distinct Bilayer Structures, Sizes and DNA Transfection Efficiency. Langmuir. doi: 10.1021/acs.langmuir.7b00912.

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Sun CW, Wu LC, Knopick PL, Bradley DS, Townes T and Terman DS. 2017. Sickle Cells Produce Functional Immune Modulators and Cytotoxics. Am J Hematol. doi: 10.1002/ajh.24836.

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Mizuno M, Katano H, Otabe K, Komori K, Kohno Y, Fujii S, Ozeki N, Horie M, Tsuji K, Koga H, Muneta T and Sekiya I. 2017. Complete human serum maintains viability and chondrogenic potential of human synovial stem cells: suitable conditions for transplantation. Stem Cell Res Ther. doi: 10.1186/s13287-017-0596-0

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Sato K, Kato A, Sekai M, Hamazaki Y and Minato N. 2017. Physiologic Thymic Involution Underlies Age-Dependent Accumulation of Senescence-Associated CD4+ T Cells. J Immunol. doi: 10.4049/jimmunol.1602005

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Griggs TF, Bochkov YA, Basnet S, Pasic TR, Brockman-Schneider RA, Palmenberg AC and Gern JE. 2017. Rhinovirus C targets ciliated airway epithelial cells. Respir Res. doi: 10.1186/s12931-017-0567-0.

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Ohno Y, Koizumi M, Nakayama H, Watanabe T, Hirooka M, Tokumoto Y, Kuroda T, Abe M, Fukuda S, Higashiyama S, Kumagi T and Hiasa Y. 2017. Downregulation of ANP32B exerts anti-apoptotic effects in hepatocellular carcinoma. PLoS One. doi: 10.1371/journal.pone.0177343

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Cho S, Wu CJ, Nguyen DT, Lin LL, Chen MC, Khan AA, Yang BH, Fu W and Lu LF. 2017. A Novel miR-24-TCF1 Axis in Modulating Effector T Cell Responses. J Immunol. doi: 10.4049/jimmunol.1601404

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Verschoor CP, Kohli V and Balion C. 2017. A comprehensive assessment of immunophenotyping performed in cryopreserved peripheral whole blood. Cytometry B Clin Cytom. doi: 10.1002/cyto.b.21526

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Dallari S, Macal M, Loureiro ME, Jo Y, Swanson L, Hesser C, Ghosh P and Zuniga EI. 2017. Src family kinases Fyn and Lyn are constitutively activated and mediate plasmacytoid dendritic cell responses. Nat Commun. doi: 10.1038/ncomms14830

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Bustos-Moran E, Blas-Rus N, Martin-Cofreces N and Sanchez-Madrid F. 2017. Microtubule associated protein-4 (MAP4) controls nanovesicle dynamics and T cell activation. J Cell Sci. doi: 10.1242/jcs.199042

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Landry J, Martinov T, Mengistu H, Dhanwada J, Benck CJ, Kline J, Boo B, Swanson L, Tonc E, Daughters R, Fife BT and Chatterjea D. 2017. Repeated hapten exposure induces persistent tactile sensitivity in mice modeling localized provoked vulvodynia. PLoS One. doi: 10.1371/journal.pone.0169672

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Oh JE, Oh DS, Jung HE and Lee HK. 2017. A mechanism for the induction of type 2 immune responses by a protease allergen in the genital tract. Proc Natl Acad Sci U S A. doi: 10.1073/pnas.1612997114

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Bowen JR, Quicke KM, Maddur MS, O'Neal JT, McDonald CE, Fedorova NB, Puri V, Shabman RS, Pulendran B and Suthar MS. 2017. Zika Virus Antagonizes Type I Interferon Responses during Infection of Human Dendritic Cells. PLoS Pathog. doi: 10.1371/journal.ppat.1006164

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Simpson-Abelson MR, Hernandez-Mir G, Childs EE, Cruz JA, Poholek AC, Chattopadhyay A, Gaffen SL and McGeachy MJ. 2017. CCAAT/Enhancer-binding protein β promotes pathogenesis of EAE. Cytokine. DOI: 10.1016/j.cyto.2017.01.005

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Luo Z, Li Z, Martin L, Hu Z, Wu H, Wan Z, Kilby M, Heath SL, Huang L and Jiang W. 2017. Increased Natural Killer Cell Activation in HIV-Infected Immunologic Non-Responders Correlates with CD4+ T Cell Recovery after Antiretroviral Therapy and Viral Suppression. PLoS One. DOI: 10.1371/journal.pone.0167640

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Trott DW, Henson GD, Ho MHT, Allison SA, Lesniewski LA and Donato AJ. 2016. Age-related arterial immune cell infiltration in mice is attenuated by caloric restriction or voluntary exercise. Exp. Gerontol. DOI: 10.1016/j.exger.2016.12.016

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Cruz LO, Hashemifar SS, Wu CJ, Cho S, Nguyen DT. Lin LL, Khan AA and Lu LF. 2017. Excessive expression of miR-27 impairs Treg-mediated immunological tolerance. J. Clin. Invest. doi:10.1172/JCI88415

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Vo H, Chiu J, Allaimo D, Mao C, Wang Y, Gong Y, Ow H, Porter T and Zhong X. 2014. High fat diet deviates PtC-specific B1 B cell phagocytosis in obese mice. Immun Inflamm Dis. 2(4): 254-261.

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Kholer SL, Pham MN, Folkvord JM, Arends T, Miller SM, Miles B, Meditz AL, McCarter AM, Levy DN and Connick E. 2016. Germinal Center T Follicular Helper Cells Are Highly Permissive to HIV-1 and Alter Their Phenotype during Virus Replication. J Immunol. doi: 10.4049/jimmunol.1502174.

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Thompson EA, Beura LK, Nelson CE, Anderson KG, and Vezys V. 2016. Shortened Intervals during heterologous Boosting Preserve Memory CD8 T Cell Function but Compromise Longevity. The Journal of Immunology. doi:10.4049/jimmunol.1501797

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Benck, CJ, Martinov, T, Fife, BT, and Chatterjea, D. 2016. Isolation of infiltrating leukocytes from mouse skin using enzymatic digest and gradient separation. J Vis Exp. (107) e53638, doi: 10.3791/53638 (2016)

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DiNardo AR, Mandalakas AM, Maphalala G, Mtetwa G, Mndebele T, Ustero P, Hlatshwayo M, Mace EM, Orange JS and Makedonas G. 2016. HIV Progression Perturbs the Balance of the Cell-Mediated and Anti-Inflammatory Adaptive and Innate Mycobacterial Immune Response. Mediators Inflamm. http://dx.doi.org/10.1155/2016/1478340

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Wood S, Feng J, Chung J, Radojcic V, Sandy-Sloat AR, Friedman A, Shelton A, Yan M, Siebel CW, Bishop DK and Maillard I. 2015. Transient Blockade of Delta-like Notch Ligands Prevents Allograft Rejection Mediated by Cellular and Humoral Mechanisms in a Mouse Model of Heart Transplantation. J Immunol. 194(6): 2899-2908.

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Burger ML, Leung KK, Bennett, MJ and Winoto A. 2014. T cell-specific inhibition of multiple apoptotic pathways blocks negative selection and causes autoimmunity. eLife 2014;10.7554/eLife.03468.

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Milner JD, Vogel TP, Forbes L, Ma CA, Stray-Pedersen A, Niemela JE, Lyons JJ, Engelhardt KR, Zhang Y, Topcaqic N et al. 2015. Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations. Blood. 125 (4): 591-599.

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Weist BM, Kurd N, Boussier J, Chan SW and Robey EA. 2015. Thymic regulatory T cell niche size is dictated by limiting IL-2 from antigen-bearing dendritic cells and feedback competition. Nat Immunol. 16(6): 635-641.

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Rao PS and Kumar S. 2016. Chronic Effects of Ethanol and/or Darunavir/Ritonavir on U937 Monocytic Cells: Regulation of Cytochrome P450 and Antioxidant Enzymes, Oxidative Stress, and Cytotoxicity. Alcohol Clin Exp Res. 40(1): 73-82.

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Lee AR, Mao C, Vo H, Gao W and Zhong X. 2015. Fluorescence tagging and inducible depletion of PD-L2-expressing B-1 B cells in vivo. Ann NY Acad Sci. doi: 10.1111/nyas.12865.

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Miles B, Miller SM, Folkvord JM, Kimball A, Chamanian M, Meditz AL, Arends T, McCarter MD, Levy DN, Rakasz EG, Skinner PJ and Connick E. 2015. Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection. Nat Commun. doi: 10.1038/ncomms9608.

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Benck CJ, Martinov T, Fife BT and Chatterjea D. 2016. Isolation of Infiltrating Leukocytes from Mouse Skin Using Enzymatic Digest and Gradient Separation. J Vis Exp. (107), e53638, doi:10.3791/53638.

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Finkin S, Yuan D, Stein I, Taniguchi K, Weber A, Unger K, Browning JL, Goossens N, Nakagawa S, Gunasekara G, Schwartz ME et al. 2015. Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma. Nat Immunol. doi: 10.1038/ni.3290.

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Malhotra D, Linehan JL, Dileepan T, Lee YJ, Purtha WE, Lu JV, Nelson RW, Fife BT, Orr HT, Anderson MS, Hogquist KA and Jenkins MK. 2016. Tolerance is established in polyclonal CD4+ T cells by distinct mechanisms, according to self-peptide expression patterns. Nat Immunol. doi: 10.1038/ni.3327.

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Beura LK, Hamilton SE, Bi K, Schenkel JM, Odumade OA, Casy KA, Thompson EA, Fraser KA, Rosator PC, Filali-Mouhim A, Sekaly RP, Jenkins MK, Vezys V, Haining N, Jameson SC, and Masopust D. 2016. Normalizing the environment recapitulates adult human immune traits in laboratory mice. Nature. doi:10.1038/nature17655

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Larsen IV, Clausius H, Kolb AW, and Brandt CR. 2016. Both CD8+ and CD4+ T-Cells Contribute to Corneal Clouding and Viral Clearance Following Vaccinia Virus Infection in C57BL/6 Mice. Journal of Virology. doi: 10.1128/JVI.00570-16

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Flores-Fernandez R, Blanco-Favela F, Fuentes-Panama EM, Chavez-Sanchez L, Gorocica-Rosete P, Pizana-Venegas A, and Chavez-Rueda AK. 2016. Prolactin Rescues Immature B-Cells from Apoptosis Induced by B-Cell Receptor Cross-Linking. Journal of Immunology Research. doi:10.1155/2016/3219017

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Gavino AC, Nahmod K, Bharadwaj U, Makedonas G, and Tweardy DJ. 2016. STAT3 Inhibition Prevents Lung Inflammation, Remodeling, and Accumulation of Th2 and Th17 Cells in a Murine Asthma Model. Experimental Allergy and Immunology. DOI: 10.1111/all.12937

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Spanier JA, Frederick DR, Taylor JJ, Heffernan JR, Kotov DI, Martinox T, Osum KC, Ruggiero JL, Rust BJ, Landry SJ, Jenkins MK, McLachlan JB, and Fife BT. 2016. Efficient Generation of Monoclonal Antibodies Against Peptide in the Context of MHCII Using Magnetic Enrichment. Nature Communications. doi:10.1038/ncomms11804

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Murphy S, Patrick K, Thoner T, Edwards RW and Gubbels Bupp MR. 2016. T cell up-regulation of CD127 is associated with reductions in the homeostatic set point of the peripheral Tcell pool during malnourishment. Biochemistry and Biophysics Reports. doi:10.1016/j.bbrep.2016.06.006

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Malo CS, Renner DN, Huseby Kelcher AM, Jin F, Hansen MJ, Pavelko KD and Johnson AJ. 2016. The Effect of Vector Silencing During Picornavirus Vaccination Against Experimental Melanoma and Glioma. PLoS One. doi:10.1371/journal.pone.0162064

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Zhang B, Kwon O, Henry G, Strand DW, Ittmann MM and Xin L. 2016. Non-Cell-Autonomous Regulation of Prostate Epithelial Homeostasis by Androgen Receptor. Molecular Cell 63, 976–989. http://dx.doi.org/10.1016/j.molcel.2016.07.025

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Cumba Garcia LM, Huseby Kelcher AM, Malo CS and Johnson AJ. 2016. Superior Isolation of Antigen-Specific Brain Infiltrating T Cells Using Manual Homogenization Technique. J. Immunol. Methods doi: 10.1016/j.jim.2016.09.002

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Ranjit S, Middle NM, Sinha N, Patters BJ, Rahman MA, Cory TJ, Rao PSS and Kumar S. 2016. Effect of Polyaryl Hydrocarbons on Cytotoxicity in Monocytic Cells: Potential Role of Cytochromes P450 and Oxidative Stress Pathways. PloS one. doi: 10.1371/journal.pone.0163827

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Boisvert M, Zhang W, Elrod EJ, Bernard NF, Villeneuve JP, Bruneau J, Marcotrigiano J, Shoukry NH and Grakoui A. 2016. Novel E2 Glycoprotein Tetramer Detects Hepatitis C Virus–Specific Memory B Cells. J. Immunol. doi: 10.4049/​jimmunol.1600763

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Huang B, Faucette AN, Pawlitz MD, Pei B, Goyert JW, Zhou JZ, El-Hage NG, Deng J, Lin J, Yao F, Dewar III RS, Jassal JS, Sandberg ML, Dai J, Cols M, Shen C, Polin LA, Nichols RA, Jones TB, Bluth MH, Puder KS, Gonik B, Nayak NR, Puscheck E, Wei WZ, Cerutti A, Colonna M and Chen K. 2016. Interleukin-33-induced expression of PIBF1 by decidual B cells protects against preterm labor. Nat. Med. doi:10.1038/nm.4244

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Gasper DJ, Neldner B, Plisch EH, Rustom H, Carrow E, Imai H, Kawaoka Y and Suresh M. 2016. Effective Respiratory CD8 T-Cell Immunity to Influenza Virus Induced by Intranasal Carbomer-Lecithin-Adjuvanted Non-replicating Vaccines. PLoS Pathog. doi:10.1371/journal.ppat.1006064

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Tedesco D, Thapa M, Gumber S, Elrod EJ, Rahman K, Ibegbu CC, Magliocca JF, Adams AB, anania F and Grakoui A. 2016. CD4+ Foxp3+ T cells promote aberrant immunoglobulin G production and maintain CD8+ T-cell suppression during chronic liver disease. Hepatology. doi:10.1002/hep.28894

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Guthmiller JJ, Zander RA and Butler NS. 2015. Measurement of the T Cell Response to Preerythrocytic Vaccination in Mice. Methods Mol Biol. 1325: 19-37.

» View on PubMed



Anti-Mouse Antibodies:

CD3 (17A2)

 

Nishi K, Ishikura S, Umebayashi M, et al. Mutant KRAS Promotes NKG2D+ T Cell Infiltration and CD155 Dependent Immune Evasion. Anticancer Res. 2020;40(8):4663-4674. doi:10.21873/anticanres.14465.

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Clark PA, Sriramaneni RN, Jin WJ, et al.  In situ vaccination at a peripheral tumor site augments response against melanoma brain metastases. Journal for ImmunoTherapy of Cancer 2020;8:e000809. doi: 10.1136/jitc-2020-000809.

» View on BMJ Journals

Andersen TK, Huszthy PC, Gopalakrishnan RP, et al. Enhanced germinal center reaction by targeting vaccine antigen to major histocompatibility complex class II molecules. NPJ Vaccines. 2019;4:9. Published 2019 Feb 11. doi:10.1038/s41541-019-0101-0.

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Oguro H, McDonald JG, Zhao Z, Umetani M, Shaul PW and Morrison SJ. 2017. 27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy. J Clin Invest. doi: 10.1172/JCI94027.

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Andersen TK, Zhou F, Cox R, Bogen B and Grødeland G. 2017. A DNA vaccine that targets hemagglutinin to antigen presenting cells protects mice against H7 influenza. J Virol. doi: 10.1128/JVI.01340-17.

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Conejero L, Khouili SC, Martínez-Cano S, Izquierdo HM, Brandi P and Sancho D. 2017. Lung CD103+ dendritic cells restrain allergic airway inflammation through IL-12 production. JCI Insight. doi: 10.1172/jci.insight.90420

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Mgbemena VE, Signer RA, Wijayatunge R, Laxson T, Morrison SJ, Ross TS. 2017. Distinct Brca1 Mutations Differentially Reduce Hematopoietic Stem Cell Function. Cell Rep. DOI: 10.1016/j.celrep.2016.12.075

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Trott DW, Henson GD, Ho MHT, Allison SA, Lesniewski LA and Donato AJ. 2016. Age-related arterial immune cell infiltration in mice is attenuated by caloric restriction or voluntary exercise. Exp. Gerontol. DOI: 10.1016/j.exger.2016.12.016

» View on PubMed

Hirao H, Uchida Y, Kadono K, Tanaka H, Niki T, Yamauchi A, Hata K, Watanabe T, Terajima H and Uemoto S. 2015. The protective function of galectin-9 in liver ischemia and reperfusion injury in mice. Liver Transpl. doi: 10.1002/lt.24159.

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Perez J, Dansou B, Herve R, Levi C, Tamouza H, Vandermeersch S, Demey-Thomas E, Haymann JP, Zafrani L, Klatzmann D, Boissier MC, Letavernier E and Baud L. 2015. Calpains Released by T Lymphocytes Cleave TLR2 To Control IL-17 Expression. J Immunol. doi: 10.4049 jimmunol.1500749.

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Arellano B, Hussain R, Miller-Little WA, Herndon E, Lambracht-Washington D, Eagar TN, Lew R, Healey D, Vernino S, Greenberg BM, and Stuve O. 2016. A Single Amino Acid Substitution Prevents Recognition of a Dominant Human Aquaporin-4 Determinant in the Context of HLA-DRB103:01 by a Murine TCR. PLoS ONE 11(4): e0152720.doi:10.1371/journal.pone.0152720

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Han Z, Brown JR, and Niederkorn. 2016. Growth and Metastasis of Intraocular Tumors in Aged Mice. Investigative Opthalmology & Visual Science. 57:2366-2376 DOI:10.1167/iovs.16-19156

» View on PubMed

Shen Z, Rodriguez-Garcia M, Patel MV, Barr FD and Wire CR. 2016. Menopausal Status Influences the Expression of Programmed Death (PD)-1 and its Ligand PD-L1 on Immune Cells from the Human Female Reproductive Tract. American Journal of Reproductive Immunology. DOI: 10.1111/aji.12532

» View on PubMed

Yamada T, Kanoh M, Nabe S, Yasuoka T, Suzuki J, Matsumoto A, Kuwahara M, Maruyama S, Fujimoto T, Sakisuka R, Yasukawa M and Yamashita M. 2016. Menin Plays a Critical Role in the Regulation of the Antigen-Specific CD8+ T Cell Response upon Listeria Infection. J. Immunol. doi: 10.4049/​jimmunol.1502295

» View

Lee LM, Ji M, Sinha M, Dong MB, Ren X, Wang Y, Lowell CA, Ghosh S, Locksley RM and DeFranco AL. 2016. Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9. PLOS one. doi:10.1371/journal.pone.0167693

» View

Park RJ, Wang T, Koundakjian D, Hultquist JF, Lamothe-Molina P, Monel B, Schumann K, Yu H,Krupzcak KM, Garcia-Beltran W, Piechocka-Trocha A, Krogan NJ, Marson A, Sabatini DM, Lander ES, Hacohen N and Walker BD. 2016. A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors. Nature Genet. doi:10.1038/ng.3741

» View on PubMed

Tedesco D, Thapa M, Gumber S, Elrod EJ, Rahman K, Ibegbu CC, Magliocca JF, Adams AB, anania F and Grakoui A. 2016. CD4+ Foxp3+ T cells promote aberrant immunoglobulin G production and maintain CD8+ T-cell suppression during chronic liver disease. Hepatology. doi:10.1002/hep.28894

» View on PubMed

Shiyang Li, John W. Bostick, Jian Ye, Joseph F. Urban, Jr., Dorina Avram, Liang Zhou. Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function. Immunity. 2018 Nov 20;49(5):915-928.e5. doi: 10.1016/j.immuni.2018.09.015

» View on PubMed

CD3e (145-2C11)

 

Even Fossum, Demo Yemane Tesfaye, Sonja Bobic, Arnar Gudjonsson, Ranveig Braathen, Mireille H. Lahoud, Irina Caminschi, Bjarne Bogen. Targeting Antigens to Different Receptors on Conventional Type 1 Dendritic Cells Impacts the Immune Response. The Journal of Immunology June 26, 2020, ji1901119; DOI: 10.4049/jimmunol.1901119.

» View on Journal of Immunology

Weber A, Pawar HN, Klein JR. Thyroid stimulating hormone β-subunit splice variant is expressed in all fractional subsets of bone marrow hematopoietic cells and peripheral blood leukocytes and is modulated during bacterial infection. Gen Comp Endocrinol. 2020 Apr 30:113495. doi: 10.1016/j.ygcen.2020.113495

» View on PubMed

Wen J, Wang YT, Valentine KM, Dos Santos Alves RP, Xu Z, Regla-Nava JA, Ngono AE, Young MP, Ferreira LCS4, Shresta S. CD4+T Cells Cross-Reactive with Dengue and Zika Viruses Protect against Zika Virus Infection. Cell Rep. 2020 Apr 28;31(4):107566. doi: 10.1016/j.celrep.2020.107566.

» View on ScienceDirect

Blagih J, Zani F, Chakravarty P, et al. Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses. Cell Rep. 2020;30(2):481-496.e6. doi:10.1016/j.celrep.2019.12.028.

» View on PubMed

Elong Ngono A, Young MP, Bunz M, et al. CD4+ T cells promote humoral immunity and viral control during Zika virus infection [published correction appears in PLoS Pathog. 2019 May 28;15(5):e1007821]. PLoS Pathog. 2019;15(1):e1007474. Published 2019 Jan 24. doi:10.1371/journal.ppat.1007474.

» View on PubMed

Kim IS, Gao Y, Welte T, et al. Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms. Nat Cell Biol. 2019;21(9):1113-1126. doi:10.1038/s41556-019-0373-7.

» View on PubMed

Atif SM, Mack DG, McKee AS, et al. Protective role of B cells in sterile particulate-induced lung injury. JCI Insight. 2019;5(12):e125494. Published 2019 May 16. doi:10.1172/jci.insight.125494.

» View on PubMed

Shimada K, Porritt RA, Markman JL, et al. T-Cell-Intrinsic Receptor Interacting Protein 2 Regulates Pathogenic T Helper 17 Cell Differentiation. Immunity. 2018;49(5):873-885.e7. doi:10.1016/j.immuni.2018.08.022.

» View on PubMed

Adami AJ, Bracken SJ, Guernsey LA, et al. Early-life antibiotics attenuate regulatory T cell generation and increase the severity of murine house dust mite-induced asthma. Pediatr Res. 2018;84(3):426-434. doi:10.1038/s41390-018-0031-y.

» View on PubMed

Nagasaka A, Mogi C, Ono H, Nishi T, Horii Y, Ohba Y, Sato K, Nakaya M, Okajima F and Kurose H. 2017. The proton-sensing G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) shows cardioprotective effects against myocardial infarction. Sci Rep. doi: 10.1038/s41598-017-07573-2.

» View on PubMed

Furata Y, Tsai SH, Kinoshita M, Fujimoto K, Okumura R, Umemoto E, Kurashima Y, Kiyono H, Kayama H and Takeda K. 2017. E-NPP3 controls plasmacytoid dendritic cell numbers in the small intestine. PLoS One. doi: 10.1371/journal.pone.0172509

» View on PubMed

Sato Y, Kato H, Ebina-Shibuya R, Itoh-Nakadai A, Okuyama R and Igarashi K. 2017. Bach2 Controls Homeostasis of Eosinophils by Restricting the Type-2 Helper Function of T Cells. Tohoku J Exp Med. doi: 10.1620/tjem.241.175

» View on PubMed

Rydyznski C, Daniels KA, Karmele EP, Brooks TR, Mahl SE, Moran MT, Li C, Sutiwisesak R, Welsh RM and Waggoner SN. 2015. Generation of cellular immune memory and B-cell immunity is impaired by natural killer cells. Nat Commun. doi: 10.1038/ncomms7375.

» View on PubMed

Van Vo A, Takenaka E, Shibuya A and Shibuya K. 2015. Expression of DNAM-1 (CD226) on inflammatory monocytes. Mol Immunol. 69: 70-76.

» View on ScienceDirect

Kawano M, Mabuchi S, Matsumoto Y, Sasano T, Takahashi R, Kuroda H, Kozasa K, Hashimoto K, Isobe A, Sawada K, Hamasaki T, Morii E and Kimura T. 2015. The significance of G-CSF expression and myeloid-derived suppressor cells in the chemoresistance of uterine cervical cancer. Sci Rep. 5:18217 doi:10.1038/srep18217.

» View on PubMed

Oh JE, Lee MS, Kim YJ and Lee HK. 2016. OASL1 deficiency promotes antiviral protection against genital herpes simplex virus type 2 infection by enhancing type I interferon production. Sci Rep. doi: 10.1038/srep19089.

» View on PubMed

Iwahashi C, Fujimoto M, Nomura S, Serada S, Nakai K, Ohguro N, Nishida K and Naka T. 2015. CTLA4-Ig suppresses development of experimental autoimmune uveitis in the induction and effector phases: comparison with blockade of interleukin-6. Exp Eye Res. doi: 10.1016/j.exer.2015.08.012.

» View on PubMed

Neyt K, GeurtsvanKessel CH and Lambrecht BN. Double-negative T resident memory cells of the lung react to influenza virus infection via CD11chi dendritic cells. 2015. Mucosal Immunol. DOI 10.1038/mi2015.91.

