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Anti-Mouse Antibody Citations

CD3 (17A2)

 

Teghanemt A, Pulipati P, Misel-Wuchter K, Day K, Yorek MS, Yi R, Keen HL, Au C, Maretzky T, Gurung P, Littman DR, Issuree PD. CD4 expression in effector T cells depends on DNA demethylation over a developmentally established stimulus-responsive element. Nat Commun. 2022 Mar 18;13(1):1477. doi: 10.1038/s41467-022-28914-4. PMID: 35304452.

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Alam MM, Yang D, Li XQ, Liu J, Back TC, Trivett A, Karim B, Barbut D, Zasloff M, Oppenheim JJ. Alpha synuclein, the culprit in Parkinson disease, is required for normal immune function. Cell Rep. 2022 Jan 11;38(2):110090. doi: 10.1016/j.celrep.2021.110090. PMID: 35021075.

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Stephens WZ, Kubinak JL, Ghazaryan A, Bauer KM, Bell R, Buhrke K, Chiaro TR, Weis AM, Tang WW, Monts JK, Soto R, Ekiz HA, O'Connell RM, Round JL. Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition. Cell Rep. 2021 Nov 2;37(5):109916. doi: 10.1016/j.celrep.2021.109916. PMID: 34731608.

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Rappe JCF, Finsterbusch K, Crotta S, Mack M, Priestnall SL, Wack A. A TLR7 antagonist restricts interferon-dependent and -independent immunopathology in a mouse model of severe influenza. J Exp Med. 2021 Nov 1;218(11):e20201631. doi: 10.1084/jem.20201631. Epub 2021 Sep 2. PMID: 34473195.

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Nguyen NH, Glassman FY, Dingman RK, Shenoy GN, Wohlfert EA, Kay JG, Bankert RB, Balu-Iyer SV. Rational design of a nanoparticle platform for oral prophylactic immunotherapy to prevent immunogenicity of therapeutic proteins. Sci Rep. 2021 Sep 8;11(1):17853. doi: 10.1038/s41598-021-97333-0. PMID: 34497305; PMCID: PMC8426360.

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Sheppard S, Santosa EK, Lau CM, Violante S, Giovanelli P, Kim H, Cross JR, Li MO, Sun JC. Lactate dehydrogenase A-dependent aerobic glycolysis promotes natural killer cell anti-viral and anti-tumor function. Cell Rep. 2021 Jun 1;35(9):109210. doi: 10.1016/j.celrep.2021.109210. PMID: 34077737.

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Asakawa T, Onizawa M, Saito C, et al. Oral administration of D-serine prevents the onset and progression of colitis in mice. J Gastroenterol. 2021 Aug;56(8):732-745. doi: 10.1007/s00535-021-01792-1. Epub 2021 Jun 20. PMID: 34148144.

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Trott DW, Islam MT, Buckley DJ, Donato AJ, Dutson T, Sorensen ES, Cai J, Gogulamudi VR, Phuong TTT, Lesniewski LA. T lymphocyte depletion ameliorates age-related metabolic impairments in mice. Geroscience. 2021 Apr 24. doi: 10.1007/s11357-021-00368-4. PMID: 33893902.

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Wiedemann GM, Grassmann S, Lau CM, Rapp M, Villarino AV, Friedrich C, Gasteiger G, O'Shea JJ, Sun JC. Divergent Role for STAT5 in the Adaptive Responses of Natural Killer Cells. Cell Rep. 2020 Dec 15;33(11):108498. doi: 10.1016/j.celrep.2020.108498. PMID: 33326784.

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Ishida Y, Kuninaka Y, Nosaka M, Kimura A, Taruya A, Furuta M, Mukaida N, Kondo T. Prevention of CaCl2-induced aortic inflammation and subsequent aneurysm formation by the CCL3-CCR5 axis. Nat Commun. 2020 Nov 25;11(1):5994. doi: 10.1038/s41467-020-19763-0. PMID: 33239616.

» View on Nature Communications 

Diaz-Salazar C, Sun JC. Coordinated Viral Control by Cytotoxic Lymphocytes Ensures Optimal Adaptive NK Cell Responses. Cell Rep. 2020 Sep 22;32(12):108186. doi: 10.1016/j.celrep.2020.108186. PMID: 32966792. 

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Poudel B, Yorek MS, Mazgaeen L, Brown SA, Kanneganti TD, Gurung P. Acute IL-4 Governs Pathogenic T Cell Responses during Leishmania major Infection. Immunohorizons. 2020 Sep 18;4(9):546-560. doi: 10.4049/immunohorizons.2000076. PMID: 32948646.

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Clark PA, Sriramaneni RN, Jin WJ, et al.  In situ vaccination at a peripheral tumor site augments response against melanoma brain metastases. Journal for ImmunoTherapy of Cancer 2020;8:e000809. doi: 10.1136/jitc-2020-000809.

» View on BMJ Journals

Andersen TK, Huszthy PC, Gopalakrishnan RP, et al. Enhanced germinal center reaction by targeting vaccine antigen to major histocompatibility complex class II molecules. NPJ Vaccines. 2019;4:9. Published 2019 Feb 11. doi:10.1038/s41541-019-0101-0.

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CD3e (145-2C11)

 

Wu B, Zhang X, Chiang HC, Pan H, Yuan B, Mitra P, Qi L, Simonyan H, Young CN, Yvon E, Hu Y, Zhang N, Li R. RNA polymerase II pausing factor NELF in CD8+ T cells promotes antitumor immunity. Nat Commun. 2022 Apr 20;13(1):2155. doi: 10.1038/s41467-022-29869-2. PMID: 35444206; PMCID: PMC9021285.

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Rivera-Torruco G, Martínez-Mendiola CA, Angeles-Floriano T, Jaimes-Ortega GA, Maravillas-Montero JL, García-Contreras R, González Y, Juárez E, Nava P, Ortiz-Navarrete V, Medina-Contreras O, Licona-Limón P, Valle-Rios R. Isthmin 1 is Expressed by Progenitor-Like Cells in the Lung: Phenotypical Analysis of Isthmin 1+ Hematopoietic Stem-Like Cells in Homeostasis and during Infection. J Immunol Res. 2022 Apr 1;2022:2909487. doi: 10.1155/2022/2909487. PMID: 35402623; PMCID: PMC8993550.

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Brandi P, Conejero L, Cueto FJ, Martínez-Cano S, Dunphy G, Gómez MJ, Relaño C, Saz-Leal P, Enamorado M, Quintas A, Dopazo A, Amores-Iniesta J, Del Fresno C, Nistal-Villán E, Ardavín C, Nieto A, Casanovas M, Subiza JL, Sancho D. Trained immunity induction by the inactivated mucosal vaccine MV130 protects against experimental viral respiratory infections. Cell Rep. 2022 Jan 4;38(1):110184. doi: 10.1016/j.celrep.2021.110184. PMID: 34986349.

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Kim E, Paik D, Ramirez RN, Biggs DG, Park Y, Kwon HK, Choi GB, Huh JR. Maternal gut bacteria drive intestinal inflammation in offspring with neurodevelopmental disorders by altering the chromatin landscape of CD4+ T cells. Immunity. 2021 Nov 30:S1074-7613(21)00496-9. doi: 10.1016/j.immuni.2021.11.005. Epub ahead of print. PMID: 34879222.

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Stephens WZ, Kubinak JL, Ghazaryan A, Bauer KM, Bell R, Buhrke K, Chiaro TR, Weis AM, Tang WW, Monts JK, Soto R, Ekiz HA, O'Connell RM, Round JL. Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition. Cell Rep. 2021 Nov 2;37(5):109916. doi: 10.1016/j.celrep.2021.109916. PMID: 34731608.

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Kinsella S, Evandy CA, Cooper K, Iovino L, deRoos PC, Hopwo KS, Granadier DW, Smith CW, Rafii S, Dudakov JA. Attenuation of apoptotic cell detection triggers thymic regeneration after damage. Cell Rep. 2021 Oct 5;37(1):109789. doi: 10.1016/j.celrep.2021.109789. PMID: 34610317.

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Fu Z, Dean JW, Xiong L, et al. Mitochondrial transcription factor A in RORγt+ lymphocytes regulate small intestine homeostasis and metabolism. Nat Commun. 2021 Jul 22;12(1):4462. doi: 10.1038/s41467-021-24755-9. PMID: 34294718.

» View on Nature Communications

Ortega-Molina A, Lebrero-Fernández C, Sanz A, et al. Inhibition of Rag GTPase signaling in mice suppresses B cell responses and lymphomagenesis with minimal detrimental trade-offs. Cell Rep. 2021 Jul 13;36(2):109372. doi: 10.1016/j.celrep.2021.109372. PMID: 34260908. 

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Mohammadi MR, Rodriguez SM, Luong JC, et al. Exosome loaded immunomodulatory biomaterials alleviate local immune response in immunocompetent diabetic mice post islet xenotransplantation. Commun Biol. 2021 Jun 3;4(1):685. doi: 10.1038/s42003-021-02229-4. PMID: 34083739; PMCID: PMC8175379.

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Li K, Yuan Z, Lyu J, Ahn E, Davis SJ, Ahmed R, Zhu C. PD-1 suppresses TCR-CD8 cooperativity during T-cell antigen recognition. Nat Commun. 2021 May 12;12(1):2746. doi: 10.1038/s41467-021-22965-9. PMID: 33980853; PMCID: PMC8115078.

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Dikiy S, Li J, Bai L, Jiang M, Janke L, Zong X, Hao X, Hoyos B, Wang ZM, Xu B, Fan Y, Rudensky AY, Feng Y. A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance. Immunity. 2021 May 11;54(5):931-946.e11. doi: 10.1016/j.immuni.2021.03.020. Epub 2021 Apr 9. PMID: 33838102; PMCID: PMC8317508.

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C Khouili S, Cook ECL, Hernández-García E, Martínez-López M, Conde-Garrosa R, Iborra S. SHP-1 Regulates Antigen Cross-Presentation and Is Exploited by Leishmania to Evade Immunity. Cell Rep. 2020 Dec 1;33(9):108468. doi: 10.1016/j.celrep.2020.108468. PMID: 33264612.

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Saeki N, Imai Y. Reprogramming of synovial macrophage metabolism by synovial fibroblasts under inflammatory conditions. Cell Commun Signal. 2020 Nov 30;18(1):188. doi: 10.1186/s12964-020-00678-8. PMID: 33256735; PMCID: PMC7708128. 

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Castillo-González R, Cibrian D, Fernández-Gallego N, Ramírez-Huesca M, Saiz ML, Navarro MN, Fresno M, Fuente H, Sánchez-Madrid F. Galectin-1 expression in CD8+ T lymphocytes controls inflammation in contact hypersensitivity. J Invest Dermatol. 2020 Nov 9:S0022-202X(20)32281-8. doi: 10.1016/j.jid.2020.10.020. PMID: 33181141.

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Velasco-de Andrés M, Català C, Casadó-Llombart S, et al. The lymphocytic scavenger receptor CD5 shows therapeutic potential in mouse models of fungal infection. Antimicrob Agents Chemother. 2020 Oct 12:AAC.01103-20. doi: 10.1128/AAC.01103-20. PMID: 33046489. 

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Aihara R, Kunimura K, Watanabe M, Uruno T, Yamane N, Sakurai T, Sakata D, Nishimura F, Fukui Y. DOCK8 controls survival of group 3 innate lymphoid cells in the gut through Cdc42 activation. Int Immunol. 2020 Sep 28:dxaa066. doi: 10.1093/intimm/dxaa066. PMID: 32986079.   

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Yashiro T, Yura S, Tobita A, Toyoda Y, Kasakura K, Nishiyama C. Pterostilbene reduces colonic inflammation by suppressing dendritic cell activation and promoting regulatory T cell development. FASEB J. 2020 Sep 22. doi: 10.1096/fj.202001502R. PMID: 32964554.  

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Forte D, García-Fernández M, Sánchez-Aguilera A, Stavropoulou V, Fielding C, Martín-Pérez D, López JA, Costa ASH, Tronci L, Nikitopoulou E, Barber M, Gallipoli P, Marando L, Fernández de Castillejo CL, Tzankov A, Dietmann S, Cavo M, Catani L, Curti A, Vázquez J, Frezza C, Huntly BJ, Schwaller J, Méndez-Ferrer S. Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy. Cell Metab. 2020 Sep 16:S1550-4131(20)30479-4. doi: 10.1016/j.cmet.2020.09.001. PMID: 32966766.   

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Semionatto IF, Palameta S, Toscaro JM, Manrique-Rincón AJ, Ruas LP, Paes Leme AF, Bajgelman MC. Extracellular vesicles produced by immunomodulatory cells harboring OX40 ligand and 4-1BB ligand enhance antitumor immunity. Sci Rep. 2020 Sep 16;10(1):15160. doi: 10.1038/s41598-020-72122-3. PMID: 32939048.  

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Wu B, Chiang HC, Sun X, et al. Genetic ablation of adipocyte PD-L1 reduces tumor growth but accentuates obesity-associated inflammation. J Immunother Cancer. 2020;8(2):e000964. doi:10.1136/jitc-2020-000964.

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Chen D, Duan Z, Zhou W, et al. Japanese encephalitis virus-primed CD8+ T cells prevent antibody-dependent enhancement of Zika virus pathogenesis. J Exp Med. 2020;217(9):e20192152. doi:10.1084/jem.20192152.

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Even Fossum, Demo Yemane Tesfaye, Sonja Bobic, Arnar Gudjonsson, Ranveig Braathen, Mireille H. Lahoud, Irina Caminschi, Bjarne Bogen. Targeting Antigens to Different Receptors on Conventional Type 1 Dendritic Cells Impacts the Immune Response. The Journal of Immunology June 26, 2020, ji1901119; DOI: 10.4049/jimmunol.1901119.

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Weber A, Pawar HN, Klein JR. Thyroid stimulating hormone β-subunit splice variant is expressed in all fractional subsets of bone marrow hematopoietic cells and peripheral blood leukocytes and is modulated during bacterial infection. Gen Comp Endocrinol. 2020 Apr 30:113495. doi: 10.1016/j.ygcen.2020.113495

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Wen J, Wang YT, Valentine KM, Dos Santos Alves RP, Xu Z, Regla-Nava JA, Ngono AE, Young MP, Ferreira LCS4, Shresta S. CD4+T Cells Cross-Reactive with Dengue and Zika Viruses Protect against Zika Virus Infection. Cell Rep. 2020 Apr 28;31(4):107566. doi: 10.1016/j.celrep.2020.107566.

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Blagih J, Zani F, Chakravarty P, et al. Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses. Cell Rep. 2020;30(2):481-496.e6. doi:10.1016/j.celrep.2019.12.028.

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Elong Ngono A, Young MP, Bunz M, et al. CD4+ T cells promote humoral immunity and viral control during Zika virus infection [published correction appears in PLoS Pathog. 2019 May 28;15(5):e1007821]. PLoS Pathog. 2019;15(1):e1007474. Published 2019 Jan 24. doi:10.1371/journal.ppat.1007474.

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Kim IS, Gao Y, Welte T, et al. Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms. Nat Cell Biol. 2019;21(9):1113-1126. doi:10.1038/s41556-019-0373-7.

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Atif SM, Mack DG, McKee AS, et al. Protective role of B cells in sterile particulate-induced lung injury. JCI Insight. 2019;5(12):e125494. Published 2019 May 16. doi:10.1172/jci.insight.125494.

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Shimada K, Porritt RA, Markman JL, et al. T-Cell-Intrinsic Receptor Interacting Protein 2 Regulates Pathogenic T Helper 17 Cell Differentiation. Immunity. 2018;49(5):873-885.e7. doi:10.1016/j.immuni.2018.08.022.

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Adami AJ, Bracken SJ, Guernsey LA, et al. Early-life antibiotics attenuate regulatory T cell generation and increase the severity of murine house dust mite-induced asthma. Pediatr Res. 2018;84(3):426-434. doi:10.1038/s41390-018-0031-y.

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Nagasaka A, Mogi C, Ono H, Nishi T, Horii Y, Ohba Y, Sato K, Nakaya M, Okajima F and Kurose H. 2017. The proton-sensing G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) shows cardioprotective effects against myocardial infarction. Sci Rep. doi: 10.1038/s41598-017-07573-2.

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Furata Y, Tsai SH, Kinoshita M, Fujimoto K, Okumura R, Umemoto E, Kurashima Y, Kiyono H, Kayama H and Takeda K. 2017. E-NPP3 controls plasmacytoid dendritic cell numbers in the small intestine. PLoS One. doi: 10.1371/journal.pone.0172509

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Sato Y, Kato H, Ebina-Shibuya R, Itoh-Nakadai A, Okuyama R and Igarashi K. 2017. Bach2 Controls Homeostasis of Eosinophils by Restricting the Type-2 Helper Function of T Cells. Tohoku J Exp Med. doi: 10.1620/tjem.241.175

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Rydyznski C, Daniels KA, Karmele EP, Brooks TR, Mahl SE, Moran MT, Li C, Sutiwisesak R, Welsh RM and Waggoner SN. 2015. Generation of cellular immune memory and B-cell immunity is impaired by natural killer cells. Nat Commun. doi: 10.1038/ncomms7375.

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Van Vo A, Takenaka E, Shibuya A and Shibuya K. 2015. Expression of DNAM-1 (CD226) on inflammatory monocytes. Mol Immunol. 69: 70-76.

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Kawano M, Mabuchi S, Matsumoto Y, Sasano T, Takahashi R, Kuroda H, Kozasa K, Hashimoto K, Isobe A, Sawada K, Hamasaki T, Morii E and Kimura T. 2015. The significance of G-CSF expression and myeloid-derived suppressor cells in the chemoresistance of uterine cervical cancer. Sci Rep. 5:18217 doi:10.1038/srep18217.

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Oh JE, Lee MS, Kim YJ and Lee HK. 2016. OASL1 deficiency promotes antiviral protection against genital herpes simplex virus type 2 infection by enhancing type I interferon production. Sci Rep. doi: 10.1038/srep19089.

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Iwahashi C, Fujimoto M, Nomura S, Serada S, Nakai K, Ohguro N, Nishida K and Naka T. 2015. CTLA4-Ig suppresses development of experimental autoimmune uveitis in the induction and effector phases: comparison with blockade of interleukin-6. Exp Eye Res. doi: 10.1016/j.exer.2015.08.012.

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Neyt K, GeurtsvanKessel CH and Lambrecht BN. Double-negative T resident memory cells of the lung react to influenza virus infection via CD11chi dendritic cells. 2015. Mucosal Immunol. DOI 10.1038/mi2015.91.

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Giuilliams M, Dutertre C, Scott CL, McGovern N, Sichien D, Chakarov S, Gassen SV, Chen J, Poidinger M, De Prijck S, Tavernier SJ, Low I, Irac SE, Mattar CN, Sumatoh HR, Low GH, Chung TJ, Chan DK, Tan KK, Hon TL, Fossum E, Bogen B, Choolani M, Chan JK, Larbi A, Luche H, Henri S, Saeys Y, Newell EW, Lambrecht BN, Malissen B and Ginhoux F. 2016. Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species. Immunity. doi: 10.1016/j.immuni.2016.08.015

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Huo M, Huang Y, Qu D, Zhang H, Wong WT, Chawla A, Huang Y and Tian XY. 2016. Myeloid Bmal1 deletion increases monocyte recruitment and worsens atherosclerosis. FASEB J. doi:10.1096/fj.201601030R

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Uzodinma U. Uche, Ann R. Piccirillo, Shunsuke Kataoka, Stephanie J. Grebinoski, Louise M. D’Cruz, and Lawrence P. Kane. PIK3IP1/TrIP restricts activation of T cells through inhibition of PI3K/Akt. J Exp Med. 2018 Dec 3;215(12):3165-3179. doi: 10.1084/jem.20172018

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Kovats. A Major Population of Functional KLRG1- ILC2s in Female Lungs Contributes to a Sex Bias in ILC2 Numbers. Immunohorizons. 2018 Feb;2(2):74-86. doi: 10.4049/immunohorizons.1800008

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Derek W. Trobaugh, Chengqun Sun, Matthew D. Dunn, Douglas S. Reed, William B. Klimstra. Rational design of a live-attenuated eastern equine encephalitis virus vaccine through informed mutation of virulence determinants. PLoS Pathog. 2019 Feb 11;15(2):e1007584. doi: 10.1371/journal.ppat.1007584

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Erola Ainsua-Enrich, Ibrahim Hatipoglu, Sapana Kadel, Sean Turner, Jinny Paul, Simar Singh, Harini Bagavant, and Susan Kovats. IRF4-dependent dendritic cells regulate CD8+ T cell differentiation and memory responses in influenza infection. Mucosal Immunol. 2019 Jul;12(4):1025-1037. doi: 10.1038/s41385-019-0173-1

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Shiyang Li, John W. Bostick, Jian Ye, Joseph F. Urban, Jr., Dorina Avram, Liang Zhou. Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function. Immunity. 2018 Nov 20;49(5):915-928.e5. doi: 10.1016/j.immuni.2018.09.015

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Rita Kansal, Noah Richardson, Indira Neeli, Saleem Khawaja, Damian Chamberlain, Marium Ghani, Qurat-ul-ain Ghani, Louisa Balazs, Sarka Beranova-Giorgianni, Francesco Giorgianni, James N. Kochenderfer, Tony Marion, Lorraine M. Albritton, Marko Radic. Sustained B cell depletion by CD19-targeted CAR T cells is a highly effective treatment for murine lupus. Sci Transl Med. 2019 Mar 6;11(482). pii: eaav1648. doi: 10.1126/scitranslmed.aav1648

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» View on PubMed CD4 (SK3)

 

Roth TL, Li PJ, Blaeschke F, Nies JF, Apathy R, Mowery C, Yu R, Nguyen MLT, Lee Y, Truong A, Hiatt J, Wu D, Nguyen DN, Goodman D, Bluestone JA, Ye CJ, Roybal K, Shifrut E, Marson A. Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies. Cell. 2020 Apr 15. pii: S0092-8674(20)30332-9. doi: 10.1016/j.cell.2020.03.039.

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Sun CW, Wu LC, Knopick PL, Bradley DS, Townes T and Terman DS. 2017. Sickle Cells Produce Functional Immune Modulators and Cytotoxics. Am J Hematol. doi: 10.1002/ajh.24836.

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CD4 (RM4-5)

 

Hong H, Lee J, Park GY, Kim S, Park J, Park JS, Song Y, Lee S, Kim TJ, Lee YJ, Roh TY, Kwok SK, Kim SW, Tan Q, Lee Y. Postnatal regulation of B-1a cell development and survival by the CIC-PER2-BHLHE41 axis. Cell Rep. 2022 Feb 15;38(7):110386. doi: 10.1016/j.celrep.2022.110386. PMID: 35172136.

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Whittington KB, Prislovsky A, Beaty J, Albritton L, Radic M, Rosloniec EF. CD8+ T Cells Expressing an HLA-DR1 Chimeric Antigen Receptor Target Autoimmune CD4+ T Cells in an Antigen-Specific Manner and Inhibit the Development of Autoimmune Arthritis. J Immunol. 2021 Nov 24:ji2100643. doi: 10.4049/jimmunol.2100643. Epub ahead of print. PMID: 34819392.

» View on The Journal of Immunology

Baba T, Yoshida T, Tanabe Y, et al. Cytoplasmic DNA accumulation preferentially triggers cell death of myeloid leukemia cells by interacting with intracellular DNA sensing pathway. Cell Death Dis. 2021 Mar 26;12(4):322. doi: 10.1038/s41419-021-03587-x. PMID: 33771977.  

» View on Nature

Clark NM, Martinez LM, Murdock S, deLigio JT, Olex AL, Effi C, Dozmorov MG, Bos PD. Regulatory T Cells Support Breast Cancer Progression by Opposing IFN-γ-Dependent Functional Reprogramming of Myeloid Cells. Cell Rep. 2020 Dec 8;33(10):108482. doi: 10.1016/j.celrep.2020.108482. PMID: 33296659.

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Ishida Y, Kuninaka Y, Nosaka M, Kimura A, Taruya A, Furuta M, Mukaida N, Kondo T. Prevention of CaCl2-induced aortic inflammation and subsequent aneurysm formation by the CCL3-CCR5 axis. Nat Commun. 2020 Nov 25;11(1):5994. doi: 10.1038/s41467-020-19763-0. PMID: 33239616.

» View on Nature Communications 

Castillo-González R, Cibrian D, Fernández-Gallego N, Ramírez-Huesca M, Saiz ML, Navarro MN, Fresno M, Fuente H, Sánchez-Madrid F. Galectin-1 expression in CD8+ T lymphocytes controls inflammation in contact hypersensitivity. J Invest Dermatol. 2020 Nov 9:S0022-202X(20)32281-8. doi: 10.1016/j.jid.2020.10.020. PMID: 33181141.

» View on ScienceDirect

Park GY, Lee GW, Kim S, Hong H, et al. Deletion Timing of Cic Alleles during Hematopoiesis Determines the Degree of Peripheral CD4+ T Cell Activation and Proliferation. Immune Netw. 2020 Oct 27;20(5):e43. doi: 10.4110/in.2020.20.e43. PMID: 33163251; PMCID: PMC7609164.

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Poudel B, Yorek MS, Mazgaeen L, Brown SA, Kanneganti TD, Gurung P. Acute IL-4 Governs Pathogenic T Cell Responses during Leishmania major Infection. Immunohorizons. 2020 Sep 18;4(9):546-560. doi: 10.4049/immunohorizons.2000076. PMID: 32948646.

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Hiroshi Kobayashi and Keiyo Takubo. Protocol for the Maintenance of Quiescent Murine Hematopoietic Stem Cells. STAR Protocols.  Published 2 August 2020. https://doi.org/10.1016/j.xpro.2020.100078. 

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Kayla R. Kulhanek, Darienne R. Myers, Olga Ksionda, Yvonne Vercoulen, Damia Romero-Moya, Jeroen P. Roose.  Protocol for Barcoding T Cells Combined with Timed Stimulations. STAR Protocols 2020, 100067, ISSN 2666-1667.  https://doi.org/10.1016/j.xpro.2020.100067.

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Dolina JS, Lee J, Griswold RQ, Labarta-Bajo L, Kannan S, Greenbaum JA, Bahia El Idrissi N, Pont MJ, Croft M, Schoenberger SP. TLR9 Sensing of Self-DNA Controls Cell-Mediated Immunity to Listeria Infection via Rapid Conversion of Conventional CD4+ T Cells to Treg. Cell Rep. 2020 Apr 7;31(1):107249. doi: 10.1016/j.celrep.2020.01.040.

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Markman, J.L., Porritt, R.A., Wakita, D. et al. Loss of testosterone impairs anti-tumor neutrophil function. Nat Commun 11, 1613 (2020). https://doi.org/10.1038/s41467-020-153.

» View on Nature Communications

Blagih J, Zani F, Chakravarty P, et al. Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses. Cell Rep. 2020;30(2):481-496.e6. doi:10.1016/j.celrep.2019.12.028.

» View on PubMed

Kobayashi H, Morikawa T, Okinaga A, et al. Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo. Cell Rep. 2019;28(1):145-158.e9. doi:10.1016/j.celrep.2019.06.008.

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Agelidis AM, Hadigal SR, Jaishankar D and Shukla D. 2017. Viral Activation of Heparanase Drives Pathogenesis of Herpes Simplex Virus-1. Cell Rep. doi: 10.1016/j.celrep.2017.06.041.

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Conejero L, Khouili SC, Martínez-Cano S, Izquierdo HM, Brandi P and Sancho D. 2017. Lung CD103+ dendritic cells restrain allergic airway inflammation through IL-12 production. JCI Insight. doi: 10.1172/jci.insight.90420

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Bally APR, Lu P, Tang Y, Austin JW, Scharer CD, Ahmed R and Boss JM. 2015. NF-ΚB Regulates PD-1 Expression in Macrophages. J Immunol. 194(9): 4545-4554.

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Levine AG, Arvey A, Jin W and Rudensky AY. 2014. Continuous requirement for the TCR in regulatory T cell function. Nature Immunol. 15(11): 1070-1078.

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Onizawa M, Oshima S, Schulze-Topphoff U, Oses-Prieto JA, Lu T, Tavares R, Produhomme T, Duong B, Whang MI, Advincula R, Agelidis A, et al. 2015. The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis. Nat Immunol. 16(6): 618-627.

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Bapat SP, Nyoung Suh J, Fang S, Liu S, Zhang Y, Cheng A, Zhou C, Liang Y, LeBlanc M, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM and Zheng Y. 2015. Depletion of fat-resident Treg cells prevents age-associated insulin resistance. Nature. 528: 137-141.

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Weist BM, Kurd N, Boussier J, Chan SW and Robey EA. 2015. Thymic regulatory T cell niche size is dictated by limiting IL-2 from antigen-bearing dendritic cells and feedback competition. Nat Immunol. 16(6): 635-641.

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Sekiya T, Kondo T, Shichita T, Morita R, Ichinose H and Yoshimura A. 2015. Suppression of Th2 and Tfh immune reactions by Nr4a receptors in mature T reg cells. J Exp Med. 212(10): 1623-1640.

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Rios D, Wood MB, Li J, Chassaing B, Gewirtz AT and Williams IR. 2015. Antigen sampling by intestinal M cells is the principal pathway initiating mucosal IgA production to commensal enteric bacteria. Mucosal Immunol. doi: 10.1038/mi.2015.121.

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Mande P, Zirak B, Ko WC, Taravati K, Bride KL, Brodeur TY, Deng A, Dresser K, Jiang Z, Ettinger R, Fitzgerald KA, Rosenblum MD, Harris JE, Marshak-Rothstein A. Fas ligand promotes an inducible TLR-dependent model of cutaneous lupus-like inflammation. J Clin Invest. 2018 Jul 2;128(7):2966-2978. doi: 10.1172/JCI98219

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Jordy Saravia, Hu Zeng1, Yogesh Dhungana, Daniel Bastardo Blanco, Thanh-Long M. Nguyen, Nicole M. Chapman, Yanyan Wang, Apurva Kanneganti, Shaofeng Liu, Jana L. Raynor, Peter Vogel, Geoffrey Neale, Peter Carmeliet, Hongbo Chi. Homeostasis and transitional activation of regulatory T cells require c-Myc. Sci Adv. 2020 Jan 1;6(1):eaaw6443. doi: 10.1126/sciadv.aaw6443

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Hao Shi, Nicole M. Chapman, Jing Wen, Cliff Guy, Lingyun Long, Yogesh Dhungana, Sherri Rankin, Stephane Pelletier, Peter Vogel, Hong Wang, Junmin Peng, Kun-Liang Guan, and Hongbo Chi. Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb. Immunity. 2019 Dec 17;51(6):1012-1027.e7. doi: 10.1016/j.immuni.2019.10.001

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CD4 (GK1.5)

 

Avalos A, Tietsort JT, Suwankitwat N, Woods JD, Jackson SW, Christodoulou A, Morrill C, Liggitt HD, Zhu C, Li QZ, Bui KK, Park H, Iritani BM. Hem-1 regulates protective humoral immunity and limits autoantibody production in a B cell-specific manner. JCI Insight. 2022 May 9;7(9):e153597. doi: 10.1172/jci.insight.153597. PMID: 35531955; PMCID: PMC9090261.

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Brian BF 4th, Sauer ML, Greene JT, Senevirathne SE, Lindstedt AJ, Funk OL, Ruis BL, Ramirez LA, Auger JL, Swanson WL, Nunez MG, Moriarity BS, Lowell CA, Binstadt BA, Freedman TS. A dominant function of LynB kinase in preventing autoimmunity. Sci Adv. 2022 Apr 22;8(16):eabj5227. doi: 10.1126/sciadv.abj5227. Epub 2022 Apr 22. PMID: 35452291.

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Prakhar P, Gonzalez V, Park JH. High-yield enrichment of mouse small intestine intraepithelial lymphocytes by immunomagnetic depletion of EpCAM+ cells. STAR Protoc. 2022 Feb 25;3(1):101207. doi: 10.1016/j.xpro.2022.101207. PMID: 35243383; PMCID: PMC8885746.

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Brandi P, Conejero L, Cueto FJ, Martínez-Cano S, Dunphy G, Gómez MJ, Relaño C, Saz-Leal P, Enamorado M, Quintas A, Dopazo A, Amores-Iniesta J, Del Fresno C, Nistal-Villán E, Ardavín C, Nieto A, Casanovas M, Subiza JL, Sancho D. Trained immunity induction by the inactivated mucosal vaccine MV130 protects against experimental viral respiratory infections. Cell Rep. 2022 Jan 4;38(1):110184. doi: 10.1016/j.celrep.2021.110184. PMID: 34986349.

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Chun N, Ang RL, Chan M, Fairchild RL, Baldwin Iii WM, Horwitz JK, Gelles JD, Chipuk JE, Kelliher MA, Pavlov VI, Li Y, Homann D, Heeger PS, Ting AT. T cell-derived tumor necrosis factor induces cytotoxicity by activating RIPK1-dependent target cell death. JCI Insight. 2021 Nov 9:e148643. doi: 10.1172/jci.insight.148643. Epub ahead of print. PMID: 34752416.

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Stephens WZ, Kubinak JL, Ghazaryan A, Bauer KM, Bell R, Buhrke K, Chiaro TR, Weis AM, Tang WW, Monts JK, Soto R, Ekiz HA, O'Connell RM, Round JL. Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition. Cell Rep. 2021 Nov 2;37(5):109916. doi: 10.1016/j.celrep.2021.109916. PMID: 34731608.

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Sun Y, Lu D, Yin Y, Song J, Liu Y, Hao W, Qi F, Zhang G, Zhang X, Liu L, Lin Z, Liang H, Zhao X, Jin Y, Yin Y. PTENα functions as an immune suppressor and promotes immune resistance in PTEN-mutant cancer. Nat Commun. 2021 Aug 26;12(1):5147. doi: 10.1038/s41467-021-25417-6. PMID: 34446716.

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Fu Z, Dean JW, Xiong L, et al. Mitochondrial transcription factor A in RORγt+ lymphocytes regulate small intestine homeostasis and metabolism. Nat Commun. 2021 Jul 22;12(1):4462. doi: 10.1038/s41467-021-24755-9. PMID: 34294718.

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Trott DW, Islam MT, Buckley DJ, Donato AJ, Dutson T, Sorensen ES, Cai J, Gogulamudi VR, Phuong TTT, Lesniewski LA. T lymphocyte depletion ameliorates age-related metabolic impairments in mice. Geroscience. 2021 Apr 24. doi: 10.1007/s11357-021-00368-4. PMID: 33893902.

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Sumiyoshi M, Kotani Y, Ikuta Y, et al. Arf1 and Arf6 Synergistically Maintain Survival of T Cells during Activation. J Immunol. 2020 Dec 11:ji2000971. doi: 10.4049/jimmunol.2000971. PMID: 33310872. 

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C Khouili S, Cook ECL, Hernández-García E, Martínez-López M, Conde-Garrosa R, Iborra S. SHP-1 Regulates Antigen Cross-Presentation and Is Exploited by Leishmania to Evade Immunity. Cell Rep. 2020 Dec 1;33(9):108468. doi: 10.1016/j.celrep.2020.108468. PMID: 33264612.

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Li C, Park JH. Assessing IL-2-Induced STAT5 Phosphorylation in Fixed, Permeabilized Foxp3+ Treg Cells by Multiparameter Flow Cytometry. STAR Protoc. 2020 Dec 1;1(3):100195. doi: 10.1016/j.xpro.2020.100195. PMID: 33377089; PMCID: PMC7757559.

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Shen M, Song Y, Ichinose T, et al. In vivo immune activation of splenocytes following exposure to tar from Asian sand dust. J Toxicol Environ Health A. 2020;1-10. doi:10.1080/15287394.2020.1806160.  

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Clark PA, Sriramaneni RN, Jin WJ, et al.  In situ vaccination at a peripheral tumor site augments response against melanoma brain metastases. Journal for ImmunoTherapy of Cancer 2020;8:e000809. doi: 10.1136/jitc-2020-000809.

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Blagih J, Zani F, Chakravarty P, et al. Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses. Cell Rep. 2020;30(2):481-496.e6. doi:10.1016/j.celrep.2019.12.028.

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Andersen TK, Huszthy PC, Gopalakrishnan RP, et al. Enhanced germinal center reaction by targeting vaccine antigen to major histocompatibility complex class II molecules. NPJ Vaccines. 2019;4:9. Published 2019 Feb 11. doi:10.1038/s41541-019-0101-0.

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Kim IS, Gao Y, Welte T, et al. Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms. Nat Cell Biol. 2019;21(9):1113-1126. doi:10.1038/s41556-019-0373-7.

» View on PubMed

Yang BH, Wang K, Wan S, et al. TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases. Cell Rep. 2019;27(12):3629-3645.e6. doi:10.1016/j.celrep.2019.05.061.

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Lam LKM, Watson AM, Ryman KD, Klimstra WB. Gamma-interferon exerts a critical early restriction on replication and dissemination of yellow fever virus vaccine strain 17D-204. NPJ Vaccines. 2018;3:5. Published 2018 Jan 23. doi:10.1038/s41541-017-0039-z.

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Shimada K, Porritt RA, Markman JL, et al. T-Cell-Intrinsic Receptor Interacting Protein 2 Regulates Pathogenic T Helper 17 Cell Differentiation. Immunity. 2018;49(5):873-885.e7. doi:10.1016/j.immuni.2018.08.022.

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Manrique-Rincón AJ, Beraldo CM, Toscaro JM and Bajgelman MC. 2017. Exploring Synergy in Combinations of Tumor-Derived Vaccines That Harbor 4-1BBL, OX40L, and GM-CSF. Front Immunol. doi: 10.3389/fimmu.2017.01150.

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Kurosawa M, Arakaki R, Yamada A, Tsunematsu T, Kudo Y, Sprent J and Ishimaru N. 2017. NF-κB2 Controls Migratory Activity of Memory T Cells by Regulating Expression of CXCR4 in A Mouse Model of Sjögren's Syndrome. Arthritis Rheumatol. doi: 10.1002/art.40230.

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Trott DW, Henson GD, Ho MHT, Allison SA, Lesniewski LA and Donato AJ. 2016. Age-related arterial immune cell infiltration in mice is attenuated by caloric restriction or voluntary exercise. Exp. Gerontol. DOI: 10.1016/j.exger.2016.12.016

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Zander RA, Guthmiller JJ, Graham AC, Pope RL, Burke BE, Carr DJ and Butler NS. 2016. Type I Interferons Induce T Regulatory 1 Responses and Restrict Humoral Immunity during Experimental Malaria. PLOS Pathogens. DOI:10.1371/journal.ppat.1005945

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Kitai Y, Kawasaki T, Sueyoshi T, Kobiyama K, Ishii KJ, Zou J, Akira S, Matsuda T and Kawai T. 2017. DNA-Containing Exosomes Derived from Cancer Cells Treated with Topotecan Activate a STING-Dependent Pathway and Reinforce Antitumor Immunity. J. Immunol. DOI: 10.4049/jimmunol.1601694

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Higashino-Kameda M, Yabe-Wada T, Matsuba S, Takeda K, Anzawa K, Mochizuki T, Makimura K, Saijo S, Iwakura Y, Toga H and Nakamura A. 2015. A critical rold of Dectin-1 in hypersensitivity pneumonitis. Inflamm Res. DOI 10.1007/s00011-015-0910-1.

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Fiege JK, Burback Bj and Shimizu Y. 2015. Negative Regulation of Memory Phenotype CD8 T Cell Conversion by Adhesion and Degranulation-Promoting Adapter Protein. J Immunol. 195(7): 3119-3128.

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Oh JE, Lee MS, Kim YJ and Lee HK. 2016. OASL1 deficiency promotes antiviral protection against genital herpes simplex virus type 2 infection by enhancing type I interferon production. Sci Rep. doi: 10.1038/srep19089.

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Cruz-Adalia A, Ramirez-Santiago G, Torres-Torresano M, Garcia-Ferreras R and Veiga Chacon E. 2016.T Cells Capture Bacteria by Transinfection from Dendritic Cells. J Vis Exp. (107), e52976, doi: 10.3791/52976

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Sato Y, Mii A, Hamazaki Y, Fujita H, Nakata H, Masuda K, Nishiyama S, Shibuya S, Haga H, Ogawa O, Shimizu A, Narumiya S, Kaisho T, Arita M, Yanagisawa M, Miyasaka M, Sharma K, Minato N, Kawamoto H and Yanagita M. 2016. Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney. JCI Insight. 2016;1(11):e87680. doi:10.1172/jci.insight.87680.

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Watson AM, Matthew Lam LK, Klimstra WB and Ryman KD. 2016. The 17D-204 Vaccine Strain-Induced Protection Against Virulent Yellow Fever Virus is Mediated by Humoral Immunity and CD4+ But Not CD8+ T Cells. PLoS Pathog. doi:10.1371/journal.ppat.1005786

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Huo M, Huang Y, Qu D, Zhang H, Wong WT, Chawla A, Huang Y and Tian XY. 2016. Myeloid Bmal1 deletion increases monocyte recruitment and worsens atherosclerosis. FASEB J. doi:10.1096/fj.201601030R

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Uzodinma U. Uche, Ann R. Piccirillo, Shunsuke Kataoka, Stephanie J. Grebinoski, Louise M. D’Cruz, and Lawrence P. Kane. PIK3IP1/TrIP restricts activation of T cells through inhibition of PI3K/Akt. J Exp Med. 2018 Dec 3;215(12):3165-3179. doi: 10.1084/jem.20172018

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Avery L, Filderman J, Szymczak-Workman AL, Kane LP4. Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2455-2460. doi: 10.1073/pnas.1712107115

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Rita Kansal, Noah Richardson, Indira Neeli, Saleem Khawaja, Damian Chamberlain, Marium Ghani, Qurat-ul-ain Ghani, Louisa Balazs, Sarka Beranova-Giorgianni, Francesco Giorgianni, James N. Kochenderfer, Tony Marion, Lorraine M. Albritton, Marko Radic. Sustained B cell depletion by CD19-targeted CAR T cells is a highly effective treatment for murine lupus. Sci Transl Med. 2019 Mar 6;11(482). pii: eaav1648. doi: 10.1126/scitranslmed.aav1648

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Qiumei Du, Ashley R. Hoover, Igor Dozmorov, Ondine B. Cleaver,Joshua T. Mendell, Nicolai S.C. van Oers. MIR205HG Is a Long Noncoding RNA that Regulates Growth Hormone and Prolactin Production in the Anterior Pituitary. Dev Cell. 2019 May 20;49(4):618-631.e5. doi: 10.1016/j.devcel.2019.03.012

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CD5 (53-7.3)

 

Shiyang Li, John W. Bostick, Jian Ye, Joseph F. Urban, Jr., Dorina Avram, Liang Zhou. Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function. Immunity. 2018 Nov 20;49(5):915-928.e5. doi: 10.1016/j.immuni.2018.09.015

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Noviski M, Mueller JL, Satterthwaite A, Garrett-Sinha LA, Brombacher F, Zikherman J. IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate. Elife. 2018;7:e35074. Published 2018 Mar 9. doi:10.7554/eLife.35074.