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Giuilliams M, Dutertre C, Scott CL, McGovern N, Sichien D, Chakarov S, Gassen SV, Chen J, Poidinger M, De Prijck S, Tavernier SJ, Low I, Irac SE, Mattar CN, Sumatoh HR, Low GH, Chung TJ, Chan DK, Tan KK, Hon TL, Fossum E, Bogen B, Choolani M, Chan JK, Larbi A, Luche H, Henri S, Saeys Y, Newell EW, Lambrecht BN, Malissen B and Ginhoux F. 2016. Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species. Immunity. doi: 10.1016/j.immuni.2016.08.015

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Huo M, Huang Y, Qu D, Zhang H, Wong WT, Chawla A, Huang Y and Tian XY. 2016. Myeloid Bmal1 deletion increases monocyte recruitment and worsens atherosclerosis. FASEB J. doi:10.1096/fj.201601030R

» View on PubMed

Uzodinma U. Uche, Ann R. Piccirillo, Shunsuke Kataoka, Stephanie J. Grebinoski, Louise M. D’Cruz, and Lawrence P. Kane. PIK3IP1/TrIP restricts activation of T cells through inhibition of PI3K/Akt. J Exp Med. 2018 Dec 3;215(12):3165-3179. doi: 10.1084/jem.20172018

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Kovats. A Major Population of Functional KLRG1- ILC2s in Female Lungs Contributes to a Sex Bias in ILC2 Numbers. Immunohorizons. 2018 Feb;2(2):74-86. doi: 10.4049/immunohorizons.1800008

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Derek W. Trobaugh, Chengqun Sun, Matthew D. Dunn, Douglas S. Reed, William B. Klimstra. Rational design of a live-attenuated eastern equine encephalitis virus vaccine through informed mutation of virulence determinants. PLoS Pathog. 2019 Feb 11;15(2):e1007584. doi: 10.1371/journal.ppat.1007584

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Erola Ainsua-Enrich, Ibrahim Hatipoglu, Sapana Kadel, Sean Turner, Jinny Paul, Simar Singh, Harini Bagavant, and Susan Kovats. IRF4-dependent dendritic cells regulate CD8+ T cell differentiation and memory responses in influenza infection. Mucosal Immunol. 2019 Jul;12(4):1025-1037. doi: 10.1038/s41385-019-0173-1

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Shiyang Li, John W. Bostick, Jian Ye, Joseph F. Urban, Jr., Dorina Avram, Liang Zhou. Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function. Immunity. 2018 Nov 20;49(5):915-928.e5. doi: 10.1016/j.immuni.2018.09.015

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Rita Kansal, Noah Richardson, Indira Neeli, Saleem Khawaja, Damian Chamberlain, Marium Ghani, Qurat-ul-ain Ghani, Louisa Balazs, Sarka Beranova-Giorgianni, Francesco Giorgianni, James N. Kochenderfer, Tony Marion, Lorraine M. Albritton, Marko Radic. Sustained B cell depletion by CD19-targeted CAR T cells is a highly effective treatment for murine lupus. Sci Transl Med. 2019 Mar 6;11(482). pii: eaav1648. doi: 10.1126/scitranslmed.aav1648

» View on PubMed

CD4 (SK3)

 

Roth TL, Li PJ, Blaeschke F, Nies JF, Apathy R, Mowery C, Yu R, Nguyen MLT, Lee Y, Truong A, Hiatt J, Wu D, Nguyen DN, Goodman D, Bluestone JA, Ye CJ, Roybal K, Shifrut E, Marson A. Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies. Cell. 2020 Apr 15. pii: S0092-8674(20)30332-9. doi: 10.1016/j.cell.2020.03.039.

» View on ScienceDirect

Sun CW, Wu LC, Knopick PL, Bradley DS, Townes T and Terman DS. 2017. Sickle Cells Produce Functional Immune Modulators and Cytotoxics. Am J Hematol. doi: 10.1002/ajh.24836.

» View on PubMed

CD4 (RM4-5)

 

Hiroshi Kobayashi and Keiyo Takubo. Protocol for the Maintenance of Quiescent Murine Hematopoietic Stem Cells. STAR Protocols.  Published 2 August 2020. https://doi.org/10.1016/j.xpro.2020.100078. 

» View on ScienceDirect

Kayla R. Kulhanek, Darienne R. Myers, Olga Ksionda, Yvonne Vercoulen, Damia Romero-Moya, Jeroen P. Roose.  Protocol for Barcoding T Cells Combined with Timed Stimulations. STAR Protocols 2020, 100067, ISSN 2666-1667.  https://doi.org/10.1016/j.xpro.2020.100067.

» View on ScienceDirect

Dolina JS, Lee J, Griswold RQ, Labarta-Bajo L, Kannan S, Greenbaum JA, Bahia El Idrissi N, Pont MJ, Croft M, Schoenberger SP. TLR9 Sensing of Self-DNA Controls Cell-Mediated Immunity to Listeria Infection via Rapid Conversion of Conventional CD4+ T Cells to Treg. Cell Rep. 2020 Apr 7;31(1):107249. doi: 10.1016/j.celrep.2020.01.040.

» View on ScienceDirect

Markman, J.L., Porritt, R.A., Wakita, D. et al. Loss of testosterone impairs anti-tumor neutrophil function. Nat Commun 11, 1613 (2020). https://doi.org/10.1038/s41467-020-153.

» View on Nature Communications

Blagih J, Zani F, Chakravarty P, et al. Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses. Cell Rep. 2020;30(2):481-496.e6. doi:10.1016/j.celrep.2019.12.028.

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Kobayashi H, Morikawa T, Okinaga A, et al. Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo. Cell Rep. 2019;28(1):145-158.e9. doi:10.1016/j.celrep.2019.06.008.

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Agelidis AM, Hadigal SR, Jaishankar D and Shukla D. 2017. Viral Activation of Heparanase Drives Pathogenesis of Herpes Simplex Virus-1. Cell Rep. doi: 10.1016/j.celrep.2017.06.041.

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Conejero L, Khouili SC, Martínez-Cano S, Izquierdo HM, Brandi P and Sancho D. 2017. Lung CD103+ dendritic cells restrain allergic airway inflammation through IL-12 production. JCI Insight. doi: 10.1172/jci.insight.90420

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Bally APR, Lu P, Tang Y, Austin JW, Scharer CD, Ahmed R and Boss JM. 2015. NF-ΚB Regulates PD-1 Expression in Macrophages. J Immunol. 194(9): 4545-4554.

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Levine AG, Arvey A, Jin W and Rudensky AY. 2014. Continuous requirement for the TCR in regulatory T cell function. Nature Immunol. 15(11): 1070-1078.

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Onizawa M, Oshima S, Schulze-Topphoff U, Oses-Prieto JA, Lu T, Tavares R, Produhomme T, Duong B, Whang MI, Advincula R, Agelidis A, et al. 2015. The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis. Nat Immunol. 16(6): 618-627.

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Bapat SP, Nyoung Suh J, Fang S, Liu S, Zhang Y, Cheng A, Zhou C, Liang Y, LeBlanc M, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM and Zheng Y. 2015. Depletion of fat-resident Treg cells prevents age-associated insulin resistance. Nature. 528: 137-141.

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Weist BM, Kurd N, Boussier J, Chan SW and Robey EA. 2015. Thymic regulatory T cell niche size is dictated by limiting IL-2 from antigen-bearing dendritic cells and feedback competition. Nat Immunol. 16(6): 635-641.

» View on PubMed

Sekiya T, Kondo T, Shichita T, Morita R, Ichinose H and Yoshimura A. 2015. Suppression of Th2 and Tfh immune reactions by Nr4a receptors in mature T reg cells. J Exp Med. 212(10): 1623-1640.

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Rios D, Wood MB, Li J, Chassaing B, Gewirtz AT and Williams IR. 2015. Antigen sampling by intestinal M cells is the principal pathway initiating mucosal IgA production to commensal enteric bacteria. Mucosal Immunol. doi: 10.1038/mi.2015.121.

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Mande P, Zirak B, Ko WC, Taravati K, Bride KL, Brodeur TY, Deng A, Dresser K, Jiang Z, Ettinger R, Fitzgerald KA, Rosenblum MD, Harris JE, Marshak-Rothstein A. Fas ligand promotes an inducible TLR-dependent model of cutaneous lupus-like inflammation. J Clin Invest. 2018 Jul 2;128(7):2966-2978. doi: 10.1172/JCI98219

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Jordy Saravia, Hu Zeng1, Yogesh Dhungana, Daniel Bastardo Blanco, Thanh-Long M. Nguyen, Nicole M. Chapman, Yanyan Wang, Apurva Kanneganti, Shaofeng Liu, Jana L. Raynor, Peter Vogel, Geoffrey Neale, Peter Carmeliet, Hongbo Chi. Homeostasis and transitional activation of regulatory T cells require c-Myc. Sci Adv. 2020 Jan 1;6(1):eaaw6443. doi: 10.1126/sciadv.aaw6443

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Hao Shi, Nicole M. Chapman, Jing Wen, Cliff Guy, Lingyun Long, Yogesh Dhungana, Sherri Rankin, Stephane Pelletier, Peter Vogel, Hong Wang, Junmin Peng, Kun-Liang Guan, and Hongbo Chi. Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb. Immunity. 2019 Dec 17;51(6):1012-1027.e7. doi: 10.1016/j.immuni.2019.10.001

» View on PubMed

CD4 (GK1.5)

 

Clark PA, Sriramaneni RN, Jin WJ, et al.  In situ vaccination at a peripheral tumor site augments response against melanoma brain metastases. Journal for ImmunoTherapy of Cancer 2020;8:e000809. doi: 10.1136/jitc-2020-000809.

» View on BMJ Journals

Blagih J, Zani F, Chakravarty P, et al. Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses. Cell Rep. 2020;30(2):481-496.e6. doi:10.1016/j.celrep.2019.12.028.

» View on PubMed

Andersen TK, Huszthy PC, Gopalakrishnan RP, et al. Enhanced germinal center reaction by targeting vaccine antigen to major histocompatibility complex class II molecules. NPJ Vaccines. 2019;4:9. Published 2019 Feb 11. doi:10.1038/s41541-019-0101-0.

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Kim IS, Gao Y, Welte T, et al. Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms. Nat Cell Biol. 2019;21(9):1113-1126. doi:10.1038/s41556-019-0373-7.

» View on PubMed

Yang BH, Wang K, Wan S, et al. TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases. Cell Rep. 2019;27(12):3629-3645.e6. doi:10.1016/j.celrep.2019.05.061.

» View on PubMed

Lam LKM, Watson AM, Ryman KD, Klimstra WB. Gamma-interferon exerts a critical early restriction on replication and dissemination of yellow fever virus vaccine strain 17D-204. NPJ Vaccines. 2018;3:5. Published 2018 Jan 23. doi:10.1038/s41541-017-0039-z.

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Shimada K, Porritt RA, Markman JL, et al. T-Cell-Intrinsic Receptor Interacting Protein 2 Regulates Pathogenic T Helper 17 Cell Differentiation. Immunity. 2018;49(5):873-885.e7. doi:10.1016/j.immuni.2018.08.022.

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Manrique-Rincón AJ, Beraldo CM, Toscaro JM and Bajgelman MC. 2017. Exploring Synergy in Combinations of Tumor-Derived Vaccines That Harbor 4-1BBL, OX40L, and GM-CSF. Front Immunol. doi: 10.3389/fimmu.2017.01150.

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Kurosawa M, Arakaki R, Yamada A, Tsunematsu T, Kudo Y, Sprent J and Ishimaru N. 2017. NF-κB2 Controls Migratory Activity of Memory T Cells by Regulating Expression of CXCR4 in A Mouse Model of Sjögren's Syndrome. Arthritis Rheumatol. doi: 10.1002/art.40230.

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Trott DW, Henson GD, Ho MHT, Allison SA, Lesniewski LA and Donato AJ. 2016. Age-related arterial immune cell infiltration in mice is attenuated by caloric restriction or voluntary exercise. Exp. Gerontol. DOI: 10.1016/j.exger.2016.12.016

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Zander RA, Guthmiller JJ, Graham AC, Pope RL, Burke BE, Carr DJ and Butler NS. 2016. Type I Interferons Induce T Regulatory 1 Responses and Restrict Humoral Immunity during Experimental Malaria. PLOS Pathogens. DOI:10.1371/journal.ppat.1005945

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Kitai Y, Kawasaki T, Sueyoshi T, Kobiyama K, Ishii KJ, Zou J, Akira S, Matsuda T and Kawai T. 2017. DNA-Containing Exosomes Derived from Cancer Cells Treated with Topotecan Activate a STING-Dependent Pathway and Reinforce Antitumor Immunity. J. Immunol. DOI: 10.4049/jimmunol.1601694

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Higashino-Kameda M, Yabe-Wada T, Matsuba S, Takeda K, Anzawa K, Mochizuki T, Makimura K, Saijo S, Iwakura Y, Toga H and Nakamura A. 2015. A critical rold of Dectin-1 in hypersensitivity pneumonitis. Inflamm Res. DOI 10.1007/s00011-015-0910-1.

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Fiege JK, Burback Bj and Shimizu Y. 2015. Negative Regulation of Memory Phenotype CD8 T Cell Conversion by Adhesion and Degranulation-Promoting Adapter Protein. J Immunol. 195(7): 3119-3128.

» View on PubMed

Oh JE, Lee MS, Kim YJ and Lee HK. 2016. OASL1 deficiency promotes antiviral protection against genital herpes simplex virus type 2 infection by enhancing type I interferon production. Sci Rep. doi: 10.1038/srep19089.

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Cruz-Adalia A, Ramirez-Santiago G, Torres-Torresano M, Garcia-Ferreras R and Veiga Chacon E. 2016.T Cells Capture Bacteria by Transinfection from Dendritic Cells. J Vis Exp. (107), e52976, doi: 10.3791/52976

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Sato Y, Mii A, Hamazaki Y, Fujita H, Nakata H, Masuda K, Nishiyama S, Shibuya S, Haga H, Ogawa O, Shimizu A, Narumiya S, Kaisho T, Arita M, Yanagisawa M, Miyasaka M, Sharma K, Minato N, Kawamoto H and Yanagita M. 2016. Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney. JCI Insight. 2016;1(11):e87680. doi:10.1172/jci.insight.87680.

» View

Watson AM, Matthew Lam LK, Klimstra WB and Ryman KD. 2016. The 17D-204 Vaccine Strain-Induced Protection Against Virulent Yellow Fever Virus is Mediated by Humoral Immunity and CD4+ But Not CD8+ T Cells. PLoS Pathog. doi:10.1371/journal.ppat.1005786

» View on PubMed

Huo M, Huang Y, Qu D, Zhang H, Wong WT, Chawla A, Huang Y and Tian XY. 2016. Myeloid Bmal1 deletion increases monocyte recruitment and worsens atherosclerosis. FASEB J. doi:10.1096/fj.201601030R

» View on PubMed

Uzodinma U. Uche, Ann R. Piccirillo, Shunsuke Kataoka, Stephanie J. Grebinoski, Louise M. D’Cruz, and Lawrence P. Kane. PIK3IP1/TrIP restricts activation of T cells through inhibition of PI3K/Akt. J Exp Med. 2018 Dec 3;215(12):3165-3179. doi: 10.1084/jem.20172018

» View on PubMed

Avery L, Filderman J, Szymczak-Workman AL, Kane LP4. Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2455-2460. doi: 10.1073/pnas.1712107115

» View on PubMed

Rita Kansal, Noah Richardson, Indira Neeli, Saleem Khawaja, Damian Chamberlain, Marium Ghani, Qurat-ul-ain Ghani, Louisa Balazs, Sarka Beranova-Giorgianni, Francesco Giorgianni, James N. Kochenderfer, Tony Marion, Lorraine M. Albritton, Marko Radic. Sustained B cell depletion by CD19-targeted CAR T cells is a highly effective treatment for murine lupus. Sci Transl Med. 2019 Mar 6;11(482). pii: eaav1648. doi: 10.1126/scitranslmed.aav1648

» View on PubMed

Qiumei Du, Ashley R. Hoover, Igor Dozmorov, Ondine B. Cleaver,Joshua T. Mendell, Nicolai S.C. van Oers. MIR205HG Is a Long Noncoding RNA that Regulates Growth Hormone and Prolactin Production in the Anterior Pituitary. Dev Cell. 2019 May 20;49(4):618-631.e5. doi: 10.1016/j.devcel.2019.03.012

» View on PubMed

CD5 (53-7.3)

 

Shiyang Li, John W. Bostick, Jian Ye, Joseph F. Urban, Jr., Dorina Avram, Liang Zhou. Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function. Immunity. 2018 Nov 20;49(5):915-928.e5. doi: 10.1016/j.immuni.2018.09.015

» View on PubMed

Noviski M, Mueller JL, Satterthwaite A, Garrett-Sinha LA, Brombacher F, Zikherman J. IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate. Elife. 2018;7:e35074. Published 2018 Mar 9. doi:10.7554/eLife.35074.

» View on PubMed

Oguro H, McDonald JG, Zhao Z, Umetani M, Shaul PW and Morrison SJ. 2017. 27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy. J Clin Invest. doi: 10.1172/JCI94027.

» View on PubMed

CD8a (OKT8)

 

Roth TL, Li PJ, Blaeschke F, Nies JF, Apathy R, Mowery C, Yu R, Nguyen MLT, Lee Y, Truong A, Hiatt J, Wu D, Nguyen DN, Goodman D, Bluestone JA, Ye CJ, Roybal K, Shifrut E, Marson A. Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies. Cell. 2020 Apr 15. pii: S0092-8674(20)30332-9. doi: 10.1016/j.cell.2020.03.039.

» View on ScienceDirect

Sun CW, Wu LC, Knopick PL, Bradley DS, Townes T and Terman DS. 2017. Sickle Cells Produce Functional Immune Modulators and Cytotoxics. Am J Hematol. doi: 10.1002/ajh.24836.

» View on PubMed

CD8a (53-6.7)

 

Hiroshi Kobayashi and Keiyo Takubo. Protocol for the Maintenance of Quiescent Murine Hematopoietic Stem Cells. STAR Protocols.  Published 2 August 2020. https://doi.org/10.1016/j.xpro.2020.100078. 

» View on ScienceDirect

Slade CD, Reagin KL, Lakshmanan HG, Klonowski KD, Watford WT. Placenta-specific 8 limits IFNγ production by CD4 T cells in vitro and promotes establishment of influenza-specific CD8 T cells in vivo. PLoS One. 2020;15(7):e0235706. Published 2020 Jul 8. doi:10.1371/journal.pone.0235706.

» View on PubMed

Liao, W., Ma, C., Zhang, N. Isolation of Mouse Kidney-Resident CD8+ T cells for Flow Cytometry Analysis. J. Vis. Exp. (160), e61559, doi:10.3791/61559 (2020).

» View on JoVE Journal

Dolina JS, Lee J, Griswold RQ, Labarta-Bajo L, Kannan S, Greenbaum JA, Bahia El Idrissi N, Pont MJ, Croft M, Schoenberger SP. TLR9 Sensing of Self-DNA Controls Cell-Mediated Immunity to Listeria Infection via Rapid Conversion of Conventional CD4+ T Cells to Treg. Cell Rep. 2020 Apr 7;31(1):107249. doi: 10.1016/j.celrep.2020.01.040.

» View on ScienceDirect

Kim IS, Gao Y, Welte T, et al. Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms. Nat Cell Biol. 2019;21(9):1113-1126. doi:10.1038/s41556-019-0373-7.

» View on PubMed

Yang BH, Wang K, Wan S, et al. TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases. Cell Rep. 2019;27(12):3629-3645.e6. doi:10.1016/j.celrep.2019.05.061.

» View on PubMed

Kobayashi H, Morikawa T, Okinaga A, et al. Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo. Cell Rep. 2019;28(1):145-158.e9. doi:10.1016/j.celrep.2019.06.008.

» View on PubMed

Adami AJ, Bracken SJ, Guernsey LA, et al. Early-life antibiotics attenuate regulatory T cell generation and increase the severity of murine house dust mite-induced asthma. Pediatr Res. 2018;84(3):426-434. doi:10.1038/s41390-018-0031-y.

» View on PubMed

Shimada K, Porritt RA, Markman JL, et al. T-Cell-Intrinsic Receptor Interacting Protein 2 Regulates Pathogenic T Helper 17 Cell Differentiation. Immunity. 2018;49(5):873-885.e7. doi:10.1016/j.immuni.2018.08.022.

» View on PubMed

Ganuza M, Hall T, Finkelstein D, Chabot A, Kang G and McKinney-Freeman S. (2017) Lifelong haematopoiesis is established by hundreds of precursors throughout mammalian ontogeny. Nat Cell Biol. DOI: 10.1038/ncb3607

» View on PubMed

Conejero L, Khouili SC, Martínez-Cano S, Izquierdo HM, Brandi P and Sancho D. 2017. Lung CD103+ dendritic cells restrain allergic airway inflammation through IL-12 production. JCI Insight. doi: 10.1172/jci.insight.90420

» View on PubMed

Ratiu JJ, Racine JJ, Hasham MG, Wang Q, Branca JA, Chapman HD, Zhu J, Donghia N, Philip V, Schott WH, Wasserfall C, Atkinson MA, Mills KD, Leeth CM and Serreze DV. 2017. Genetic and Small Molecule Disruption of the AID/RAD51 Axis Similarly Protects Nonobese Diabetic Mice from Type 1 Diabetes through Expansion of Regulatory B Lymphocytes. J Immunol. doi: 10.4049/jimmunol.1700024.

» View on PubMed

Shiokawa A, Kotaki R, Takano T, Nakajima-Adachi H and Hachimura S. 2017. Mesenteric lymph node CD11b- CD103+ PD-L1High dendritic cells highly induce regulatory T cells. Immunology. doi: 10.1111/imm.12747

» View on PubMed

Oguro H, McDonald JG, Zhao Z, Umetani M, Shaul PW and Morrison SJ. 2017. 27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy. J Clin Invest. doi: 10.1172/JCI94027.

» View on PubMed

Kersh AE, Edwards LJ and Evavold BD. 2014. Progression of Relapsing-Remitting Demyelinating Disease Does Not Require Increased TCR Affinity or Epitope Spread. J. Immunol. 193(9): 4429-4438.

» View on PubMed

Bally APR, Lu P, Tang Y, Austin JW, Scharer CD, Ahmed R and Boss JM. 2015. NF-ΚB Regulates PD-1 Expression in Macrophages. J Immunol. 194(9): 4545-4554.

» View on PubMed

Han BY, Wu S, Foo C-S, Horton RM, Jenne CN, Watson SR, Whittle B, Goodnow CC and Cyster JG. 2014. Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment. eLife doi: 10.7554/eLife.03549

» View on PubMed

Martinez RJ, Neeld DK and Evavold BD. 2015. Identification of T cell clones without the need for sequencing. J Immunol Methods. doi: 10.1016/j.jim.2015.04.018.

» View on PubMed

Weist BM, Kurd N, Boussier J, Chan SW and Robey EA. 2015. Thymic regulatory T cell niche size is dictated by limiting IL-2 from antigen-bearing dendritic cells and feedback competition. Nat Immunol. 16(6): 635-641.

» View on PubMed

Fiege JK, Burback Bj and Shimizu Y. 2015. Negative Regulation of Memory Phenotype CD8 T Cell Conversion by Adhesion and Degranulation-Promoting Adapter Protein. J Immunol. 195(7): 3119-3128.

» View on PubMed

Manz BN, Tan YX, Courtney A, Rutaganira F, Palmer E, Shokat KM and Weiss A. 2015. Small molecule inhibition of Csk alters affinity recognition by T cells. Elife. doi: 10.7554/eLife.08088.

» View on PubMed

Finkin S, Yuan D, Stein I, Taniguchi K, Weber A, Unger K, Browning JL, Goossens N, Nakagawa S, Gunasekara G, Schwartz ME et al. 2015. Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma. Nat Immunol. doi: 10.1038/ni.3290.

» View on PubMed

Carey AJ, Gracias DT, Thayer JL, Boesteanu AC, Kumova OK, Mueller YM, Hope JL, Fraietta JA, van Zessen DB and Katsikis PD. 2016. Rapid Evolution of the CD8+ TCR Repertoire in Neonatal Mice. J Immunol. doi: 10.4049/​jimmunol.1502126.

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Come C, Cvrljevic A, Khan MM, Treise I, Adler T, Aguilar-Pimental JA, Au-Yeung B, Sittig E, Laajala TD, Chen Y, Oeder S, Calzada-Wack J, Horsch M, Aittokallio T, Busch DH, Ollert MW, Neff F, Beckers J, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Chen Z, Lahesmaa R, and Westermarck J. 2016. CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection. PLoS ONE 11(4):e0152996. doi:10.1371/journal.pone.0152996

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Martin SD, Brown SD, Wick DA, Nielsen JS, Kroeger DR, Twumasi-Boateng K, Holt RA, and Nelson BH. 2016. Low Mutation Burden in Ovarian Cancer May Limit the Utility of Neoantigen-Targeted Vaccines. PLoS ONE. doi:10.1371/journal.pone.0155189

» View on PubMed

Watson AM, Matthew Lam LK, Klimstra WB and Ryman KD. 2016. The 17D-204 Vaccine Strain-Induced Protection Against Virulent Yellow Fever Virus is Mediated by Humoral Immunity and CD4+ But Not CD8+ T Cells. PLoS Pathog. doi:10.1371/journal.ppat.1005786

» View on PubMed

Asirvatham-Jeyaraj N, Fiege JK, Han R, Foss J, Banek CT, Burbach BJ, Razzoli M, Bartolomucci A, Shimizu Y, Panoskaltsis-Mortari A and Osborn JW. 2016. Renal Denervation Normalizes Arterial Pressure with No Effect on Glucose Metabolism or Renal Inflammation in Obese Hypertensive Mice. Hypertensions AHA. doi: 10.1161/HYPERTENSIONAHA.116.07993

» View on PubMed

Rampuria P, Lang GA, Devera TS, Gilmore C, Ballard JD, Lang ML. 2016. Coordination between T helper cells, iNKT cells, and their follicular helper sub-sets in the humoral immune response against Clostridium difficile toxin B. J Leukoc Biol. doi:10.1189/jlb.4A0616-271R

» View on PubMed

Bally APR, Tang Y, Lee JT, Barwick BG, Martinez R, Evavold BD and Boss JM. 2016. Conserved Region C Functions To Regulate PD-1 Expression and Subsequent CD8 T Cell Memory. J. Immunol. doi: 10.4049/​jimmunol.1601464

» View on PubMed

Ma C, Mishra S, Demel EL, Liu Y and Zhang N. 2016. TGF-β Controls the Formation of Kidney-Resident T Cells via Promoting Effector T Cell Extravasation. J. Immunol. doi: 10.4049/​jimmunol.1601500

» View on PubMed

Uzodinma U. Uche, Ann R. Piccirillo, Shunsuke Kataoka, Stephanie J. Grebinoski, Louise M. D’Cruz, and Lawrence P. Kane. PIK3IP1/TrIP restricts activation of T cells through inhibition of PI3K/Akt. J Exp Med. 2018 Dec 3;215(12):3165-3179. doi: 10.1084/jem.20172018

» View on PubMed

Avery L, Filderman J, Szymczak-Workman AL, Kane LP4. Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2455-2460. doi: 10.1073/pnas.1712107115

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Derek W. Trobaugh, Chengqun Sun, Matthew D. Dunn, Douglas S. Reed, William B. Klimstra. Rational design of a live-attenuated eastern equine encephalitis virus vaccine through informed mutation of virulence determinants. PLoS Pathog. 2019 Feb 11;15(2):e1007584. doi: 10.1371/journal.ppat.1007584

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Rita Kansal, Noah Richardson, Indira Neeli, Saleem Khawaja, Damian Chamberlain, Marium Ghani, Qurat-ul-ain Ghani, Louisa Balazs, Sarka Beranova-Giorgianni, Francesco Giorgianni, James N. Kochenderfer, Tony Marion, Lorraine M. Albritton, Marko Radic. Sustained B cell depletion by CD19-targeted CAR T cells is a highly effective treatment for murine lupus. Sci Transl Med. 2019 Mar 6;11(482). pii: eaav1648. doi: 10.1126/scitranslmed.aav1648

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Qiumei Du, Ashley R. Hoover, Igor Dozmorov, Ondine B. Cleaver,Joshua T. Mendell, Nicolai S.C. van Oers. MIR205HG Is a Long Noncoding RNA that Regulates Growth Hormone and Prolactin Production in the Anterior Pituitary. Dev Cell. 2019 May 20;49(4):618-631.e5. doi: 10.1016/j.devcel.2019.03.012

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Jessica K. Fiege, Ian A. Stone, Elizabeth J. Fay, Matthew W. Markman, Sathi Wijeyesinghe, Marissa G. Macchietto, Steven Shen, David Masopust and Ryan A. Langlois. The Impact of TCR Signal Strength on Resident Memory T Cell Formation during Influenza Virus Infection. J Immunol. 2019 Aug 15;203(4):936-945. doi: 10.4049/jimmunol.1900093

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Matthew A. Huggins, Frances V. Sjaastad, Mark Pierson, Tamara A. Kucaba, Whitney Swanson, Christopher Staley, Alexa R. Weingarden, Isaac J. Jensen, Derek B. Danahy, Vladimir P. Badovinac, Stephen C. Jameson, Vaiva Vezys, David Masopust, Alexander Khoruts, Thomas S. Griffith, and Sara E. Hamilton. Microbial Exposure Enhances Immunity to Pathogens Recognized by TLR2 but Increases Susceptibility to Cytokine Storm through TLR4 Sensitization. Cell Rep. 2019 Aug 13;28(7):1729-1743.e5. doi: 10.1016/j.celrep.2019.07.028

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Jordy Saravia, Hu Zeng1, Yogesh Dhungana, Daniel Bastardo Blanco, Thanh-Long M. Nguyen, Nicole M. Chapman, Yanyan Wang, Apurva Kanneganti, Shaofeng Liu, Jana L. Raynor, Peter Vogel, Geoffrey Neale, Peter Carmeliet, Hongbo Chi. Homeostasis and transitional activation of regulatory T cells require c-Myc. Sci Adv. 2020 Jan 1;6(1):eaaw6443. doi: 10.1126/sciadv.aaw6443

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Hao Shi, Nicole M. Chapman, Jing Wen, Cliff Guy, Lingyun Long, Yogesh Dhungana, Sherri Rankin, Stephane Pelletier, Peter Vogel, Hong Wang, Junmin Peng, Kun-Liang Guan, and Hongbo Chi. Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb. Immunity. 2019 Dec 17;51(6):1012-1027.e7. doi: 10.1016/j.immuni.2019.10.001

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CD8a (2.43)

 

Toriyama K, Kuwahara M, Kondoh H, et al. T cell-specific deletion of Pgam1 reveals a critical role for glycolysis in T cell responses. Commun Biol. 2020;3(1):394. Published 2020 Jul 24. doi:10.1038/s42003-020-01122-w.