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Oguro H, McDonald JG, Zhao Z, Umetani M, Shaul PW and Morrison SJ. 2017. 27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy. J Clin Invest. doi: 10.1172/JCI94027.

» View on PubMed

CD8a (OKT8)

Mishra S, Liao W, Liu Y, Yang M, Ma C, Wu H, Zhao M, Zhang X, Qiu Y, Lu Q, Zhang N. TGF-β and Eomes control the homeostasis of CD8+ regulatory T cells. J Exp Med. 2021 Jan 4;218(1):e20200030. doi: 10.1084/jem.20200030. PMID: 32991667; PMCID: PMC7527976.

» View on PubMed

 

Roth TL, Li PJ, Blaeschke F, Nies JF, Apathy R, Mowery C, Yu R, Nguyen MLT, Lee Y, Truong A, Hiatt J, Wu D, Nguyen DN, Goodman D, Bluestone JA, Ye CJ, Roybal K, Shifrut E, Marson A. Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies. Cell. 2020 Apr 15. pii: S0092-8674(20)30332-9. doi: 10.1016/j.cell.2020.03.039.

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Sun CW, Wu LC, Knopick PL, Bradley DS, Townes T and Terman DS. 2017. Sickle Cells Produce Functional Immune Modulators and Cytotoxics. Am J Hematol. doi: 10.1002/ajh.24836.

» View on PubMed

CD8a (53-6.7)

 

Brian BF 4th, Sauer ML, Greene JT, Senevirathne SE, Lindstedt AJ, Funk OL, Ruis BL, Ramirez LA, Auger JL, Swanson WL, Nunez MG, Moriarity BS, Lowell CA, Binstadt BA, Freedman TS. A dominant function of LynB kinase in preventing autoimmunity. Sci Adv. 2022 Apr 22;8(16):eabj5227. doi: 10.1126/sciadv.abj5227. Epub 2022 Apr 22. PMID: 35452291.

» View on PubMed

Burrack AL, Schmiechen ZC, Patterson MT, Miller EA, Spartz EJ, Rollins MR, Raynor JF, Mitchell JS, Kaisho T, Fife BT, Stromnes IM. Distinct myeloid antigen-presenting cells dictate differential fates of tumor-specific CD8+ T cells in pancreatic cancer. JCI Insight. 2022 Apr 8;7(7):e151593. doi: 10.1172/jci.insight.151593. PMID: 35393950. 

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Kim SY, Gupta P, Johns SC, Zuniga EI, Teijaro JR, Fuster MM. Genetic alteration of heparan sulfate in CD11c + immune cells inhibits inflammation and facilitates pathogen clearance during influenza A virus infection. Sci Rep. 2022 Mar 30;12(1):5382. doi: 10.1038/s41598-022-09197-7. PMID: 35354833; PMCID: PMC8968721.

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Sin JH, Kashyap S, Acenas D, Cortez JT, Lee J, Marson A, Matloubian M, Waterfield MR. ATF7ip Targets Transposable Elements for H3K9me3 Deposition to Modify CD8+ T Cell Effector and Memory Responses. J Immunol. 2022 Feb 2:ji2100996. doi: 10.4049/jimmunol.2100996. Epub ahead of print. PMID: 35110421

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Alam MM, Yang D, Li XQ, Liu J, Back TC, Trivett A, Karim B, Barbut D, Zasloff M, Oppenheim JJ. Alpha synuclein, the culprit in Parkinson disease, is required for normal immune function. Cell Rep. 2022 Jan 11;38(2):110090. doi: 10.1016/j.celrep.2021.110090. PMID: 35021075.

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Sun Y, Lu D, Yin Y, Song J, Liu Y, Hao W, Qi F, Zhang G, Zhang X, Liu L, Lin Z, Liang H, Zhao X, Jin Y, Yin Y. PTENα functions as an immune suppressor and promotes immune resistance in PTEN-mutant cancer. Nat Commun. 2021 Aug 26;12(1):5147. doi: 10.1038/s41467-021-25417-6. PMID: 34446716.

» View on Nature Communications

Pingili AK, Chaib M, Sipe LM, et al. Immune checkpoint blockade reprograms systemic immune landscape and tumor microenvironment in obesity-associated breast cancer. Cell Rep. 2021 Jun 22;35(12):109285. doi: 10.1016/j.celrep.2021.109285. PMID: 34161764.

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Burbach BJ, O'Flanagan SD, Shao Q, et al. Irreversible electroporation augments checkpoint immunotherapy in prostate cancer and promotes tumor antigen-specific tissue-resident memory CD8+ T cells. Nat Commun. 2021 Jun 23;12(1):3862. doi: 10.1038/s41467-021-24132-6. PMID: 34162858.

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Wu M, Xia X, Hu J, Fowlkes NW, Li S. WSX1 act as a tumor suppressor in hepatocellular carcinoma by downregulating neoplastic PD-L1 expression. Nat Commun. 2021 Jun 9;12(1):3500. doi: 10.1038/s41467-021-23864-9. PMID: 34108491; PMCID: PMC8190270.

» View on Nature Communications

Trott DW, Islam MT, Buckley DJ, Donato AJ, Dutson T, Sorensen ES, Cai J, Gogulamudi VR, Phuong TTT, Lesniewski LA. T lymphocyte depletion ameliorates age-related metabolic impairments in mice. Geroscience. 2021 Apr 24. doi: 10.1007/s11357-021-00368-4. PMID: 33893902.

» View on PubMed

Baba T, Yoshida T, Tanabe Y, et al. Cytoplasmic DNA accumulation preferentially triggers cell death of myeloid leukemia cells by interacting with intracellular DNA sensing pathway. Cell Death Dis. 2021 Mar 26;12(4):322. doi: 10.1038/s41419-021-03587-x. PMID: 33771977.  

» View on Nature

Sumiyoshi M, Kotani Y, Ikuta Y, et al. Arf1 and Arf6 Synergistically Maintain Survival of T Cells during Activation. J Immunol. 2020 Dec 11:ji2000971. doi: 10.4049/jimmunol.2000971. PMID: 33310872. 

» View on PubMed

Clark NM, Martinez LM, Murdock S, deLigio JT, Olex AL, Effi C, Dozmorov MG, Bos PD. Regulatory T Cells Support Breast Cancer Progression by Opposing IFN-γ-Dependent Functional Reprogramming of Myeloid Cells. Cell Rep. 2020 Dec 8;33(10):108482. doi: 10.1016/j.celrep.2020.108482. PMID: 33296659.

» View on ScienceDirect

C Khouili S, Cook ECL, Hernández-García E, Martínez-López M, Conde-Garrosa R, Iborra S. SHP-1 Regulates Antigen Cross-Presentation and Is Exploited by Leishmania to Evade Immunity. Cell Rep. 2020 Dec 1;33(9):108468. doi: 10.1016/j.celrep.2020.108468. PMID: 33264612.

» View on PubMed

Mishra S, Liao W, Liu Y, Yang M, Ma C, Wu H, Zhao M, Zhang X, Qiu Y, Lu Q, Zhang N. TGF-β and Eomes control the homeostasis of CD8+ regulatory T cells. J Exp Med. 2021 Jan 4;218(1):e20200030. doi: 10.1084/jem.20200030. PMID: 32991667; PMCID: PMC7527976.

» View on PubMed

Ishida Y, Kuninaka Y, Nosaka M, Kimura A, Taruya A, Furuta M, Mukaida N, Kondo T. Prevention of CaCl2-induced aortic inflammation and subsequent aneurysm formation by the CCL3-CCR5 axis. Nat Commun. 2020 Nov 25;11(1):5994. doi: 10.1038/s41467-020-19763-0. PMID: 33239616.

» View on Nature Communications 

Castillo-González R, Cibrian D, Fernández-Gallego N, Ramírez-Huesca M, Saiz ML, Navarro MN, Fresno M, Fuente H, Sánchez-Madrid F. Galectin-1 expression in CD8+ T lymphocytes controls inflammation in contact hypersensitivity. J Invest Dermatol. 2020 Nov 9:S0022-202X(20)32281-8. doi: 10.1016/j.jid.2020.10.020. PMID: 33181141.

» View on ScienceDirect

Poudel B, Yorek MS, Mazgaeen L, Brown SA, Kanneganti TD, Gurung P. Acute IL-4 Governs Pathogenic T Cell Responses during Leishmania major Infection. Immunohorizons. 2020 Sep 18;4(9):546-560. doi: 10.4049/immunohorizons.2000076. PMID: 32948646.

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Sakamoto A, Maruyama M. Contribution of DOCK11 to the Expansion of Antigen-Specific Populations among Germinal Center B Cells. Immunohorizons. 2020;4(9):520-529. Published 2020 Sep 2. doi:10.4049/immunohorizons.2000048

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Wali S, Flores JR, Jaramillo AM, et al. Immune Modulation to Improve Survival of Viral Pneumonia in Mice.  Am J Respir Cell Mol Biol. 2020;10.1165/rcmb.2020-0241OC. doi:10.1165/rcmb.2020-0241OC

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Kotaki R, Kawashima M, Yamaguchi A, et al. Overexpression of miR-669m inhibits erythroblast differentiation. Sci Rep. 2020;10(1):13554. Published 2020 Aug 11. doi:10.1038/s41598-020-70442-y.

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Hiroshi Kobayashi and Keiyo Takubo. Protocol for the Maintenance of Quiescent Murine Hematopoietic Stem Cells. STAR Protocols.  Published 2 August 2020. https://doi.org/10.1016/j.xpro.2020.100078. 

» View on ScienceDirect

Slade CD, Reagin KL, Lakshmanan HG, Klonowski KD, Watford WT. Placenta-specific 8 limits IFNγ production by CD4 T cells in vitro and promotes establishment of influenza-specific CD8 T cells in vivo. PLoS One. 2020;15(7):e0235706. Published 2020 Jul 8. doi:10.1371/journal.pone.0235706.

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Liao, W., Ma, C., Zhang, N. Isolation of Mouse Kidney-Resident CD8+ T cells for Flow Cytometry Analysis. J. Vis. Exp. (160), e61559, doi:10.3791/61559 (2020).

» View on JoVE Journal

Dolina JS, Lee J, Griswold RQ, Labarta-Bajo L, Kannan S, Greenbaum JA, Bahia El Idrissi N, Pont MJ, Croft M, Schoenberger SP. TLR9 Sensing of Self-DNA Controls Cell-Mediated Immunity to Listeria Infection via Rapid Conversion of Conventional CD4+ T Cells to Treg. Cell Rep. 2020 Apr 7;31(1):107249. doi: 10.1016/j.celrep.2020.01.040.

» View on ScienceDirect

Kim IS, Gao Y, Welte T, et al. Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms. Nat Cell Biol. 2019;21(9):1113-1126. doi:10.1038/s41556-019-0373-7.

» View on PubMed

Yang BH, Wang K, Wan S, et al. TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases. Cell Rep. 2019;27(12):3629-3645.e6. doi:10.1016/j.celrep.2019.05.061.

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Kobayashi H, Morikawa T, Okinaga A, et al. Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo. Cell Rep. 2019;28(1):145-158.e9. doi:10.1016/j.celrep.2019.06.008.

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Adami AJ, Bracken SJ, Guernsey LA, et al. Early-life antibiotics attenuate regulatory T cell generation and increase the severity of murine house dust mite-induced asthma. Pediatr Res. 2018;84(3):426-434. doi:10.1038/s41390-018-0031-y.

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Shimada K, Porritt RA, Markman JL, et al. T-Cell-Intrinsic Receptor Interacting Protein 2 Regulates Pathogenic T Helper 17 Cell Differentiation. Immunity. 2018;49(5):873-885.e7. doi:10.1016/j.immuni.2018.08.022.

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Ganuza M, Hall T, Finkelstein D, Chabot A, Kang G and McKinney-Freeman S. (2017) Lifelong haematopoiesis is established by hundreds of precursors throughout mammalian ontogeny. Nat Cell Biol. DOI: 10.1038/ncb3607

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Conejero L, Khouili SC, Martínez-Cano S, Izquierdo HM, Brandi P and Sancho D. 2017. Lung CD103+ dendritic cells restrain allergic airway inflammation through IL-12 production. JCI Insight. doi: 10.1172/jci.insight.90420

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Ratiu JJ, Racine JJ, Hasham MG, Wang Q, Branca JA, Chapman HD, Zhu J, Donghia N, Philip V, Schott WH, Wasserfall C, Atkinson MA, Mills KD, Leeth CM and Serreze DV. 2017. Genetic and Small Molecule Disruption of the AID/RAD51 Axis Similarly Protects Nonobese Diabetic Mice from Type 1 Diabetes through Expansion of Regulatory B Lymphocytes. J Immunol. doi: 10.4049/jimmunol.1700024.

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Shiokawa A, Kotaki R, Takano T, Nakajima-Adachi H and Hachimura S. 2017. Mesenteric lymph node CD11b- CD103+ PD-L1High dendritic cells highly induce regulatory T cells. Immunology. doi: 10.1111/imm.12747

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Oguro H, McDonald JG, Zhao Z, Umetani M, Shaul PW and Morrison SJ. 2017. 27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy. J Clin Invest. doi: 10.1172/JCI94027.

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Kersh AE, Edwards LJ and Evavold BD. 2014. Progression of Relapsing-Remitting Demyelinating Disease Does Not Require Increased TCR Affinity or Epitope Spread. J. Immunol. 193(9): 4429-4438.

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Bally APR, Lu P, Tang Y, Austin JW, Scharer CD, Ahmed R and Boss JM. 2015. NF-ΚB Regulates PD-1 Expression in Macrophages. J Immunol. 194(9): 4545-4554.

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Han BY, Wu S, Foo C-S, Horton RM, Jenne CN, Watson SR, Whittle B, Goodnow CC and Cyster JG. 2014. Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment. eLife doi: 10.7554/eLife.03549

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Martinez RJ, Neeld DK and Evavold BD. 2015. Identification of T cell clones without the need for sequencing. J Immunol Methods. doi: 10.1016/j.jim.2015.04.018.

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Weist BM, Kurd N, Boussier J, Chan SW and Robey EA. 2015. Thymic regulatory T cell niche size is dictated by limiting IL-2 from antigen-bearing dendritic cells and feedback competition. Nat Immunol. 16(6): 635-641.

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Fiege JK, Burback Bj and Shimizu Y. 2015. Negative Regulation of Memory Phenotype CD8 T Cell Conversion by Adhesion and Degranulation-Promoting Adapter Protein. J Immunol. 195(7): 3119-3128.

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Manz BN, Tan YX, Courtney A, Rutaganira F, Palmer E, Shokat KM and Weiss A. 2015. Small molecule inhibition of Csk alters affinity recognition by T cells. Elife. doi: 10.7554/eLife.08088.

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Finkin S, Yuan D, Stein I, Taniguchi K, Weber A, Unger K, Browning JL, Goossens N, Nakagawa S, Gunasekara G, Schwartz ME et al. 2015. Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma. Nat Immunol. doi: 10.1038/ni.3290.

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Carey AJ, Gracias DT, Thayer JL, Boesteanu AC, Kumova OK, Mueller YM, Hope JL, Fraietta JA, van Zessen DB and Katsikis PD. 2016. Rapid Evolution of the CD8+ TCR Repertoire in Neonatal Mice. J Immunol. doi: 10.4049/​jimmunol.1502126.

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Come C, Cvrljevic A, Khan MM, Treise I, Adler T, Aguilar-Pimental JA, Au-Yeung B, Sittig E, Laajala TD, Chen Y, Oeder S, Calzada-Wack J, Horsch M, Aittokallio T, Busch DH, Ollert MW, Neff F, Beckers J, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Chen Z, Lahesmaa R, and Westermarck J. 2016. CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection. PLoS ONE 11(4):e0152996. doi:10.1371/journal.pone.0152996

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Martin SD, Brown SD, Wick DA, Nielsen JS, Kroeger DR, Twumasi-Boateng K, Holt RA, and Nelson BH. 2016. Low Mutation Burden in Ovarian Cancer May Limit the Utility of Neoantigen-Targeted Vaccines. PLoS ONE. doi:10.1371/journal.pone.0155189

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Watson AM, Matthew Lam LK, Klimstra WB and Ryman KD. 2016. The 17D-204 Vaccine Strain-Induced Protection Against Virulent Yellow Fever Virus is Mediated by Humoral Immunity and CD4+ But Not CD8+ T Cells. PLoS Pathog. doi:10.1371/journal.ppat.1005786

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Asirvatham-Jeyaraj N, Fiege JK, Han R, Foss J, Banek CT, Burbach BJ, Razzoli M, Bartolomucci A, Shimizu Y, Panoskaltsis-Mortari A and Osborn JW. 2016. Renal Denervation Normalizes Arterial Pressure with No Effect on Glucose Metabolism or Renal Inflammation in Obese Hypertensive Mice. Hypertensions AHA. doi: 10.1161/HYPERTENSIONAHA.116.07993

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Rampuria P, Lang GA, Devera TS, Gilmore C, Ballard JD, Lang ML. 2016. Coordination between T helper cells, iNKT cells, and their follicular helper sub-sets in the humoral immune response against Clostridium difficile toxin B. J Leukoc Biol. doi:10.1189/jlb.4A0616-271R

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Bally APR, Tang Y, Lee JT, Barwick BG, Martinez R, Evavold BD and Boss JM. 2016. Conserved Region C Functions To Regulate PD-1 Expression and Subsequent CD8 T Cell Memory. J. Immunol. doi: 10.4049/​jimmunol.1601464

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Ma C, Mishra S, Demel EL, Liu Y and Zhang N. 2016. TGF-β Controls the Formation of Kidney-Resident T Cells via Promoting Effector T Cell Extravasation. J. Immunol. doi: 10.4049/​jimmunol.1601500

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Uzodinma U. Uche, Ann R. Piccirillo, Shunsuke Kataoka, Stephanie J. Grebinoski, Louise M. D’Cruz, and Lawrence P. Kane. PIK3IP1/TrIP restricts activation of T cells through inhibition of PI3K/Akt. J Exp Med. 2018 Dec 3;215(12):3165-3179. doi: 10.1084/jem.20172018

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Avery L, Filderman J, Szymczak-Workman AL, Kane LP4. Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2455-2460. doi: 10.1073/pnas.1712107115

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Derek W. Trobaugh, Chengqun Sun, Matthew D. Dunn, Douglas S. Reed, William B. Klimstra. Rational design of a live-attenuated eastern equine encephalitis virus vaccine through informed mutation of virulence determinants. PLoS Pathog. 2019 Feb 11;15(2):e1007584. doi: 10.1371/journal.ppat.1007584

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Rita Kansal, Noah Richardson, Indira Neeli, Saleem Khawaja, Damian Chamberlain, Marium Ghani, Qurat-ul-ain Ghani, Louisa Balazs, Sarka Beranova-Giorgianni, Francesco Giorgianni, James N. Kochenderfer, Tony Marion, Lorraine M. Albritton, Marko Radic. Sustained B cell depletion by CD19-targeted CAR T cells is a highly effective treatment for murine lupus. Sci Transl Med. 2019 Mar 6;11(482). pii: eaav1648. doi: 10.1126/scitranslmed.aav1648

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Qiumei Du, Ashley R. Hoover, Igor Dozmorov, Ondine B. Cleaver,Joshua T. Mendell, Nicolai S.C. van Oers. MIR205HG Is a Long Noncoding RNA that Regulates Growth Hormone and Prolactin Production in the Anterior Pituitary. Dev Cell. 2019 May 20;49(4):618-631.e5. doi: 10.1016/j.devcel.2019.03.012

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Jessica K. Fiege, Ian A. Stone, Elizabeth J. Fay, Matthew W. Markman, Sathi Wijeyesinghe, Marissa G. Macchietto, Steven Shen, David Masopust and Ryan A. Langlois. The Impact of TCR Signal Strength on Resident Memory T Cell Formation during Influenza Virus Infection. J Immunol. 2019 Aug 15;203(4):936-945. doi: 10.4049/jimmunol.1900093

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Matthew A. Huggins, Frances V. Sjaastad, Mark Pierson, Tamara A. Kucaba, Whitney Swanson, Christopher Staley, Alexa R. Weingarden, Isaac J. Jensen, Derek B. Danahy, Vladimir P. Badovinac, Stephen C. Jameson, Vaiva Vezys, David Masopust, Alexander Khoruts, Thomas S. Griffith, and Sara E. Hamilton. Microbial Exposure Enhances Immunity to Pathogens Recognized by TLR2 but Increases Susceptibility to Cytokine Storm through TLR4 Sensitization. Cell Rep. 2019 Aug 13;28(7):1729-1743.e5. doi: 10.1016/j.celrep.2019.07.028

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Jordy Saravia, Hu Zeng1, Yogesh Dhungana, Daniel Bastardo Blanco, Thanh-Long M. Nguyen, Nicole M. Chapman, Yanyan Wang, Apurva Kanneganti, Shaofeng Liu, Jana L. Raynor, Peter Vogel, Geoffrey Neale, Peter Carmeliet, Hongbo Chi. Homeostasis and transitional activation of regulatory T cells require c-Myc. Sci Adv. 2020 Jan 1;6(1):eaaw6443. doi: 10.1126/sciadv.aaw6443

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Hao Shi, Nicole M. Chapman, Jing Wen, Cliff Guy, Lingyun Long, Yogesh Dhungana, Sherri Rankin, Stephane Pelletier, Peter Vogel, Hong Wang, Junmin Peng, Kun-Liang Guan, and Hongbo Chi. Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb. Immunity. 2019 Dec 17;51(6):1012-1027.e7. doi: 10.1016/j.immuni.2019.10.001

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CD8a (2.43)

 

Sturmlechner I, Zhang C, Sine CC, van Deursen EJ, Jeganathan KB, Hamada N, Grasic J, Friedman D, Stutchman JT, Can I, Hamada M, Lim DY, Lee JH, Ordog T, Laberge RM, Shapiro V, Baker DJ, Li H, van Deursen JM. p21 produces a bioactive secretome that places stressed cells under immunosurveillance. Science. 2021 Oct 29;374(6567):eabb3420. doi: 10.1126/science.abb3420. Epub 2021 Oct 29. PMID: 34709885.

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Nguyen NH, Glassman FY, Dingman RK, Shenoy GN, Wohlfert EA, Kay JG, Bankert RB, Balu-Iyer SV. Rational design of a nanoparticle platform for oral prophylactic immunotherapy to prevent immunogenicity of therapeutic proteins. Sci Rep. 2021 Sep 8;11(1):17853. doi: 10.1038/s41598-021-97333-0. PMID: 34497305; PMCID: PMC8426360.

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Castillo-Gonzalez R, Cibrian D, Fernandez-Gallego N, Ramirez-Huesca M, Saiz M L, et al. Galectin-1 expression in CD8+ lymphocytes controls inflammation in contact hypersensitivity. Journal of Investigative Dermatology 2021;141(6):1522-1532

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Toriyama K, Kuwahara M, Kondoh H, et al. T cell-specific deletion of Pgam1 reveals a critical role for glycolysis in T cell responses. Commun Biol. 2020;3(1):394. Published 2020 Jul 24. doi:10.1038/s42003-020-01122-w.

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Lam LKM, Watson AM, Ryman KD, Klimstra WB. Gamma-interferon exerts a critical early restriction on replication and dissemination of yellow fever virus vaccine strain 17D-204. NPJ Vaccines. 2018;3:5. Published 2018 Jan 23. doi:10.1038/s41541-017-0039-z.

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Agelidis AM, Hadigal SR, Jaishankar D and Shukla D. 2017. Viral Activation of Heparanase Drives Pathogenesis of Herpes Simplex Virus-1. Cell Rep. doi: 10.1016/j.celrep.2017.06.041.

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Trott DW, Henson GD, Ho MHT, Allison SA, Lesniewski LA and Donato AJ. 2016. Age-related arterial immune cell infiltration in mice is attenuated by caloric restriction or voluntary exercise. Exp. Gerontol. DOI: 10.1016/j.exger.2016.12.016

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Sato Y, Mii A, Hamazaki Y, Fujita H, Nakata H, Masuda K, Nishiyama S, Shibuya S, Haga H, Ogawa O, Shimizu A, Narumiya S, Kaisho T, Arita M, Yanagisawa M, Miyasaka M, Sharma K, Minato N, Kawamoto H and Yanagita M. 2016. Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney. JCI Insight. 2016;1(11):e87680. doi:10.1172/jci.insight.87680.

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CD11b (M1/70)

 

Núñez-Ruiz A, Sánchez-Brena F, López-Pacheco C, Acevedo-Domínguez NA, Soldevila G. Obesity modulates the immune macroenvironment associated with breast cancer development. PLoS One. 2022 Apr 26;17(4):e0266827. doi: 10.1371/journal.pone.0266827. PMID: 35472214; PMCID: PMC9041840.

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Burrack AL, Schmiechen ZC, Patterson MT, Miller EA, Spartz EJ, Rollins MR, Raynor JF, Mitchell JS, Kaisho T, Fife BT, Stromnes IM. Distinct myeloid antigen-presenting cells dictate differential fates of tumor-specific CD8+ T cells in pancreatic cancer. JCI Insight. 2022 Apr 8;7(7):e151593. doi: 10.1172/jci.insight.151593. PMID: 35393950. 

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Rivera-Torruco G, Martínez-Mendiola CA, Angeles-Floriano T, Jaimes-Ortega GA, Maravillas-Montero JL, García-Contreras R, González Y, Juárez E, Nava P, Ortiz-Navarrete V, Medina-Contreras O, Licona-Limón P, Valle-Rios R. Isthmin 1 is Expressed by Progenitor-Like Cells in the Lung: Phenotypical Analysis of Isthmin 1+ Hematopoietic Stem-Like Cells in Homeostasis and during Infection. J Immunol Res. 2022 Apr 1;2022:2909487. doi: 10.1155/2022/2909487. PMID: 35402623; PMCID: PMC8993550.

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Sánchez-Navarro A, Martínez-Rojas MÁ, Albarrán-Godinez A, Pérez-Villalva R, Auwerx J, de la Cruz A, Noriega LG, Rosetti F, Bobadilla NA. Sirtuin 7 Deficiency Reduces Inflammation and Tubular Damage Induced by an Episode of Acute Kidney Injury. Int J Mol Sci. 2022 Feb 25;23(5):2573. doi: 10.3390/ijms23052573. PMID: 35269715.

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Monteith AJ, Miller JM, Beavers WN, Juttukonda LJ, Skaar EP. Increased dietary manganese impairs NET formation rendering neutrophils ineffective at combating Staphylococcus aureus. Infect Immun. 2022 Feb 22:iai0068521. doi: 10.1128/iai.00685-21. Epub ahead of print. PMID: 35191757.

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Adrover JM, Carrau L, Daßler-Plenker J, Bram Y, Chandar V, Houghton S, Redmond D, Merrill JR, Shevik M, tenOever BR, Lyons SK, Schwartz RE, Egeblad M. Disulfiram inhibits neutrophil extracellular trap formation protecting rodents from acute lung injury and SARS-CoV-2 infection. JCI Insight. 2022 Feb 8:e157342. doi: 10.1172/jci.insight.157342. Epub ahead of print. PMID: 35133984.

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Raihan MO, McGregor BA, Velaris NA, Brishti A, Hur J, Porter JE. Method of Microglial DNA-RNA Purification from a Single Brain of an Adult Mouse. Methods Protoc. 2021 Dec 2;4(4):86. doi: 10.3390/mps4040086. PMID: 34940397; PMCID: PMC8704779.

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Chen DL, Sheng H, Zhang DS, Jin Y, Zhao BT, Chen N, Song K, Xu RH. The circular RNA circDLG1 promotes gastric cancer progression and anti-PD-1 resistance through the regulation of CXCL12 by sponging miR-141-3p. Mol Cancer. 2021 Dec 15;20(1):166. doi: 10.1186/s12943-021-01475-8. PMID: 34911533; PMCID: PMC8672580.

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Oda Y, Takahashi C, Harada S, Nakamura S, Sun D, Kiso K, Urata Y, Miyachi H, Fujiyoshi Y, Honigmann A, Uchida S, Ishihama Y, Toyoshima F. Discovery of anti-inflammatory physiological peptides that promote tissue repair by reinforcing epithelial barrier formation. Sci Adv. 2021 Nov 19;7(47):eabj6895. doi: 10.1126/sciadv.abj6895. Epub 2021 Nov 17. PMID: 34788088.

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Stephens WZ, Kubinak JL, Ghazaryan A, Bauer KM, Bell R, Buhrke K, Chiaro TR, Weis AM, Tang WW, Monts JK, Soto R, Ekiz HA, O'Connell RM, Round JL. Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition. Cell Rep. 2021 Nov 2;37(5):109916. doi: 10.1016/j.celrep.2021.109916. PMID: 34731608.

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Pingili AK, Chaib M, Sipe LM, et al. Immune checkpoint blockade reprograms systemic immune landscape and tumor microenvironment in obesity-associated breast cancer. Cell Rep. 2021 Jun 22;35(12):109285. doi: 10.1016/j.celrep.2021.109285. PMID: 34161764.

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Lei Y, Guerra Martinez C, Torres-Odio S, et al. Elevated type I interferon responses potentiate metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice. Sci Adv. 2021 May 26;7(22):eabe7548. doi: 10.1126/sciadv.abe7548. PMID: 34039599.

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Nishina T, Deguchi Y, Ohshima D, et a. Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer. Nat Commun. 2021 Apr 16;12(1):2281. doi: 10.1038/s41467-021-22450-3. PMID: 33863879.

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Baba T, Yoshida T, Tanabe Y, et al. Cytoplasmic DNA accumulation preferentially triggers cell death of myeloid leukemia cells by interacting with intracellular DNA sensing pathway. Cell Death Dis. 2021 Mar 26;12(4):322. doi: 10.1038/s41419-021-03587-x. PMID: 33771977.  

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Li Y, Han Y, Su R, Liu Y, Chong G, Xu D, He R, Liu Y, Dong H, Shi D, Li Y. Photosensitizer-Laden Neutrophils Are Controlled Remotely for Cancer Immunotherapy. Cell Rep. 2020 Dec 15;33(11):108499. doi: 10.1016/j.celrep.2020.108499. PMID: 33326787. 

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Saeki N, Imai Y. Reprogramming of synovial macrophage metabolism by synovial fibroblasts under inflammatory conditions. Cell Commun Signal. 2020 Nov 30;18(1):188. doi: 10.1186/s12964-020-00678-8. PMID: 33256735; PMCID: PMC7708128. 

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Bescucci DM, Clarke ST, Brown CLJ, et al. The absence of murine cathelicidin-related antimicrobial peptide impacts host responses enhancing Salmonella enterica serovar Typhimurium infection. Gut Pathog. 2020 Nov 13;12(1):53. doi: 10.1186/s13099-020-00386-1. PMID: 33292444; PMCID: PMC7666523.

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Ishida Y, Kuninaka Y, Nosaka M, Kimura A, Taruya A, Furuta M, Mukaida N, Kondo T. Prevention of CaCl2-induced aortic inflammation and subsequent aneurysm formation by the CCL3-CCR5 axis. Nat Commun. 2020 Nov 25;11(1):5994. doi: 10.1038/s41467-020-19763-0. PMID: 33239616.

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Velasco-de Andrés M, Català C, Casadó-Llombart S, et al. The lymphocytic scavenger receptor CD5 shows therapeutic potential in mouse models of fungal infection. Antimicrob Agents Chemother. 2020 Oct 12:AAC.01103-20. doi: 10.1128/AAC.01103-20. PMID: 33046489. 

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Ito T, Kometani K, Minato N, Hamazaki Y. Bone Marrow Endothelial Cells Take Up Blood-Borne Immune Complexes via Fcγ Receptor IIb2 in an Erythropoietin-Dependent Manner. J Immunol. 2020;ji1901101. doi:10.4049/jimmunol.1901101.   

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Racine JJ, Chapman HD, Doty R, Cairns BM, Hines TJ, Tadenev ALD, Anderson LC, Green T, Dyer ME, Wotton JM, Bichler Z, White JK, Ettinger R, Burgess RW, Serreze DV. T Cells from NOD-PerIg Mice Target Both Pancreatic and Neuronal Tissue. J Immunol. 2020 Sep 16:ji2000114. doi: 10.4049/jimmunol.2000114. PMID: 32938729.

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Hiroshi Kobayashi and Keiyo Takubo. Protocol for the Maintenance of Quiescent Murine Hematopoietic Stem Cells. STAR Protocols. Published 2 August 2020. https://doi.org/10.1016/j.xpro.2020.100078. 

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Lechuga-Vieco AV, Latorre-Pellicer A, Johnston IG, et al. Cell identity and nucleo-mitochondrial genetic context modulate OXPHOS performance and determine somatic heteroplasmy dynamics. Sci Adv. 2020;6(31):eaba5345. Published 2020 Jul 29. doi:10.1126/sciadv.aba5345. 

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Komura N, Mabuchi S, Shimura K, et al. The role of myeloid-derived suppressor cells in increasing cancer stem-like cells and promoting PD-L1 expression in epithelial ovarian cancer. 2020 Jun 19. Cancer Immunol Immunother. 2020;10.1007/s00262-020-02628-2. doi:10.1007/s00262-020-02628-2.

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Roa, J.A., Sarkar, D., Zanaty, M. et al. Preliminary results in the analysis of the immune response after aneurysmal subarachnoid hemorrhage. Sci Rep 10, 11809 (2020). https://doi.org/10.1038/s41598-020-68861-y.

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Kim IS, Gao Y, Welte T, et al. Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms. Nat Cell Biol. 2019;21(9):1113-1126. doi:10.1038/s41556-019-0373-7.

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Andersen TK, Huszthy PC, Gopalakrishnan RP, et al. Enhanced germinal center reaction by targeting vaccine antigen to major histocompatibility complex class II molecules. NPJ Vaccines. 2019;4:9. Published 2019 Feb 11. doi:10.1038/s41541-019-0101-0.

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Udden SN, Kwak YT, Godfrey V, et al. NLRP12 suppresses hepatocellular carcinoma via downregulation of cJun N-terminal kinase activation in the hepatocyte. Elife. 2019;8:e40396. Published 2019 Apr 16. doi:10.7554/eLife.40396.

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Kobayashi H, Morikawa T, Okinaga A, et al. Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo. Cell Rep. 2019;28(1):145-158.e9. doi:10.1016/j.celrep.2019.06.008.

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Bahnan W, Boucher JC, Gayle P, et al. The eIF2α Kinase Heme-Regulated Inhibitor Protects the Host from Infection by Regulating Intracellular Pathogen Trafficking. Infect Immun. 2018;86(3):e00707-17. Published 2018 Feb 20. doi:10.1128/IAI.00707-17.

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Palacios M, Miner TA, Frederick DR, et al. Identification of Two Regulators of Virulence That Are Conserved in Klebsiella pneumoniae Classical and Hypervirulent Strains. mBio. 2018;9(4):e01443-18. Published 2018 Aug 7. doi:10.1128/mBio.01443-18.

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Scharer CD, Barwick BG, Guo M, Bally APR, Boss JM. Plasma cell differentiation is controlled by multiple cell division-coupled epigenetic programs. Nat Commun. 2018;9(1):1698. Published 2018 Apr 27. doi:10.1038/s41467-018-04125-8.

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Guo M, Price MJ, Patterson DG, et al. EZH2 Represses the B Cell Transcriptional Program and Regulates Antibody-Secreting Cell Metabolism and Antibody Production. J Immunol. 2018;200(3):1039-1052. doi:10.4049/jimmunol.1701470.

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Suwanpradid J, Shih M, Pontius L, Yang B, Birukova A, Guttman-Yassky E, Corcoran DL, Que LG, Tighe RM and MacLeod AS. 2017. Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity. J Immunol. doi: 10.4049/jimmunol.1700739.

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Kuroda H, Mabuchi S, Kozasa K, Yokoi E, Matsumoto Y, Komura N, Kawano M, Hashimoto K, Sawada K and Kimura T. 2017. PM01183 inhibits myeloid-derived suppressor cells in vitro and in vivo. Immunotherapy. doi: 10.2217/imt-2017-0046.

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Johnson LE, Olson BM and McNeel DG. 2017. Pretreatment antigen-specific immunity and regulation - association with subsequent immune response to anti-tumor DNA vaccination. J Immunother Cancer. doi: 10.1186/s40425-017-0260-3.

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Shiokawa A, Kotaki R, Takano T, Nakajima-Adachi H and Hachimura S. 2017. Mesenteric lymph node CD11b- CD103+ PD-L1High dendritic cells highly induce regulatory T cells. Immunology. doi: 10.1111/imm.12747

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Kishimoto Y, Asakawa S, Sato T, Takano T, Nakajyo T, Mizuno N, Segawa R, Yoshikawa T, Hiratsuka M, Yanai K, Ohtsu H and Hirasawa N. 2017. Induced histamine regulates Ni elution from an implanted Ni wire in mice by downregulating neutrophil migration. Exp Dermatol. doi: 10.1111/exd.13315.

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Zaman TS, Arimochi H, Maruyama S, Ishifune C, Tsukumo SI, Kitamura A and Yasutomo K. 2017. Notch Balances Th17 and Induced Regulatory T Cell Functions in Dendritic Cells by Regulating Aldh1a2 Expression. J Immunol. doi: 10.4049/jimmunol.1700645.

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Shiyang Li, John W. Bostick, Jian Ye, Joseph F. Urban, Jr., Dorina Avram, Liang Zhou. Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function. Immunity. 2018 Nov 20;49(5):915-928.e5. doi: 10.1016/j.immuni.2018.09.015

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Nicholas N. Jarjour, Elizabeth A. Schwarzkopf, Tara R. Bradstreet, Irina Shchukina, Chih-Chung Lin, Stanley Ching-Cheng Huang, Chin-Wen Lai, Melissa E. Cook, Reshma Taneja, Thaddeus S. Stappenbeck, Gwendalyn J. Randolph, Maxim N. Artyomov, Joseph F. Urban Jr., and Brian T. Edelson. Bhlhe40 mediates tissue-specific control of macrophage proliferation in homeostasis and type 2 immunity. Nat Immunol. 2019 Jun;20(6):687-700. doi: 10.1038/s41590-019-0382-5

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CD11c (N418)

 

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Xu L, Su B, Mo L, Zhao C, Zhao Z, Li H, Hu Z, Li J. Norcantharidin Induces Immunogenic Cell Death of Bladder Cancer Cells through Promoting Autophagy in Acidic Culture. Int J Mol Sci. 2022 Apr 1;23(7):3944. doi: 10.3390/ijms23073944. PMID: 35409302; PMCID: PMC8999362. 

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Kumar D, Sehrawat S. Divergent Effects of a Transient Corticosteroid Therapy on Virus-Specific Quiescent and Effector CD8+ T Cells. Front Immunol. 2019;10:1521. Published 2019 Jul 12. doi:10.3389/fimmu.2019.01521.

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Vogel CF, Chang WL, Kado S, McColloh K, Vogel H, Wu D, Haarmann-Stemmann T, Yang G, Leung PS, Matsumura F and Gershwin ME. 2016. Transgenic Overexpression of Aryl Hydrocarbon Receptor Repressor (AhRR) and AhR-Mediated Induction of CYP1A1, Cytokines, and Acute Toxicity. Environ Health Perspect. DOI:10.1289/ehp.1510194.

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Come C, Cvrljevic A, Khan MM, Treise I, Adler T, Aguilar-Pimental JA, Au-Yeung B, Sittig E, Laajala TD, Chen Y, Oeder S, Calzada-Wack J, Horsch M, Aittokallio T, Busch DH, Ollert MW, Neff F, Beckers J, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Chen Z, Lahesmaa R, and Westermarck J. 2016. CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection. PLoS ONE 11(4):e0152996. doi:10.1371/journal.pone.0152996

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Gilchuk P, Hill TM, Guy C, McMaster SR, Boyd KL, Rabacal WA, Lu P, Shyr Y, Kohlmeier JE, Sebzda E, Green DR and Joyce S.2016. A Distinct Lung-Interstitium-Resident Memory CD8+ T Cell Subset Confers Enhanced Protection to Lower Respiratory Tract Infection. Cell Reports. DOI:10.1016/j.celrep.2016.07.037

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Barwick BG, Scharer CD, Bally APR and Boss JM. 2016. Plasma Cell Differentiation is Coupled to Division-Dependent DNA Hypomethylation and Gene Regulation. Nat Immunol. 17(10):1216-25

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Olguin-Alor R, de la Fuente-Granada M, Bonifaz LC, Antonio-Herrara L, Garcia-Zepada EA and Soldevilla G. 2016. A Key Role for Inhibins in Dendritic Cell Maturation and Function. PLOS one. doi:10.1371/journal.pone.0167813

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Ito A, Hong C, Oka K, Salazar JV, Diehl C, Witztum JL, Diaz M, Castrillo A, Bensinger SJ, Chan L and Tontonoz P. 2016. Cholesterol Accumulation in CD11c+ Immune Cells Is a Causal and Targetable Factor in Autoimmune Disease. Immunity. doi: 10.1016/j.immuni.2016.11.008

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Kovats. A Major Population of Functional KLRG1- ILC2s in Female Lungs Contributes to a Sex Bias in ILC2 Numbers. Immunohorizons. 2018 Feb;2(2):74-86. doi: 10.4049/immunohorizons.1800008

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Erola Ainsua-Enrich, Ibrahim Hatipoglu, Sapana Kadel, Sean Turner, Jinny Paul, Simar Singh, Harini Bagavant, and Susan Kovats. IRF4-dependent dendritic cells regulate CD8+ T cell differentiation and memory responses in influenza infection. Mucosal Immunol. 2019 Jul;12(4):1025-1037. doi: 10.1038/s41385-019-0173-1

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Shiyang Li, John W. Bostick, Jian Ye, Joseph F. Urban, Jr., Dorina Avram, Liang Zhou. Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function. Immunity. 2018 Nov 20;49(5):915-928.e5. doi: 10.1016/j.immuni.2018.09.015

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Nicholas N. Jarjour, Elizabeth A. Schwarzkopf, Tara R. Bradstreet, Irina Shchukina, Chih-Chung Lin, Stanley Ching-Cheng Huang, Chin-Wen Lai, Melissa E. Cook, Reshma Taneja, Thaddeus S. Stappenbeck, Gwendalyn J. Randolph, Maxim N. Artyomov, Joseph F. Urban Jr., and Brian T. Edelson. Bhlhe40 mediates tissue-specific control of macrophage proliferation in homeostasis and type 2 immunity. Nat Immunol. 2019 Jun;20(6):687-700. doi: 10.1038/s41590-019-0382-5

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Qiumei Du, Ashley R. Hoover, Igor Dozmorov, Ondine B. Cleaver,Joshua T. Mendell, Nicolai S.C. van Oers. MIR205HG Is a Long Noncoding RNA that Regulates Growth Hormone and Prolactin Production in the Anterior Pituitary. Dev Cell. 2019 May 20;49(4):618-631.e5. doi: 10.1016/j.devcel.2019.03.012

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Picarda E, Galbo PM Jr, Zong H, Rajan MR, Wallenius V, Zheng D, Börgeson E, Singh R, Pessin J, Zang X. The immune checkpoint B7-H3 (CD276) regulates adipocyte progenitor metabolism and obesity development. Sci Adv. 2022 Apr 29;8(17):eabm7012. doi: 10.1126/sciadv.abm7012. Epub 2022 Apr 27. PMID: 35476450; PMCID: PMC9045715.