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Lam LKM, Watson AM, Ryman KD, Klimstra WB. Gamma-interferon exerts a critical early restriction on replication and dissemination of yellow fever virus vaccine strain 17D-204. NPJ Vaccines. 2018;3:5. Published 2018 Jan 23. doi:10.1038/s41541-017-0039-z.

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Agelidis AM, Hadigal SR, Jaishankar D and Shukla D. 2017. Viral Activation of Heparanase Drives Pathogenesis of Herpes Simplex Virus-1. Cell Rep. doi: 10.1016/j.celrep.2017.06.041.

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Trott DW, Henson GD, Ho MHT, Allison SA, Lesniewski LA and Donato AJ. 2016. Age-related arterial immune cell infiltration in mice is attenuated by caloric restriction or voluntary exercise. Exp. Gerontol. DOI: 10.1016/j.exger.2016.12.016

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Sato Y, Mii A, Hamazaki Y, Fujita H, Nakata H, Masuda K, Nishiyama S, Shibuya S, Haga H, Ogawa O, Shimizu A, Narumiya S, Kaisho T, Arita M, Yanagisawa M, Miyasaka M, Sharma K, Minato N, Kawamoto H and Yanagita M. 2016. Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney. JCI Insight. 2016;1(11):e87680. doi:10.1172/jci.insight.87680.

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CD11b (M1/70)

 

Hiroshi Kobayashi and Keiyo Takubo. Protocol for the Maintenance of Quiescent Murine Hematopoietic Stem Cells. STAR Protocols.  Published 2 August 2020. https://doi.org/10.1016/j.xpro.2020.100078. 

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Komura N, Mabuchi S, Shimura K, et al. The role of myeloid-derived suppressor cells in increasing cancer stem-like cells and promoting PD-L1 expression in epithelial ovarian cancer. 2020 Jun 19. Cancer Immunol Immunother. 2020;10.1007/s00262-020-02628-2. doi:10.1007/s00262-020-02628-2.

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Roa, J.A., Sarkar, D., Zanaty, M. et al. Preliminary results in the analysis of the immune response after aneurysmal subarachnoid hemorrhage. Sci Rep 10, 11809 (2020). https://doi.org/10.1038/s41598-020-68861-y.

» View on Nature 

Kim IS, Gao Y, Welte T, et al. Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms. Nat Cell Biol. 2019;21(9):1113-1126. doi:10.1038/s41556-019-0373-7.

» View on PubMed

Andersen TK, Huszthy PC, Gopalakrishnan RP, et al. Enhanced germinal center reaction by targeting vaccine antigen to major histocompatibility complex class II molecules. NPJ Vaccines. 2019;4:9. Published 2019 Feb 11. doi:10.1038/s41541-019-0101-0.

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Udden SN, Kwak YT, Godfrey V, et al. NLRP12 suppresses hepatocellular carcinoma via downregulation of cJun N-terminal kinase activation in the hepatocyte. Elife. 2019;8:e40396. Published 2019 Apr 16. doi:10.7554/eLife.40396.

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Kobayashi H, Morikawa T, Okinaga A, et al. Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo. Cell Rep. 2019;28(1):145-158.e9. doi:10.1016/j.celrep.2019.06.008.

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Bahnan W, Boucher JC, Gayle P, et al. The eIF2α Kinase Heme-Regulated Inhibitor Protects the Host from Infection by Regulating Intracellular Pathogen Trafficking. Infect Immun. 2018;86(3):e00707-17. Published 2018 Feb 20. doi:10.1128/IAI.00707-17.

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Palacios M, Miner TA, Frederick DR, et al. Identification of Two Regulators of Virulence That Are Conserved in Klebsiella pneumoniae Classical and Hypervirulent Strains. mBio. 2018;9(4):e01443-18. Published 2018 Aug 7. doi:10.1128/mBio.01443-18.

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Scharer CD, Barwick BG, Guo M, Bally APR, Boss JM. Plasma cell differentiation is controlled by multiple cell division-coupled epigenetic programs. Nat Commun. 2018;9(1):1698. Published 2018 Apr 27. doi:10.1038/s41467-018-04125-8.

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Guo M, Price MJ, Patterson DG, et al. EZH2 Represses the B Cell Transcriptional Program and Regulates Antibody-Secreting Cell Metabolism and Antibody Production. J Immunol. 2018;200(3):1039-1052. doi:10.4049/jimmunol.1701470.

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Suwanpradid J, Shih M, Pontius L, Yang B, Birukova A, Guttman-Yassky E, Corcoran DL, Que LG, Tighe RM and MacLeod AS. 2017. Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity. J Immunol. doi: 10.4049/jimmunol.1700739.

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Kuroda H, Mabuchi S, Kozasa K, Yokoi E, Matsumoto Y, Komura N, Kawano M, Hashimoto K, Sawada K and Kimura T. 2017. PM01183 inhibits myeloid-derived suppressor cells in vitro and in vivo. Immunotherapy. doi: 10.2217/imt-2017-0046.

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Johnson LE, Olson BM and McNeel DG. 2017. Pretreatment antigen-specific immunity and regulation - association with subsequent immune response to anti-tumor DNA vaccination. J Immunother Cancer. doi: 10.1186/s40425-017-0260-3.

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Shiokawa A, Kotaki R, Takano T, Nakajima-Adachi H and Hachimura S. 2017. Mesenteric lymph node CD11b- CD103+ PD-L1High dendritic cells highly induce regulatory T cells. Immunology. doi: 10.1111/imm.12747

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Kishimoto Y, Asakawa S, Sato T, Takano T, Nakajyo T, Mizuno N, Segawa R, Yoshikawa T, Hiratsuka M, Yanai K, Ohtsu H and Hirasawa N. 2017. Induced histamine regulates Ni elution from an implanted Ni wire in mice by downregulating neutrophil migration. Exp Dermatol. doi: 10.1111/exd.13315.

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Zaman TS, Arimochi H, Maruyama S, Ishifune C, Tsukumo SI, Kitamura A and Yasutomo K. 2017. Notch Balances Th17 and Induced Regulatory T Cell Functions in Dendritic Cells by Regulating Aldh1a2 Expression. J Immunol. doi: 10.4049/jimmunol.1700645.

» View on Journal of Immunology

Abe Y, Kamachi F, Kawamoto T, Makino F, Ito J, Kojima Y, et al. 2013. TIM-4 Has Dual Function in the Induction and Effector Phases of Murine Arthritis. J Immunol. 191(9): 4562-4572.

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Vogel CF, Chang WL, Kado S, McColloh K, Vogel H, Wu D, Haarmann-Stemmann T, Yang G, Leung PS, Matsumura F and Gershwin ME. 2016. Transgenic Overexpression of Aryl Hydrocarbon Receptor Repressor (AhRR) and AhR-Mediated Induction of CYP1A1, Cytokines, and Acute Toxicity. Environ Health Perspect. DOI:10.1289/ehp.1510194.

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Come C, Cvrljevic A, Khan MM, Treise I, Adler T, Aguilar-Pimental JA, Au-Yeung B, Sittig E, Laajala TD, Chen Y, Oeder S, Calzada-Wack J, Horsch M, Aittokallio T, Busch DH, Ollert MW, Neff F, Beckers J, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Chen Z, Lahesmaa R, and Westermarck J. 2016. CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection. PLoS ONE 11(4):e0152996. doi:10.1371/journal.pone.0152996

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Sato T, Kishimoto Y, Asakawa S, Mizuno N, Hiratsuka M and Hirasawa N. 2016. Involvement of COX-2 in nickel elution from a wire implanted subcutaneously in mice. Toxicology. Volumes 363–364, 1 July 2016, Pages 37–45

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Gilchuk P, Hill TM, Guy C, McMaster SR, Boyd KL, Rabacal WA, Lu P, Shyr Y, Kohlmeier JE, Sebzda E, Green DR and Joyce S.2016. A Distinct Lung-Interstitium-Resident Memory CD8+ T Cell Subset Confers Enhanced Protection to Lower Respiratory Tract Infection. Cell Reports. DOI: 10.1016/j.celrep.2016.07.037

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Hastings AK, Erickson JJ, Schuster JE, Boyd KL, Tollefson SJ, Johnson M, Gilchuk P, Joyce S and Williams JV. 2015. Role of type I interferon signaling in human metapneumovirus pathogenesis and control of viral replication. J Virol. 89(8): 4405-4420.

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Barwick BG, Scharer CD, Bally APR and Boss JM. 2016. Plasma Cell Differentiation is Coupled to Division-Dependent DNA Hypomethylation and Gene Regulation. Nat Immunol. 17(10):1216-25

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Taylor RA, Chang CF, Goods BA, Hammond MD, Mac Grory B, Ai Y, Steinschneider AF, Renfroe SC, Askenase MH, McCullough LD, Kasner SE, Mullen MT, Hafler DA, Love JC, Sansing LH. 2016. TGF-β1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage. J. Clin. Invest. doi:10.1172/JCI88647

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Dill R and Walker AM. 2016. Role of Prolactin in Promotion of Immune Cell Migration into the Mammary Gland. J. Mammary Gland Biol. Neoplasia. doi: 10.1007/s10911-016-9369-0

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Huo M, Huang Y, Qu D, Zhang H, Wong WT, Chawla A, Huang Y and Tian XY. 2016. Myeloid Bmal1 deletion increases monocyte recruitment and worsens atherosclerosis. FASEB J. doi:10.1096/fj.201601030R

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Kovats. A Major Population of Functional KLRG1- ILC2s in Female Lungs Contributes to a Sex Bias in ILC2 Numbers. Immunohorizons. 2018 Feb;2(2):74-86. doi: 10.4049/immunohorizons.1800008

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Martinov T, Swanson LA, Breed ER, Tucker CG, Dwyer AJ, Johnson JK, Mitchell JS, Sahli NL, Wilson JC, Singh LM, Hogquist KA, Spanier JA, Fife BT. Programmed Death-1 Restrains the Germinal Center in Type 1 Diabetes. J Immunol. 2019 Aug 15;203(4):844-852. doi: 10.4049/jimmunol.1801535

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Shiyang Li, John W. Bostick, Jian Ye, Joseph F. Urban, Jr., Dorina Avram, Liang Zhou. Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function. Immunity. 2018 Nov 20;49(5):915-928.e5. doi: 10.1016/j.immuni.2018.09.015

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Nicholas N. Jarjour, Elizabeth A. Schwarzkopf, Tara R. Bradstreet, Irina Shchukina, Chih-Chung Lin, Stanley Ching-Cheng Huang, Chin-Wen Lai, Melissa E. Cook, Reshma Taneja, Thaddeus S. Stappenbeck, Gwendalyn J. Randolph, Maxim N. Artyomov, Joseph F. Urban Jr., and Brian T. Edelson. Bhlhe40 mediates tissue-specific control of macrophage proliferation in homeostasis and type 2 immunity. Nat Immunol. 2019 Jun;20(6):687-700. doi: 10.1038/s41590-019-0382-5

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Oguro H, McDonald JG, Zhao Z, Umetani M, Shaul PW and Morrison SJ. 2017. 27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy. J Clin Invest. doi: 10.1172/JCI94027.

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CD11c (N418)

 

She L, Alanazi HH, Yan L, et al. Sensing and signaling of immunogenic extracellular RNAs restrain group 2 innate lymphoid cell-driven acute lung inflammation and airway hyperresponsiveness. PLoS One. 2020;15(7):e0236744. Published 2020 Jul 30. doi:10.1371/journal.pone.0236744.

 » View on PubMed

Roa, J.A., Sarkar, D., Zanaty, M. et al. Preliminary results in the analysis of the immune response after aneurysmal subarachnoid hemorrhage. Sci Rep 10, 11809 (2020). https://doi.org/10.1038/s41598-020-68861-y.

 » View on Nature 

Markman, J.L., Porritt, R.A., Wakita, D. et al. Loss of testosterone impairs anti-tumor neutrophil function. Nat Commun 11, 1613 (2020). https://doi.org/10.1038/s41467-020-15397-4.

» View on Nature Communications

Udden SN, Kwak YT, Godfrey V, et al. NLRP12 suppresses hepatocellular carcinoma via downregulation of cJun N-terminal kinase activation in the hepatocyte. Elife. 2019;8:e40396. Published 2019 Apr 16. doi:10.7554/eLife.40396.

» View on PubMed

Kumar D, Sehrawat S. Divergent Effects of a Transient Corticosteroid Therapy on Virus-Specific Quiescent and Effector CD8+ T Cells. Front Immunol. 2019;10:1521. Published 2019 Jul 12. doi:10.3389/fimmu.2019.01521.

» View on PubMed

Udden SN, Kwak YT, Godfrey V, et al. NLRP12 suppresses hepatocellular carcinoma via downregulation of cJun N-terminal kinase activation in the hepatocyte. Elife. 2019;8:e40396. Published 2019 Apr 16. doi:10.7554/eLife.40396.

» View on PubMed

Milasan A, Jean G, Dallaire F, Tardif JC, Merhi Y, Sorci-Thomas M and Martel C. 2017. Apolipoprotein A-I Modulates Atherosclerosis Through Lymphatic Vessel-Dependent Mechanisms in Mice. J Am Heart Assoc. doi: 10.1161/JAHA.117.006892.

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Frederick DR, Goggins JA, Sabbagh LM, Freytag LC, Clements JD and McLachlan JB. 2017. Adjuvant selection regulates gut migration and phenotypic diversity of antigen-specific CD4+ T cells following parenteral immunization. Mucosal Immunol. doi: 10.1038/mi.2017.70.

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Briseño CG, Gargaro M, Durai V, Davidson JT, Theisen DJ, Anderson DA 3rd, Novack DV, Murphy TL and Murphy KM. 2017. Deficiency of transcription factor RelB perturbs myeloid and DC development by hematopoietic-extrinsic mechanisms. Proc Natl Acad Sci U S A. doi: 10.1073/pnas.1619863114

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Watkins HC, Rappazzo G, Higgins JS, Sun X, Brock N, Chau A, Misra A, Cannizzo JPB, King MR, Maines TR, Leifer CA, Whittaker GR, DeLisa MP and Putnam D. 2017. Safe recombinant outer membrane vesicles that display M2e elicit heterologous influenza protection. Mol. Ther. DOI: 10.1016/j.ymthe.2017.01.010

» View on PubMed

Zaman TS, Arimochi H, Maruyama S, Ishifune C, Tsukumo SI, Kitamura A and Yasutomo K. 2017. Notch Balances Th17 and Induced Regulatory T Cell Functions in Dendritic Cells by Regulating Aldh1a2 Expression. J Immunol. doi: 10.4049/jimmunol.1700645.

» View on Journal of Immunology

Tani Y, Isobe Y, Imoto Y, Segi-Nishida E, Sugimoto Y, Arai H, and Arita M. 2014. Eosinophils control the resolution of inflammation and draining lymph node hypertrophy through the proresolving mediators and CXCL13 pathway in mice. FASEB J. 28(9): 4036-4043.

» View on PubMed

Goshima F, Esaki S, Luo C, Kamakura M, Kimura H, and Nishiyama Y. 2014. Oncolytic viral therapy with a combination of HF10, a herpes simplex virus type 1 variant and granulocyte-macrophage colony-stimulating factor for murine ovarian cancer. Int J Cancer. 134(12): 2865-2877.

» View on PubMed

Rydyznski C, Daniels KA, Karmele EP, Brooks TR, Mahl SE, Moran MT, Li C, Sutiwisesak R, Welsh RM and Waggoner SN. 2015. Generation of cellular immune memory and B-cell immunity is impaired by natural killer cells. Nat Commun. doi: 10.1038/ncomms7375.

» View on PubMed

Taniguchi A, Miyahara N, Waseda K, Kurimoto E, Fujii U, Tanimoto Y, Kataoka M, Yamamoto Y, Gelfand EW, Yamamoto H, Tanimoto M and Kanehiro A. 2015. Contrasting Roles for the Receptor for Advanced Glycation End-Products on Structural Cells in Allergic Airway Inflammation versus Airway Hyperresponsiveness. Am J Physiol Lung Cell Mol Physiol. DOI: 10.1152/ajplung.00087.2015.

» View on American Journal of Physiology

Manz BN, Tan YX, Courtney A, Rutaganira F, Palmer E, Shokat KM and Weiss A. 2015. Small molecule inhibition of Csk alters affinity recognition by T cells. Elife. doi: 10.7554/eLife.08088.

» View on PubMed

Vogel CF, Chang WL, Kado S, McColloh K, Vogel H, Wu D, Haarmann-Stemmann T, Yang G, Leung PS, Matsumura F and Gershwin ME. 2016. Transgenic Overexpression of Aryl Hydrocarbon Receptor Repressor (AhRR) and AhR-Mediated Induction of CYP1A1, Cytokines, and Acute Toxicity. Environ Health Perspect. DOI:10.1289/ehp.1510194.

» View on PubMed

Come C, Cvrljevic A, Khan MM, Treise I, Adler T, Aguilar-Pimental JA, Au-Yeung B, Sittig E, Laajala TD, Chen Y, Oeder S, Calzada-Wack J, Horsch M, Aittokallio T, Busch DH, Ollert MW, Neff F, Beckers J, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Chen Z, Lahesmaa R, and Westermarck J. 2016. CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection. PLoS ONE 11(4):e0152996. doi:10.1371/journal.pone.0152996

» View on PubMed

Beamer, GL, Seaver, BP, Jessop F, Shepherd DM, and Beamer CA. 2016. Acute Exposure to Crystalline Silica Reduces Macrophage Activation in Response to Bacterial Lipoproteins. Front Immunol. Volume 7: doi: 10.3389/fimmu.2016.00049

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Li J, Lu E, Yi T, and Cyster JG. 2016. EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells. Nature. doi:10.1038/nature17947

» View on PubMed

Gilchuk P, Hill TM, Guy C, McMaster SR, Boyd KL, Rabacal WA, Lu P, Shyr Y, Kohlmeier JE, Sebzda E, Green DR and Joyce S.2016. A Distinct Lung-Interstitium-Resident Memory CD8+ T Cell Subset Confers Enhanced Protection to Lower Respiratory Tract Infection. Cell Reports. DOI:10.1016/j.celrep.2016.07.037

» View on PubMed

Barwick BG, Scharer CD, Bally APR and Boss JM. 2016. Plasma Cell Differentiation is Coupled to Division-Dependent DNA Hypomethylation and Gene Regulation. Nat Immunol. 17(10):1216-25

» View on PubMed

Coleman CM, Sisk JM, Halasz G, Zhong J, Beck SE, Matthews KL, Venkataraman T, Rajagopalan S, Kyratsous CA and Frieman MB. 2016. CD8+ T cells and Macrophages Regulate Pathogenesis in a Mouse Model of MERS-CoV Disease. J. Virol. doi: 10.1128/JVI.01825-16

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Olguin-Alor R, de la Fuente-Granada M, Bonifaz LC, Antonio-Herrara L, Garcia-Zepada EA and Soldevilla G. 2016. A Key Role for Inhibins in Dendritic Cell Maturation and Function. PLOS one. doi:10.1371/journal.pone.0167813

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Ito A, Hong C, Oka K, Salazar JV, Diehl C, Witztum JL, Diaz M, Castrillo A, Bensinger SJ, Chan L and Tontonoz P. 2016. Cholesterol Accumulation in CD11c+ Immune Cells Is a Causal and Targetable Factor in Autoimmune Disease. Immunity. doi: 10.1016/j.immuni.2016.11.008

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Kovats. A Major Population of Functional KLRG1- ILC2s in Female Lungs Contributes to a Sex Bias in ILC2 Numbers. Immunohorizons. 2018 Feb;2(2):74-86. doi: 10.4049/immunohorizons.1800008

» View on PubMed

Erola Ainsua-Enrich, Ibrahim Hatipoglu, Sapana Kadel, Sean Turner, Jinny Paul, Simar Singh, Harini Bagavant, and Susan Kovats. IRF4-dependent dendritic cells regulate CD8+ T cell differentiation and memory responses in influenza infection. Mucosal Immunol. 2019 Jul;12(4):1025-1037. doi: 10.1038/s41385-019-0173-1

» View on PubMed

Shiyang Li, John W. Bostick, Jian Ye, Joseph F. Urban, Jr., Dorina Avram, Liang Zhou. Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function. Immunity. 2018 Nov 20;49(5):915-928.e5. doi: 10.1016/j.immuni.2018.09.015

» View on PubMed

Nicholas N. Jarjour, Elizabeth A. Schwarzkopf, Tara R. Bradstreet, Irina Shchukina, Chih-Chung Lin, Stanley Ching-Cheng Huang, Chin-Wen Lai, Melissa E. Cook, Reshma Taneja, Thaddeus S. Stappenbeck, Gwendalyn J. Randolph, Maxim N. Artyomov, Joseph F. Urban Jr., and Brian T. Edelson. Bhlhe40 mediates tissue-specific control of macrophage proliferation in homeostasis and type 2 immunity. Nat Immunol. 2019 Jun;20(6):687-700. doi: 10.1038/s41590-019-0382-5

» View on PubMed

Qiumei Du, Ashley R. Hoover, Igor Dozmorov, Ondine B. Cleaver,Joshua T. Mendell, Nicolai S.C. van Oers. MIR205HG Is a Long Noncoding RNA that Regulates Growth Hormone and Prolactin Production in the Anterior Pituitary. Dev Cell. 2019 May 20;49(4):618-631.e5. doi: 10.1016/j.devcel.2019.03.012

» View on PubMed

CD16/CD32 (2.4G2)

 

Kajihara N, Kitagawa F, Kobayashi T, Wada H, Otsuka R, Seino KI. Interleukin-34 contributes to poor prognosis in triple-negative breast cancer [published online ahead of print, 2020 Jun 23]. Breast Cancer. 2020;10.1007/s12282-020-01123-x. doi:10.1007/s12282-020-01123-x.

» View on PubMed

Wormsbaecher C, Hindman AR, Avendano A, et al. In utero estrogenic endocrine disruption alters the stroma to increase extracellular matrix density and mammary gland stiffness. Breast Cancer Res. 2020;22(1):41. Published 2020 May 5. doi:10.1186/s13058-020-01275-w.

» View on PubMed

McDaniel MM, Kottyan LC, Singh H, Pasare C. Suppression of Inflammasome Activation by IRF8 and IRF4 in cDCs Is Critical for T Cell Priming. Cell Rep. 2020 May 5;31(5):107604. doi: 10.1016/j.celrep.2020.107604

» View on PubMed

Markman, J.L., Porritt, R.A., Wakita, D. et al. Loss of testosterone impairs anti-tumor neutrophil function. Nat Commun 11, 1613 (2020). https://doi.org/10.1038/s41467-020-15397-4.

» View on Nature Communications

Kumar D, Sehrawat S. Divergent Effects of a Transient Corticosteroid Therapy on Virus-Specific Quiescent and Effector CD8+ T Cells. Front Immunol. 2019;10:1521. Published 2019 Jul 12. doi:10.3389/fimmu.2019.01521.

» View on PubMed

Kim IS, Gao Y, Welte T, et al. Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms. Nat Cell Biol. 2019;21(9):1113-1126. doi:10.1038/s41556-019-0373-7.

» View on PubMed

Atif SM, Mack DG, McKee AS, et al. Protective role of B cells in sterile particulate-induced lung injury. JCI Insight. 2019;5(12):e125494. Published 2019 May 16. doi:10.1172/jci.insight.125494.

» View on PubMed

Yang BH, Wang K, Wan S, et al. TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases. Cell Rep. 2019;27(12):3629-3645.e6. doi:10.1016/j.celrep.2019.05.061.

» View on PubMed

Dutta R, Lunzer MM, Auger JL, Akgün E, Portoghese PS, Binstadt BA. A bivalent compound targeting CCR5 and the mu opioid receptor treats inflammatory arthritis pain in mice without inducing pharmacologic tolerance. Arthritis Res Ther. 2018;20(1):154. Published 2018 Jul 27. doi:10.1186/s13075-018-1661-5.