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Wu B, Zhang X, Chiang HC, Pan H, Yuan B, Mitra P, Qi L, Simonyan H, Young CN, Yvon E, Hu Y, Zhang N, Li R. RNA polymerase II pausing factor NELF in CD8+ T cells promotes antitumor immunity. Nat Commun. 2022 Apr 20;13(1):2155. doi: 10.1038/s41467-022-29869-2. PMID: 35444206; PMCID: PMC9021285.

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Brian BF 4th, Sauer ML, Greene JT, Senevirathne SE, Lindstedt AJ, Funk OL, Ruis BL, Ramirez LA, Auger JL, Swanson WL, Nunez MG, Moriarity BS, Lowell CA, Binstadt BA, Freedman TS. A dominant function of LynB kinase in preventing autoimmunity. Sci Adv. 2022 Apr 22;8(16):eabj5227. doi: 10.1126/sciadv.abj5227. Epub 2022 Apr 22. PMID: 35452291.

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Burrack AL, Schmiechen ZC, Patterson MT, Miller EA, Spartz EJ, Rollins MR, Raynor JF, Mitchell JS, Kaisho T, Fife BT, Stromnes IM. Distinct myeloid antigen-presenting cells dictate differential fates of tumor-specific CD8+ T cells in pancreatic cancer. JCI Insight. 2022 Apr 8;7(7):e151593. doi: 10.1172/jci.insight.151593. PMID: 35393950. 

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Carson CS, Becker KW, Garland KM, Pagendarm HM, Stone PT, Arora K, Wang-Bishop L, Baljon JJ, Cruz LD, Joyce S, Wilson JT. A nanovaccine for enhancing cellular immunity via cytosolic Co-delivery of antigen and PolyIC RNA. J Control Release. 2022 Mar 14:S0168-3659(22)00146-8. doi: 10.1016/j.jconrel.2022.03.020. Epub ahead of print. PMID: 35301055.

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Sánchez-Navarro A, Martínez-Rojas MÁ, Albarrán-Godinez A, Pérez-Villalva R, Auwerx J, de la Cruz A, Noriega LG, Rosetti F, Bobadilla NA. Sirtuin 7 Deficiency Reduces Inflammation and Tubular Damage Induced by an Episode of Acute Kidney Injury. Int J Mol Sci. 2022 Feb 25;23(5):2573. doi: 10.3390/ijms23052573. PMID: 35269715.

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Monteith AJ, Miller JM, Beavers WN, Juttukonda LJ, Skaar EP. Increased dietary manganese impairs NET formation rendering neutrophils ineffective at combating Staphylococcus aureus. Infect Immun. 2022 Feb 22:iai0068521. doi: 10.1128/iai.00685-21. Epub ahead of print. PMID: 35191757.

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Yuan M, Zhai Y, Men Y, Zhao M, Sun X, Ma Z, Bao Y, Yang X, Sun S, Liu Y, Zhang W, Hui Z. Anlotinib Enhances the Antitumor Activity of High-Dose Irradiation Combined with Anti-PD-L1 by Potentiating the Tumor Immune Microenvironment in Murine Lung Cancer. Oxid Med Cell Longev. 2022 Feb 1;2022:5479491. doi: 10.1155/2022/5479491. PMID: 35154567; PMCID: PMC8825674.

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Kang Y, Lim J, Saravanakumar G, Kim J, Park M, Im S, Kim WJ. Immunostimulation of tumor microenvironment by targeting tumor-associated macrophages with hypoxia-responsive nanocomplex for enhanced anti-tumor therapy. J Control Release. 2022 Jan 19;343:78-88. doi: 10.1016/j.jconrel.2022.01.021. Epub ahead of print. PMID: 35065158.

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Brandi P, Conejero L, Cueto FJ, Martínez-Cano S, Dunphy G, Gómez MJ, Relaño C, Saz-Leal P, Enamorado M, Quintas A, Dopazo A, Amores-Iniesta J, Del Fresno C, Nistal-Villán E, Ardavín C, Nieto A, Casanovas M, Subiza JL, Sancho D. Trained immunity induction by the inactivated mucosal vaccine MV130 protects against experimental viral respiratory infections. Cell Rep. 2022 Jan 4;38(1):110184. doi: 10.1016/j.celrep.2021.110184. PMID: 34986349.

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Hernández-García E, Cueto FJ, Cook ECL, Redondo-Urzainqui A, Charro-Zanca S, Robles-Vera I, Conde-Garrosa R, Nikolić I, Sabio G, Sancho D, Iborra S. Conventional type 1 dendritic cells protect against age-related adipose tissue dysfunction and obesity. Cell Mol Immunol. 2022 Jan 4. doi: 10.1038/s41423-021-00812-7. Epub ahead of print. PMID: 34983945.

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Ishikura N, Sugimoto M, Yorozu K, Kurasawa M, Kondoh O. Anti‑VEGF antibody triggers the effect of anti‑PD‑L1 antibody in PD‑L1low and immune desert‑like mouse tumors. Oncol Rep. 2022 Feb;47(2):36. doi: 10.3892/or.2021.8247. Epub 2021 Dec 27. PMID: 34958105.

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Raihan MO, McGregor BA, Velaris NA, Brishti A, Hur J, Porter JE. Method of Microglial DNA-RNA Purification from a Single Brain of an Adult Mouse. Methods Protoc. 2021 Dec 2;4(4):86. doi: 10.3390/mps4040086. PMID: 34940397; PMCID: PMC8704779.

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Oda Y, Takahashi C, Harada S, Nakamura S, Sun D, Kiso K, Urata Y, Miyachi H, Fujiyoshi Y, Honigmann A, Uchida S, Ishihama Y, Toyoshima F. Discovery of anti-inflammatory physiological peptides that promote tissue repair by reinforcing epithelial barrier formation. Sci Adv. 2021 Nov 19;7(47):eabj6895. doi: 10.1126/sciadv.abj6895. Epub 2021 Nov 17. PMID: 34788088.

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Bickett TE, Knitz MW, Piper M, Oweida AJ, Gadwa J, Darragh LB, Nguyen D, Bhatia S, Bhuvane S, Phan AV, Van Court B, Corbo S, Pham T, Dent AL, Lenz L, Karam SD. Dichotomous Effects of Cellular Expression of STAT3 on Tumor Growth of HNSCC. Mol Ther. 2021 Nov 15:S1525-0016(21)00582-7. doi: 10.1016/j.ymthe.2021.11.011. Epub ahead of print. PMID: 34793974.

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Winkels H, Ghosheh Y, Kobiyama K, Kiosses WB, Orecchioni M, Ehinger E, Suryawanshi V, Herrera-De La Mata S, Marchovecchio P, Riffelmacher T, Thiault N, Kronenberg M, Wolf D, Seumois G, Vijayanand P, Ley K. Thymus-Derived CD4+CD8+ Cells Reside in Mediastinal Adipose Tissue and the Aortic Arch. J Immunol. 2021 Nov 5:ji2100208. doi: 10.4049/jimmunol.2100208. Epub ahead of print. PMID: 34740961.

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Stephens WZ, Kubinak JL, Ghazaryan A, Bauer KM, Bell R, Buhrke K, Chiaro TR, Weis AM, Tang WW, Monts JK, Soto R, Ekiz HA, O'Connell RM, Round JL. Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition. Cell Rep. 2021 Nov 2;37(5):109916. doi: 10.1016/j.celrep.2021.109916. PMID: 34731608.

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Monteith AJ, Miller JM, Maxwell CN, Chazin WJ, Skaar EP. Neutrophil extracellular traps enhance macrophage killing of bacterial pathogens. Sci Adv. 2021 Sep 10;7(37):eabj2101. doi: 10.1126/sciadv.abj2101. Epub 2021 Sep 10. PMID: 34516771.

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Takai J, Shimada T, Nakamura T, Engel JD, Moriguchi T. Gata2 heterozygous mutant mice exhibit reduced inflammatory responses and impaired bacterial clearance. iScience. 2021 Jul 29;24(8):102836. doi: 10.1016/j.isci.2021.102836. PMID: 34471858; PMCID: PMC8390858.

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Fu Z, Dean JW, Xiong L, et al. Mitochondrial transcription factor A in RORγt+ lymphocytes regulate small intestine homeostasis and metabolism. Nat Commun. 2021 Jul 22;12(1):4462. doi: 10.1038/s41467-021-24755-9. PMID: 34294718.

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Pingili AK, Chaib M, Sipe LM, et al. Immune checkpoint blockade reprograms systemic immune landscape and tumor microenvironment in obesity-associated breast cancer. Cell Rep. 2021 Jun 22;35(12):109285. doi: 10.1016/j.celrep.2021.109285. PMID: 34161764.

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Xu C, Sun S, Johnson T, Qi R, Zhang S, Zhang J, Yang K. The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity. Cell Rep. 2021 Jun 15;35(11):109235. doi: 10.1016/j.celrep.2021.109235. PMID: 34133924.

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Lei Y, Guerra Martinez C, Torres-Odio S, et al. Elevated type I interferon responses potentiate metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice. Sci Adv. 2021 May 26;7(22):eabe7548. doi: 10.1126/sciadv.abe7548. PMID: 34039599.

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Yan J, Zhao Q, Wang J, Tian X, Wang J, Xia X, Ott M, Rao G, Heimberger AB, Li S. FGL2-wired macrophages secrete CXCL7 to regulate the stem-like functionality of glioma cells. Cancer Lett. 2021 May 28;506:83-94. doi: 10.1016/j.canlet.2021.02.021. Epub 2021 Mar 4. PMID: 33676940; PMCID: PMC8009861.

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Knitz MW, Bickett TE, Darragh LB, et al. Targeting resistance to radiation-immunotherapy in cold HNSCCs by modulating the Treg-dendritic cell axis. J Immunother Cancer. 2021 Apr;9(4):e001955. doi: 10.1136/jitc-2020-001955. PMID: 33883256.

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Nishina T, Deguchi Y, Ohshima D, et a. Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer. Nat Commun. 2021 Apr 16;12(1):2281. doi: 10.1038/s41467-021-22450-3. PMID: 33863879.

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Lee W, Kingstad-Bakke B, Paulson B, et al. Carbomer-based adjuvant elicits CD8 T-cell immunity by inducing a distinct metabolic state in cross-presenting dendritic cells. PLoS Pathog. 2021 Jan 14;17(1):e1009168. doi: 10.1371/journal.ppat.1009168. PMID: 33444400.

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Prokopi A, Tripp CH, Tummers B, et al. Skin dendritic cells in melanoma are key for successful checkpoint blockade therapy. J Immunother Cancer. 2021 Jan;9(1):e000832. doi: 10.1136/jitc-2020-000832. PMID: 33408092.

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CD16/CD32 (2.4G2)

O'Melia MJ, Rohner NA, Manspeaker MP, et al. Quality of CD8+ T cell immunity evoked in lymph nodes is compartmentalized by route of antigen transport and functional in tumor context. Sci Adv. 2020 Dec 11;6(50):eabd7134. doi: 10.1126/sciadv.abd7134. PMID: 33310857.

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C Khouili S, Cook ECL, Hernández-García E, Martínez-López M, Conde-Garrosa R, Iborra S. SHP-1 Regulates Antigen Cross-Presentation and Is Exploited by Leishmania to Evade Immunity. Cell Rep. 2020 Dec 1;33(9):108468. doi: 10.1016/j.celrep.2020.108468. PMID: 33264612.

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Castillo-González R, Cibrian D, Fernández-Gallego N, Ramírez-Huesca M, Saiz ML, Navarro MN, Fresno M, Fuente H, Sánchez-Madrid F. Galectin-1 expression in CD8+ T lymphocytes controls inflammation in contact hypersensitivity. J Invest Dermatol. 2020 Nov 9:S0022-202X(20)32281-8. doi: 10.1016/j.jid.2020.10.020. PMID: 33181141.

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Baniel CC, Sumiec EG, Hank JA, Bates AM, et al. Intratumoral injection reduces toxicity and antibody-mediated neutralization of immunocytokine in a mouse melanoma model. J Immunother Cancer. 2020 Oct;8(2):e001262. doi: 10.1136/jitc-2020-001262. PMID: 33115944.

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Sestito LF, Thomas SN. Lymph-directed nitric oxide increases immune cell access to lymph-borne nanoscale solutes. Biomaterials. 2020 Sep 18;265:120411. doi: 10.1016/j.biomaterials. 2020.120411. Epub ahead of print. PMID: 33080460.

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Marinaik CB, Kingstad-Bakke B, Lee W, Hatta M, Sonsalla M, Larsen A, Neldner B, Gasper DJ, Kedl RM, Kawaoka Y, Suresh M. Programming Multifaceted Pulmonary T Cell Immunity by Combination Adjuvants. Cell Rep Med. 2020 Sep 22;1(6):100095. doi: 10.1016/j.xcrm.2020.100095. PMID: 32984856; PMCID: PMC7508055.

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Innamarato P, Asby S, Morse J, Mackay A, Hall M, Kidd S, Nagle L, Sarnaik AA, Pilon-Thomas S. Intratumoral Activation of 41BB Costimulatory Signals Enhances CD8 T Cell Expansion and Modulates Tumor-Infiltrating Myeloid Cells. J Immunol. 2020 Oct 5:ji2000759. doi: 10.4049/jimmunol.2000759. PMID: 33020146.

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Nguyen R, Patel AG, Griffiths LM, et al. Next-generation humanized patient-derived xenograft mouse model for pre-clinical antibody studies in neuroblastoma. Cancer Immunol Immunother. 2020;10.1007/s00262-020-02713-6. doi:10.1007/s00262-020-02713-6.

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Tsukasaki M, Asano T, Muro R, et al. OPG Production Matters Where It Happened. Cell Rep. 2020;32(10):108124. doi:10.1016/j.celrep.2020.108124.

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Shen M, Song Y, Ichinose T, et al. In vivo immune activation of splenocytes following exposure to tar from Asian sand dust. J Toxicol Environ Health A. 2020;1-10. doi:10.1080/15287394.2020.1806160.  

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Yamamuro T, Kawabata T, Fukuhara A, et al. Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy. Nat Commun. 2020;11(1):4150. Published 2020 Aug 18. doi:10.1038/s41467-020-17985-w.  

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Wu B, Chiang HC, Sun X, et al. Genetic ablation of adipocyte PD-L1 reduces tumor growth but accentuates obesity-associated inflammation. J Immunother Cancer. 2020;8(2):e000964. doi:10.1136/jitc-2020-000964.

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Kajihara N, Kitagawa F, Kobayashi T, Wada H, Otsuka R, Seino KI. Interleukin-34 contributes to poor prognosis in triple-negative breast cancer [published online ahead of print, 2020 Jun 23]. Breast Cancer. 2020;10.1007/s12282-020-01123-x. doi:10.1007/s12282-020-01123-x.

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Wormsbaecher C, Hindman AR, Avendano A, et al. In utero estrogenic endocrine disruption alters the stroma to increase extracellular matrix density and mammary gland stiffness. Breast Cancer Res. 2020;22(1):41. Published 2020 May 5. doi:10.1186/s13058-020-01275-w.

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McDaniel MM, Kottyan LC, Singh H, Pasare C. Suppression of Inflammasome Activation by IRF8 and IRF4 in cDCs Is Critical for T Cell Priming. Cell Rep. 2020 May 5;31(5):107604. doi: 10.1016/j.celrep.2020.107604

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Markman, J.L., Porritt, R.A., Wakita, D. et al. Loss of testosterone impairs anti-tumor neutrophil function. Nat Commun 11, 1613 (2020). https://doi.org/10.1038/s41467-020-15397-4.

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Kumar D, Sehrawat S. Divergent Effects of a Transient Corticosteroid Therapy on Virus-Specific Quiescent and Effector CD8+ T Cells. Front Immunol. 2019;10:1521. Published 2019 Jul 12. doi:10.3389/fimmu.2019.01521.

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Kim IS, Gao Y, Welte T, et al. Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms. Nat Cell Biol. 2019;21(9):1113-1126. doi:10.1038/s41556-019-0373-7.

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Atif SM, Mack DG, McKee AS, et al. Protective role of B cells in sterile particulate-induced lung injury. JCI Insight. 2019;5(12):e125494. Published 2019 May 16. doi:10.1172/jci.insight.125494.

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Yang BH, Wang K, Wan S, et al. TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases. Cell Rep. 2019;27(12):3629-3645.e6. doi:10.1016/j.celrep.2019.05.061.

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Dutta R, Lunzer MM, Auger JL, Akgün E, Portoghese PS, Binstadt BA. A bivalent compound targeting CCR5 and the mu opioid receptor treats inflammatory arthritis pain in mice without inducing pharmacologic tolerance. Arthritis Res Ther. 2018;20(1):154. Published 2018 Jul 27. doi:10.1186/s13075-018-1661-5.

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Guo M, Price MJ, Patterson DG, et al. EZH2 Represses the B Cell Transcriptional Program and Regulates Antibody-Secreting Cell Metabolism and Antibody Production. J Immunol. 2018;200(3):1039-1052. doi:10.4049/jimmunol.1701470.

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Bapat, Sagar P., Zheng, YE, Evans, Ronald, Downes, Michael, Atkins, Annette R., YU, Ruth T. COMPOSITIONS AND METHODS FOR TREATING AGE-RELATED DIABETES AND RELATED DISORDERS. 2020 May.

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Adami AJ, Bracken SJ, Guernsey LA, et al. Early-life antibiotics attenuate regulatory T cell generation and increase the severity of murine house dust mite-induced asthma. Pediatr Res. 2018;84(3):426-434. doi:10.1038/s41390-018-0031-y.

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Ishisono K, Yabe T and Kitaguchi K. 2017. Citrus pectin attenuates endotoxin shock via suppression of Toll-like receptor signaling in Peyer's patch myeloid cells. J Nutr Biochem. doi: 10.1016/j.jnutbio.2017.07.016

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Oh DS, Oh JE, Jung HE and Lee HK. 2017. Transient Depletion of CD169+ Cells Contributes to Impaired Early Protection and Effector CD8+ T Cell Recruitment against Mucosal Respiratory Syncytial Virus Infection. Front Immunol. doi: 10.3389/fimmu.2017.00819

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Conejero L, Khouili SC, Martínez-Cano S, Izquierdo HM, Brandi P and Sancho D. 2017. Lung CD103+ dendritic cells restrain allergic airway inflammation through IL-12 production. JCI Insight. doi: 10.1172/jci.insight.90420

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Ratiu JJ, Racine JJ, Hasham MG, Wang Q, Branca JA, Chapman HD, Zhu J, Donghia N, Philip V, Schott WH, Wasserfall C, Atkinson MA, Mills KD, Leeth CM and Serreze DV. 2017. Genetic and Small Molecule Disruption of the AID/RAD51 Axis Similarly Protects Nonobese Diabetic Mice from Type 1 Diabetes through Expansion of Regulatory B Lymphocytes. J Immunol. doi: 10.4049/jimmunol.1700024.

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Sato Y, Kato H, Ebina-Shibuya R, Itoh-Nakadai A, Okuyama R and Igarashi K. 2017. Bach2 Controls Homeostasis of Eosinophils by Restricting the Type-2 Helper Function of T Cells. Tohoku J Exp Med. doi: 10.1620/tjem.241.175

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Shim YR and Lee HK. 2015. Caspase-1 Independent Viral Clearance and Adaptive Immunity Against Mucosal Respiratory Syncytial Virus Infection. Immune Netw. 15(2): 73-82.

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Rydyznski C, Daniels KA, Karmele EP, Brooks TR, Mahl SE, Moran MT, Li C, Sutiwisesak R, Welsh RM and Waggoner SN. 2015. Generation of cellular immune memory and B-cell immunity is impaired by natural killer cells. Nat Commun. doi: 10.1038/ncomms7375.

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Oh JE, Lee MS, Kim YJ and Lee HK. 2016. OASL1 deficiency promotes antiviral protection against genital herpes simplex virus type 2 infection by enhancing type I interferon production. Sci Rep. doi: 10.1038/srep19089.