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Guo M, Price MJ, Patterson DG, et al. EZH2 Represses the B Cell Transcriptional Program and Regulates Antibody-Secreting Cell Metabolism and Antibody Production. J Immunol. 2018;200(3):1039-1052. doi:10.4049/jimmunol.1701470.

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Bapat, Sagar P., Zheng, YE, Evans, Ronald, Downes, Michael, Atkins, Annette R., YU, Ruth T. COMPOSITIONS AND METHODS FOR TREATING AGE-RELATED DIABETES AND RELATED DISORDERS. 2020 May.

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Adami AJ, Bracken SJ, Guernsey LA, et al. Early-life antibiotics attenuate regulatory T cell generation and increase the severity of murine house dust mite-induced asthma. Pediatr Res. 2018;84(3):426-434. doi:10.1038/s41390-018-0031-y.

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Ishisono K, Yabe T and Kitaguchi K. 2017. Citrus pectin attenuates endotoxin shock via suppression of Toll-like receptor signaling in Peyer's patch myeloid cells. J Nutr Biochem. doi: 10.1016/j.jnutbio.2017.07.016

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Oh DS, Oh JE, Jung HE and Lee HK. 2017. Transient Depletion of CD169+ Cells Contributes to Impaired Early Protection and Effector CD8+ T Cell Recruitment against Mucosal Respiratory Syncytial Virus Infection. Front Immunol. doi: 10.3389/fimmu.2017.00819

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Conejero L, Khouili SC, Martínez-Cano S, Izquierdo HM, Brandi P and Sancho D. 2017. Lung CD103+ dendritic cells restrain allergic airway inflammation through IL-12 production. JCI Insight. doi: 10.1172/jci.insight.90420

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Ratiu JJ, Racine JJ, Hasham MG, Wang Q, Branca JA, Chapman HD, Zhu J, Donghia N, Philip V, Schott WH, Wasserfall C, Atkinson MA, Mills KD, Leeth CM and Serreze DV. 2017. Genetic and Small Molecule Disruption of the AID/RAD51 Axis Similarly Protects Nonobese Diabetic Mice from Type 1 Diabetes through Expansion of Regulatory B Lymphocytes. J Immunol. doi: 10.4049/jimmunol.1700024.

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Sato Y, Kato H, Ebina-Shibuya R, Itoh-Nakadai A, Okuyama R and Igarashi K. 2017. Bach2 Controls Homeostasis of Eosinophils by Restricting the Type-2 Helper Function of T Cells. Tohoku J Exp Med. doi: 10.1620/tjem.241.175

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Shim YR and Lee HK. 2015. Caspase-1 Independent Viral Clearance and Adaptive Immunity Against Mucosal Respiratory Syncytial Virus Infection. Immune Netw. 15(2): 73-82.

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Rydyznski C, Daniels KA, Karmele EP, Brooks TR, Mahl SE, Moran MT, Li C, Sutiwisesak R, Welsh RM and Waggoner SN. 2015. Generation of cellular immune memory and B-cell immunity is impaired by natural killer cells. Nat Commun. doi: 10.1038/ncomms7375.

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Oh JE, Lee MS, Kim YJ and Lee HK. 2016. OASL1 deficiency promotes antiviral protection against genital herpes simplex virus type 2 infection by enhancing type I interferon production. Sci Rep. doi: 10.1038/srep19089.

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Benck CJ, Martinov T, Fife BT and Chatterjea D. 2016. Isolation of Infiltrating Leukocytes from Mouse Skin Using Enzymatic Digest and Gradient Separation. J Vis Exp. (107), e53638, doi:10.3791/53638.

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Ishizuka M, Miyazaki Y, Masuo M, Shuara K, Tateishi T, Yasui M and Inase N. Interleukin-17A and Neutrophils in a Murine Model of Bird-Related Hypersensitivity Pneumonitis. 2015. PLoS One. doi: 10.1371/journal.pone.0137978.

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Ohta T, Sugiyama, M, Hemmi, H, Yamazaki C, Okura S, Sasaki I, Fukuda Y, Orimo T, Ishii K, Hoshino K, Ginhoux F, and Kaisho T. 2016. Crucial roles of XCR1-expressing dendritic cells and the XCR1-XCL1 chemokine axis in intestinal immune homeostasis. Sci Rep. 6, 23505; doi: 10.1038/srep23505

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Miyata Y, Otsuki M, Kita S and Shimomura I. 2016. Identification of Mouse Mesenteric and Subcutaneous in vitro Adipogenic Cells. Sci Rep. 6:21041. doi: 10.1038/srep21041.

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Carey AJ, Gracias DT, Thayer JL, Boesteanu AC, Kumova OK, Mueller YM, Hope JL, Fraietta JA, van Zessen DB and Katsikis PD. 2016. Rapid Evolution of the CD8+ TCR Repertoire in Neonatal Mice. J Immunol. doi: 10.4049 jimmunol.1502126.

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Vogel CF, Chang WL, Kado S, McColloh K, Vogel H, Wu D, Haarmann-Stemmann T, Yang G, Leung PS, Matsumura F and Gershwin ME. 2016. Transgenic Overexpression of Aryl Hydrocarbon Receptor Repressor (AhRR) and AhR-Mediated Induction of CYP1A1, Cytokines, and Acute Toxicity. Environ Health Perspect. DOI:10.1289/ehp.1510194.

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Benck, CJ, Martinov, T, Fife, BT, and Chatterjea, D. 2016. Isolation of infiltrating leukocytes from mouse skin using enzymatic digest and gradient separation. J Vis Exp. (107) e53638, doi: 10.3791/53638 (2016)

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Mula RVR, Machiah D, Holland L, Wang X, Parihar, H, Sharma AC, Selvaraj P, and Shashidharamurthy R. 2016. Immune Complex-Induced Nitric Oxide-Mediated Vascular Endothelial Cell Death by Phagocytes is Prevented with Decoy FcγReceptors. PLoS ONE 11(4):e0153620. doi:10.1371/journal.pone.0153620

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Yokoyama C, Aoyama T, Ido T, Kakino A, Shiraki T, Tanaka T, Nishigaki K, Hasegawa A, Fujita Y, Sawamura T, and Minatoguchi S. 2016. Deletion of LOX-1 Protects against Heart Failure Induced by Doxorubicin. PloS ONE. doi:10.1371/journal.pone.0154994

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Nabekura T and Lanier LL. 2016. Activating Receptors for Self-MHC Class I Enhance Effector Functions and Memory Differentiation of NK Cells during Mouse Cytomegalovirus Infection. Immunity. Volume 45 , Issue 1 , 74 - 82

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Murphy S, Patrick K, Thoner T, Edwards RW and Gubbels Bupp MR. 2016. T cell up-regulation of CD127 is associated with reductions in the homeostatic set point of the peripheral Tcell pool during malnourishment. Biochemistry and Biophysics Reports. doi:10.1016/j.bbrep.2016.06.006

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Barwick BG, Scharer CD, Bally APR and Boss JM. 2016. Plasma Cell Differentiation is Coupled to Division-Dependent DNA Hypomethylation and Gene Regulation. Nat Immunol. 17(10):1216-25

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Suda J, Dara L, Yang L, Aghajan M, Song Y, Kaplowitz N and Liu Z. 2016. Knockdown of RIPK1 Markedly Exacerbates Murine Immune-Mediated Liver Injury through Massive Apoptosis of Hepatocytes, Independent of Necroptosis and Inhibition of NF-κB. J. Immunol. doi: 10.4049/​jimmunol.1600690

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Sato K, Honda S, Shibuya A and Shibuya K. Improved Protocol for Isolation of Naïve Follicular Dendritic Cells. 2016. Mol. Immunol. doi: 10.1016/j.molimm.2016.09.011

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Adam L. Burrack, Ellen J. Spartz, Jackson F. Raynor, Iris Wang, Margaret Olson, Ingunn M. Stromnes. Combination PD-1 and PD-L1 Blockade Promotes Durable Neoantigen-Specific T Cell-Mediated Immunity in Pancreatic Ductal Adenocarcinoma. Cell Rep. 2019 Aug 20;28(8):2140-2155.e6. doi: 10.1016/j.celrep.2019.07.059

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Derek W. Trobaugh, Chengqun Sun, Matthew D. Dunn, Douglas S. Reed, William B. Klimstra. Rational design of a live-attenuated eastern equine encephalitis virus vaccine through informed mutation of virulence determinants. PLoS Pathog. 2019 Feb 11;15(2):e1007584. doi: 10.1371/journal.ppat.1007584

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Shiyang Li, John W. Bostick, Jian Ye, Joseph F. Urban, Jr., Dorina Avram, Liang Zhou. Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function. Immunity. 2018 Nov 20;49(5):915-928.e5. doi: 10.1016/j.immuni.2018.09.015

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Sarika Saraswati, Stephanie M.W. Marrow, Lester A. Watch1 & Pampee P. Young. Identification of a pro-angiogenic functional role for FSP1-positive fibroblast subtype in wound healing. Nat Commun. 2019 Jul 9;10(1):3027. doi: 10.1038/s41467-019-10965-9

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Grinberg-Bleyer Y, Oh H, Desrichard A, Bhatt DM, Caron R, Chan TA, Schmid RM, Klein U, Hayden MS and Ghosh S. 2017. NF-κB c-Rel Is Crucial for the Regulatory T Cell Immune Checkpoint in Cancer. Cell. doi: 10.1016/j.cell.2017.08.004. 

» View on PubMed

CD19 (1D3)

 

Even Fossum, Demo Yemane Tesfaye, Sonja Bobic, Arnar Gudjonsson, Ranveig Braathen, Mireille H. Lahoud, Irina Caminschi, Bjarne Bogen. Targeting Antigens to Different Receptors on Conventional Type 1 Dendritic Cells Impacts the Immune Response. The Journal of Immunology June 26, 2020, ji1901119; DOI: 10.4049/jimmunol.1901119.

» View on Journal of Immunology

Karki R, Sharma BR, Lee E, et al. Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer. JCI Insight. 2020;5(12):136720. Published 2020 Jun 18. doi:10.1172/jci.insight.136720.

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Jonathan J Pinney, Fátima Rivera-Escalera, Charles C Chu, Hannah E Whitehead, Karl VanDerMeid, Ashley M Nelson, Michelle C Barbeau, Clive S Zent, Michael R Elliott; Macrophage hypophagia as a mechanism of innate immune exhaustion in mAb-induced cell clearance. Blood.2020005571. doi: https://doi.org/10.1182/blood.2020005571.

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Weber A, Pawar HN, Klein JR. Thyroid stimulating hormone β-subunit splice variant is expressed in all fractional subsets of bone marrow hematopoietic cells and peripheral blood leukocytes and is modulated during bacterial infection. Gen Comp Endocrinol. 2020 Apr 30:113495. doi: 10.1016/j.ygcen.2020.113495

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Adami AJ, Bracken SJ, Guernsey LA, et al. Early-life antibiotics attenuate regulatory T cell generation and increase the severity of murine house dust mite-induced asthma. Pediatr Res. 2018;84(3):426-434. doi:10.1038/s41390-018-0031-y.

» View on PubMed

Palacios M, Miner TA, Frederick DR, et al. Identification of Two Regulators of Virulence That Are Conserved in Klebsiella pneumoniae Classical and Hypervirulent Strains. mBio. 2018;9(4):e01443-18. Published 2018 Aug 7. doi:10.1128/mBio.01443-18.

» View on PubMed

Guo M, Price MJ, Patterson DG, et al. EZH2 Represses the B Cell Transcriptional Program and Regulates Antibody-Secreting Cell Metabolism and Antibody Production. J Immunol. 2018;200(3):1039-1052. doi:10.4049/jimmunol.1701470.

» View on PubMed

Andersen TK, Zhou F, Cox R, Bogen B and Grødeland G. 2017. A DNA vaccine that targets hemagglutinin to antigen presenting cells protects mice against H7 influenza. J Virol. doi: 10.1128/JVI.01340-17.

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Fan J, Luo J, Yan C, Hao R, Zhao X, Jia R, He J, Xu D, Miao M and Li X. 2017. Methotrexate, combined with cyclophosphamide attenuates murine collagen induced arthritis by modulating the expression level of Breg and DCs. Mol Immunol. doi: 10.1016/j.molimm.2017.07.001

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Ratiu JJ, Racine JJ, Hasham MG, Wang Q, Branca JA, Chapman HD, Zhu J, Donghia N, Philip V, Schott WH, Wasserfall C, Atkinson MA, Mills KD, Leeth CM and Serreze DV. 2017. Genetic and Small Molecule Disruption of the AID/RAD51 Axis Similarly Protects Nonobese Diabetic Mice from Type 1 Diabetes through Expansion of Regulatory B Lymphocytes. J Immunol. doi: 10.4049/jimmunol.1700024.

» View on PubMed

Strother RK, Danahy DB, Kotov DI, Kucaba TA, Zacharias ZR, Griffith TS, Legge KL and Badovinac VP. 2016. Polymicrobial Sepsis Diminishes Dendritic Cell Numbers and Function Directly Contributing to Impaired Primary CD8 T Cell Responses In Vivo. J. Immunol. doi: 10.4049/jimmunol.1601463

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Gudjonsson A, Lysen A, Balan S, Sundvold-Gjerstad V, Arnold-Schrauf C, Richter L, Bækkevold ES, Dalod M, Bogen B and Fossum E. 2017. Targeting Influenza Virus Hemagglutinin to Xcr1+ Dendritic Cells in the Absence of Receptor-Mediated Endocytosis Enhances Protective Antibody Responses. J Immunol. doi: 10.4049/jimmunol.1601881

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Guthmiller JJ, Graham AC, Zander RA, Pope RL and Butler NS. 2017. Cutting Edge: IL-10 Is Essential for the Generation of Germinal Center B Cell Responses and Anti-Plasmodium Humoral Immunity. DOI:10.4049/jimmunol.1601762

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Rydyznski C, Daniels KA, Karmele EP, Brooks TR, Mahl SE, Moran MT, Li C, Sutiwisesak R, Welsh RM and Waggoner SN. 2015. Generation of cellular immune memory and B-cell immunity is impaired by natural killer cells. Nat Commun. doi: 10.1038/ncomms7375.

» View on PubMed

Taniguchi A, Miyahara N, Waseda K, Kurimoto E, Fujii U, Tanimoto Y, Kataoka M, Yamamoto Y, Gelfand EW, Yamamoto H, Tanimoto M and Kanehiro A. 2015. Contrasting Roles for the Receptor for Advanced Glycation End-Products on Structural Cells in Allergic Airway Inflammation versus Airway Hyperresponsiveness. Am J Physiol Lung Cell Mol Physiol. DOI: 10.1152/ajplung.00087.2015.

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Manz BN, Tan YX, Courtney A, Rutaganira F, Palmer E, Shokat KM and Weiss A. 2015. Small molecule inhibition of Csk alters affinity recognition by T cells. Elife. doi: 10.7554/eLife.08088.

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Rios D, Wood MB, Li J, Chassaing B, Gewirtz AT and Williams IR. 2015. Antigen sampling by intestinal M cells is the principal pathway initiating mucosal IgA production to commensal enteric bacteria. Mucosal Immunol. doi: 10.1038/mi.2015.121.

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Come C, Cvrljevic A, Khan MM, Treise I, Adler T, Aguilar-Pimental JA, Au-Yeung B, Sittig E, Laajala TD, Chen Y, Oeder S, Calzada-Wack J, Horsch M, Aittokallio T, Busch DH, Ollert MW, Neff F, Beckers J, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Chen Z, Lahesmaa R, and Westermarck J. 2016. CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection. PLoS ONE 11(4):e0152996. doi:10.1371/journal.pone.0152996

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Man SM, Karki R, Sasai M, Place DE, Kesavardhana S, Temirov J, Frase S, Zhu Q, Malireddi RKS, Kuriakose T, Peters JL, Neale G, Brown SA, Yamamoto M and Kannegant T. 2016. IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes. Cell. doi: 10.1016/j.cell.2016.09.012

» View on PubMed

Strother RK, Danahy DB, Kotov DI, Kucaba TA, Zacharias ZR, Griffith TS, Legge KL and Badovinac VP. 2016. Polymicrobial Sepsis Diminishes Dendritic Cell Numbers and Function Directly Contributing to Impaired Primary CD8 T Cell Responses In Vivo. J. Immunol. doi: 10.4049/​jimmunol.1601463

» View on PubMed

Okamura K, Kitamura A, Sasaki Y, Chung DH, Kagami S, Iwai K and Yasutomo K. 2016. Survival of mature T cells depends on signaling through HOIP. Sci Rep. doi:10.1038/srep36135

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Forster M, Farrington K, Petrov JC, Belle JI, Mindt BC, Witalis M, Duerr CU, Fritz JH and Nijnik A. 2016. MYSM1-dependent checkpoints in B cell lineage differentiation and B cell–mediated immune response. J. Leukoc. Biol. doi:10.1189/jlb.1AB0415-177RR

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Ortega SB, Noorbhai I, Poinsatte K, Kong X, Anderson A, Monson NL and Stowe AM. 2015. Stroke Induces a Rapid Adaptive Autoimmune Response to Novel Neuronal Antigens. Discov. Med. (106):381-92

» View on PubMed

Uzodinma U. Uche, Ann R. Piccirillo, Shunsuke Kataoka, Stephanie J. Grebinoski, Louise M. D’Cruz, and Lawrence P. Kane. PIK3IP1/TrIP restricts activation of T cells through inhibition of PI3K/Akt. J Exp Med. 2018 Dec 3;215(12):3165-3179. doi: 10.1084/jem.20172018

» View on PubMed

Shiyang Li, John W. Bostick, Jian Ye, Joseph F. Urban, Jr., Dorina Avram, Liang Zhou. Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function. Immunity. 2018 Nov 20;49(5):915-928.e5. doi: 10.1016/j.immuni.2018.09.015

» View on PubMed

Rita Kansal, Noah Richardson, Indira Neeli, Saleem Khawaja, Damian Chamberlain, Marium Ghani, Qurat-ul-ain Ghani, Louisa Balazs, Sarka Beranova-Giorgianni, Francesco Giorgianni, James N. Kochenderfer, Tony Marion, Lorraine M. Albritton, Marko Radic. Sustained B cell depletion by CD19-targeted CAR T cells is a highly effective treatment for murine lupus. Sci Transl Med. 2019 Mar 6;11(482). pii: eaav1648. doi: 10.1126/scitranslmed.aav1648

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Nicholas N. Jarjour, Elizabeth A. Schwarzkopf, Tara R. Bradstreet, Irina Shchukina, Chih-Chung Lin, Stanley Ching-Cheng Huang, Chin-Wen Lai, Melissa E. Cook, Reshma Taneja, Thaddeus S. Stappenbeck, Gwendalyn J. Randolph, Maxim N. Artyomov, Joseph F. Urban Jr., and Brian T. Edelson. Bhlhe40 mediates tissue-specific control of macrophage proliferation in homeostasis and type 2 immunity. Nat Immunol. 2019 Jun;20(6):687-700. doi: 10.1038/s41590-019-0382-5

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Qiumei Du, Ashley R. Hoover, Igor Dozmorov, Ondine B. Cleaver,Joshua T. Mendell, Nicolai S.C. van Oers. MIR205HG Is a Long Noncoding RNA that Regulates Growth Hormone and Prolactin Production in the Anterior Pituitary. Dev Cell. 2019 May 20;49(4):618-631.e5. doi: 10.1016/j.devcel.2019.03.012

» View on PubMed

CD25 (PC61.5)

 

Kayla R. Kulhanek, Darienne R. Myers, Olga Ksionda, Yvonne Vercoulen, Damia Romero-Moya, Jeroen P. Roose.  Protocol for Barcoding T Cells Combined with Timed Stimulations. STAR Protocols 2020, 100067, ISSN 2666-1667.  https://doi.org/10.1016/j.xpro.2020.100067.

» View on ScienceDirect

Ishikawa Y, Kitaoka S, Kawano Y, et al. Repeated social defeat stress induces neutrophil mobilization in mice: maintenance after cessation of stress and strain-dependent difference [published online ahead of print, 2020 Jul 17]. Br J Pharmacol. 2020;10.1111/bph.15203. doi:10.1111/bph.15203.

» View on PubMed

Slade CD, Reagin KL, Lakshmanan HG, Klonowski KD, Watford WT. Placenta-specific 8 limits IFNγ production by CD4 T cells in vitro and promotes establishment of influenza-specific CD8 T cells in vivo. PLoS One. 2020;15(7):e0235706. Published 2020 Jul 8. doi:10.1371/journal.pone.0235706.

» View on PubMed

Dolina JS, Lee J, Griswold RQ, Labarta-Bajo L, Kannan S, Greenbaum JA, Bahia El Idrissi N, Pont MJ, Croft M, Schoenberger SP. TLR9 Sensing of Self-DNA Controls Cell-Mediated Immunity to Listeria Infection via Rapid Conversion of Conventional CD4+ T Cells to Treg. Cell Rep. 2020 Apr 7;31(1):107249. doi: 10.1016/j.celrep.2020.01.040.

» View on ScienceDirect

Shimada K, Porritt RA, Markman JL, et al. T-Cell-Intrinsic Receptor Interacting Protein 2 Regulates Pathogenic T Helper 17 Cell Differentiation. Immunity. 2018;49(5):873-885.e7. doi:10.1016/j.immuni.2018.08.022.

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Palacios-Arreola MI, Nava-Castro KE, Río-Araiza VHD, Pérez-Sánchez NY and Morales-Montor J. 2017. A single neonatal administration of Bisphenol A induces higher tumour weight associated to changes in tumour microenvironment in the adulthood. Sci Rep. doi: 10.1038/s41598-017-10135-1.

» View on PubMed

Conejero L, Khouili SC, Martínez-Cano S, Izquierdo HM, Brandi P and Sancho D. 2017. Lung CD103+ dendritic cells restrain allergic airway inflammation through IL-12 production. JCI Insight. doi: 10.1172/jci.insight.90420

» View on PubMed

Sato Y, Kato H, Ebina-Shibuya R, Itoh-Nakadai A, Okuyama R and Igarashi K. 2017. Bach2 Controls Homeostasis of Eosinophils by Restricting the Type-2 Helper Function of T Cells. Tohoku J Exp Med. doi: 10.1620/tjem.241.175

» View on PubMed

Zander RA, Guthmiller JJ, Graham AC, Pope RL, Burke BE, Carr DJ and Butler NS. 2016. Type I Interferons Induce T Regulatory 1 Responses and Restrict Humoral Immunity during Experimental Malaria. PLOS Pathogens. DOI:10.1371/journal.ppat.1005945

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Martinez-Lopez M, Iborra S, Conde-Garrosa R and Sancho D. 2014. Batf3-dependent CD103+ dendritic cells are major producers of IL-12 that drive local Th1 immunity against Leishmania major infection in mice. Eur J Immunol. 45(1): 119-129.

» View on PubMed

Ortega SB, Noorbhai I, Poinsatte K, Kong X, Anderson A, Monson NL and Stowe AM. 2015. Stroke Induces a Rapid Adaptive Autoimmune Response to Novel Neuronal Antigens. Discov. Med. (106):381-92

» View on PubMed

Uzodinma U. Uche, Ann R. Piccirillo, Shunsuke Kataoka, Stephanie J. Grebinoski, Louise M. D’Cruz, and Lawrence P. Kane. PIK3IP1/TrIP restricts activation of T cells through inhibition of PI3K/Akt. J Exp Med. 2018 Dec 3;215(12):3165-3179. doi: 10.1084/jem.20172018

» View on PubMed

Erola Ainsua-Enrich, Ibrahim Hatipoglu, Sapana Kadel, Sean Turner, Jinny Paul, Simar Singh, Harini Bagavant, and Susan Kovats. IRF4-dependent dendritic cells regulate CD8+ T cell differentiation and memory responses in influenza infection. Mucosal Immunol. 2019 Jul;12(4):1025-1037. doi: 10.1038/s41385-019-0173-1

» View on PubMed

Jordy Saravia, Hu Zeng1, Yogesh Dhungana, Daniel Bastardo Blanco, Thanh-Long M. Nguyen, Nicole M. Chapman, Yanyan Wang, Apurva Kanneganti, Shaofeng Liu, Jana L. Raynor, Peter Vogel, Geoffrey Neale, Peter Carmeliet, Hongbo Chi. Homeostasis and transitional activation of regulatory T cells require c-Myc. Sci Adv. 2020 Jan 1;6(1):eaaw6443. doi: 10.1126/sciadv.aaw6443

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Hao Shi, Nicole M. Chapman, Jing Wen, Cliff Guy, Lingyun Long, Yogesh Dhungana, Sherri Rankin, Stephane Pelletier, Peter Vogel, Hong Wang, Junmin Peng, Kun-Liang Guan, and Hongbo Chi. Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb. Immunity. 2019 Dec 17;51(6):1012-1027.e7. doi: 10.1016/j.immuni.2019.10.001

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Oh H, Grinberg-Bleyer Y, Liao W, Maloney D, Wang P, Wu Z, Wang J, Bhatt DM, Heise N, Schmid RM, Hayden MS, Klein U, Rabadan R and Ghosh S. 2017. An NF-κB Transcription-Factor-Dependent Lineage-Specific Transcriptional Program Promotes Regulatory T Cell Identity and Function. Immunity. doi: 10.1016/j.immuni.2017.08.010.

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Grinberg-Bleyer Y, Oh H, Desrichard A, Bhatt DM, Caron R, Chan TA, Schmid RM, Klein U, Hayden MS and Ghosh S. 2017. NF-κB c-Rel Is Crucial for the Regulatory T Cell Immune Checkpoint in Cancer. Cell. doi: 10.1016/j.cell.2017.08.004. 

» View on PubMed

CD28 (37.51)

Avery L, Filderman J, Szymczak-Workman AL, Kane LP4. Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2455-2460. doi: 10.1073/pnas.1712107115

» View on PubMed

CD44 (IM7

 

Toriyama K, Kuwahara M, Kondoh H, et al. T cell-specific deletion of Pgam1 reveals a critical role for glycolysis in T cell responses. Commun Biol. 2020;3(1):394. Published 2020 Jul 24. doi:10.1038/s42003-020-01122-w.

» View on Communications Biology

Kayla R. Kulhanek, Darienne R. Myers, Olga Ksionda, Yvonne Vercoulen, Damia Romero-Moya, Jeroen P. Roose.  Protocol for Barcoding T Cells Combined with Timed Stimulations. STAR Protocols 2020, 100067, ISSN 2666-1667.  https://doi.org/10.1016/j.xpro.2020.100067.

» View on ScienceDirect

Iida Y, Yoshikawa R, Murata A, et al. Local injection of CCL19-expressing mesenchymal stem cells augments the therapeutic efficacy of anti-PD-L1 antibody by promoting infiltration of immune cells. J Immunother Cancer. 2020;8(2):e000582. doi:10.1136/jitc-2020-000582.

» View on PubMed

Slade CD, Reagin KL, Lakshmanan HG, Klonowski KD, Watford WT. Placenta-specific 8 limits IFNγ production by CD4 T cells in vitro and promotes establishment of influenza-specific CD8 T cells in vivo. PLoS One. 2020;15(7):e0235706. Published 2020 Jul 8. doi:10.1371/journal.pone.0235706.

» View on PubMed

Kiatpakdee B, Sato K, Otsuka Y, Arashiki N, Chen Y, Tsumita T, Otsu W, Yamamoto A, Kawata R, Yamazaki J, Sugimoto Y, Takada K, Mohandas N, Inaba M. Cholesterol-binding protein TSPO2 coordinates maturation and proliferation of terminally differentiating erythroblasts. J Biol Chem. 2020 May 1. pii: jbc.RA119.011679. doi: 10.1074/jbc.RA119.011679.

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Atif SM, Mack DG, McKee AS, et al. Protective role of B cells in sterile particulate-induced lung injury. JCI Insight. 2019;5(12):e125494. Published 2019 May 16. doi:10.1172/jci.insight.125494.

» View on PubMed

Wang H, Hogquist KA. CCR7 defines a precursor for murine iNKT cells in thymus and periphery. Elife. 2018;7:e34793. Published 2018 Aug 13. doi:10.7554/eLife.34793.

» View on PubMed

Govindarajan S, Gaublomme D, Van der Cruyssen R, et al. Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha. Nat Commun. 2018;9(1):5340. Published 2018 Dec 17. doi:10.1038/s41467-018-07758-x.

» View on Nature Communications

Sato Y, Kato H, Ebina-Shibuya R, Itoh-Nakadai A, Okuyama R and Igarashi K. 2017. Bach2 Controls Homeostasis of Eosinophils by Restricting the Type-2 Helper Function of T Cells. Tohoku J Exp Med. doi: 10.1620/tjem.241.175

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Rydyznski C, Daniels KA, Karmele EP, Brooks TR, Mahl SE, Moran MT, Li C, Sutiwisesak R, Welsh RM and Waggoner SN. 2015. Generation of cellular immune memory and B-cell immunity is impaired by natural killer cells. Nat Commun. doi: 10.1038/ncomms7375.

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Bapat SP, Nyoung Suh J, Fang S, Liu S, Zhang Y, Cheng A, Zhou C, Liang Y, LeBlanc M, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM and Zheng Y. 2015. Depletion of fat-resident Treg cells prevents age-associated insulin resistance. Nature. 528: 137-141.

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Schwerk A, Altshuler J, Roch M, Gossen M, Winter C, Berg J, Kurtz A, Akyuz L and Steiner B. 2015. Adipose-derived human mesenchymal stem cells induce long-term neurogenic and anti-inflammatory effects and improve cognitive but not motor performance in a rat model of Parkinson's disease. Regen Med. 10(4): 431-445.

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Carey AJ, Gracias DT, Thayer JL, Boesteanu AC, Kumova OK, Mueller YM, Hope JL, Fraietta JA, van Zessen DB and Katsikis PD. 2016. Rapid Evolution of the CD8+ TCR Repertoire in Neonatal Mice. J Immunol. doi: 10.4049 jimmunol.1502126.

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Watson AM, Matthew Lam LK, Klimstra WB and Ryman KD. 2016. The 17D-204 Vaccine Strain-Induced Protection Against Virulent Yellow Fever Virus is Mediated by Humoral Immunity and CD4+ But Not CD8+ T Cells. PLoS Pathog. doi:10.1371/journal.ppat.1005786

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Uzodinma U. Uche, Ann R. Piccirillo, Shunsuke Kataoka, Stephanie J. Grebinoski, Louise M. D’Cruz, and Lawrence P. Kane. PIK3IP1/TrIP restricts activation of T cells through inhibition of PI3K/Akt. J Exp Med. 2018 Dec 3;215(12):3165-3179. doi: 10.1084/jem.20172018

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Avery L, Filderman J, Szymczak-Workman AL, Kane LP4. Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2455-2460. doi: 10.1073/pnas.1712107115

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Jordy Saravia, Hu Zeng1, Yogesh Dhungana, Daniel Bastardo Blanco, Thanh-Long M. Nguyen, Nicole M. Chapman, Yanyan Wang, Apurva Kanneganti, Shaofeng Liu, Jana L. Raynor, Peter Vogel, Geoffrey Neale, Peter Carmeliet, Hongbo Chi. Homeostasis and transitional activation of regulatory T cells require c-Myc. Sci Adv. 2020 Jan 1;6(1):eaaw6443. doi: 10.1126/sciadv.aaw6443

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Hao Shi, Nicole M. Chapman, Jing Wen, Cliff Guy, Lingyun Long, Yogesh Dhungana, Sherri Rankin, Stephane Pelletier, Peter Vogel, Hong Wang, Junmin Peng, Kun-Liang Guan, and Hongbo Chi. Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb. Immunity. 2019 Dec 17;51(6):1012-1027.e7. doi: 10.1016/j.immuni.2019.10.001

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Oh H, Grinberg-Bleyer Y, Liao W, Maloney D, Wang P, Wu Z, Wang J, Bhatt DM, Heise N, Schmid RM, Hayden MS, Klein U, Rabadan R and Ghosh S. 2017. An NF-κB Transcription-Factor-Dependent Lineage-Specific Transcriptional Program Promotes Regulatory T Cell Identity and Function. Immunity. doi: 10.1016/j.immuni.2017.08.010.

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Grinberg-Bleyer Y, Oh H, Desrichard A, Bhatt DM, Caron R, Chan TA, Schmid RM, Klein U, Hayden MS and Ghosh S. 2017. NF-κB c-Rel Is Crucial for the Regulatory T Cell Immune Checkpoint in Cancer. Cell. doi: 10.1016/j.cell.2017.08.004. 

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CD45R (B220) (RA3-6B2)

Hiroshi Kobayashi and Keiyo Takubo. Protocol for the Maintenance of Quiescent Murine Hematopoietic Stem Cells. STAR Protocols.  Published 2 August 2020. https://doi.org/10.1016/j.xpro.2020.100078. 

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Even Fossum, Demo Yemane Tesfaye, Sonja Bobic, Arnar Gudjonsson, Ranveig Braathen, Mireille H. Lahoud, Irina Caminschi, Bjarne Bogen. Targeting Antigens to Different Receptors on Conventional Type 1 Dendritic Cells Impacts the Immune Response. The Journal of Immunology June 26, 2020, ji1901119; DOI: 10.4049/jimmunol.1901119.

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Jonathan J Pinney, Fátima Rivera-Escalera, Charles C Chu, Hannah E Whitehead, Karl VanDerMeid, Ashley M Nelson, Michelle C Barbeau, Clive S Zent, Michael R Elliott; Macrophage hypophagia as a mechanism of innate immune exhaustion in mAb-induced cell clearance. Blood.2020005571. doi: https://doi.org/10.1182/blood.2020005571.

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Ju Youn Lee, Seung Hoon Han, Min Hee Park, Im-Sook Song, Min-Koo Choi, Eunsoo Yu, Cheol-Min Park, Hee-Jin Kim, Seung Hyun Kim, Edward H Schuchman, Hee Kyung Jin, Jae-Sung Bae. N-AS-triggered SPMs Are Direct Regulators of Microglia in a Model of Alzheimer's Disease. Nat Commun. 2020 May 12;11(1):2358. doi: 10.1038/s41467-020-16080-4.

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Kobayashi H, Morikawa T, Okinaga A, et al. Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo. Cell Rep. 2019;28(1):145-158.e9. doi:10.1016/j.celrep.2019.06.008.

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Yang BH, Wang K, Wan S, et al. TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases. Cell Rep. 2019;27(12):3629-3645.e6. doi:10.1016/j.celrep.2019.05.061.

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Shimada K, Porritt RA, Markman JL, et al. T-Cell-Intrinsic Receptor Interacting Protein 2 Regulates Pathogenic T Helper 17 Cell Differentiation. Immunity. 2018;49(5):873-885.e7. doi:10.1016/j.immuni.2018.08.022.

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Scharer CD, Barwick BG, Guo M, Bally APR, Boss JM. Plasma cell differentiation is controlled by multiple cell division-coupled epigenetic programs. Nat Commun. 2018;9(1):1698. Published 2018 Apr 27. doi:10.1038/s41467-018-04125-8.

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Adami AJ, Bracken SJ, Guernsey LA, et al. Early-life antibiotics attenuate regulatory T cell generation and increase the severity of murine house dust mite-induced asthma. Pediatr Res. 2018;84(3):426-434. doi:10.1038/s41390-018-0031-y.

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Guo M, Price MJ, Patterson DG, et al. EZH2 Represses the B Cell Transcriptional Program and Regulates Antibody-Secreting Cell Metabolism and Antibody Production. J Immunol. 2018;200(3):1039-1052. doi:10.4049/jimmunol.1701470.

» View on PubMed

Oguro H, McDonald JG, Zhao Z, Umetani M, Shaul PW and Morrison SJ. 2017. 27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy. J Clin Invest. doi: 10.1172/JCI94027.

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Ganuza M, Hall T, Finkelstein D, Chabot A, Kang G and McKinney-Freeman S. (2017) Lifelong haematopoiesis is established by hundreds of precursors throughout mammalian ontogeny. Nat Cell Biol. DOI: 10.1038/ncb3607

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Gudjonsson A, Lysen A, Balan S, Sundvold-Gjerstad V, Arnold-Schrauf C, Richter L, Bækkevold ES, Dalod M, Bogen B and Fossum E. 2017. Targeting Influenza Virus Hemagglutinin to Xcr1+ Dendritic Cells in the Absence of Receptor-Mediated Endocytosis Enhances Protective Antibody Responses. J Immunol. doi: 10.4049/jimmunol.1601881

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Mgbemena VE, Signer RA, Wijayatunge R, Laxson T, Morrison SJ, Ross TS. 2017. Distinct Brca1 Mutations Differentially Reduce Hematopoietic Stem Cell Function. Cell Rep. DOI: 10.1016/j.celrep.2016.12.075

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Zander RA, Guthmiller JJ, Graham AC, Pope RL, Burke BE, Carr DJ and Butler NS. 2016. Type I Interferons Induce T Regulatory 1 Responses and Restrict Humoral Immunity during Experimental Malaria. PLOS Pathogens. DOI:10.1371/journal.ppat.1005945

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Rydyznski C, Daniels KA, Karmele EP, Brooks TR, Mahl SE, Moran MT, Li C, Sutiwisesak R, Welsh RM and Waggoner SN. 2015. Generation of cellular immune memory and B-cell immunity is impaired by natural killer cells. Nat Commun. doi: 10.1038/ncomms7375.

» View on PubMed

Fiege JK, Burback Bj and Shimizu Y. 2015. Negative Regulation of Memory Phenotype CD8 T Cell Conversion by Adhesion and Degranulation-Promoting Adapter Protein. J Immunol. 195(7): 3119-3128.

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Come C, Cvrljevic A, Khan MM, Treise I, Adler T, Aguilar-Pimental JA, Au-Yeung B, Sittig E, Laajala TD, Chen Y, Oeder S, Calzada-Wack J, Horsch M, Aittokallio T, Busch DH, Ollert MW, Neff F, Beckers J, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Chen Z, Lahesmaa R, and Westermarck J. 2016. CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection. PLoS ONE 11(4):e0152996. doi:10.1371/journal.pone.0152996

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Spanier JA, Frederick DR, Taylor JJ, Heffernan JR, Kotov DI, Martinox T, Osum KC, Ruggiero JL, Rust BJ, Landry SJ, Jenkins MK, McLachlan JB, and Fife BT. 2016. Efficient Generation of Monoclonal Antibodies Against Peptide in the Context of MHCII Using Magnetic Enrichment. Nature Communications. doi:10.1038/ncomms11804

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Iraolagoitia XL, Spallanzani RG, Torres NI, Araya RA, Ziblat A, Domaica CI, Sierra JM, Nunex SY, Secchiari F, Gajewski TF, Zwirner NW and Fuertes MB. 2016 NK Cells Restrain Spontaneous Antitumor CD8+ T Cell Priming Through PD-1/PD-L1 Interactions with Dendritic Cells. J. Immunol. 197:953-961

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Lee LM, Ji M, Sinha M, Dong MB, Ren X, Wang Y, Lowell CA, Ghosh S, Locksley RM and DeFranco AL. 2016. Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9. PLOS one. doi:10.1371/journal.pone.0167693

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Mande P, Zirak B, Ko WC, Taravati K, Bride KL, Brodeur TY, Deng A, Dresser K, Jiang Z, Ettinger R, Fitzgerald KA, Rosenblum MD, Harris JE, Marshak-Rothstein A. Fas ligand promotes an inducible TLR-dependent model of cutaneous lupus-like inflammation. J Clin Invest. 2018 Jul 2;128(7):2966-2978. doi: 10.1172/JCI98219

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Kovats. A Major Population of Functional KLRG1- ILC2s in Female Lungs Contributes to a Sex Bias in ILC2 Numbers. Immunohorizons. 2018 Feb;2(2):74-86. doi: 10.4049/immunohorizons.1800008

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Shiyang Li, John W. Bostick, Jian Ye, Joseph F. Urban, Jr., Dorina Avram, Liang Zhou. Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function. Immunity. 2018 Nov 20;49(5):915-928.e5. doi: 10.1016/j.immuni.2018.09.015

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Qiumei Du, Ashley R. Hoover, Igor Dozmorov, Ondine B. Cleaver,Joshua T. Mendell, Nicolai S.C. van Oers. MIR205HG Is a Long Noncoding RNA that Regulates Growth Hormone and Prolactin Production in the Anterior Pituitary. Dev Cell. 2019 May 20;49(4):618-631.e5. doi: 10.1016/j.devcel.2019.03.012

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Jordy Saravia, Hu Zeng1, Yogesh Dhungana, Daniel Bastardo Blanco, Thanh-Long M. Nguyen, Nicole M. Chapman, Yanyan Wang, Apurva Kanneganti, Shaofeng Liu, Jana L. Raynor, Peter Vogel, Geoffrey Neale, Peter Carmeliet, Hongbo Chi. Homeostasis and transitional activation of regulatory T cells require c-Myc. Sci Adv. 2020 Jan 1;6(1):eaaw6443. doi: 10.1126/sciadv.aaw6443

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Suwanpradid J, Shih M, Pontius L, Yang B, Birukova A, Guttman-Yassky E, Corcoran DL, Que LG, Tighe RM and MacLeod AS. 2017. Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity. J Immunol. doi: 10.4049/jimmunol.1700739.

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CD45 (30-F11)

 

Takahashi D, Hoshina N, Kabumoto Y, et al. Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells. EBioMedicine. 2020;58:102913. doi:10.1016/j.ebiom.2020.102913.

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Clark PA, Sriramaneni RN, Jin WJ, et al.  In situ vaccination at a peripheral tumor site augments response against melanoma brain metastases. Journal for ImmunoTherapy of Cancer 2020;8:e000809. doi: 10.1136/jitc-2020-000809.

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Iida Y, Yoshikawa R, Murata A, et al. Local injection of CCL19-expressing mesenchymal stem cells augments the therapeutic efficacy of anti-PD-L1 antibody by promoting infiltration of immune cells. J Immunother Cancer. 2020;8(2):e000582. doi:10.1136/jitc-2020-000582.

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Kim IS, Gao Y, Welte T, et al. Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms. Nat Cell Biol. 2019;21(9):1113-1126. doi:10.1038/s41556-019-0373-7.

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Kumar D, Sehrawat S. Divergent Effects of a Transient Corticosteroid Therapy on Virus-Specific Quiescent and Effector CD8+ T Cells. Front Immunol. 2019;10:1521. Published 2019 Jul 12. doi:10.3389/fimmu.2019.01521.

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Diaz-Flores E, Comeaux EQ, Kim KL, et al. Bcl-2 Is a Therapeutic Target for Hypodiploid B-Lineage Acute Lymphoblastic Leukemia. Cancer Res. 2019;79(9):2339-2351. doi:10.1158/0008-5472.CAN-18-0236.

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Atif SM, Mack DG, McKee AS, et al. Protective role of B cells in sterile particulate-induced lung injury. JCI Insight. 2019;5(12):e125494. Published 2019 May 16. doi:10.1172/jci.insight.125494.

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Palacios M, Miner TA, Frederick DR, et al. Identification of Two Regulators of Virulence That Are Conserved in Klebsiella pneumoniae Classical and Hypervirulent Strains. mBio. 2018;9(4):e01443-18. Published 2018 Aug 7. doi:10.1128/mBio.01443-18.

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Milasan A, Jean G, Dallaire F, Tardif JC, Merhi Y, Sorci-Thomas M and Martel C. 2017. Apolipoprotein A-I Modulates Atherosclerosis Through Lymphatic Vessel-Dependent Mechanisms in Mice. J Am Heart Assoc. doi: 10.1161/JAHA.117.006892.

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Liao W, Pham V, Liu L, Riazifar M, Pone EJ, Zhang SX, Ma F, Lu M, Walsh CM and Zhao W. 2015. Mesenchymal stem cells engineered to express selectin ligands and IL-10 exert enhanced therapeutic efficacy in murine experimental autoimmune encephalomyelitis. Biomaterials. doi:10.1016/j.biomaterials.2015.11.005

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Benck CJ, Martinov T, Fife BT and Chatterjea D. 2016. Isolation of Infiltrating Leukocytes from Mouse Skin Using Enzymatic Digest and Gradient Separation. J Vis Exp. (107), e53638, doi:10.3791/53638.

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Grinberg-Bleyer Y, Oh H, Desrichard A, Bhatt DM, Caron R, Chan TA, Schmid RM, Klein U, Hayden MS and Ghosh S. 2017. NF-κB c-Rel Is Crucial for the Regulatory T Cell Immune Checkpoint in Cancer. Cell. doi: 10.1016/j.cell.2017.08.004. 

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Oguro H, McDonald JG, Zhao Z, Umetani M, Shaul PW and Morrison SJ. 2017. 27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy. J Clin Invest. doi: 10.1172/JCI94027.

» View on PubMed

CD45.1 (A20)

 

Guo M, Price MJ, Patterson DG, et al. EZH2 Represses the B Cell Transcriptional Program and Regulates Antibody-Secreting Cell Metabolism and Antibody Production. J Immunol. 2018;200(3):1039-1052. doi:10.4049/jimmunol.1701470.

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Briseño CG, Gargaro M, Durai V, Davidson JT, Theisen DJ, Anderson DA 3rd, Novack DV, Murphy TL and Murphy KM. 2017. Deficiency of transcription factor RelB perturbs myeloid and DC development by hematopoietic-extrinsic mechanisms. Proc Natl Acad Sci U S A. doi: 10.1073/pnas.1619863114

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Mgbemena VE, Signer RA, Wijayatunge R, Laxson T, Morrison SJ, Ross TS. 2017. Distinct Brca1 Mutations Differentially Reduce Hematopoietic Stem Cell Function. Cell Rep. DOI: 10.1016/j.celrep.2016.12.075

» View on PubMed

Guthmiller JJ, Graham AC, Zander RA, Pope RL and Butler NS. 2017. Cutting Edge: IL-10 Is Essential for the Generation of Germinal Center B Cell Responses and Anti-Plasmodium Humoral Immunity. DOI:10.4049/jimmunol.1601762

» View on PubMed

Fiege JK, Burback Bj and Shimizu Y. 2015. Negative Regulation of Memory Phenotype CD8 T Cell Conversion by Adhesion and Degranulation-Promoting Adapter Protein. J Immunol. 195(7): 3119-3128.

» View on PubMed

Lin CC, Bradstreet TR, Schwarzkopf EA, Jarjour NN, Chou C, Archambault AS, Sim J, Zinselmeyer BH, Carrero JA, Wu GF, Taneja R, Artyomov MN, Russell JH and Edelson BT. IL-1 induced Bhlhe40 identifies pathogenic T helper cells in a model of autoimmune neuroinflammation. J Exp Med. 213(2): 251-271.

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Miro-Mur F, Perez-de Puig I, Ferrer-Ferrer M, Ura X, Justicia C, Chamorro A and Planas AM. 2015. Immature monocytes recruited to the ischemic mouse brain differentiate into macrophages with features ofalternative activation. Brain Behav Immun. doi: 10.1016/j.bbi.2015.08.010.

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Marsh SE, Abud EM, Lakatos A, Karimzadeh A, Yeung ST, Davtyan H, Fote GM, Lau L, Weinger JG, Lane TE, Inlay MA, Poon WW and Blurton-Jones M. 2016. The adaptive immune system restrains Alzheimer's disease pathogenesis by modulating microglial function. Proc Natl Acad Sci USA. doi: 10.1073/pnas.1525466113.

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Benck, CJ, Martinov, T, Fife, BT, and Chatterjea, D. 2016. Isolation of infiltrating leukocytes from mouse skin using enzymatic digest and gradient separation. J Vis Exp. (107) e53638, doi: 10.3791/53638 (2016)

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Barwick BG, Scharer CD, Bally APR and Boss JM. 2016. Plasma Cell Differentiation is Coupled to Division-Dependent DNA Hypomethylation and Gene Regulation. Nat Immunol. 17(10):1216-25

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Shiyang Li, John W. Bostick, Jian Ye, Joseph F. Urban, Jr., Dorina Avram, Liang Zhou. Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function. Immunity. 2018 Nov 20;49(5):915-928.e5. doi: 10.1016/j.immuni.2018.09.015

» View on PubMed

Nicholas N. Jarjour, Elizabeth A. Schwarzkopf, Tara R. Bradstreet, Irina Shchukina, Chih-Chung Lin, Stanley Ching-Cheng Huang, Chin-Wen Lai, Melissa E. Cook, Reshma Taneja, Thaddeus S. Stappenbeck, Gwendalyn J. Randolph, Maxim N. Artyomov, Joseph F. Urban Jr., and Brian T. Edelson. Bhlhe40 mediates tissue-specific control of macrophage proliferation in homeostasis and type 2 immunity. Nat Immunol. 2019 Jun;20(6):687-700. doi: 10.1038/s41590-019-0382-5

» View on PubMed

Jordy Saravia, Hu Zeng1, Yogesh Dhungana, Daniel Bastardo Blanco, Thanh-Long M. Nguyen, Nicole M. Chapman, Yanyan Wang, Apurva Kanneganti, Shaofeng Liu, Jana L. Raynor, Peter Vogel, Geoffrey Neale, Peter Carmeliet, Hongbo Chi. Homeostasis and transitional activation of regulatory T cells require c-Myc. Sci Adv. 2020 Jan 1;6(1):eaaw6443. doi: 10.1126/sciadv.aaw6443

» View on PubMed

Hao Shi, Nicole M. Chapman, Jing Wen, Cliff Guy, Lingyun Long, Yogesh Dhungana, Sherri Rankin, Stephane Pelletier, Peter Vogel, Hong Wang, Junmin Peng, Kun-Liang Guan, and Hongbo Chi. Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb. Immunity. 2019 Dec 17;51(6):1012-1027.e7. doi: 10.1016/j.immuni.2019.10.001

» View on PubMed

Oguro H, McDonald JG, Zhao Z, Umetani M, Shaul PW and Morrison SJ. 2017. 27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy. J Clin Invest. doi: 10.1172/JCI94027.

» View on PubMed

CD45.2 (104)

 

Karki R, Sharma BR, Lee E, et al. Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer. JCI Insight. 2020;5(12):136720. Published 2020 Jun 18. doi:10.1172/jci.insight.136720.

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Dolina JS, Lee J, Griswold RQ, Labarta-Bajo L, Kannan S, Greenbaum JA, Bahia El Idrissi N, Pont MJ, Croft M, Schoenberger SP. TLR9 Sensing of Self-DNA Controls Cell-Mediated Immunity to Listeria Infection via Rapid Conversion of Conventional CD4+ T Cells to Treg. Cell Rep. 2020 Apr 7;31(1):107249. doi: 10.1016/j.celrep.2020.01.040.

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Markman, J.L., Porritt, R.A., Wakita, D. et al. Loss of testosterone impairs anti-tumor neutrophil function. Nat Commun 11, 1613 (2020). https://doi.org/10.1038/s41467-020-153.

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Guo M, Price MJ, Patterson DG, et al. EZH2 Represses the B Cell Transcriptional Program and Regulates Antibody-Secreting Cell Metabolism and Antibody Production. J Immunol. 2018;200(3):1039-1052. doi:10.4049/jimmunol.1701470.

» View on PubMed

Sato Y, Kato H, Ebina-Shibuya R, Itoh-Nakadai A, Okuyama R and Igarashi K. 2017. Bach2 Controls Homeostasis of Eosinophils by Restricting the Type-2 Helper Function of T Cells. Tohoku J Exp Med. doi: 10.1620/tjem.241.175

» View on PubMed

Mgbemena VE, Signer RA, Wijayatunge R, Laxson T, Morrison SJ, Ross TS. 2017. Distinct Brca1 Mutations Differentially Reduce Hematopoietic Stem Cell Function. Cell Rep. DOI: 10.1016/j.celrep.2016.12.075

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Trott DW, Henson GD, Ho MHT, Allison SA, Lesniewski LA and Donato AJ. 2016. Age-related arterial immune cell infiltration in mice is attenuated by caloric restriction or voluntary exercise. Exp. Gerontol. DOI: 10.1016/j.exger.2016.12.016

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Guthmiller JJ, Graham AC, Zander RA, Pope RL and Butler NS. 2017. Cutting Edge: IL-10 Is Essential for the Generation of Germinal Center B Cell Responses and Anti-Plasmodium Humoral Immunity. DOI:10.4049/jimmunol.1601762

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Kamimura Y and Lanier LL. 2015. Homeostatic Control of Memory Cell Progenitors in the Natural Killer Cell Lineage. Cell Rep. 10(2): 280-291.

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Martinez-Lopez M, Iborra S, Conde-Garrosa R and Sancho D. 2014. Batf3-dependent CD103+ dendritic cells are major producers of IL-12 that drive local Th1 immunity against Leishmania major infection in mice. Eur J Immunol. 45(1): 119-129.

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Fiege JK, Burback Bj and Shimizu Y. 2015. Negative Regulation of Memory Phenotype CD8 T Cell Conversion by Adhesion and Degranulation-Promoting Adapter Protein. J Immunol. 195(7): 3119-3128.

» View on PubMed

Lin CC, Bradstreet TR, Schwarzkopf EA, Jarjour NN, Chou C, Archambault AS, Sim J, Zinselmeyer BH, Carrero JA, Wu GF, Taneja R, Artyomov MN, Russell JH and Edelson BT. IL-1 induced Bhlhe40 identifies pathogenic T helper cells in a model of autoimmune neuroinflammation. J Exp Med. 213(2): 251-271.