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Benck CJ, Martinov T, Fife BT and Chatterjea D. 2016. Isolation of Infiltrating Leukocytes from Mouse Skin Using Enzymatic Digest and Gradient Separation. J Vis Exp. (107), e53638, doi:10.3791/53638.

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Ishizuka M, Miyazaki Y, Masuo M, Shuara K, Tateishi T, Yasui M and Inase N. Interleukin-17A and Neutrophils in a Murine Model of Bird-Related Hypersensitivity Pneumonitis. 2015. PLoS One. doi: 10.1371/journal.pone.0137978.

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Ohta T, Sugiyama, M, Hemmi, H, Yamazaki C, Okura S, Sasaki I, Fukuda Y, Orimo T, Ishii K, Hoshino K, Ginhoux F, and Kaisho T. 2016. Crucial roles of XCR1-expressing dendritic cells and the XCR1-XCL1 chemokine axis in intestinal immune homeostasis. Sci Rep. 6, 23505; doi: 10.1038/srep23505

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Miyata Y, Otsuki M, Kita S and Shimomura I. 2016. Identification of Mouse Mesenteric and Subcutaneous in vitro Adipogenic Cells. Sci Rep. 6:21041. doi: 10.1038/srep21041.

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Carey AJ, Gracias DT, Thayer JL, Boesteanu AC, Kumova OK, Mueller YM, Hope JL, Fraietta JA, van Zessen DB and Katsikis PD. 2016. Rapid Evolution of the CD8+ TCR Repertoire in Neonatal Mice. J Immunol. doi: 10.4049 jimmunol.1502126.

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Vogel CF, Chang WL, Kado S, McColloh K, Vogel H, Wu D, Haarmann-Stemmann T, Yang G, Leung PS, Matsumura F and Gershwin ME. 2016. Transgenic Overexpression of Aryl Hydrocarbon Receptor Repressor (AhRR) and AhR-Mediated Induction of CYP1A1, Cytokines, and Acute Toxicity. Environ Health Perspect. DOI:10.1289/ehp.1510194.

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Benck, CJ, Martinov, T, Fife, BT, and Chatterjea, D. 2016. Isolation of infiltrating leukocytes from mouse skin using enzymatic digest and gradient separation. J Vis Exp. (107) e53638, doi: 10.3791/53638 (2016)

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Mula RVR, Machiah D, Holland L, Wang X, Parihar, H, Sharma AC, Selvaraj P, and Shashidharamurthy R. 2016. Immune Complex-Induced Nitric Oxide-Mediated Vascular Endothelial Cell Death by Phagocytes is Prevented with Decoy FcγReceptors. PLoS ONE 11(4):e0153620. doi:10.1371/journal.pone.0153620

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Yokoyama C, Aoyama T, Ido T, Kakino A, Shiraki T, Tanaka T, Nishigaki K, Hasegawa A, Fujita Y, Sawamura T, and Minatoguchi S. 2016. Deletion of LOX-1 Protects against Heart Failure Induced by Doxorubicin. PloS ONE. doi:10.1371/journal.pone.0154994

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Nabekura T and Lanier LL. 2016. Activating Receptors for Self-MHC Class I Enhance Effector Functions and Memory Differentiation of NK Cells during Mouse Cytomegalovirus Infection. Immunity. Volume 45 , Issue 1 , 74 - 82

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Murphy S, Patrick K, Thoner T, Edwards RW and Gubbels Bupp MR. 2016. T cell up-regulation of CD127 is associated with reductions in the homeostatic set point of the peripheral Tcell pool during malnourishment. Biochemistry and Biophysics Reports. doi:10.1016/j.bbrep.2016.06.006

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Barwick BG, Scharer CD, Bally APR and Boss JM. 2016. Plasma Cell Differentiation is Coupled to Division-Dependent DNA Hypomethylation and Gene Regulation. Nat Immunol. 17(10):1216-25

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Suda J, Dara L, Yang L, Aghajan M, Song Y, Kaplowitz N and Liu Z. 2016. Knockdown of RIPK1 Markedly Exacerbates Murine Immune-Mediated Liver Injury through Massive Apoptosis of Hepatocytes, Independent of Necroptosis and Inhibition of NF-κB. J. Immunol. doi: 10.4049/​jimmunol.1600690

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Sato K, Honda S, Shibuya A and Shibuya K. Improved Protocol for Isolation of Naïve Follicular Dendritic Cells. 2016. Mol. Immunol. doi: 10.1016/j.molimm.2016.09.011

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Adam L. Burrack, Ellen J. Spartz, Jackson F. Raynor, Iris Wang, Margaret Olson, Ingunn M. Stromnes. Combination PD-1 and PD-L1 Blockade Promotes Durable Neoantigen-Specific T Cell-Mediated Immunity in Pancreatic Ductal Adenocarcinoma. Cell Rep. 2019 Aug 20;28(8):2140-2155.e6. doi: 10.1016/j.celrep.2019.07.059

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Derek W. Trobaugh, Chengqun Sun, Matthew D. Dunn, Douglas S. Reed, William B. Klimstra. Rational design of a live-attenuated eastern equine encephalitis virus vaccine through informed mutation of virulence determinants. PLoS Pathog. 2019 Feb 11;15(2):e1007584. doi: 10.1371/journal.ppat.1007584

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Shiyang Li, John W. Bostick, Jian Ye, Joseph F. Urban, Jr., Dorina Avram, Liang Zhou. Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function. Immunity. 2018 Nov 20;49(5):915-928.e5. doi: 10.1016/j.immuni.2018.09.015

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Sarika Saraswati, Stephanie M.W. Marrow, Lester A. Watch1 & Pampee P. Young. Identification of a pro-angiogenic functional role for FSP1-positive fibroblast subtype in wound healing. Nat Commun. 2019 Jul 9;10(1):3027. doi: 10.1038/s41467-019-10965-9

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Grinberg-Bleyer Y, Oh H, Desrichard A, Bhatt DM, Caron R, Chan TA, Schmid RM, Klein U, Hayden MS and Ghosh S. 2017. NF-κB c-Rel Is Crucial for the Regulatory T Cell Immune Checkpoint in Cancer. Cell. doi: 10.1016/j.cell.2017.08.004. 

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CD19 (1D3)

Avalos A, Tietsort JT, Suwankitwat N, Woods JD, Jackson SW, Christodoulou A, Morrill C, Liggitt HD, Zhu C, Li QZ, Bui KK, Park H, Iritani BM. Hem-1 regulates protective humoral immunity and limits autoantibody production in a B cell-specific manner. JCI Insight. 2022 May 9;7(9):e153597. doi: 10.1172/jci.insight.153597. PMID: 35531955; PMCID: PMC9090261.

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Hong H, Lee J, Park GY, Kim S, Park J, Park JS, Song Y, Lee S, Kim TJ, Lee YJ, Roh TY, Kwok SK, Kim SW, Tan Q, Lee Y. Postnatal regulation of B-1a cell development and survival by the CIC-PER2-BHLHE41 axis. Cell Rep. 2022 Feb 15;38(7):110386. doi: 10.1016/j.celrep.2022.110386. PMID: 35172136.

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Stephens WZ, Kubinak JL, Ghazaryan A, Bauer KM, Bell R, Buhrke K, Chiaro TR, Weis AM, Tang WW, Monts JK, Soto R, Ekiz HA, O'Connell RM, Round JL. Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition. Cell Rep. 2021 Nov 2;37(5):109916. doi: 10.1016/j.celrep.2021.109916. PMID: 34731608.

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Hirano KI, Hosokawa H, Koizumi M, et al. LMO2 is essential to maintain the ability of progenitors to differentiate into T-cell lineage in mice. Elife. 2021 Aug 12;10:e68227. doi: 10.7554/eLife.68227. PMID: 34382935; PMCID: PMC8360648.

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Clark NM, Martinez LM, Murdock S, deLigio JT, Olex AL, Effi C, Dozmorov MG, Bos PD. Regulatory T Cells Support Breast Cancer Progression by Opposing IFN-γ-Dependent Functional Reprogramming of Myeloid Cells. Cell Rep. 2020 Dec 8;33(10):108482. doi: 10.1016/j.celrep.2020.108482. PMID: 33296659.

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Xia L, Shi Y, Su J, Friedemann T, et al. Shufeng Jiedu, a promising herbal therapy for moderate COVID-19:Antiviral and anti-inflammatory properties, pathways of bioactive compounds, and a clinical real-world pragmatic study. Phytomedicine. 2020 Oct 22:153390. doi: 10.1016/j.phymed.2020.153390. PMID: 33158717; PMCID: PMC7581328. 

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Daisuke Morichika, Akihiko Taniguchi, Naohiro Oda et al. Loss of IL-33 enhances elastase-induced and cigarette smoke extract-induced emphysema in mice. 04 August 2020. Research Square. https://doi.org/10.21203/rs.3.rs-52288/v1

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Even Fossum, Demo Yemane Tesfaye, Sonja Bobic, Arnar Gudjonsson, Ranveig Braathen, Mireille H. Lahoud, Irina Caminschi, Bjarne Bogen. Targeting Antigens to Different Receptors on Conventional Type 1 Dendritic Cells Impacts the Immune Response. The Journal of Immunology June 26, 2020, ji1901119; DOI: 10.4049/jimmunol.1901119.

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Karki R, Sharma BR, Lee E, et al. Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer. JCI Insight. 2020;5(12):136720. Published 2020 Jun 18. doi:10.1172/jci.insight.136720.

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Jonathan J Pinney, Fátima Rivera-Escalera, Charles C Chu, Hannah E Whitehead, Karl VanDerMeid, Ashley M Nelson, Michelle C Barbeau, Clive S Zent, Michael R Elliott; Macrophage hypophagia as a mechanism of innate immune exhaustion in mAb-induced cell clearance. Blood.2020005571. doi: https://doi.org/10.1182/blood.2020005571.

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Weber A, Pawar HN, Klein JR. Thyroid stimulating hormone β-subunit splice variant is expressed in all fractional subsets of bone marrow hematopoietic cells and peripheral blood leukocytes and is modulated during bacterial infection. Gen Comp Endocrinol. 2020 Apr 30:113495. doi: 10.1016/j.ygcen.2020.113495

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Adami AJ, Bracken SJ, Guernsey LA, et al. Early-life antibiotics attenuate regulatory T cell generation and increase the severity of murine house dust mite-induced asthma. Pediatr Res. 2018;84(3):426-434. doi:10.1038/s41390-018-0031-y.

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Palacios M, Miner TA, Frederick DR, et al. Identification of Two Regulators of Virulence That Are Conserved in Klebsiella pneumoniae Classical and Hypervirulent Strains. mBio. 2018;9(4):e01443-18. Published 2018 Aug 7. doi:10.1128/mBio.01443-18.

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Guo M, Price MJ, Patterson DG, et al. EZH2 Represses the B Cell Transcriptional Program and Regulates Antibody-Secreting Cell Metabolism and Antibody Production. J Immunol. 2018;200(3):1039-1052. doi:10.4049/jimmunol.1701470.

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Andersen TK, Zhou F, Cox R, Bogen B and Grødeland G. 2017. A DNA vaccine that targets hemagglutinin to antigen presenting cells protects mice against H7 influenza. J Virol. doi: 10.1128/JVI.01340-17.

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Fan J, Luo J, Yan C, Hao R, Zhao X, Jia R, He J, Xu D, Miao M and Li X. 2017. Methotrexate, combined with cyclophosphamide attenuates murine collagen induced arthritis by modulating the expression level of Breg and DCs. Mol Immunol. doi: 10.1016/j.molimm.2017.07.001

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Ratiu JJ, Racine JJ, Hasham MG, Wang Q, Branca JA, Chapman HD, Zhu J, Donghia N, Philip V, Schott WH, Wasserfall C, Atkinson MA, Mills KD, Leeth CM and Serreze DV. 2017. Genetic and Small Molecule Disruption of the AID/RAD51 Axis Similarly Protects Nonobese Diabetic Mice from Type 1 Diabetes through Expansion of Regulatory B Lymphocytes. J Immunol. doi: 10.4049/jimmunol.1700024.

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Strother RK, Danahy DB, Kotov DI, Kucaba TA, Zacharias ZR, Griffith TS, Legge KL and Badovinac VP. 2016. Polymicrobial Sepsis Diminishes Dendritic Cell Numbers and Function Directly Contributing to Impaired Primary CD8 T Cell Responses In Vivo. J. Immunol. doi: 10.4049/jimmunol.1601463

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Gudjonsson A, Lysen A, Balan S, Sundvold-Gjerstad V, Arnold-Schrauf C, Richter L, Bækkevold ES, Dalod M, Bogen B and Fossum E. 2017. Targeting Influenza Virus Hemagglutinin to Xcr1+ Dendritic Cells in the Absence of Receptor-Mediated Endocytosis Enhances Protective Antibody Responses. J Immunol. doi: 10.4049/jimmunol.1601881

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Guthmiller JJ, Graham AC, Zander RA, Pope RL and Butler NS. 2017. Cutting Edge: IL-10 Is Essential for the Generation of Germinal Center B Cell Responses and Anti-Plasmodium Humoral Immunity. DOI:10.4049/jimmunol.1601762

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Rydyznski C, Daniels KA, Karmele EP, Brooks TR, Mahl SE, Moran MT, Li C, Sutiwisesak R, Welsh RM and Waggoner SN. 2015. Generation of cellular immune memory and B-cell immunity is impaired by natural killer cells. Nat Commun. doi: 10.1038/ncomms7375.

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Taniguchi A, Miyahara N, Waseda K, Kurimoto E, Fujii U, Tanimoto Y, Kataoka M, Yamamoto Y, Gelfand EW, Yamamoto H, Tanimoto M and Kanehiro A. 2015. Contrasting Roles for the Receptor for Advanced Glycation End-Products on Structural Cells in Allergic Airway Inflammation versus Airway Hyperresponsiveness. Am J Physiol Lung Cell Mol Physiol. DOI: 10.1152/ajplung.00087.2015.

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Manz BN, Tan YX, Courtney A, Rutaganira F, Palmer E, Shokat KM and Weiss A. 2015. Small molecule inhibition of Csk alters affinity recognition by T cells. Elife. doi: 10.7554/eLife.08088.

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Rios D, Wood MB, Li J, Chassaing B, Gewirtz AT and Williams IR. 2015. Antigen sampling by intestinal M cells is the principal pathway initiating mucosal IgA production to commensal enteric bacteria. Mucosal Immunol. doi: 10.1038/mi.2015.121.

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Come C, Cvrljevic A, Khan MM, Treise I, Adler T, Aguilar-Pimental JA, Au-Yeung B, Sittig E, Laajala TD, Chen Y, Oeder S, Calzada-Wack J, Horsch M, Aittokallio T, Busch DH, Ollert MW, Neff F, Beckers J, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Chen Z, Lahesmaa R, and Westermarck J. 2016. CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection. PLoS ONE 11(4):e0152996. doi:10.1371/journal.pone.0152996

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Man SM, Karki R, Sasai M, Place DE, Kesavardhana S, Temirov J, Frase S, Zhu Q, Malireddi RKS, Kuriakose T, Peters JL, Neale G, Brown SA, Yamamoto M and Kannegant T. 2016. IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes. Cell. doi: 10.1016/j.cell.2016.09.012

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Strother RK, Danahy DB, Kotov DI, Kucaba TA, Zacharias ZR, Griffith TS, Legge KL and Badovinac VP. 2016. Polymicrobial Sepsis Diminishes Dendritic Cell Numbers and Function Directly Contributing to Impaired Primary CD8 T Cell Responses In Vivo. J. Immunol. doi: 10.4049/​jimmunol.1601463

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Okamura K, Kitamura A, Sasaki Y, Chung DH, Kagami S, Iwai K and Yasutomo K. 2016. Survival of mature T cells depends on signaling through HOIP. Sci Rep. doi:10.1038/srep36135

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Forster M, Farrington K, Petrov JC, Belle JI, Mindt BC, Witalis M, Duerr CU, Fritz JH and Nijnik A. 2016. MYSM1-dependent checkpoints in B cell lineage differentiation and B cell–mediated immune response. J. Leukoc. Biol. doi:10.1189/jlb.1AB0415-177RR

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Ortega SB, Noorbhai I, Poinsatte K, Kong X, Anderson A, Monson NL and Stowe AM. 2015. Stroke Induces a Rapid Adaptive Autoimmune Response to Novel Neuronal Antigens. Discov. Med. (106):381-92

» View on PubMed

Uzodinma U. Uche, Ann R. Piccirillo, Shunsuke Kataoka, Stephanie J. Grebinoski, Louise M. D’Cruz, and Lawrence P. Kane. PIK3IP1/TrIP restricts activation of T cells through inhibition of PI3K/Akt. J Exp Med. 2018 Dec 3;215(12):3165-3179. doi: 10.1084/jem.20172018

» View on PubMed

Shiyang Li, John W. Bostick, Jian Ye, Joseph F. Urban, Jr., Dorina Avram, Liang Zhou. Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function. Immunity. 2018 Nov 20;49(5):915-928.e5. doi: 10.1016/j.immuni.2018.09.015

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Rita Kansal, Noah Richardson, Indira Neeli, Saleem Khawaja, Damian Chamberlain, Marium Ghani, Qurat-ul-ain Ghani, Louisa Balazs, Sarka Beranova-Giorgianni, Francesco Giorgianni, James N. Kochenderfer, Tony Marion, Lorraine M. Albritton, Marko Radic. Sustained B cell depletion by CD19-targeted CAR T cells is a highly effective treatment for murine lupus. Sci Transl Med. 2019 Mar 6;11(482). pii: eaav1648. doi: 10.1126/scitranslmed.aav1648

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Nicholas N. Jarjour, Elizabeth A. Schwarzkopf, Tara R. Bradstreet, Irina Shchukina, Chih-Chung Lin, Stanley Ching-Cheng Huang, Chin-Wen Lai, Melissa E. Cook, Reshma Taneja, Thaddeus S. Stappenbeck, Gwendalyn J. Randolph, Maxim N. Artyomov, Joseph F. Urban Jr., and Brian T. Edelson. Bhlhe40 mediates tissue-specific control of macrophage proliferation in homeostasis and type 2 immunity. Nat Immunol. 2019 Jun;20(6):687-700. doi: 10.1038/s41590-019-0382-5

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Qiumei Du, Ashley R. Hoover, Igor Dozmorov, Ondine B. Cleaver,Joshua T. Mendell, Nicolai S.C. van Oers. MIR205HG Is a Long Noncoding RNA that Regulates Growth Hormone and Prolactin Production in the Anterior Pituitary. Dev Cell. 2019 May 20;49(4):618-631.e5. doi: 10.1016/j.devcel.2019.03.012

» View on PubMed


CD25 (PC61.5)

Avalos A, Tietsort JT, Suwankitwat N, Woods JD, Jackson SW, Christodoulou A, Morrill C, Liggitt HD, Zhu C, Li QZ, Bui KK, Park H, Iritani BM. Hem-1 regulates protective humoral immunity and limits autoantibody production in a B cell-specific manner. JCI Insight. 2022 May 9;7(9):e153597. doi: 10.1172/jci.insight.153597. PMID: 35531955; PMCID: PMC9090261.

» View on PubMed

Kotake K, Kumazawa T, Adachi T. Long-term administration of Tetragenococcus halophilus No. 1 over generations affects the immune system of mice. PLoS One. 2022 Apr 26;17(4):e0267473. doi: 10.1371/journal.pone.0267473. PMID: 35472068; PMCID: PMC9041805.

» View on PubMed

Brandi P, Conejero L, Cueto FJ, Martínez-Cano S, Dunphy G, Gómez MJ, Relaño C, Saz-Leal P, Enamorado M, Quintas A, Dopazo A, Amores-Iniesta J, Del Fresno C, Nistal-Villán E, Ardavín C, Nieto A, Casanovas M, Subiza JL, Sancho D. Trained immunity induction by the inactivated mucosal vaccine MV130 protects against experimental viral respiratory infections. Cell Rep. 2022 Jan 4;38(1):110184. doi: 10.1016/j.celrep.2021.110184. PMID: 34986349.

» View on ScienceDirect

Castillo-González R, Cibrian D, Fernández-Gallego N, Ramírez-Huesca M, Saiz ML, Navarro MN, Fresno M, Fuente H, Sánchez-Madrid F. Galectin-1 expression in CD8+ T lymphocytes controls inflammation in contact hypersensitivity. J Invest Dermatol. 2020 Nov 9:S0022-202X(20)32281-8. doi: 10.1016/j.jid.2020.10.020. PMID: 33181141.

» View on ScienceDirect

Kayla R. Kulhanek, Darienne R. Myers, Olga Ksionda, Yvonne Vercoulen, Damia Romero-Moya, Jeroen P. Roose.  Protocol for Barcoding T Cells Combined with Timed Stimulations. STAR Protocols 2020, 100067, ISSN 2666-1667.  https://doi.org/10.1016/j.xpro.2020.100067.

» View on ScienceDirect

Ishikawa Y, Kitaoka S, Kawano Y, et al. Repeated social defeat stress induces neutrophil mobilization in mice: maintenance after cessation of stress and strain-dependent difference [published online ahead of print, 2020 Jul 17]. Br J Pharmacol. 2020;10.1111/bph.15203. doi:10.1111/bph.15203.

» View on PubMed

Slade CD, Reagin KL, Lakshmanan HG, Klonowski KD, Watford WT. Placenta-specific 8 limits IFNγ production by CD4 T cells in vitro and promotes establishment of influenza-specific CD8 T cells in vivo. PLoS One. 2020;15(7):e0235706. Published 2020 Jul 8. doi:10.1371/journal.pone.0235706.