» View on PubMed

Rios D, Wood MB, Li J, Chassaing B, Gewirtz AT and Williams IR. 2015. Antigen sampling by intestinal M cells is the principal pathway initiating mucosal IgA production to commensal enteric bacteria. Mucosal Immunol. doi: 10.1038/mi.2015.121.

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Khan TN, Mooster JL, Kilgore AM, Osborn JF, and Nolz JC. 2016. Local Antigen in Nonlymphoid Tissue Promotes Resident Memory CD8+ T Cell Formation During Viral Infection. The Journal of Experimental Medicine. doi: 10.1084/jem.20151855

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Paul D, Baena V, Ge S, Jiang X, Jellison ER, Kiprono T, Agalliu D and Pachter JS. 2016. Appearance of claudin-5+ leukocytes in the central nervous system during neuroinflammation: a novel role for endothelial-derived extracellular vesicles. J. Neuroinflammation DOI: 10.1186/s12974-016-0755-8

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Tedesco D, Thapa M, Gumber S, Elrod EJ, Rahman K, Ibegbu CC, Magliocca JF, Adams AB, anania F and Grakoui A. 2016. CD4+ Foxp3+ T cells promote aberrant immunoglobulin G production and maintain CD8+ T-cell suppression during chronic liver disease. Hepatology. doi:10.1002/hep.28894

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Erola Ainsua-Enrich, Ibrahim Hatipoglu, Sapana Kadel, Sean Turner, Jinny Paul, Simar Singh, Harini Bagavant, and Susan Kovats. IRF4-dependent dendritic cells regulate CD8+ T cell differentiation and memory responses in influenza infection. Mucosal Immunol. 2019 Jul;12(4):1025-1037. doi: 10.1038/s41385-019-0173-1

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Nicholas N. Jarjour, Elizabeth A. Schwarzkopf, Tara R. Bradstreet, Irina Shchukina, Chih-Chung Lin, Stanley Ching-Cheng Huang, Chin-Wen Lai, Melissa E. Cook, Reshma Taneja, Thaddeus S. Stappenbeck, Gwendalyn J. Randolph, Maxim N. Artyomov, Joseph F. Urban Jr., and Brian T. Edelson. Bhlhe40 mediates tissue-specific control of macrophage proliferation in homeostasis and type 2 immunity. Nat Immunol. 2019 Jun;20(6):687-700. doi: 10.1038/s41590-019-0382-5

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Matthew A. Huggins, Frances V. Sjaastad, Mark Pierson, Tamara A. Kucaba, Whitney Swanson, Christopher Staley, Alexa R. Weingarden, Isaac J. Jensen, Derek B. Danahy, Vladimir P. Badovinac, Stephen C. Jameson, Vaiva Vezys, David Masopust, Alexander Khoruts, Thomas S. Griffith, and Sara E. Hamilton. Microbial Exposure Enhances Immunity to Pathogens Recognized by TLR2 but Increases Susceptibility to Cytokine Storm through TLR4 Sensitization. Cell Rep. 2019 Aug 13;28(7):1729-1743.e5. doi: 10.1016/j.celrep.2019.07.028

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Jordy Saravia, Hu Zeng1, Yogesh Dhungana, Daniel Bastardo Blanco, Thanh-Long M. Nguyen, Nicole M. Chapman, Yanyan Wang, Apurva Kanneganti, Shaofeng Liu, Jana L. Raynor, Peter Vogel, Geoffrey Neale, Peter Carmeliet, Hongbo Chi. Homeostasis and transitional activation of regulatory T cells require c-Myc. Sci Adv. 2020 Jan 1;6(1):eaaw6443. doi: 10.1126/sciadv.aaw6443

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Hao Shi, Nicole M. Chapman, Jing Wen, Cliff Guy, Lingyun Long, Yogesh Dhungana, Sherri Rankin, Stephane Pelletier, Peter Vogel, Hong Wang, Junmin Peng, Kun-Liang Guan, and Hongbo Chi. Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb. Immunity. 2019 Dec 17;51(6):1012-1027.e7. doi: 10.1016/j.immuni.2019.10.001

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Oguro H, McDonald JG, Zhao Z, Umetani M, Shaul PW and Morrison SJ. 2017. 27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy. J Clin Invest. doi: 10.1172/JCI94027.

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CD62L (MEL-14)

 

Toriyama K, Kuwahara M, Kondoh H, et al. T cell-specific deletion of Pgam1 reveals a critical role for glycolysis in T cell responses. Commun Biol. 2020;3(1):394. Published 2020 Jul 24. doi:10.1038/s42003-020-01122-w.

» View on Communications Biology

Govindarajan S, Gaublomme D, Van der Cruyssen R, et al. Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha. Nat Commun. 2018;9(1):5340. Published 2018 Dec 17. doi:10.1038/s41467-018-07758-x.

» View on Nature Communications

Pannu J, Belle JI, Forster M, Duerr CU, Shen S, Kane L, Harcourt K, Fritz JH, Clare S and Nijnik A. 2015. Ubiquitin Specific Protease 21 Is Dispensable for Normal Development, Hematopoiesis and Lymphocyte Differentiation. PloS one.10(2):e0117304.

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Fenutría R, Martinez VG, Simões I, Postigo J, Gil V, Martínez-Florensa M, Sintes J, Naves R, Cashman KS, et al. 2014. Transgenic Expression of Soluble Human CD5 Enhances Experimentally-Induced Autoimmune and Anti-Tumoral Immune Responses. PloS one. 9(1): e84895.

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Bapat SP, Nyoung Suh J, Fang S, Liu S, Zhang Y, Cheng A, Zhou C, Liang Y, LeBlanc M, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM and Zheng Y. 2015. Depletion of fat-resident Treg cells prevents age-associated insulin resistance. Nature. 528: 137-141.

» View on PubMed

Watson AM, Matthew Lam LK, Klimstra WB and Ryman KD. 2016. The 17D-204 Vaccine Strain-Induced Protection Against Virulent Yellow Fever Virus is Mediated by Humoral Immunity and CD4+ But Not CD8+ T Cells. PLoS Pathog. doi:10.1371/journal.ppat.1005786

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Anstadt EJ, Fujiwara M, Wasko N, Nichols F and Clark RB. 2016. TLR Tolerance as a Treatment for Central Nervous System Autoimmunity. J. Immunol. doi: 10.4049/​jimmunol.1600876

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Avery L, Filderman J, Szymczak-Workman AL, Kane LP4. Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2455-2460. doi: 10.1073/pnas.1712107115

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Erola Ainsua-Enrich, Ibrahim Hatipoglu, Sapana Kadel, Sean Turner, Jinny Paul, Simar Singh, Harini Bagavant, and Susan Kovats. IRF4-dependent dendritic cells regulate CD8+ T cell differentiation and memory responses in influenza infection. Mucosal Immunol. 2019 Jul;12(4):1025-1037. doi: 10.1038/s41385-019-0173-1

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Jordy Saravia, Hu Zeng1, Yogesh Dhungana, Daniel Bastardo Blanco, Thanh-Long M. Nguyen, Nicole M. Chapman, Yanyan Wang, Apurva Kanneganti, Shaofeng Liu, Jana L. Raynor, Peter Vogel, Geoffrey Neale, Peter Carmeliet, Hongbo Chi. Homeostasis and transitional activation of regulatory T cells require c-Myc. Sci Adv. 2020 Jan 1;6(1):eaaw6443. doi: 10.1126/sciadv.aaw6443

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Jun Wei, Lingyun Long, Wenting Zheng, Yogesh Dhungana, Seon Ah Lim, Cliff Guy, Yanyan Wang, Yong Dong Wang, Chenxi Qian, Beisi Xu, Anil KC, Jordy Saravia, Hongling Huang, Jiyang Yu, John G. Doench, Terrence L. Geiger, & Hongbo Chi. Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy. Nature. 2019 Dec;576(7787):471-476. doi: 10.1038/s41586-019-1821-z

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Hao Shi, Nicole M. Chapman, Jing Wen, Cliff Guy, Lingyun Long, Yogesh Dhungana, Sherri Rankin, Stephane Pelletier, Peter Vogel, Hong Wang, Junmin Peng, Kun-Liang Guan, and Hongbo Chi. Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb. Immunity. 2019 Dec 17;51(6):1012-1027.e7. doi: 10.1016/j.immuni.2019.10.001

» View on PubMed

Grinberg-Bleyer Y, Oh H, Desrichard A, Bhatt DM, Caron R, Chan TA, Schmid RM, Klein U, Hayden MS and Ghosh S. 2017. NF-κB c-Rel Is Crucial for the Regulatory T Cell Immune Checkpoint in Cancer. Cell. doi: 10.1016/j.cell.2017.08.004. 

» View on PubMed

CD69 (H1.2F3)

 

Kumar D, Sehrawat S. Divergent Effects of a Transient Corticosteroid Therapy on Virus-Specific Quiescent and Effector CD8+ T Cells. Front Immunol. 2019;10:1521. Published 2019 Jul 12. doi:10.3389/fimmu.2019.01521.

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Noviski M, Mueller JL, Satterthwaite A, Garrett-Sinha LA, Brombacher F, Zikherman J. IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate. Elife. 2018;7:e35074. Published 2018 Mar 9. doi:10.7554/eLife.35074.

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CD80 (B7-1) (16-10A1)

Nagaoka M, Yashiro T, Uchida Y, Ando T, Hara M, Arai H, Ogawa H, Okumura K, Kasakura K and Nishiyama C. 2017. The Orphan Nuclear Receptor NR4A3 Is Involved in the Function of Dendritic Cells. J Immunol. doi: 10.4049/jimmunol.1601911.

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Chaganty BKR, Lu Y, Qiu S, Somanchi SS, Lee DA and Fan Z. 2015. Trastuzumab upregulates expression of HLA-ABC and T cell costimulatory molecules through engagement of natural killer cells and stimulation of IFN-γ secretion. OncoImmunology. DOI: 10.1080/2162402X.2015.1100790

» View

CD86 (GL-1)

Chaganty BKR, Lu Y, Qiu S, Somanchi SS, Lee DA and Fan Z. 2015. Trastuzumab upregulates expression of HLA-ABC and T cell costimulatory molecules through engagement of natural killer cells and stimulation of IFN-γ secretion. OncoImmunology. DOI: 10.1080/2162402X.2015.1100790

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Olguin-Alor R, de la Fuente-Granada M, Bonifaz LC, Antonio-Herrara L, Garcia-Zepada EA and Soldevilla G. 2016. A Key Role for Inhibins in Dendritic Cell Maturation and Function. PLOS one. doi:10.1371/journal.pone.0167813

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Ito A, Hong C, Oka K, Salazar JV, Diehl C, Witztum JL, Diaz M, Castrillo A, Bensinger SJ, Chan L and Tontonoz P. 2016. Cholesterol Accumulation in CD11c+ Immune Cells Is a Causal and Targetable Factor in Autoimmune Disease. Immunity. doi: 10.1016/j.immuni.2016.11.008

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CD90.2 (30-H12)

Majhi RK, Sahoo SS, Yadav M, Pratheek BM, Chattopadhyay S and Goswami C. 2015. Functional Expression of TRPV Channels in T cells And Their Implications in Immune Regulation. FEBS J. doi: 10.1111/febs.13306.

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CD115 (c-fms) (AFS98)

Nicholas N. Jarjour, Elizabeth A. Schwarzkopf, Tara R. Bradstreet, Irina Shchukina, Chih-Chung Lin, Stanley Ching-Cheng Huang, Chin-Wen Lai, Melissa E. Cook, Reshma Taneja, Thaddeus S. Stappenbeck, Gwendalyn J. Randolph, Maxim N. Artyomov, Joseph F. Urban Jr., and Brian T. Edelson. Bhlhe40 mediates tissue-specific control of macrophage proliferation in homeostasis and type 2 immunity. Nat Immunol. 2019 Jun;20(6):687-700. doi: 10.1038/s41590-019-0382-5

» View on PubMed

CD117 (c-Kit) (ACK2)

 

Iida Y, Yoshikawa R, Murata A, et al. Local injection of CCL19-expressing mesenchymal stem cells augments the therapeutic efficacy of anti-PD-L1 antibody by promoting infiltration of immune cells. J Immunother Cancer. 2020;8(2):e000582. doi:10.1136/jitc-2020-000582.

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CD127 (Il-7Ra) (A7R34)

Watson AM, Matthew Lam LK, Klimstra WB and Ryman KD. 2016. The 17D-204 Vaccine Strain-Induced Protection Against Virulent Yellow Fever Virus is Mediated by Humoral Immunity and CD4+ But Not CD8+ T Cells. PLoS Pathog. doi:10.1371/journal.ppat.1005786

» View on PubMed

Avery L, Filderman J, Szymczak-Workman AL, Kane LP4. Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2455-2460. doi: 10.1073/pnas.1712107115

» View on PubMed

CD127 (A7R34)

 

Kumar D, Sehrawat S. Divergent Effects of a Transient Corticosteroid Therapy on Virus-Specific Quiescent and Effector CD8+ T Cells. Front Immunol. 2019;10:1521. Published 2019 Jul 12. doi:10.3389/fimmu.2019.01521.

» View on PubMed

Uzodinma U. Uche, Ann R. Piccirillo, Shunsuke Kataoka, Stephanie J. Grebinoski, Louise M. D’Cruz, and Lawrence P. Kane. PIK3IP1/TrIP restricts activation of T cells through inhibition of PI3K/Akt. J Exp Med. 2018 Dec 3;215(12):3165-3179. doi: 10.1084/jem.20172018

» View on PubMed

Shiyang Li, John W. Bostick, Jian Ye, Joseph F. Urban, Jr., Dorina Avram, Liang Zhou. Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function. Immunity. 2018 Nov 20;49(5):915-928.e5. doi: 10.1016/j.immuni.2018.09.015

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Iraolagoitia XL, Spallanzani RG, Torres NI, Araya RA, Ziblat A, Domaica CI, Sierra JM, Nunex SY, Secchiari F, Gajewski TF, Zwirner NW and Fuertes MB. 2016 NK Cells Restrain Spontaneous Antitumor CD8+ T Cell Priming Through PD-1/PD-L1 Interactions with Dendritic Cells. J. Immunol. 197:953-961

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Karmaus PWF, Herrada AA, Guy C, Neale G, Dhungana Y, Long L, Vogel P, Avila J, Clish CB and Chi H. 2017. Critical roles of mTORC1 signaling and metabolic reprogramming for M-CSF-mediated myelopoiesis. J Exp Med. doi: 10.1084/jem.20161855.

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CD152 (CTLA-4) (UC10-4F10-11)

Yang BH, Wang K, Wan S, et al. TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases. Cell Rep. 2019;27(12):3629-3645.e6. doi:10.1016/j.celrep.2019.05.061.

» View on PubMed

Yoshida Y, Mikami N, Matsushima Y, Otani F, Miyawaki M, Takatsuji M, Banno R, Tsuji T, Fujita T, Tsujikawa K and Kohno T. 2015. Functional Mechanism(s) of the Inhibition of Disease Progression by Combination Treatment with Fingolimod plus Pathogenic Antigen in a Glucose-6-phosphate Isomerase Peptide-Induced Arthritis Mouse Model. Biol Pharm Bull. DOI:10.1248/bpb.b14-00873.

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Gilchuk P, Hill TM, Guy C, McMaster SR, Boyd KL, Rabacal WA, Lu P, Shyr Y, Kohlmeier JE, Sebzda E, Green DR and Joyce S.2016. A Distinct Lung-Interstitium-Resident Memory CD8+ T Cell Subset Confers Enhanced Protection to Lower Respiratory Tract Infection. Cell Reports. DOI: 10.1016/j.celrep.2016.07.037

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CD274 (PD-L1, B7-H1) (10F.9G2)

Iraolagoitia XL, Spallanzani RG, Torres NI, Araya RA, Ziblat A, Domaica CI, Sierra JM, Nunex SY, Secchiari F, Gajewski TF, Zwirner NW and Fuertes MB. 2016 NK Cells Restrain Spontaneous Antitumor CD8+ T Cell Priming Through PD-1/PD-L1 Interactions with Dendritic Cells. J. Immunol. 197:953-961

» View on PubMed

CD279 (PD-1) (J43.1)

Jordy Saravia, Hu Zeng1, Yogesh Dhungana, Daniel Bastardo Blanco, Thanh-Long M. Nguyen, Nicole M. Chapman, Yanyan Wang, Apurva Kanneganti, Shaofeng Liu, Jana L. Raynor, Peter Vogel, Geoffrey Neale, Peter Carmeliet, Hongbo Chi. Homeostasis and transitional activation of regulatory T cells require c-Myc. Sci Adv. 2020 Jan 1;6(1):eaaw6443. doi: 10.1126/sciadv.aaw6443

» View on PubMed

Kumar D, Sehrawat S. Divergent Effects of a Transient Corticosteroid Therapy on Virus-Specific Quiescent and Effector CD8+ T Cells. Front Immunol. 2019;10:1521. Published 2019 Jul 12. doi:10.3389/fimmu.2019.01521.

» View on PubMed

Grinberg-Bleyer Y, Oh H, Desrichard A, Bhatt DM, Caron R, Chan TA, Schmid RM, Klein U, Hayden MS and Ghosh S. 2017. NF-κB c-Rel Is Crucial for the Regulatory T Cell Immune Checkpoint in Cancer. Cell. doi: 10.1016/j.cell.2017.08.004. 

» View on PubMed

F4/80 (BM8.1)

 

Bapat, Sagar P., Zheng, YE, Evans, Ronald, Downes, Michael, Atkins, Annette R., YU, Ruth T. COMPOSITIONS AND METHODS FOR TREATING AGE-RELATED DIABETES AND RELATED DISORDERS. 2020 May.

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Markman, J.L., Porritt, R.A., Wakita, D. et al. Loss of testosterone impairs anti-tumor neutrophil function. Nat Commun 11, 1613 (2020). https://doi.org/10.1038/s41467-020-15397-4.

» View on Nature Communications

Udden SN, Kwak YT, Godfrey V, et al. NLRP12 suppresses hepatocellular carcinoma via downregulation of cJun N-terminal kinase activation in the hepatocyte. Elife. 2019;8:e40396. Published 2019 Apr 16. doi:10.7554/eLife.40396.

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Lam LKM, Watson AM, Ryman KD, Klimstra WB. Gamma-interferon exerts a critical early restriction on replication and dissemination of yellow fever virus vaccine strain 17D-204. NPJ Vaccines. 2018;3:5. Published 2018 Jan 23. doi:10.1038/s41541-017-0039-z.

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Palacios M, Miner TA, Frederick DR, et al. Identification of Two Regulators of Virulence That Are Conserved in Klebsiella pneumoniae Classical and Hypervirulent Strains. mBio. 2018;9(4):e01443-18. Published 2018 Aug 7. doi:10.1128/mBio.01443-18.

» View on PubMed

Kanemaru H, Yamane F, Fukushima K, Matsuki T, Kawasaki T, Ebina I, Kuniyoshi K, Tanaka H, Maruyama K, Maeda K, Satoh T and Akira S. 2017. Antitumor effect of Batf2 through IL-12 p40 up-regulation in tumor-associated macrophages. Proc Natl Acad Sci U S A. doi: 10.1073/pnas.1708598114.

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Visvabharathy L and Freitag NE. 2017. Propofol sedation exacerbates kidney pathology and dissemination of bacteria during Staphylococcus aureus bloodstream infections.Infect Immun. doi: 10.1128/IAI.00097-17

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Trott DW, Henson GD, Ho MHT, Allison SA, Lesniewski LA and Donato AJ. 2016. Age-related arterial immune cell infiltration in mice is attenuated by caloric restriction or voluntary exercise. Exp. Gerontol. DOI: 10.1016/j.exger.2016.12.016

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Bracken SJ, Adami AJ, Szczepanek SM, Ehsan M, Natarajan P, Guernsey LA, Shahriari N, Rafti E, Matson AP, Schramm CM and Thrall RS. 2015. Long-Term Exposure to House Dust Mite Leads to the Suppression of Allergic Airway Disease Despite Persistent Lung Inflammation. Int Arch Allergy Immunol. 166(4): 243-258.

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Singh V, Holla S, Ramachandra SG and Balaji KN. 2015. WNT-Inflammasome Signaling Mediates NOD2-Induced Development of Acute Arthritis in Mice. J. Immunol. 194(7): 3351-3360.

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Skeldon AM, Morizot A, Douglas T, Santoro N, Kursawe R, Kozlitina J, Caprio S, Mehal WZ and Saleh M. 2015. Caspase-12, but Not Caspase-11, Inhibits Obesity and Insulin Resistance. J Immunol. doi: 10.4049 jimmunol.1501529

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Bapat SP, Nyoung Suh J, Fang S, Liu S, Zhang Y, Cheng A, Zhou C, Liang Y, LeBlanc M, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM and Zheng Y. 2015. Depletion of fat-resident Treg cells prevents age-associated insulin resistance. Nature. 528: 137-141.

» View on PubMed

Spanier JA, Frederick DR, Taylor JJ, Heffernan JR, Kotov DI, Martinox T, Osum KC, Ruggiero JL, Rust BJ, Landry SJ, Jenkins MK, McLachlan JB, and Fife BT. 2016. Efficient Generation of Monoclonal Antibodies Against Peptide in the Context of MHCII Using Magnetic Enrichment. Nature Communications. doi:10.1038/ncomms11804

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Rezvani M, Español-Suñer R, Malato Y, Dumont L, Grimm AA, Kienle E, Bindman JG, Wiedtke E, Hsu BY, Naqvi SJ, Derderian SC, Schwabe RF, Corvera CU, Grimm D and Willenbring H. 2016. In vivo reprogramming of myofibroblasts into hepatocytes as a therapeutic strategy for liver fibrosis. Cell Stem Cell. 18(6):809-16.

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Daniels MJK, Rivers-Auty J, Schilling T, Spencer NG, Watremez W, Fasolino V, Booth SJ, White CS, Baldwin AG, Freeman S, Wong R, Latta C, Yu S, Jackson J, Fischer N, Koziel V, Pillot T, Bagnall J, Allan SM, Paszek P, Galea J, Harte MK, Eder C, Lawrence CB and Brough D. 2016. Fenamate NSAIDs Inhibit the NLRP3 Inflammasome and Protect Against Alzheimer's Disease in Rodent Models. Nat. Commun. doi:10.1038/ncomms12504

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Ganatra HA, Varisco BM, Harmon K, Lahni P, Opoka A and Wong HR. 2016. Zinc supplementation leads to immune modulation and improved survival in a juvenile model of murine sepsis. Innate Immun. doi: 10.1177/1753425916677073

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Boro M, Singh V and Balaji N. 2016. Mycobacterium tuberculosis-triggered Hippo pathway orchestrates CXCL1/2 expression to modulate host immune responses. Sci. Rep. doi:10.1038/srep37695

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Adam L. Burrack, Ellen J. Spartz, Jackson F. Raynor, Iris Wang, Margaret Olson, Ingunn M. Stromnes. Combination PD-1 and PD-L1 Blockade Promotes Durable Neoantigen-Specific T Cell-Mediated Immunity in Pancreatic Ductal Adenocarcinoma. Cell Rep. 2019 Aug 20;28(8):2140-2155.e6. doi: 10.1016/j.celrep.2019.07.059

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Jessica K. Fiege, Ian A. Stone, Rebekah E. Dumm, Barbara M. Waring, Brian T. FifeI, Judith Agudo, Brian D. Brown, Nicholas S. Heaton, Ryan A. Langlois. Long-term surviving influenza infected cells evade CD8+ T cell mediated clearance. PLoS Pathog. 2019 Sep 26;15(9):e1008077. doi: 10.1371/journal.ppat.1008077

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Fc epsilon Receptor I alpha (FceR1) (MAR-1)

Shiyang Li, John W. Bostick, Jian Ye, Joseph F. Urban, Jr., Dorina Avram, Liang Zhou. Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function. Immunity. 2018 Nov 20;49(5):915-928.e5. doi: 10.1016/j.immuni.2018.09.015

» View on PubMed

IFN-g (XMG1.2)

 

Atkin-Smith GK, Duan M, Zanker DJ, Loh L, Nguyen THO, Koutsakos M, Nguyen T, Jiang X, Carrera J, Phan TK, Liu C, Paone S, Oveissi S, Hodge AL, Baxter AA, Kedzierska K, Mackenzie JM, Hulett MD, Bilsel P, Chen W, Poon IKH. Monocyte apoptotic bodies are vehicles for influenza A virus propagation. Commun Biol. 2020 May 8;3(1):223. doi: 10.1038/s42003-020-0955-8.

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Blagih J, Zani F, Chakravarty P, et al. Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses. Cell Rep. 2020;30(2):481-496.e6. doi:10.1016/j.celrep.2019.12.028.

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Kotov JA, Kotov DI, Linehan JL, Bardwell VJ, Gearhart MD, Jenkins MK. BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors. J Exp Med. 2019;216(6):1450-1464. doi:10.1084/jem.20182376.

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Elong Ngono A, Young MP, Bunz M, et al. CD4+ T cells promote humoral immunity and viral control during Zika virus infection [published correction appears in PLoS Pathog. 2019 May 28;15(5):e1007821]. PLoS Pathog. 2019;15(1):e1007474. Published 2019 Jan 24. doi:10.1371/journal.ppat.1007474.

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Kumar D, Sehrawat S. Divergent Effects of a Transient Corticosteroid Therapy on Virus-Specific Quiescent and Effector CD8+ T Cells. Front Immunol. 2019;10:1521. Published 2019 Jul 12. doi:10.3389/fimmu.2019.01521.

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Shimada K, Porritt RA, Markman JL, et al. T-Cell-Intrinsic Receptor Interacting Protein 2 Regulates Pathogenic T Helper 17 Cell Differentiation. Immunity. 2018;49(5):873-885.e7. doi:10.1016/j.immuni.2018.08.022.

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Lam LKM, Watson AM, Ryman KD, Klimstra WB. Gamma-interferon exerts a critical early restriction on replication and dissemination of yellow fever virus vaccine strain 17D-204. NPJ Vaccines. 2018;3:5. Published 2018 Jan 23. doi:10.1038/s41541-017-0039-z.

» View on PubMed

Oyler-Yaniv J, Oyler-Yaniv A, Shakiba M, Min NK, Chen YH, Cheng SY, Krichevsky O, Altan-Bonnet N and Altan-Bonnet G. 2017. Catch and Release of Cytokines Mediated by Tumor Phosphatidylserine Converts Transient Exposure into Long-Lived Inflammation. Mol Cell. doi: 10.1016/j.molcel.2017.05.011.

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Rydyznski C, Daniels KA, Karmele EP, Brooks TR, Mahl SE, Moran MT, Li C, Sutiwisesak R, Welsh RM and Waggoner SN. 2015. Generation of cellular immune memory and B-cell immunity is impaired by natural killer cells. Nat Commun. doi: 10.1038/ncomms7375.