» View on PubMed

Dolina JS, Lee J, Griswold RQ, Labarta-Bajo L, Kannan S, Greenbaum JA, Bahia El Idrissi N, Pont MJ, Croft M, Schoenberger SP. TLR9 Sensing of Self-DNA Controls Cell-Mediated Immunity to Listeria Infection via Rapid Conversion of Conventional CD4+ T Cells to Treg. Cell Rep. 2020 Apr 7;31(1):107249. doi: 10.1016/j.celrep.2020.01.040.

» View on ScienceDirect

Shimada K, Porritt RA, Markman JL, et al. T-Cell-Intrinsic Receptor Interacting Protein 2 Regulates Pathogenic T Helper 17 Cell Differentiation. Immunity. 2018;49(5):873-885.e7. doi:10.1016/j.immuni.2018.08.022.

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Palacios-Arreola MI, Nava-Castro KE, Río-Araiza VHD, Pérez-Sánchez NY and Morales-Montor J. 2017. A single neonatal administration of Bisphenol A induces higher tumour weight associated to changes in tumour microenvironment in the adulthood. Sci Rep. doi: 10.1038/s41598-017-10135-1.

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Conejero L, Khouili SC, Martínez-Cano S, Izquierdo HM, Brandi P and Sancho D. 2017. Lung CD103+ dendritic cells restrain allergic airway inflammation through IL-12 production. JCI Insight. doi: 10.1172/jci.insight.90420

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Sato Y, Kato H, Ebina-Shibuya R, Itoh-Nakadai A, Okuyama R and Igarashi K. 2017. Bach2 Controls Homeostasis of Eosinophils by Restricting the Type-2 Helper Function of T Cells. Tohoku J Exp Med. doi: 10.1620/tjem.241.175

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Zander RA, Guthmiller JJ, Graham AC, Pope RL, Burke BE, Carr DJ and Butler NS. 2016. Type I Interferons Induce T Regulatory 1 Responses and Restrict Humoral Immunity during Experimental Malaria. PLOS Pathogens. DOI:10.1371/journal.ppat.1005945

» View on PubMed

Martinez-Lopez M, Iborra S, Conde-Garrosa R and Sancho D. 2014. Batf3-dependent CD103+ dendritic cells are major producers of IL-12 that drive local Th1 immunity against Leishmania major infection in mice. Eur J Immunol. 45(1): 119-129.

» View on PubMed

Ortega SB, Noorbhai I, Poinsatte K, Kong X, Anderson A, Monson NL and Stowe AM. 2015. Stroke Induces a Rapid Adaptive Autoimmune Response to Novel Neuronal Antigens. Discov. Med. (106):381-92

» View on PubMed

Uzodinma U. Uche, Ann R. Piccirillo, Shunsuke Kataoka, Stephanie J. Grebinoski, Louise M. D’Cruz, and Lawrence P. Kane. PIK3IP1/TrIP restricts activation of T cells through inhibition of PI3K/Akt. J Exp Med. 2018 Dec 3;215(12):3165-3179. doi: 10.1084/jem.20172018

» View on PubMed

Erola Ainsua-Enrich, Ibrahim Hatipoglu, Sapana Kadel, Sean Turner, Jinny Paul, Simar Singh, Harini Bagavant, and Susan Kovats. IRF4-dependent dendritic cells regulate CD8+ T cell differentiation and memory responses in influenza infection. Mucosal Immunol. 2019 Jul;12(4):1025-1037. doi: 10.1038/s41385-019-0173-1

» View on PubMed

Jordy Saravia, Hu Zeng1, Yogesh Dhungana, Daniel Bastardo Blanco, Thanh-Long M. Nguyen, Nicole M. Chapman, Yanyan Wang, Apurva Kanneganti, Shaofeng Liu, Jana L. Raynor, Peter Vogel, Geoffrey Neale, Peter Carmeliet, Hongbo Chi. Homeostasis and transitional activation of regulatory T cells require c-Myc. Sci Adv. 2020 Jan 1;6(1):eaaw6443. doi: 10.1126/sciadv.aaw6443

» View on PubMed

Hao Shi, Nicole M. Chapman, Jing Wen, Cliff Guy, Lingyun Long, Yogesh Dhungana, Sherri Rankin, Stephane Pelletier, Peter Vogel, Hong Wang, Junmin Peng, Kun-Liang Guan, and Hongbo Chi. Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb. Immunity. 2019 Dec 17;51(6):1012-1027.e7. doi: 10.1016/j.immuni.2019.10.001

» View on PubMed

Oh H, Grinberg-Bleyer Y, Liao W, Maloney D, Wang P, Wu Z, Wang J, Bhatt DM, Heise N, Schmid RM, Hayden MS, Klein U, Rabadan R and Ghosh S. 2017. An NF-κB Transcription-Factor-Dependent Lineage-Specific Transcriptional Program Promotes Regulatory T Cell Identity and Function. Immunity. doi: 10.1016/j.immuni.2017.08.010.

» View on PubMed

Grinberg-Bleyer Y, Oh H, Desrichard A, Bhatt DM, Caron R, Chan TA, Schmid RM, Klein U, Hayden MS and Ghosh S. 2017. NF-κB c-Rel Is Crucial for the Regulatory T Cell Immune Checkpoint in Cancer. Cell. doi: 10.1016/j.cell.2017.08.004. 

» View on PubMed

CD28 (37.51)

 

Teghanemt A, Pulipati P, Misel-Wuchter K, Day K, Yorek MS, Yi R, Keen HL, Au C, Maretzky T, Gurung P, Littman DR, Issuree PD. CD4 expression in effector T cells depends on DNA demethylation over a developmentally established stimulus-responsive element. Nat Commun. 2022 Mar 18;13(1):1477. doi: 10.1038/s41467-022-28914-4. PMID: 35304452.

» View on NatureCommunications

Hong H, Lee J, Park GY, Kim S, Park J, Park JS, Song Y, Lee S, Kim TJ, Lee YJ, Roh TY, Kwok SK, Kim SW, Tan Q, Lee Y. Postnatal regulation of B-1a cell development and survival by the CIC-PER2-BHLHE41 axis. Cell Rep. 2022 Feb 15;38(7):110386. doi: 10.1016/j.celrep.2022.110386. PMID: 35172136.

» View on ScienceDirect

Ortega-Molina A, Lebrero-Fernández C, Sanz A, et al. Inhibition of Rag GTPase signaling in mice suppresses B cell responses and lymphomagenesis with minimal detrimental trade-offs. Cell Rep. 2021 Jul 13;36(2):109372. doi: 10.1016/j.celrep.2021.109372. PMID: 34260908. 

» View on ScienceDirect

Asakawa T, Onizawa M, Saito C, et al. Oral administration of D-serine prevents the onset and progression of colitis in mice. J Gastroenterol. 2021 Aug;56(8):732-745. doi: 10.1007/s00535-021-01792-1. Epub 2021 Jun 20. PMID: 34148144.

» View on PubMed

Mohammadi MR, Rodriguez SM, Luong JC, et al. Exosome loaded immunomodulatory biomaterials alleviate local immune response in immunocompetent diabetic mice post islet xenotransplantation. Commun Biol. 2021 Jun 3;4(1):685. doi: 10.1038/s42003-021-02229-4. PMID: 34083739; PMCID: PMC8175379.

» View on Communications Biology

Li K, Yuan Z, Lyu J, Ahn E, Davis SJ, Ahmed R, Zhu C. PD-1 suppresses TCR-CD8 cooperativity during T-cell antigen recognition. Nat Commun. 2021 May 12;12(1):2746. doi: 10.1038/s41467-021-22965-9. PMID: 33980853; PMCID: PMC8115078.

» View on Nature Communications

Lederer K, Castaño D, Gómez Atria D, et al. SARS-CoV-2 mRNA Vaccines Foster Potent Antigen-Specific Germinal Center Responses Associated with Neutralizing Antibody Generation. Immunity. 2020 Dec 15;53(6):1281-1295.e5. doi: 10.1016/j.immuni.2020.11.009. Epub 2020 Nov 21. PMID: 33296685; PMCID: PMC7680029.

» View on PubMed

Castillo-González R, Cibrian D, Fernández-Gallego N, Ramírez-Huesca M, Saiz ML, Navarro MN, Fresno M, Fuente H, Sánchez-Madrid F. Galectin-1 expression in CD8+ T lymphocytes controls inflammation in contact hypersensitivity. J Invest Dermatol. 2020 Nov 9:S0022-202X(20)32281-8. doi: 10.1016/j.jid.2020.10.020. PMID: 33181141.

» View on ScienceDirect

Yashiro T, Yura S, Tobita A, Toyoda Y, Kasakura K, Nishiyama C. Pterostilbene reduces colonic inflammation by suppressing dendritic cell activation and promoting regulatory T cell development. FASEB J. 2020 Sep 22. doi: 10.1096/fj.202001502R. PMID: 32964554.  

» View on PubMed

Semionatto IF, Palameta S, Toscaro JM, Manrique-Rincón AJ, Ruas LP, Paes Leme AF, Bajgelman MC. Extracellular vesicles produced by immunomodulatory cells harboring OX40 ligand and 4-1BB ligand enhance antitumor immunity. Sci Rep. 2020 Sep 16;10(1):15160. doi: 10.1038/s41598-020-72122-3. PMID: 32939048.  

» View on Scientific Reports

Avery L, Filderman J, Szymczak-Workman AL, Kane LP4. Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2455-2460. doi: 10.1073/pnas.1712107115

» View on PubMed

CD44 (IM7)

 

Kwon DI, Park ES, Kim M, Choi YH, Lee MS, Joo SH, Kang YW, Lee M, Jo SB, Lee SW, Kim JK, Lee YJ. Homeostatic serum IgE is secreted by plasma cells in the thymus and enhances mast cell survival. Nat Commun. 2022 Mar 17;13(1):1418. doi: 10.1038/s41467-022-29032-x. PMID: 35301301.

» View on NatureCommunications

Wilfahrt D, Philips RL, Lama J, Kizerwetter M, Shapiro MJ, McCue SA, Kennedy MM, Rajcula MJ, Zeng H, Shapiro VS. Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation. Elife. 2021 Dec 2;10:e70978. doi: 10.7554/eLife.70978. PMID: 34854376; PMCID: PMC8639145. 

» View on PubMed

Ortega-Molina A, Lebrero-Fernández C, Sanz A, et al. Inhibition of Rag GTPase signaling in mice suppresses B cell responses and lymphomagenesis with minimal detrimental trade-offs. Cell Rep. 2021 Jul 13;36(2):109372. doi: 10.1016/j.celrep.2021.109372. PMID: 34260908. 

» View on ScienceDirect

Burbach BJ, O'Flanagan SD, Shao Q, et al. Irreversible electroporation augments checkpoint immunotherapy in prostate cancer and promotes tumor antigen-specific tissue-resident memory CD8+ T cells. Nat Commun. 2021 Jun 23;12(1):3862. doi: 10.1038/s41467-021-24132-6. PMID: 34162858.

» View on NatureCommunications

Li K, Yuan Z, Lyu J, Ahn E, Davis SJ, Ahmed R, Zhu C. PD-1 suppresses TCR-CD8 cooperativity during T-cell antigen recognition. Nat Commun. 2021 May 12;12(1):2746. doi: 10.1038/s41467-021-22965-9. PMID: 33980853; PMCID: PMC8115078.

» View on Nature Communications

Feola M, Zamperone A, Moskop D, et al. Pleckstrin-2 is essential for erythropoiesis in β-thalassemic mice, reducing apoptosis and enhancing enucleation. Commun Biol. 2021 May 3;4(1):517. doi: 10.1038/s42003-021-02046-9. PMID: 33941818; PMCID: PMC8093212.

» View on CommunicationsBiology

Trott DW, Islam MT, Buckley DJ, Donato AJ, Dutson T, Sorensen ES, Cai J, Gogulamudi VR, Phuong TTT, Lesniewski LA. T lymphocyte depletion ameliorates age-related metabolic impairments in mice. Geroscience. 2021 Apr 24. doi: 10.1007/s11357-021-00368-4. PMID: 33893902.

» View on PubMed

Harro CM, Perez-Sanz J, Costich TL, et al. Methyltransferase inhibitors restore SATB1 protective activity against cutaneous T cell lymphoma in mice. J Clin Invest. 2020 Dec 3:135711. doi: 10.1172/JCI135711. PMID: 33270606.

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Park GY, Lee GW, Kim S, Hong H, et al. Deletion Timing of Cic Alleles during Hematopoiesis Determines the Degree of Peripheral CD4+ T Cell Activation and Proliferation. Immune Netw. 2020 Oct 27;20(5):e43. doi: 10.4110/in.2020.20.e43. PMID: 33163251; PMCID: PMC7609164.

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Toriyama K, Kuwahara M, Kondoh H, et al. T cell-specific deletion of Pgam1 reveals a critical role for glycolysis in T cell responses. Commun Biol. 2020;3(1):394. Published 2020 Jul 24. doi:10.1038/s42003-020-01122-w.

» View on Communications Biology

Kayla R. Kulhanek, Darienne R. Myers, Olga Ksionda, Yvonne Vercoulen, Damia Romero-Moya, Jeroen P. Roose.  Protocol for Barcoding T Cells Combined with Timed Stimulations. STAR Protocols 2020, 100067, ISSN 2666-1667.  https://doi.org/10.1016/j.xpro.2020.100067.

» View on ScienceDirect

Iida Y, Yoshikawa R, Murata A, et al. Local injection of CCL19-expressing mesenchymal stem cells augments the therapeutic efficacy of anti-PD-L1 antibody by promoting infiltration of immune cells. J Immunother Cancer. 2020;8(2):e000582. doi:10.1136/jitc-2020-000582.

» View on PubMed

Slade CD, Reagin KL, Lakshmanan HG, Klonowski KD, Watford WT. Placenta-specific 8 limits IFNγ production by CD4 T cells in vitro and promotes establishment of influenza-specific CD8 T cells in vivo. PLoS One. 2020;15(7):e0235706. Published 2020 Jul 8. doi:10.1371/journal.pone.0235706.

» View on PubMed

Kiatpakdee B, Sato K, Otsuka Y, Arashiki N, Chen Y, Tsumita T, Otsu W, Yamamoto A, Kawata R, Yamazaki J, Sugimoto Y, Takada K, Mohandas N, Inaba M. Cholesterol-binding protein TSPO2 coordinates maturation and proliferation of terminally differentiating erythroblasts. J Biol Chem. 2020 May 1. pii: jbc.RA119.011679. doi: 10.1074/jbc.RA119.011679.

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Atif SM, Mack DG, McKee AS, et al. Protective role of B cells in sterile particulate-induced lung injury. JCI Insight. 2019;5(12):e125494. Published 2019 May 16. doi:10.1172/jci.insight.125494.

» View on PubMed

Wang H, Hogquist KA. CCR7 defines a precursor for murine iNKT cells in thymus and periphery. Elife. 2018;7:e34793. Published 2018 Aug 13. doi:10.7554/eLife.34793.

» View on PubMed

Govindarajan S, Gaublomme D, Van der Cruyssen R, et al. Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha. Nat Commun. 2018;9(1):5340. Published 2018 Dec 17. doi:10.1038/s41467-018-07758-x.

» View on Nature Communications

Sato Y, Kato H, Ebina-Shibuya R, Itoh-Nakadai A, Okuyama R and Igarashi K. 2017. Bach2 Controls Homeostasis of Eosinophils by Restricting the Type-2 Helper Function of T Cells. Tohoku J Exp Med. doi: 10.1620/tjem.241.175

» View on PubMed

Rydyznski C, Daniels KA, Karmele EP, Brooks TR, Mahl SE, Moran MT, Li C, Sutiwisesak R, Welsh RM and Waggoner SN. 2015. Generation of cellular immune memory and B-cell immunity is impaired by natural killer cells. Nat Commun. doi: 10.1038/ncomms7375.

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Bapat SP, Nyoung Suh J, Fang S, Liu S, Zhang Y, Cheng A, Zhou C, Liang Y, LeBlanc M, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM and Zheng Y. 2015. Depletion of fat-resident Treg cells prevents age-associated insulin resistance. Nature. 528: 137-141.

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Schwerk A, Altshuler J, Roch M, Gossen M, Winter C, Berg J, Kurtz A, Akyuz L and Steiner B. 2015. Adipose-derived human mesenchymal stem cells induce long-term neurogenic and anti-inflammatory effects and improve cognitive but not motor performance in a rat model of Parkinson's disease. Regen Med. 10(4): 431-445.

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Carey AJ, Gracias DT, Thayer JL, Boesteanu AC, Kumova OK, Mueller YM, Hope JL, Fraietta JA, van Zessen DB and Katsikis PD. 2016. Rapid Evolution of the CD8+ TCR Repertoire in Neonatal Mice. J Immunol. doi: 10.4049 jimmunol.1502126.

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Watson AM, Matthew Lam LK, Klimstra WB and Ryman KD. 2016. The 17D-204 Vaccine Strain-Induced Protection Against Virulent Yellow Fever Virus is Mediated by Humoral Immunity and CD4+ But Not CD8+ T Cells. PLoS Pathog. doi:10.1371/journal.ppat.1005786

» View on PubMed

Uzodinma U. Uche, Ann R. Piccirillo, Shunsuke Kataoka, Stephanie J. Grebinoski, Louise M. D’Cruz, and Lawrence P. Kane. PIK3IP1/TrIP restricts activation of T cells through inhibition of PI3K/Akt. J Exp Med. 2018 Dec 3;215(12):3165-3179. doi: 10.1084/jem.20172018

» View on PubMed

Avery L, Filderman J, Szymczak-Workman AL, Kane LP4. Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2455-2460. doi: 10.1073/pnas.1712107115

» View on PubMed

Jordy Saravia, Hu Zeng1, Yogesh Dhungana, Daniel Bastardo Blanco, Thanh-Long M. Nguyen, Nicole M. Chapman, Yanyan Wang, Apurva Kanneganti, Shaofeng Liu, Jana L. Raynor, Peter Vogel, Geoffrey Neale, Peter Carmeliet, Hongbo Chi. Homeostasis and transitional activation of regulatory T cells require c-Myc. Sci Adv. 2020 Jan 1;6(1):eaaw6443. doi: 10.1126/sciadv.aaw6443

» View on PubMed

Hao Shi, Nicole M. Chapman, Jing Wen, Cliff Guy, Lingyun Long, Yogesh Dhungana, Sherri Rankin, Stephane Pelletier, Peter Vogel, Hong Wang, Junmin Peng, Kun-Liang Guan, and Hongbo Chi. Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb. Immunity. 2019 Dec 17;51(6):1012-1027.e7. doi: 10.1016/j.immuni.2019.10.001

» View on PubMed

Oh H, Grinberg-Bleyer Y, Liao W, Maloney D, Wang P, Wu Z, Wang J, Bhatt DM, Heise N, Schmid RM, Hayden MS, Klein U, Rabadan R and Ghosh S. 2017. An NF-κB Transcription-Factor-Dependent Lineage-Specific Transcriptional Program Promotes Regulatory T Cell Identity and Function. Immunity. doi: 10.1016/j.immuni.2017.08.010.

» View on PubMed

Grinberg-Bleyer Y, Oh H, Desrichard A, Bhatt DM, Caron R, Chan TA, Schmid RM, Klein U, Hayden MS and Ghosh S. 2017. NF-κB c-Rel Is Crucial for the Regulatory T Cell Immune Checkpoint in Cancer. Cell. doi: 10.1016/j.cell.2017.08.004. 

» View on PubMed


CD45R (B220) (RA3-6B2)

Kotake K, Kumazawa T, Adachi T. Long-term administration of Tetragenococcus halophilus No. 1 over generations affects the immune system of mice. PLoS One. 2022 Apr 26;17(4):e0267473. doi: 10.1371/journal.pone.0267473. PMID: 35472068; PMCID: PMC9041805.

» View on PubMed

Hong H, Lee J, Park GY, Kim S, Park J, Park JS, Song Y, Lee S, Kim TJ, Lee YJ, Roh TY, Kwok SK, Kim SW, Tan Q, Lee Y. Postnatal regulation of B-1a cell development and survival by the CIC-PER2-BHLHE41 axis. Cell Rep. 2022 Feb 15;38(7):110386. doi: 10.1016/j.celrep.2022.110386. PMID: 35172136.

» View on ScienceDirect

Kervevan J, Bouteau A, Lanza JS, et al. Targeting human langerin promotes HIV-1 specific humoral immune responses. PLoS Pathog. 2021 Jul 29;17(7):e1009749. doi: 10.1371/journal.ppat.1009749. PMID: 34324611.

» View on PubMed

Fu Z, Dean JW, Xiong L, et al. Mitochondrial transcription factor A in RORγt+ lymphocytes regulate small intestine homeostasis and metabolism. Nat Commun. 2021 Jul 22;12(1):4462. doi: 10.1038/s41467-021-24755-9. PMID: 34294718.

» View on Nature Communications

Burbach BJ, O'Flanagan SD, Shao Q, et al. Irreversible electroporation augments checkpoint immunotherapy in prostate cancer and promotes tumor antigen-specific tissue-resident memory CD8+ T cells. Nat Commun. 2021 Jun 23;12(1):3862. doi: 10.1038/s41467-021-24132-6. PMID: 34162858.