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Zellweger RM, Tang WW, Eddy WE, King K, Sanchez MC and Shresta S. 2015. CD8+ T Cells Can Mediate Short-Term Protection against Heterotypic Dengue Virus Reinfection in Mice. J Virol. 89(12): 6494-6505.

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Gao Y, Min K, Zhang Y, Su J, Greenwood M and Gronert K. 2015. Female-Specific Downregulation of Tissue Polymorphonuclear Neutrophils Drives Impaired Regulatory T Cell and Amplified Effector T Cell Responses in Autoimmune Dry Eye Disease. J Immunol. Doi: 10.4049 jimmunol.1500610.

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Carey AJ, Gracias DT, Thayer JL, Boesteanu AC, Kumova OK, Mueller YM, Hope JL, Fraietta JA, van Zessen DB and Katsikis PD. 2016. Rapid Evolution of the CD8+ TCR Repertoire in Neonatal Mice. J Immunol. doi: 10.4049/jimmunol.1502126.

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Khan TN, Mooster JL, Kilgore AM, Osborn JF, and Nolz JC. 2016. Local Antigen in Nonlymphoid Tissue Promotes Resident Memory CD8+ T Cell Formation During Viral Infection. The Journal of Experimental Medicine. doi: 10.1084/jem.20151855

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Watson AM, Matthew Lam LK, Klimstra WB and Ryman KD. 2016. The 17D-204 Vaccine Strain-Induced Protection Against Virulent Yellow Fever Virus is Mediated by Humoral Immunity and CD4+ But Not CD8+ T Cells. PLoS Pathog. doi:10.1371/journal.ppat.1005786

» View on PubMed

Uzodinma U. Uche, Ann R. Piccirillo, Shunsuke Kataoka, Stephanie J. Grebinoski, Louise M. D’Cruz, and Lawrence P. Kane. PIK3IP1/TrIP restricts activation of T cells through inhibition of PI3K/Akt. J Exp Med. 2018 Dec 3;215(12):3165-3179. doi: 10.1084/jem.20172018

» View on PubMed

Avery L, Filderman J, Szymczak-Workman AL, Kane LP4. Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2455-2460. doi: 10.1073/pnas.1712107115

» View on PubMed

Derek W. Trobaugh, Chengqun Sun, Matthew D. Dunn, Douglas S. Reed, William B. Klimstra. Rational design of a live-attenuated eastern equine encephalitis virus vaccine through informed mutation of virulence determinants. PLoS Pathog. 2019 Feb 11;15(2):e1007584. doi: 10.1371/journal.ppat.1007584

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Kristina S. Burrack, Matthew A. Huggins, Emily Taras, Aaron J. Johnson, Stephen C. Jameson, Sara E. Hamilton. Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells. Immunity. 2018 Apr 17;48(4):760-772.e4. doi: 10.1016/j.immuni.2018.03.012

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Matthew A. Huggins, Frances V. Sjaastad, Mark Pierson, Tamara A. Kucaba, Whitney Swanson, Christopher Staley, Alexa R. Weingarden, Isaac J. Jensen, Derek B. Danahy, Vladimir P. Badovinac, Stephen C. Jameson, Vaiva Vezys, David Masopust, Alexander Khoruts, Thomas S. Griffith, and Sara E. Hamilton. Microbial Exposure Enhances Immunity to Pathogens Recognized by TLR2 but Increases Susceptibility to Cytokine Storm through TLR4 Sensitization. Cell Rep. 2019 Aug 13;28(7):1729-1743.e5. doi: 10.1016/j.celrep.2019.07.028

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Grinberg-Bleyer Y, Oh H, Desrichard A, Bhatt DM, Caron R, Chan TA, Schmid RM, Klein U, Hayden MS and Ghosh S. 2017. NF-κB c-Rel Is Crucial for the Regulatory T Cell Immune Checkpoint in Cancer. Cell. doi: 10.1016/j.cell.2017.08.004. 

» View on PubMed

IL-2 (JES6-5H4)

 

Toriyama K, Kuwahara M, Kondoh H, et al. T cell-specific deletion of Pgam1 reveals a critical role for glycolysis in T cell responses. Commun Biol. 2020;3(1):394. Published 2020 Jul 24. doi:10.1038/s42003-020-01122-w.

» View on Communications Biology

Brincks E. L., Adams J., Wang L., Turner B., Marcinowicz A., Ke J., Essmann M., Mautino L. M., Allen C. Van, Kumar S., Vahanian N., Link C., Mautino M. R. et al Indoximod opposes the immunosuppressive effects mediated by IDO and TDO via modulation of AhR function and activation of mTORC1. Oncotarget. 2020; 11: 2438-2461.

View on Oncotarget

Brooks A, Jonkman J, Bookmyer Z and Bruns HA. 2014. Lonicera japonica alters antigen-stimulated T cell functions. Int J Herbal Med. 2(1): 13-20.

View on Flora Journal

Watson AM, Matthew Lam LK, Klimstra WB and Ryman KD. 2016. The 17D-204 Vaccine Strain-Induced Protection Against Virulent Yellow Fever Virus is Mediated by Humoral Immunity and CD4+ But Not CD8+ T Cells. PLoS Pathog. doi:10.1371/journal.ppat.1005786

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IL-4 (11B11)

Kotov JA, Kotov DI, Linehan JL, Bardwell VJ, Gearhart MD, Jenkins MK. BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors. J Exp Med. 2019;216(6):1450-1464. doi:10.1084/jem.20182376.

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Oyler-Yaniv J, Oyler-Yaniv A, Shakiba M, Min NK, Chen YH, Cheng SY, Krichevsky O, Altan-Bonnet N and Altan-Bonnet G. 2017. Catch and Release of Cytokines Mediated by Tumor Phosphatidylserine Converts Transient Exposure into Long-Lived Inflammation. Mol Cell. doi: 10.1016/j.molcel.2017.05.011.

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Onizawa M, Oshima S, Schulze-Topphoff U, Oses-Prieto JA, Lu T, Tavares R, Produhomme T, Duong B, Whang MI, Advincula R, Agelidis A, et al. 2015. The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis. Nat Immunol. 16(6): 618-627.

» View on PubMed

Watson AM, Matthew Lam LK, Klimstra WB and Ryman KD. 2016. The 17D-204 Vaccine Strain-Induced Protection Against Virulent Yellow Fever Virus is Mediated by Humoral Immunity and CD4+ But Not CD8+ T Cells. PLoS Pathog. doi:10.1371/journal.ppat.1005786

» View on PubMed

IL-10 (JES5-2A5)

Oyler-Yaniv J, Oyler-Yaniv A, Shakiba M, Min NK, Chen YH, Cheng SY, Krichevsky O, Altan-Bonnet N and Altan-Bonnet G. 2017. Catch and Release of Cytokines Mediated by Tumor Phosphatidylserine Converts Transient Exposure into Long-Lived Inflammation. Mol Cell. doi: 10.1016/j.molcel.2017.05.011.

» View on PubMed

Ly-6G (RB6-8C5)

 

Hiroshi Kobayashi and Keiyo Takubo. Protocol for the Maintenance of Quiescent Murine Hematopoietic Stem Cells. STAR Protocols.  Published 2 August 2020. https://doi.org/10.1016/j.xpro.2020.100078. 

» View on ScienceDirect

Alkhani A, Levy CS, Tsui M, Rosenberg KA, Polovina K, Mattis AN, Mack M, Van Dyken S, Wang BM, Maher JJ, Nijagal A. Ly6cLo non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic inflammation. Sci Rep. 2020 Apr 28;10(1):7165. doi: 10.1038/s41598-020-64158-2.

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Kobayashi H, Morikawa T, Okinaga A, et al. Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo. Cell Rep. 2019;28(1):145-158.e9. doi:10.1016/j.celrep.2019.06.008.

» View on PubMed

Udden SN, Kwak YT, Godfrey V, et al. NLRP12 suppresses hepatocellular carcinoma via downregulation of cJun N-terminal kinase activation in the hepatocyte. Elife. 2019;8:e40396. Published 2019 Apr 16. doi:10.7554/eLife.40396.

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Mgbemena VE, Signer RA, Wijayatunge R, Laxson T, Morrison SJ, Ross TS. 2017. Distinct Brca1 Mutations Differentially Reduce Hematopoietic Stem Cell Function. Cell Rep. DOI: 10.1016/j.celrep.2016.12.075

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Hirao H, Uchida Y, Kadono K, Tanaka H, Niki T, Yamauchi A, Hata K, Watanabe T, Terajima H and Uemoto S. 2015. The protective function of galectin-9 in liver ischemia and reperfusion injury in mice. Liver Transpl. doi: 10.1002/lt.24159.

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Bapat SP, Nyoung Suh J, Fang S, Liu S, Zhang Y, Cheng A, Zhou C, Liang Y, LeBlanc M, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM and Zheng Y. 2015. Depletion of fat-resident Treg cells prevents age-associated insulin resistance. Nature. 528: 137-141.

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Kawano M, Mabuchi S, Matsumoto Y, Sasano T, Takahashi R, Kuroda H, Kozasa K, Hashimoto K, Isobe A, Sawada K, Hamasaki T, Morii E and Kimura T. 2015. The significance of G-CSF expression and myeloid-derived suppressor cells in the chemoresistance of uterine cervical cancer. Sci Rep. 5:18217 doi:10.1038/srep18217.

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Ganatra HA, Varisco BM, Harmon K, Lahni P, Opoka A and Wong HR. 2016. Zinc supplementation leads to immune modulation and improved survival in a juvenile model of murine sepsis. Innate Immun. doi: 10.1177/1753425916677073

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Kovats. A Major Population of Functional KLRG1- ILC2s in Female Lungs Contributes to a Sex Bias in ILC2 Numbers. Immunohorizons. 2018 Feb;2(2):74-86. doi: 10.4049/immunohorizons.1800008

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Oguro H, McDonald JG, Zhao Z, Umetani M, Shaul PW and Morrison SJ. 2017. 27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy. J Clin Invest. doi: 10.1172/JCI94027.

» View on PubMed

Suwanpradid J, Shih M, Pontius L, Yang B, Birukova A, Guttman-Yassky E, Corcoran DL, Que LG, Tighe RM and MacLeod AS. 2017. Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity. J Immunol. doi: 10.4049/jimmunol.1700739.

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Ly-6G (1A8)

 

Even Fossum, Demo Yemane Tesfaye, Sonja Bobic, Arnar Gudjonsson, Ranveig Braathen, Mireille H. Lahoud, Irina Caminschi, Bjarne Bogen. Targeting Antigens to Different Receptors on Conventional Type 1 Dendritic Cells Impacts the Immune Response. The Journal of Immunology June 26, 2020, ji1901119; DOI: 10.4049/jimmunol.1901119.

» View on Journal of Immunology

Andersen TK, Huszthy PC, Gopalakrishnan RP, et al. Enhanced germinal center reaction by targeting vaccine antigen to major histocompatibility complex class II molecules. NPJ Vaccines. 2019;4:9. Published 2019 Feb 11. doi:10.1038/s41541-019-0101-0.

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Kim IS, Gao Y, Welte T, et al. Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms. Nat Cell Biol. 2019;21(9):1113-1126. doi:10.1038/s41556-019-0373-7.

» View on PubMed

Kishimoto Y, Asakawa S, Sato T, Takano T, Nakajyo T, Mizuno N, Segawa R, Yoshikawa T, Hiratsuka M, Yanai K, Ohtsu H and Hirasawa N. 2017. Induced histamine regulates Ni elution from an implanted Ni wire in mice by downregulating neutrophil migration. Exp Dermatol. doi: 10.1111/exd.13315.

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Shindo R, Katagiri T, Komazawa-Sakon S, et al. Regenerating islet-derived protein (Reg)3β plays a crucial role in attenuation of ileitis and colitis in mice. Biochem Biophys Rep. 2020;21:100738. Published 2020 Feb 7. doi:10.1016/j.bbrep.2020.100738.

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Lin CC, Bradstreet TR, Schwarzkopf EA, Jarjour NN, Chou C, Archambault AS, Sim J, Zinselmeyer BH, Carrero JA, Wu GF, Taneja R, Artyomov MN, Russell JH and Edelson BT. IL-1 induced Bhlhe40 identifies pathogenic T helper cells in a model of autoimmune neuroinflammation. J Exp Med. 213(2): 251-271.

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Vogel CF, Chang WL, Kado S, McColloh K, Vogel H, Wu D, Haarmann-Stemmann T, Yang G, Leung PS, Matsumura F and Gershwin ME. 2016. Transgenic Overexpression of Aryl Hydrocarbon Receptor Repressor (AhRR) and AhR-Mediated Induction of CYP1A1, Cytokines, and Acute Toxicity. Environ Health Perspect. DOI:10.1289/ehp.1510194.

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Sato T, Kishimoto Y, Asakawa S, Mizuno N, Hiratsuka M and Hirasawa N. 2016. Involvement of COX-2 in nickel elution from a wire implanted subcutaneously in mice. Toxicology. Volumes 363–364, 1 July 2016, Pages 37–45

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Ganatra HA, Varisco BM, Harmon K, Lahni P, Opoka A and Wong HR. 2016. Zinc supplementation leads to immune modulation and improved survival in a juvenile model of murine sepsis. Innate Immun. doi: 10.1177/1753425916677073

» View on PubMed

Tsurusaki S, Tahara-Hanaoka S, Shibagaki S, Miyake S, Imai M, Shibayama S, Kubo M and Shibuya A. 2016. Allergin-1 inhibits TLR2-mediated mast cell activation and suppresses dermatitis. Int. Immunol. doi: 10.1093/intimm/dxw046

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Sakata K, Araki K, Nakano H, Nishina T, Komazawa-Skon S, Murai S, Lee GE, Hashimoto D, Suzuki C, Uchiyama Y, Kotohara K, Gukovskaya AS, Gukovsky I, Yamamura K, Baba H and Ohmuraya M. 2016. Novel method to rescue a lethal phenotype through integration of target gene onto the X-chromosome. Sci. Rep. doi:10.1038/srep37200

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Taylor RA, Chang CF, Goods BA, Hammond MD, Mac Grory B, Ai Y, Steinschneider AF, Renfroe SC, Askenase MH, McCullough LD, Kasner SE, Mullen MT, Hafler DA, Love JC, Sansing LH. 2016. TGF-β1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage. J. Clin. Invest. doi:10.1172/JCI88647

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Lee LM, Ji M, Sinha M, Dong MB, Ren X, Wang Y, Lowell CA, Ghosh S, Locksley RM and DeFranco AL. 2016. Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9. PLOS one. doi:10.1371/journal.pone.0167693

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Shiyang Li, John W. Bostick, Jian Ye, Joseph F. Urban, Jr., Dorina Avram, Liang Zhou. Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function. Immunity. 2018 Nov 20;49(5):915-928.e5. doi: 10.1016/j.immuni.2018.09.015

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Karmaus PWF, Herrada AA, Guy C, Neale G, Dhungana Y, Long L, Vogel P, Avila J, Clish CB and Chi H. 2017. Critical roles of mTORC1 signaling and metabolic reprogramming for M-CSF-mediated myelopoiesis. J Exp Med. doi: 10.1084/jem.20161855.

» View on PubMed


NK1.1 (PK136)

Karki R, Sharma BR, Lee E, et al. Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer. JCI Insight. 2020;5(12):136720. Published 2020 Jun 18. doi:10.1172/jci.insight.136720.

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Amber Troy, Sandra C.Esparza-Gonzalez, Alicia Bartek, Elizabeth Creissen, Linda Izzo, Angelo A.Izzo. Pulmonary mucosal immunity mediated through CpG provides adequate protection against pulmonary Mycobacterium tuberculosis infection in the mouse model. A role for type I interferon. Sci Rep. 2020 May 8. https://doi.org/10.1016/j.tube.2020.101949.

» View on ScienceDirect

Yang BH, Wang K, Wan S, et al. TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases. Cell Rep. 2019;27(12):3629-3645.e6. doi:10.1016/j.celrep.2019.05.061.

» View on PubMed

Govindarajan S, Gaublomme D, Van der Cruyssen R, et al. Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha. Nat Commun. 2018;9(1):5340. Published 2018 Dec 17. doi:10.1038/s41467-018-07758-x.

» View on Nature Communications

Lam LKM, Watson AM, Ryman KD, Klimstra WB. Gamma-interferon exerts a critical early restriction on replication and dissemination of yellow fever virus vaccine strain 17D-204. NPJ Vaccines. 2018;3:5. Published 2018 Jan 23. doi:10.1038/s41541-017-0039-z.

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Oh JE, Oh DS, Jung HE and Lee HK. 2017. A mechanism for the induction of type 2 immune responses by a protease allergen in the genital tract. Proc Natl Acad Sci U S A. doi: 10.1073/pnas.1612997114

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O'Sullivan TE, Johnson LR, Kang HH, Sun JC. 2015. BNIP3- and BNIP3L-Mediated Mitophagy Promotes the Generation of Natural Killer Cell Memory. Immunity. 43: 331-342.

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Kovats. A Major Population of Functional KLRG1- ILC2s in Female Lungs Contributes to a Sex Bias in ILC2 Numbers. Immunohorizons. 2018 Feb;2(2):74-86. doi: 10.4049/immunohorizons.1800008

» View on PubMed

Shiyang Li, John W. Bostick, Jian Ye, Joseph F. Urban, Jr., Dorina Avram, Liang Zhou. Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function. Immunity. 2018 Nov 20;49(5):915-928.e5. doi: 10.1016/j.immuni.2018.09.015

» View on PubMed

TCR-beta (H57-597)

 

Karki R, Sharma BR, Lee E, et al. Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer. JCI Insight. 2020;5(12):136720. Published 2020 Jun 18. doi:10.1172/jci.insight.136720.

» View on PubMed

Raynor JL, Liu C, Dhungana Y, Guy C, Chapman NM, Shi H, Neale G, Sesaki H, Chi H. Hippo/Mst signaling coordinates cellular quiescence with terminal maturation in iNKT cell development and fate decisions. J Exp Med. 2020 Jun 1;217(6). pii: e20191157. doi: 10.1084/jem.20191157.

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Dolina JS, Lee J, Griswold RQ, Labarta-Bajo L, Kannan S, Greenbaum JA, Bahia El Idrissi N, Pont MJ, Croft M, Schoenberger SP. TLR9 Sensing of Self-DNA Controls Cell-Mediated Immunity to Listeria Infection via Rapid Conversion of Conventional CD4+ T Cells to Treg. Cell Rep. 2020 Apr 7;31(1):107249. doi: 10.1016/j.celrep.2020.01.040.

» View on ScienceDirect

Levine AG, Arvey A, Jin W and Rudensky AY. 2014. Continuous requirement for the TCR in regulatory T cell function. Nature Immunol. 15(11): 1070-1078.

» View on PubMed

Kondo M, Tanaka Y, Kuwabara T, Naito T, Kohwi-Shigematsu T and Watanabe A. 2015. SATB1 Plays a Critical Role in Establishment of Immune Tolerance. J Immunol. doi: 10.4049 ​jimmunol.1501429.

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Finkin S, Yuan D, Stein I, Taniguchi K, Weber A, Unger K, Browning JL, Goossens N, Nakagawa S, Gunasekara G, Schwartz ME et al. 2015. Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma. Nat Immunol. doi: 10.1038/ni.3290.

» View on PubMed

Avery L, Filderman J, Szymczak-Workman AL, Kane LP4. Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2455-2460. doi: 10.1073/pnas.1712107115

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Kovats. A Major Population of Functional KLRG1- ILC2s in Female Lungs Contributes to a Sex Bias in ILC2 Numbers. Immunohorizons. 2018 Feb;2(2):74-86. doi: 10.4049/immunohorizons.1800008

» View on PubMed

Qiumei Du, Ashley R. Hoover, Igor Dozmorov, Ondine B. Cleaver,Joshua T. Mendell, Nicolai S.C. van Oers. MIR205HG Is a Long Noncoding RNA that Regulates Growth Hormone and Prolactin Production in the Anterior Pituitary. Dev Cell. 2019 May 20;49(4):618-631.e5. doi: 10.1016/j.devcel.2019.03.012

» View on PubMed

Jordy Saravia, Hu Zeng1, Yogesh Dhungana, Daniel Bastardo Blanco, Thanh-Long M. Nguyen, Nicole M. Chapman, Yanyan Wang, Apurva Kanneganti, Shaofeng Liu, Jana L. Raynor, Peter Vogel, Geoffrey Neale, Peter Carmeliet, Hongbo Chi. Homeostasis and transitional activation of regulatory T cells require c-Myc. Sci Adv. 2020 Jan 1;6(1):eaaw6443. doi: 10.1126/sciadv.aaw6443

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Hao Shi, Nicole M. Chapman, Jing Wen, Cliff Guy, Lingyun Long, Yogesh Dhungana, Sherri Rankin, Stephane Pelletier, Peter Vogel, Hong Wang, Junmin Peng, Kun-Liang Guan, and Hongbo Chi. Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb. Immunity. 2019 Dec 17;51(6):1012-1027.e7. doi: 10.1016/j.immuni.2019.10.001

» View on PubMed

Grinberg-Bleyer Y, Oh H, Desrichard A, Bhatt DM, Caron R, Chan TA, Schmid RM, Klein U, Hayden MS and Ghosh S. 2017. NF-κB c-Rel Is Crucial for the Regulatory T Cell Immune Checkpoint in Cancer. Cell. doi: 10.1016/j.cell.2017.08.004.

» View on PubMed

TER-119 (TER-119)

 

Hiroshi Kobayashi and Keiyo Takubo. Protocol for the Maintenance of Quiescent Murine Hematopoietic Stem Cells. STAR Protocols.  Published 2 August 2020. https://doi.org/10.1016/j.xpro.2020.100078. 

» View on ScienceDirect

Egusquiza RJ, Ambrosio ME, Wang SG, Kay KM, Zhang C, Lehmler HJ, Blumberg B. Evaluating the Role of the Steroid and Xenobiotic Receptor (SXR/PXR) in PCB-153 Metabolism and Protection against Associated Adverse Effects during Perinatal and Chronic Exposure in Mice. Environ Health Perspect. 2020 Apr;128(4):47011. doi: 10.1289/EHP6262. Epub 2020 Apr 30.

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Kiatpakdee B, Sato K, Otsuka Y, Arashiki N, Chen Y, Tsumita T, Otsu W, Yamamoto A, Kawata R, Yamazaki J, Sugimoto Y, Takada K, Mohandas N, Inaba M. Cholesterol-binding protein TSPO2 coordinates maturation and proliferation of terminally differentiating erythroblasts. J Biol Chem. 2020 May 1. pii: jbc.RA119.011679. doi: 10.1074/jbc.RA119.011679

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Kobayashi H, Morikawa T, Okinaga A, et al. Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo. Cell Rep. 2019;28(1):145-158.e9. doi:10.1016/j.celrep.2019.06.008.

» View on PubMed

Kudo F, Ikutani M, Seki Y, Otsubo T, Kawamura YI, Dohi T, Oshima K, Hattori M, Nakae S, Takatsu K and Takaki S. 2015. Interferon-γ Constrains Cytokine Production of Group 2 Innate Lymphoid Cells. Immunology. doi: 10.1111/imm.12537.

» View on PubMed

Kovats. A Major Population of Functional KLRG1- ILC2s in Female Lungs Contributes to a Sex Bias in ILC2 Numbers. Immunohorizons. 2018 Feb;2(2):74-86. doi: 10.4049/immunohorizons.1800008

» View on PubMed

Shiyang Li, John W. Bostick, Jian Ye, Joseph F. Urban, Jr., Dorina Avram, Liang Zhou. Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function. Immunity. 2018 Nov 20;49(5):915-928.e5. doi: 10.1016/j.immuni.2018.09.015

» View on PubMed

Qiumei Du, Ashley R. Hoover, Igor Dozmorov, Ondine B. Cleaver,Joshua T. Mendell, Nicolai S.C. van Oers. MIR205HG Is a Long Noncoding RNA that Regulates Growth Hormone and Prolactin Production in the Anterior Pituitary. Dev Cell. 2019 May 20;49(4):618-631.e5. doi: 10.1016/j.devcel.2019.03.012

» View on PubMed

Oguro H, McDonald JG, Zhao Z, Umetani M, Shaul PW and Morrison SJ. 2017. 27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy. J Clin Invest. doi: 10.1172/JCI94027.

» View on PubMed

KLRG1 (2F1)

 

Blagih J, Zani F, Chakravarty P, et al. Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses. Cell Rep. 2020;30(2):481-496.e6. doi:10.1016/j.celrep.2019.12.028.

» View on PubMed

Jordy Saravia, Hu Zeng1, Yogesh Dhungana, Daniel Bastardo Blanco, Thanh-Long M. Nguyen, Nicole M. Chapman, Yanyan Wang, Apurva Kanneganti, Shaofeng Liu, Jana L. Raynor, Peter Vogel, Geoffrey Neale, Peter Carmeliet, Hongbo Chi. Homeostasis and transitional activation of regulatory T cells require c-Myc. Sci Adv. 2020 Jan 1;6(1):eaaw6443. doi: 10.1126/sciadv.aaw6443

» View on PubMed

Uzodinma U. Uche, Ann R. Piccirillo, Shunsuke Kataoka, Stephanie J. Grebinoski, Louise M. D’Cruz, and Lawrence P. Kane. PIK3IP1/TrIP restricts activation of T cells through inhibition of PI3K/Akt. J Exp Med. 2018 Dec 3;215(12):3165-3179. doi: 10.1084/jem.20172018

» View on PubMed

Kristina S. Burrack, Matthew A. Huggins, Emily Taras, Aaron J. Johnson, Stephen C. Jameson, Sara E. Hamilton. Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells. Immunity. 2018 Apr 17;48(4):760-772.e4. doi: 10.1016/j.immuni.2018.03.012

» View on PubMed

Watson AM, Matthew Lam LK, Klimstra WB and Ryman KD. 2016. The 17D-204 Vaccine Strain-Induced Protection Against Virulent Yellow Fever Virus is Mediated by Humoral Immunity and CD4+ But Not CD8+ T Cells. PLoS Pathog. doi:10.1371/journal.ppat.1005786

» View on PubMed

Grinberg-Bleyer Y, Oh H, Desrichard A, Bhatt DM, Caron R, Chan TA, Schmid RM, Klein U, Hayden MS and Ghosh S. 2017. NF-κB c-Rel Is Crucial for the Regulatory T Cell Immune Checkpoint in Cancer. Cell. doi: 10.1016/j.cell.2017.08.004. 

» View on PubMed

MHC Class II (I-A/I-E) (M5/114.15.2)

Noviski M, Mueller JL, Satterthwaite A, Garrett-Sinha LA, Brombacher F, Zikherman J. IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate. Elife. 2018;7:e35074. Published 2018 Mar 9. doi:10.7554/eLife.35074.

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Milasan A, Jean G, Dallaire F, Tardif JC, Merhi Y, Sorci-Thomas M and Martel C. 2017. Apolipoprotein A-I Modulates Atherosclerosis Through Lymphatic Vessel-Dependent Mechanisms in Mice. J Am Heart Assoc. doi: 10.1161/JAHA.117.006892.

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Visvabharathy L and Freitag NE. 2017. Propofol sedation exacerbates kidney pathology and dissemination of bacteria during Staphylococcus aureus bloodstream infections.Infect Immun. doi: 10.1128/IAI.00097-17

» View on PubMed

Watkins HC, Rappazzo G, Higgins JS, Sun X, Brock N, Chau A, Misra A, Cannizzo JPB, King MR, Maines TR, Leifer CA, Whittaker GR, DeLisa MP and Putnam D. 2017. Safe recombinant outer membrane vesicles that display M2e elicit heterologous influenza protection. Mol. Ther. DOI: 10.1016/j.ymthe.2017.01.010

» View on PubMed

Tiner BL, Sha J, Cong Y, Kirtley ML, Andersson JA and Chopra AK. 2016. Immunisation of two rodent species with new live-attenuated mutants of Yersinia pestis CO92 induces protective long-term humoral- and cell-mediated immunity against pneumonic plague. npj Vaccines. doi:10.1038/npjvaccines.2016.20

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Griffiths KL, Ahmed M, Das S, Gopal R, Horne W, Connell TD, Moynihan KD, Kolls JK, Irvine DJ, Artyomov MN, Rangel-Moreno J and Khader SA. 2016. Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy. Nat. Commun. doi:10.1038/ncomms13894

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Hyunjoon Kima, Drishti Sehgal, Tamara A. Kucaba, David M. Ferguson, Thomas S. Griffith, Jayanth Panyam. Acidic pH-responsive polymer nanoparticles as TLR7/8 agonist delivery platform for cancer immunotherapy. anoscale. 2018 Nov 15;10(44):20851-20862. doi: 10.1039/c8nr07201a

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FoxP3 (3G3)

 

Blagih J, Zani F, Chakravarty P, et al. Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses. Cell Rep. 2020;30(2):481-496.e6. doi:10.1016/j.celrep.2019.12.028.

» View on PubMed

Adami AJ, Bracken SJ, Guernsey LA, et al. Early-life antibiotics attenuate regulatory T cell generation and increase the severity of murine house dust mite-induced asthma. Pediatr Res. 2018;84(3):426-434. doi:10.1038/s41390-018-0031-y.

» View on PubMed

Biagioli M, Carino A, Cipriani S, Francisci D, Marchianò S, Scarpelli P, Sorcini D, Zampella A and Fiorucci S. 2017. The Bile Acid Receptor GPBAR1 Regulates the M1/M2 Phenotype of Intestinal Macrophages and Activation of GPBAR1 Rescues Mice from Murine Colitis. J Immunol. doi: 10.4049/jimmunol.1700183.

» View on PubMed

Okamura K, Kitamura A, Sasaki Y, Chung DH, Kagami S, Iwai K and Yasutomo K. 2016. Survival of mature T cells depends on signaling through HOIP. Sci Rep. doi:10.1038/srep36135

» View on PubMed

 IL-12/IL-23 p40 (C17.8) 

 

Kotov JA, Kotov DI, Linehan JL, Bardwell VJ, Gearhart MD, Jenkins MK. BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors. J Exp Med. 2019;216(6):1450-1464. doi:10.1084/jem.20182376.

» View on PubMed

Dolina JS, Lee J, Griswold RQ, Labarta-Bajo L, Kannan S, Greenbaum JA, Bahia El Idrissi N, Pont MJ, Croft M, Schoenberger SP. TLR9 Sensing of Self-DNA Controls Cell-Mediated Immunity to Listeria Infection via Rapid Conversion of Conventional CD4+ T Cells to Treg. Cell Rep. 2020 Apr 7;31(1):107249. doi: 10.1016/j.celrep.2020.01.040.

» View on PubMed

Clones not Specified

Dishon S, Cohen SJ, Cohen IR and Nussbaum G. 2017. Inhibition of Myeloid Differentiation Factor 88 Reduces Human and Mouse T-Cell Interleukin-17 and IFNγ Production and Ameliorates Experimental Autoimmune Encephalomyelitis Induced in Mice. Front Immunol. doi: 10.3389/fimmu.2017.00615

» View on PubMed

O'Donnell H, Pham OH, Li L, Atif SM, Lee SJ, Ravesloot MM, Stolfi JL, Nuccio SP, Broz P, Monack DM, Baumler AJ and McSorley SJ. 2014 Toll-like Receptor and Inflammasome Signals Converge to Amplify the Innate Bactericidal Capacity of T Helper 1 Cells. Immunity. 40(2): 213-224.

» View on PubMed

Nanton MR, Lee SJ, Atif SM, Nuccio SP, Taylor JJ, Baumler AJ, Way SS and McSorley SJ. 2014. Direct visualization of endogenous Salmonella-specific B cells reveals a marked delay in clonal expansion and germinal center development. Eur J Immunol. 45(2): 428-441.

» View on PubMed

Burger ML, Leung KK, Bennett, MJ and Winoto A. 2014. T cell-specific inhibition of multiple apoptotic pathways blocks negative selection and causes autoimmunity. eLife 2014;10.7554/eLife.03468.

» View on PubMed

Hsu FC, Shapiro MJ, Chen MW, McWilliams DC, Seaburg LM, Tangen SN and Shapiro VS. 2014. Immature Recent Thymic Emigrants Are Eliminated by Complement. J Immunol. 193(12): 6005-6015.

» View on PubMed

Nabekura T and Lanier LL. 2014. Antigen-specific expansion and differentiation of natural killer cells by alloantigen stimulation. J Exp Med. 211(12): 2455-2465.

» View on PubMed

Cozza EM, Cooper TK, Budgeon LR, Christensen ND and Schell TD. 2014. Protection from tumor recurrence following adoptive immunotherapy varies with host conditioning regimen despite initial regression of autochthonous murine brain tumors. Cancer Immunol Immunother. 64(3): 324-336.

» View on PubMed

Liu Z, Zhou H, Wang W, Tan W, Fu YX and Zhu M. 2014. A novel method for synthetic vaccine construction based on protein assembly. Sci Rep. 4: 7266.

» View on PubMed

Han D, Walsh MC, Kim KS, Hong SW, Lee J, Yi J, Rivas G, Surh CD and Choi Y. 2015. Microbiota-Independent Ameliorative Effects of Antibiotics on Spontaneous Th2-Associated Pathology of the Small Intestine. PLoS ONE 10(2): e0118795.

» View on PubMed

Hemmers S and Rudensky AY. 2015. The Cell-Intrinsic Circadian Clock Is Dispensable for Lymphocyte Differentiation and Function. Cell Rep. 11(9): 1339-1349.

» View on PubMed

Doe HT, Kumura D, Miyakoda M, Kimura K, Akbari M and Yui K. 2015. Expression of PD-1/LAG-3 and cytokine production by CD4+ T cells during infection with Plasmodium parasites. Microbiol Immunol. DOI: 10.1111/1348-0421.12354.

» View on PubMed

Takahashi K, Nagai N, Ogura K, Tsuneyama K, Saiki I, Irimura T and Hayakawa Y. 2015. Mammary tissue microenvironment determines T cell-dependent breast cancer-associated inflammation. Cancer Sci. 106(7): 867-874.

» View on PubMed

Gordon EB, Hart GT, Tran TM, Waisberg M, Akkaya M, Kim AS, Hamilton SE, Pena M, Yazew T, Qi CF, Lee CF, Lo YC, Miller LH, Powell JD and Pierce SK. 2015. Targeting glutamine metabolism rescues mice from late-stage cerebral malaria. Proc Natl Acad Sci USA. 112(42): 13075-13080.

» View on PubMed

Cheekatla SS, Tripathi D, Venkatasubramanian S, Nathella PK, Paidipally P, Ishibashi M, Welch E, Tvinnereim AR, Ikebe M, Valluri VL, Babu S, Kornfeld H and Vankayalapati R. 2016. NK-CD11c+ Cell Crosstalk in Diabetes Enhances IL-6-Mediated Inflammation during Mycobacterium tuberculosis Infection. PloS one. doi.org/10.1371/journal.ppat.1005972

» View on PubMed

Caruso G, Distefano DA, Parlascino P, Fresta CG, Lazzarino G, Lunte SM and Nicoletti VG. 20136. Receptor-mediated toxicity of human amylin fragment aggregated by short- and long-term incubations with copper ions. Mol. Cell. Biochem. doi:10.1007/s11010-016-2864-1

» View on PubMed




Recombinant Proteins:

Recombinant Human IL-1ß (Carrier-free)

 

Kotov JA, Kotov DI, Linehan JL, Bardwell VJ, Gearhart MD, Jenkins MK. BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors. J Exp Med. 2019;216(6):1450-1464. doi:10.1084/jem.20182376.

» View on PubMed

Recombinant Human IL-6 (Carrier-free)

Roa, J.A., Sarkar, D., Zanaty, M. et al. Preliminary results in the analysis of the immune response after aneurysmal subarachnoid hemorrhage. Sci Rep 10, 11809 (2020). https://doi.org/10.1038/s41598-020-68861-y.

» View on Nature 

Kotov JA, Kotov DI, Linehan JL, Bardwell VJ, Gearhart MD, Jenkins MK. BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors. J Exp Med. 2019;216(6):1450-1464. doi:10.1084/jem.20182376.

» View on PubMed

LaMere SA, Thompson RC, Meng X, Komori HK, Mark A and Salomon DR. 2017. H3K27 Methylation Dynamics during CD4 T Cell Activation: Regulation of JAK/STAT and IL12RB2 Expression by JMJD3. J Immunol. doi: 10.4049/jimmunol.1700475.

» View on PubMed

Müller L, Steiner SK, Rodriguez-Lorenzo L, Petri-Fink A, Rothen-Rutishauser B and Latzin P. 2017. Exposure to silver nanoparticles affects viability and function of natural killer cells, mostly via the release of ions. Cell Biol Toxicol. doi: 10.1007/s10565-017-9403-z

» View on PubMed

Nishibayashi R, Inoue R, Harada Y, Watanabe T, Makioka Y and Ushida K. 2015. RNA of Enterococcus faecalis Strain EC-12 Is a Major Component Inducing Interleukin-12 Production from Human Monocytic Cells. PLoS One. 10.1371/journal.pone.0129806.

» View on PubMed

Recombinant Human IL-12 p70 (Carrier-free)

Kyoizumi S, Kubo Y, Kajimura J, Yoshida K, Hayashi T, Nakachi K, Moore MA, van den Brink MRM and Kusunoki Y. 2017. Fate Decision Between Group 3 Innate Lymphoid and Conventional NK Cell Lineages by Notch Signaling in Human Circulating Hematopoietic Progenitors. J Immunol. doi: 10.4049/jimmunol.1601711.

» View on PubMed

Recombinant Human IL-15 (Carrier-free)

Kyoizumi S, Kubo Y, Kajimura J, Yoshida K, Hayashi T, Nakachi K, Moore MA, van den Brink MRM and Kusunoki Y. 2017. Fate Decision Between Group 3 Innate Lymphoid and Conventional NK Cell Lineages by Notch Signaling in Human Circulating Hematopoietic Progenitors. J Immunol. doi: 10.4049/jimmunol.1601711.

» View on PubMed

 Recombinant Human Noggin (Carrier-free)

Kim S, Choung S, Sun RX, Ung N1, Hashemi N, Fong EJ, Lau R, Spiller E, Gasho J, Foo J, Mumenthaler SM. Comparison of Cell and Organoid-Level Analysis of Patient- Derived 3D Organoids to Evaluate Tumor Cell Growth Dynamics and Drug Response. SLAS Discov. 2020 Apr 30:2472555220915827. doi: 10.1177/2472555220915827 

» View on PubMed

 Recombinant Human TGF-ß1 (Carrier-free)

 

Kotov JA, Kotov DI, Linehan JL, Bardwell VJ, Gearhart MD, Jenkins MK. BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors. J Exp Med. 2019;216(6):1450-1464. doi:10.1084/jem.20182376.

» View on PubMed

 Recombinant Human TNF-a (Carrier-free)

 

Roa, J.A., Sarkar, D., Zanaty, M. et al. Preliminary results in the analysis of the immune response after aneurysmal subarachnoid hemorrhage. Sci Rep 10, 11809 (2020). https://doi.org/10.1038/s41598-020-68861-y.

» View on Nature 

 Recombinant Mouse IFN-gamma (Carrier-free)

 

Iida Y, Yoshikawa R, Murata A, et al. Local injection of CCL19-expressing mesenchymal stem cells augments the therapeutic efficacy of anti-PD-L1 antibody by promoting infiltration of immune cells. J Immunother Cancer. 2020;8(2):e000582. doi:10.1136/jitc-2020-000582.

» View on PubMed

Zander RA, Obeng-Adjei N, Guthmiller JJ, Kulu DI, Li J, Ongoiba A, Traore B, Crompton PE and Butler NS. 2015. PD-1 Co-inhibitory and OX40 Co-stimulatory Crosstalk Regulates Helper T Cell Differentiation and Anti-Plasmodium Humoral Immunity. Cell Host Microbe. 17(5): 628-641.

» View on PubMed

 Recombinant Mouse GM-CSF (Carrier-free) 

 

Suwanpradid J, Shih M, Pontius L, Yang B, Birukova A, Guttman-Yassky E, Corcoran DL, Que LG, Tighe RM and MacLeod AS. 2017. Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity. J Immunol. doi: 10.4049/jimmunol.1700739.

» View on Journal of Immunology

 Recombinant Mouse IL-13 (Carrier-free) 

 

Suwanpradid J, Shih M, Pontius L, Yang B, Birukova A, Guttman-Yassky E, Corcoran DL, Que LG, Tighe RM and MacLeod AS. 2017. Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity. J Immunol. doi: 10.4049/jimmunol.1700739.

» View on Journal of Immunology

 Recombinant Mouse IL-4 (Carrier-free

 

Stearoyl-CoA desaturase mediated monounsaturated fatty acid availability supports humoral immunity. Xian Zhou, Xingxing Zhu, Chaofan Li, Yanfeng Li, Zhenqing Ye, Virginia ShapiroJohn A. Copland III, Taro Hitosugi, David Bernlohr, Jie Sun, Hu Zeng. bioRxiv 2020.04.22.028613; doi: https://doi.org/10.1101/2020.04.22.028613.

 » View on bioRxiv 

Suwanpradid J, Shih M, Pontius L, Yang B, Birukova A, Guttman-Yassky E, Corcoran DL, Que LG, Tighe RM and MacLeod AS. 2017. Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity. J Immunol. doi: 10.4049/jimmunol.1700739.

» View on Journal of Immunology

 Recombinant Mouse IL-5 (Carrier-free) 

 

Stearoyl-CoA desaturase mediated monounsaturated fatty acid availability supports humoral immunity. Xian Zhou, Xingxing Zhu, Chaofan Li, Yanfeng Li, Zhenqing Ye, Virginia Shapiro, John A. Copland III, Taro Hitosugi, David Bernlohr, Jie Sun, Hu Zeng. bioRxiv 2020.04.22.028613; doi: https://doi.org/10.1101/2020.04.22.028613.

 » View on bioRxiv 

Clones not Specified

Farmaki E, Kaza V, Papavassiliou AG, Chatzistamou I and Kiaris H. 2016. Induction of the MCP chemokine cluster cascade in the periphery by cancer cell-derived Ccl3. Cancer Lett. DOI: 10.1016/j.canlet.2016.12.028

» View on PubMed

Visvabharathy L and Freitag NE. 2017. Propofol sedation exacerbates kidney pathology and dissemination of bacteria during Staphylococcus aureus bloodstream infections.Infect Immun. doi: 10.1128/IAI.00097-17

» View on PubMed





PCR Kits

FastPROBE qPCR Hi-ROX Master Mix

Murphy S, Patrick K, Thoner T, Edwards RW and Gubbels Bupp MR. 2016. T cell up-regulation of CD127 is associated with reductions in the homeostatic set point of the peripheral Tcell pool during malnourishment. Biochemistry and Biophysics Reports. doi:10.1016/j.bbrep.2016.06.006

» View

CYBRFast™ 1-Step RT-qPCR Kit

Ramos Muniz MG, Palfreeman M, Setzu N, Sanchez MA, Saenz Portillo P, Garza KM, Gosselink KL, Spencer CT. Obesity Exacerbates the Cytokine Storm Elicited by Francisella tularensis Infection of Females and Is Associated with Increased Mortality. Biomed Res Int. 2018 Jun 26;2018:3412732. doi: 10.1155/2018/3412732

» View on PubMed

Manan M. Mehta, Samuel E. Weinberg, Elizabeth M. Steinert, Krishan Chhiba, Carlos Alberto Martinez, Peng Gao, Harris R. Perlman, Paul Bryce, Nissim Hay, and Navdeep S. Chandel. Hexokinase 2 is dispensable for T cell-dependent immunity. Cancer Metab. 2018 Aug 17;6:10. doi: 10.1186/s40170-018-0184-5

» View on PubMed

Classic++ Taq DNA Polymerase Master Mix

 

Lee MT, Le HH, Johnson EL. Dietary sphinganine is selectively assimilated by members of the mammalian gut microbiome. J Lipid Res. 2020;jlr.RA120000950. doi:10.1194/jlr.RA120000950.

» View on PubMed

FastSCRIPT cDNA Synthesis Kit

Murphy S, Patrick K, Thoner T, Edwards RW and Gubbels Bupp MR. 2016. T cell up-regulation of CD127 is associated with reductions in the homeostatic set point of the peripheral Tcell pool during malnourishment. Biochemistry and Biophysics Reports. doi:10.1016/j.bbrep.2016.06.006

» View




Caspase Inhibitors

Q-VD-OPH

Alam M, Kariya R, Kawaguchi A, Matsuda K, Kudo E and Okada S. 2016. Inhibition of Autophagy by Chloroquine Induces Apoptosis in Primary Effusion Lymphoma In Vitro and In Vivo Through Induction of Endoplasmic Reticulum Stress. Apoptosis. Volume 21(10), pp 1191–1201

» View on PubMed

Montero JA, Sanchez-Fernandez C, Lorda-Diez CI, Garcia-Porrero JA and Hurle JM. 2016. DNA damage precedes apoptosis during the regression of the interdigital tissue in vertebrate embryos. Sci. Rep. doi:10.1038/srep35478

» View on PubMed




Isotype Controls:

MOPC-21

 

Lam LKM, Watson AM, Ryman KD, Klimstra WB. Gamma-interferon exerts a critical early restriction on replication and dissemination of yellow fever virus vaccine strain 17D-204. NPJ Vaccines. 2018;3:5. Published 2018 Jan 23. doi:10.1038/s41541-017-0039-z.

» View on PubMed

Suwanpradid J, Shih M, Pontius L, Yang B, Birukova A, Guttman-Yassky E, Corcoran DL, Que LG, Tighe RM and MacLeod AS. 2017. Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity. J Immunol. doi: 10.4049/jimmunol.1700739.

» View on PubMed

O'Sullivan JA, Carroll DJ, Cao Y, Salicru AN and Bochner BS. 2017. Leveraging Siglec-8 endocytic mechanisms to kill human eosinophils and malignant mast cells. J Allergy Clin Immunol. doi: 10.1016/j.jaci.2017.06.028.

» View on PubMed

Hang Q, Isaji T, Hous S, Wang Y, Fukuda T and Gu J. 2017. A key regulator of cell adhesion: Identification and characterization of important N-glycosylation sites on integrin α5 for cell migration. Mol Cell Biol. doi: 10.1128/MCB.00558-16.

» View on PubMed

Sullivan RT, Kim CC, Fontana MF, Feeney ME, Jagannathan P, Boyle MJ, Drakeley CJ, Ssewanyana I, Nankya F, Mayanja-Kizza H, Dorsey G and Greenhouse B. 2015. PLoS Pathog. doi: 10.1371/journal.ppat.1004894.

» View on PubMed

Rat IgG1

Mukai M, Suruga N, Saeki N and Ogawa K. 2017. EphA receptors and ephrin-A ligands are upregulated by monocytic differentiation/maturation and promote cell adhesion and protrusion formation in HL60 monocytes. BMC Cell Biol. doi: 10.1186/s12860-017-0144-x.

» View on PubMed

Manlove LS, Berguam-Vrieze KE, Pauken KE, Williams RT, Jenkins MK and Farrar MA. 2015. Adaptive Immunity to Leukemia Is Inhibited by Cross-Reactive Induced Regulatory T Cells. J Immunol. 195(8): 40208-4037.

» View on PubMed

Hang Q, Isaji T, Hou S, Im S, Fukuda T and Gu J. 2015. Integrin α5 suppresses the phosphorylation of epidermal growth factor receptor and its cellular signaling of cell proliferation via N-glycosylation. J Biol Chem. doi: 10.1074/jbc.M115.682229.

» View on PubMed

Rat IgG2a

Manlove LS, Berguam-Vrieze KE, Pauken KE, Williams RT, Jenkins MK and Farrar MA. 2015. Adaptive Immunity to Leukemia Is Inhibited by Cross-Reactive Induced Regulatory T Cells. J Immunol. 195(8): 40208-4037.

» View on PubMed

Sato K, Honda S, Shibuya A and Shibuya K. Improved Protocol for Isolation of Naïve Follicular Dendritic Cells. 2016. Mol. Immunol. doi: 10.1016/j.molimm.2016.09.011

» View on PubMed




Second Step Reagents:

Streptavidin-APC

 

Noviski M, Mueller JL, Satterthwaite A, Garrett-Sinha LA, Brombacher F, Zikherman J. IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate. Elife. 2018;7:e35074. Published 2018 Mar 9. doi:10.7554/eLife.35074.

» View on PubMed



Not Specified:

Not Specified

Sanchez M, Kolar SL, Müller S, Reyes CN, Wolf AJ, Ogawa C, Singhania R, De Carvalho DD, Arditi M, Underhill DM, Martins GA and Liu GY. 2017. O-Acetylation of Peptidoglycan Limits Helper T Cell Priming and Permits Staphylococcus aureus Reinfection. Cell Host Microbe. doi: 10.1016/j.chom.2017.08.008.

» View on PubMed

Oh H, Grinberg-Bleyer Y, Liao W, Maloney D, Wang P, Wu Z, Wang J, Bhatt DM, Heise N, Schmid RM, Hayden MS, Klein U, Rabadan R and Ghosh S. 2017. An NF-κB Transcription-Factor-Dependent Lineage-Specific Transcriptional Program Promotes Regulatory T Cell Identity and Function. Immunity. doi: 10.1016/j.immuni.2017.08.010.

» View on PubMed

Grinberg-Bleyer Y, Oh H, Desrichard A, Bhatt DM, Caron R, Chan TA, Schmid RM, Klein U, Hayden MS and Ghosh S. 2017. NF-κB c-Rel Is Crucial for the Regulatory T Cell Immune Checkpoint in Cancer. Cell. doi: 10.1016/j.cell.2017.08.004.

» View on PubMed

Versteeg K, Menicucci AR, Woolsey C, Mire CE, Geisbert JB, Cross RW, Agans KN, Jeske D, Messaoudi I and Geisbert TW. 2017. Infection with the Makona variant results in a delayed and distinct host immune response compared to previous Ebola virus variants. Sci Rep. doi: 10.1038/s41598-017-09963-y.

» View on PubMed

Nabekura T, Gotthardt D, Niizuma K, Trsan T, Jenus T, Jonjic S and Lanier LL. 2017. Cutting Edge: NKG2D Signaling Enhances NK Cell Responses but Alone Is Insufficient To Drive Expansion during Mouse Cytomegalovirus Infection. J Immunol. doi: 10.4049/jimmunol.1700799.

» View on PubMed

Zaman TS, Arimochi H, Maruyama S, Ishifune C, Tsukumo SI, Kitamura A and Yasutomo K. 2017. Notch Balances Th17 and Induced Regulatory T Cell Functions in Dendritic Cells by Regulating Aldh1a2 Expression. J Immunol. doi: 10.4049/jimmunol.1700645.

» View on PubMed

Oguro H, McDonald JG, Zhao Z, Umetani M, Shaul PW and Morrison SJ. 2017. 27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy. J Clin Invest. doi: 10.1172/JCI94027.

» View on PubMed

Karmaus PWF, Herrada AA, Guy C, Neale G, Dhungana Y, Long L, Vogel P, Avila J, Clish CB and Chi H. 2017. Critical roles of mTORC1 signaling and metabolic reprogramming for M-CSF-mediated myelopoiesis. J Exp Med. doi: 10.1084/jem.20161855.

» View on PubMed

Lesteberg K, Orange J and Makedonas G. 2017. Recycling endosomes in human cytotoxic T lymphocytes constitute an auxiliary intracellular trafficking pathway for newly synthesized perforin. Immunol Res. doi: 10.1007/s12026-017-8945-8.

» View on PubMed

Arnold N and Messaoudi I. 2017. Simian varicella virus causes robust transcriptional changes in T cells that support viral replication. Virus Res. doi: 10.1016/j.virusres.2017.07.004.

» View on PubMed

Moghaddas F, Llamas R, De Nardo D, Martinez-Banaclocha H, Martinez-Garcia JJ, Mesa-Del-Castillo P, Baker PJ, Gargallo V, Mensa-Vilaro A, Canna S, Wicks IP, Pelegrin P, Arostegui JI and Masters SL. 2017. A novel Pyrin-Associated Autoinflammation with Neutrophilic Dermatosis mutation further defines 14-3-3 binding of pyrin and distinction to Familial Mediterranean Fever. Ann Rheum Dis. 2. doi: 10.1136/annrheumdis-2017-211473.

» View on PubMed

St Leger AJ, Desai JV, Drummond RA, Kugadas A, Almaghrabi F, Silver P, Raychaudhuri K, Gadjeva M, Iwakura Y, Lionakis MS and Caspi RR. 2017. An Ocular Commensal Protects against Corneal Infection by Driving an Interleukin-17 Response from Mucosal γδ T Cells. Immunity. doi: 10.1016/j.immuni.2017.06.014

» View on PubMed

Suwanpradid J, Shih M, Pontius L, Yang B, Birukova A, Guttman-Yassky E, Corcoran DL, Que LG, Tighe RM and MacLeod AS. 2017. Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity. J Immunol. doi: 10.4049/jimmunol.1700739.

» View on PubMed

O'Sullivan JA, Carroll DJ, Cao Y, Salicru AN and Bochner BS. 2017. Leveraging Siglec-8 endocytic mechanisms to kill human eosinophils and malignant mast cells. J Allergy Clin Immunol. doi: 10.1016/j.jaci.2017.06.028.

» View on PubMed

Tien SH, Crabtree JN, Gray HL and Peterson EJ. 2017. Immunologic response to vaccine challenge in pregnant PTPN22 R620W carriers and non-carriers. PLoS One. doi: 10.1371/journal.pone.0181338.

» View on PubMed