» View on NatureCommunications

Davenport BJ, Morrison TE, Kedl RM, Klarquist J. Conserved and Novel Mouse CD8 T Cell Epitopes within SARS-CoV-2 Spike Receptor Binding Domain Protein Identified following Subunit Vaccination. J Immunol. 2021 May 10:ji2100195. doi: 10.4049/jimmunol.2100195. PMID: 33972373.

» View on JournalofImmunology

Baba T, Yoshida T, Tanabe Y, et al. Cytoplasmic DNA accumulation preferentially triggers cell death of myeloid leukemia cells by interacting with intracellular DNA sensing pathway. Cell Death Dis. 2021 Mar 26;12(4):322. doi: 10.1038/s41419-021-03587-x. PMID: 33771977.  

» View on Nature

Aihara R, Kunimura K, Watanabe M, Uruno T, Yamane N, Sakurai T, Sakata D, Nishimura F, Fukui Y. DOCK8 controls survival of group 3 innate lymphoid cells in the gut through Cdc42 activation. Int Immunol. 2020 Sep 28:dxaa066. doi: 10.1093/intimm/dxaa066. PMID: 32986079.   

» View on PubMed

Racine JJ, Chapman HD, Doty R, Cairns BM, Hines TJ, Tadenev ALD, Anderson LC, Green T, Dyer ME, Wotton JM, Bichler Z, White JK, Ettinger R, Burgess RW, Serreze DV. T Cells from NOD-PerIg Mice Target Both Pancreatic and Neuronal Tissue. J Immunol. 2020 Sep 16:ji2000114. doi: 10.4049/jimmunol.2000114. PMID: 32938729.

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Hiroshi Kobayashi and Keiyo Takubo. Protocol for the Maintenance of Quiescent Murine Hematopoietic Stem Cells. STAR Protocols.  Published 2 August 2020. https://doi.org/10.1016/j.xpro.2020.100078. 

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Even Fossum, Demo Yemane Tesfaye, Sonja Bobic, Arnar Gudjonsson, Ranveig Braathen, Mireille H. Lahoud, Irina Caminschi, Bjarne Bogen. Targeting Antigens to Different Receptors on Conventional Type 1 Dendritic Cells Impacts the Immune Response. The Journal of Immunology June 26, 2020, ji1901119; DOI: 10.4049/jimmunol.1901119.

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Jonathan J Pinney, Fátima Rivera-Escalera, Charles C Chu, Hannah E Whitehead, Karl VanDerMeid, Ashley M Nelson, Michelle C Barbeau, Clive S Zent, Michael R Elliott; Macrophage hypophagia as a mechanism of innate immune exhaustion in mAb-induced cell clearance. Blood.2020005571. doi: https://doi.org/10.1182/blood.2020005571.

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Ju Youn Lee, Seung Hoon Han, Min Hee Park, Im-Sook Song, Min-Koo Choi, Eunsoo Yu, Cheol-Min Park, Hee-Jin Kim, Seung Hyun Kim, Edward H Schuchman, Hee Kyung Jin, Jae-Sung Bae. N-AS-triggered SPMs Are Direct Regulators of Microglia in a Model of Alzheimer's Disease. Nat Commun. 2020 May 12;11(1):2358. doi: 10.1038/s41467-020-16080-4.

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Simões IT, Aranda F, Casadó-Llombart S, et al. Multifaceted effects of soluble human CD6 in experimental cancer models. J Immunother Cancer. 2020 Mar;8(1):e000172. doi: 10.1136/jitc-2019-000172. PMID: 32217757; PMCID: PMC7174071.

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Kobayashi H, Morikawa T, Okinaga A, et al. Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo. Cell Rep. 2019;28(1):145-158.e9. doi:10.1016/j.celrep.2019.06.008.

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Yang BH, Wang K, Wan S, et al. TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases. Cell Rep. 2019;27(12):3629-3645.e6. doi:10.1016/j.celrep.2019.05.061.

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Shimada K, Porritt RA, Markman JL, et al. T-Cell-Intrinsic Receptor Interacting Protein 2 Regulates Pathogenic T Helper 17 Cell Differentiation. Immunity. 2018;49(5):873-885.e7. doi:10.1016/j.immuni.2018.08.022.

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Scharer CD, Barwick BG, Guo M, Bally APR, Boss JM. Plasma cell differentiation is controlled by multiple cell division-coupled epigenetic programs. Nat Commun. 2018;9(1):1698. Published 2018 Apr 27. doi:10.1038/s41467-018-04125-8.

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Adami AJ, Bracken SJ, Guernsey LA, et al. Early-life antibiotics attenuate regulatory T cell generation and increase the severity of murine house dust mite-induced asthma. Pediatr Res. 2018;84(3):426-434. doi:10.1038/s41390-018-0031-y.

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Guo M, Price MJ, Patterson DG, et al. EZH2 Represses the B Cell Transcriptional Program and Regulates Antibody-Secreting Cell Metabolism and Antibody Production. J Immunol. 2018;200(3):1039-1052. doi:10.4049/jimmunol.1701470.

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Oguro H, McDonald JG, Zhao Z, Umetani M, Shaul PW and Morrison SJ. 2017. 27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy. J Clin Invest. doi: 10.1172/JCI94027.

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Ganuza M, Hall T, Finkelstein D, Chabot A, Kang G and McKinney-Freeman S. (2017) Lifelong haematopoiesis is established by hundreds of precursors throughout mammalian ontogeny. Nat Cell Biol. DOI: 10.1038/ncb3607

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Gudjonsson A, Lysen A, Balan S, Sundvold-Gjerstad V, Arnold-Schrauf C, Richter L, Bækkevold ES, Dalod M, Bogen B and Fossum E. 2017. Targeting Influenza Virus Hemagglutinin to Xcr1+ Dendritic Cells in the Absence of Receptor-Mediated Endocytosis Enhances Protective Antibody Responses. J Immunol. doi: 10.4049/jimmunol.1601881

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Mgbemena VE, Signer RA, Wijayatunge R, Laxson T, Morrison SJ, Ross TS. 2017. Distinct Brca1 Mutations Differentially Reduce Hematopoietic Stem Cell Function. Cell Rep. DOI: 10.1016/j.celrep.2016.12.075

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Zander RA, Guthmiller JJ, Graham AC, Pope RL, Burke BE, Carr DJ and Butler NS. 2016. Type I Interferons Induce T Regulatory 1 Responses and Restrict Humoral Immunity during Experimental Malaria. PLOS Pathogens. DOI:10.1371/journal.ppat.1005945

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Rydyznski C, Daniels KA, Karmele EP, Brooks TR, Mahl SE, Moran MT, Li C, Sutiwisesak R, Welsh RM and Waggoner SN. 2015. Generation of cellular immune memory and B-cell immunity is impaired by natural killer cells. Nat Commun. doi: 10.1038/ncomms7375.

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Fiege JK, Burback Bj and Shimizu Y. 2015. Negative Regulation of Memory Phenotype CD8 T Cell Conversion by Adhesion and Degranulation-Promoting Adapter Protein. J Immunol. 195(7): 3119-3128.

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Come C, Cvrljevic A, Khan MM, Treise I, Adler T, Aguilar-Pimental JA, Au-Yeung B, Sittig E, Laajala TD, Chen Y, Oeder S, Calzada-Wack J, Horsch M, Aittokallio T, Busch DH, Ollert MW, Neff F, Beckers J, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Chen Z, Lahesmaa R, and Westermarck J. 2016. CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection. PLoS ONE 11(4):e0152996. doi:10.1371/journal.pone.0152996

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Spanier JA, Frederick DR, Taylor JJ, Heffernan JR, Kotov DI, Martinox T, Osum KC, Ruggiero JL, Rust BJ, Landry SJ, Jenkins MK, McLachlan JB, and Fife BT. 2016. Efficient Generation of Monoclonal Antibodies Against Peptide in the Context of MHCII Using Magnetic Enrichment. Nature Communications. doi:10.1038/ncomms11804

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Iraolagoitia XL, Spallanzani RG, Torres NI, Araya RA, Ziblat A, Domaica CI, Sierra JM, Nunex SY, Secchiari F, Gajewski TF, Zwirner NW and Fuertes MB. 2016 NK Cells Restrain Spontaneous Antitumor CD8+ T Cell Priming Through PD-1/PD-L1 Interactions with Dendritic Cells. J. Immunol. 197:953-961

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Lee LM, Ji M, Sinha M, Dong MB, Ren X, Wang Y, Lowell CA, Ghosh S, Locksley RM and DeFranco AL. 2016. Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9. PLOS one. doi:10.1371/journal.pone.0167693

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Mande P, Zirak B, Ko WC, Taravati K, Bride KL, Brodeur TY, Deng A, Dresser K, Jiang Z, Ettinger R, Fitzgerald KA, Rosenblum MD, Harris JE, Marshak-Rothstein A. Fas ligand promotes an inducible TLR-dependent model of cutaneous lupus-like inflammation. J Clin Invest. 2018 Jul 2;128(7):2966-2978. doi: 10.1172/JCI98219

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Kovats. A Major Population of Functional KLRG1- ILC2s in Female Lungs Contributes to a Sex Bias in ILC2 Numbers. Immunohorizons. 2018 Feb;2(2):74-86. doi: 10.4049/immunohorizons.1800008

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Shiyang Li, John W. Bostick, Jian Ye, Joseph F. Urban, Jr., Dorina Avram, Liang Zhou. Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function. Immunity. 2018 Nov 20;49(5):915-928.e5. doi: 10.1016/j.immuni.2018.09.015

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Qiumei Du, Ashley R. Hoover, Igor Dozmorov, Ondine B. Cleaver,Joshua T. Mendell, Nicolai S.C. van Oers. MIR205HG Is a Long Noncoding RNA that Regulates Growth Hormone and Prolactin Production in the Anterior Pituitary. Dev Cell. 2019 May 20;49(4):618-631.e5. doi: 10.1016/j.devcel.2019.03.012

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Jordy Saravia, Hu Zeng1, Yogesh Dhungana, Daniel Bastardo Blanco, Thanh-Long M. Nguyen, Nicole M. Chapman, Yanyan Wang, Apurva Kanneganti, Shaofeng Liu, Jana L. Raynor, Peter Vogel, Geoffrey Neale, Peter Carmeliet, Hongbo Chi. Homeostasis and transitional activation of regulatory T cells require c-Myc. Sci Adv. 2020 Jan 1;6(1):eaaw6443. doi: 10.1126/sciadv.aaw6443

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Suwanpradid J, Shih M, Pontius L, Yang B, Birukova A, Guttman-Yassky E, Corcoran DL, Que LG, Tighe RM and MacLeod AS. 2017. Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity. J Immunol. doi: 10.4049/jimmunol.1700739.

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CD45 (30-F11)

 

Ishikura N, Sugimoto M, Yorozu K, Kurasawa M, Kondoh O. Anti‑VEGF antibody triggers the effect of anti‑PD‑L1 antibody in PD‑L1low and immune desert‑like mouse tumors. Oncol Rep. 2022 Feb;47(2):36. doi: 10.3892/or.2021.8247. Epub 2021 Dec 27. PMID: 34958105.

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Stephens WZ, Kubinak JL, Ghazaryan A, Bauer KM, Bell R, Buhrke K, Chiaro TR, Weis AM, Tang WW, Monts JK, Soto R, Ekiz HA, O'Connell RM, Round JL. Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition. Cell Rep. 2021 Nov 2;37(5):109916. doi: 10.1016/j.celrep.2021.109916. PMID: 34731608.

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Cui M, Atmanli A, Morales MG, Tan W, Chen K, Xiao X, Xu L, Liu N, Bassel-Duby R, Olson EN. Nrf1 promotes heart regeneration and repair by regulating proteostasis and redox balance. Nat Commun. 2021 Sep 6;12(1):5270. doi: 10.1038/s41467-021-25653-w. PMID: 34489413.

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Zhu Q, Ma Y, Liang J, Wei Z, Li M, Zhang Y, Liu M, He H, Qu C, Cai J, Wang X, Zeng Y, Jiao Y. AHR mediates the aflatoxin B1 toxicity associated with hepatocellular carcinoma. Signal Transduct Target Ther. 2021 Aug 9;6(1):299. doi: 10.1038/s41392-021-00713-1. PMID: 34373448.

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Mayes-Hopfinger L, Enache A, Xie J, Huang CL, Köchl R, Tybulewicz VLJ, Fernandes-Alnemri T, Alnemri ES. Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis. Nat Commun. 2021 Jul 27;12(1):4546. doi: 10.1038/s41467-021-24784-4. PMID: 34315884.

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Pingili AK, Chaib M, Sipe LM, et al. Immune checkpoint blockade reprograms systemic immune landscape and tumor microenvironment in obesity-associated breast cancer. Cell Rep. 2021 Jun 22;35(12):109285. doi: 10.1016/j.celrep.2021.109285. PMID: 34161764.

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Baniel CC, Sumiec EG, Hank JA, Bates AM, et al. Intratumoral injection reduces toxicity and antibody-mediated neutralization of immunocytokine in a mouse melanoma model. J Immunother Cancer. 2020 Oct;8(2):e001262. doi: 10.1136/jitc-2020-001262. PMID: 33115944.

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Shubina M, Tummers B, Boyd DF, et al. Necroptosis restricts influenza A virus as a stand-alone cell death mechanism. J Exp Med. 2020;217(11):e20191259. doi:10.1084/jem.20191259.

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Takahashi D, Hoshina N, Kabumoto Y, et al. Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells. EBioMedicine. 2020;58:102913. doi:10.1016/j.ebiom.2020.102913.

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Clark PA, Sriramaneni RN, Jin WJ, et al.  In situ vaccination at a peripheral tumor site augments response against melanoma brain metastases. Journal for ImmunoTherapy of Cancer 2020;8:e000809. doi: 10.1136/jitc-2020-000809.

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Iida Y, Yoshikawa R, Murata A, et al. Local injection of CCL19-expressing mesenchymal stem cells augments the therapeutic efficacy of anti-PD-L1 antibody by promoting infiltration of immune cells. J Immunother Cancer. 2020;8(2):e000582. doi:10.1136/jitc-2020-000582.

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Kim IS, Gao Y, Welte T, et al. Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms. Nat Cell Biol. 2019;21(9):1113-1126. doi:10.1038/s41556-019-0373-7.

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Kumar D, Sehrawat S. Divergent Effects of a Transient Corticosteroid Therapy on Virus-Specific Quiescent and Effector CD8+ T Cells. Front Immunol. 2019;10:1521. Published 2019 Jul 12. doi:10.3389/fimmu.2019.01521.

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Diaz-Flores E, Comeaux EQ, Kim KL, et al. Bcl-2 Is a Therapeutic Target for Hypodiploid B-Lineage Acute Lymphoblastic Leukemia. Cancer Res. 2019;79(9):2339-2351. doi:10.1158/0008-5472.CAN-18-0236.

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Atif SM, Mack DG, McKee AS, et al. Protective role of B cells in sterile particulate-induced lung injury. JCI Insight. 2019;5(12):e125494. Published 2019 May 16. doi:10.1172/jci.insight.125494.

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Palacios M, Miner TA, Frederick DR, et al. Identification of Two Regulators of Virulence That Are Conserved in Klebsiella pneumoniae Classical and Hypervirulent Strains. mBio. 2018;9(4):e01443-18. Published 2018 Aug 7. doi:10.1128/mBio.01443-18.

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Milasan A, Jean G, Dallaire F, Tardif JC, Merhi Y, Sorci-Thomas M and Martel C. 2017. Apolipoprotein A-I Modulates Atherosclerosis Through Lymphatic Vessel-Dependent Mechanisms in Mice. J Am Heart Assoc. doi: 10.1161/JAHA.117.006892.

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Liao W, Pham V, Liu L, Riazifar M, Pone EJ, Zhang SX, Ma F, Lu M, Walsh CM and Zhao W. 2015. Mesenchymal stem cells engineered to express selectin ligands and IL-10 exert enhanced therapeutic efficacy in murine experimental autoimmune encephalomyelitis. Biomaterials. doi:10.1016/j.biomaterials.2015.11.005

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Benck CJ, Martinov T, Fife BT and Chatterjea D. 2016. Isolation of Infiltrating Leukocytes from Mouse Skin Using Enzymatic Digest and Gradient Separation. J Vis Exp. (107), e53638, doi:10.3791/53638.

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Grinberg-Bleyer Y, Oh H, Desrichard A, Bhatt DM, Caron R, Chan TA, Schmid RM, Klein U, Hayden MS and Ghosh S. 2017. NF-κB c-Rel Is Crucial for the Regulatory T Cell Immune Checkpoint in Cancer. Cell. doi: 10.1016/j.cell.2017.08.004. 

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Oguro H, McDonald JG, Zhao Z, Umetani M, Shaul PW and Morrison SJ. 2017. 27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy. J Clin Invest. doi: 10.1172/JCI94027.

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CD45.1 (A20)

 

Rahim T, Levinson MA, Carufe KEW, Burak M, Meas R, Maher S, Bothwell ALM, Gades N, Sweasy JB. The hematopoietic compartment is sufficient for lupus development resulting from the POLB-Y265C mutation. PLoS One. 2022 Apr 29;17(4):e0267913. doi: 10.1371/journal.pone.0267913. PMID: 35486639; PMCID: PMC9053796.

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Stephens WZ, Kubinak JL, Ghazaryan A, Bauer KM, Bell R, Buhrke K, Chiaro TR, Weis AM, Tang WW, Monts JK, Soto R, Ekiz HA, O'Connell RM, Round JL. Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition. Cell Rep. 2021 Nov 2;37(5):109916. doi: 10.1016/j.celrep.2021.109916. PMID: 34731608.

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Nishina T, Deguchi Y, Ohshima D, et a. Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer. Nat Commun. 2021 Apr 16;12(1):2281. doi: 10.1038/s41467-021-22450-3. PMID: 33863879.

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Baba T, Yoshida T, Tanabe Y, et al. Cytoplasmic DNA accumulation preferentially triggers cell death of myeloid leukemia cells by interacting with intracellular DNA sensing pathway. Cell Death Dis. 2021 Mar 26;12(4):322. doi: 10.1038/s41419-021-03587-x. PMID: 33771977.  

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Caddy SL, Vaysburd M, Papa G, Wing M, O'Connell K, Stoycheva D, Foss S, Terje Andersen J, Oxenius A, James LC. Viral nucleoprotein antibodies activate TRIM21 and induce T cell immunity. EMBO J. 2020 Dec 1:e106228. doi: 10.15252/embj.2020106228. PMID: 33258165. 

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Mishra S, Liao W, Liu Y, Yang M, Ma C, Wu H, Zhao M, Zhang X, Qiu Y, Lu Q, Zhang N. TGF-β and Eomes control the homeostasis of CD8+ regulatory T cells. J Exp Med. 2021 Jan 4;218(1):e20200030. doi: 10.1084/jem.20200030. PMID: 32991667; PMCID: PMC7527976.

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Scharer CD, Patterson DG, Mi T, Price MJ, Hicks SL, Boss JM. Antibody-secreting cell destiny emerges during the initial stages of B-cell activation. Nat Commun. 2020;11(1):3989. Published 2020 Aug 10. doi:10.1038/s41467-020-17798-x.

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Guo M, Price MJ, Patterson DG, et al. EZH2 Represses the B Cell Transcriptional Program and Regulates Antibody-Secreting Cell Metabolism and Antibody Production. J Immunol. 2018;200(3):1039-1052. doi:10.4049/jimmunol.1701470.

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Briseño CG, Gargaro M, Durai V, Davidson JT, Theisen DJ, Anderson DA 3rd, Novack DV, Murphy TL and Murphy KM. 2017. Deficiency of transcription factor RelB perturbs myeloid and DC development by hematopoietic-extrinsic mechanisms. Proc Natl Acad Sci U S A. doi: 10.1073/pnas.1619863114

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Mgbemena VE, Signer RA, Wijayatunge R, Laxson T, Morrison SJ, Ross TS. 2017. Distinct Brca1 Mutations Differentially Reduce Hematopoietic Stem Cell Function. Cell Rep. DOI: 10.1016/j.celrep.2016.12.075

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Guthmiller JJ, Graham AC, Zander RA, Pope RL and Butler NS. 2017. Cutting Edge: IL-10 Is Essential for the Generation of Germinal Center B Cell Responses and Anti-Plasmodium Humoral Immunity. DOI:10.4049/jimmunol.1601762

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Fiege JK, Burback Bj and Shimizu Y. 2015. Negative Regulation of Memory Phenotype CD8 T Cell Conversion by Adhesion and Degranulation-Promoting Adapter Protein. J Immunol. 195(7): 3119-3128.

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Lin CC, Bradstreet TR, Schwarzkopf EA, Jarjour NN, Chou C, Archambault AS, Sim J, Zinselmeyer BH, Carrero JA, Wu GF, Taneja R, Artyomov MN, Russell JH and Edelson BT. IL-1 induced Bhlhe40 identifies pathogenic T helper cells in a model of autoimmune neuroinflammation. J Exp Med. 213(2): 251-271.

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Miro-Mur F, Perez-de Puig I, Ferrer-Ferrer M, Ura X, Justicia C, Chamorro A and Planas AM. 2015. Immature monocytes recruited to the ischemic mouse brain differentiate into macrophages with features ofalternative activation. Brain Behav Immun. doi: 10.1016/j.bbi.2015.08.010.

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Marsh SE, Abud EM, Lakatos A, Karimzadeh A, Yeung ST, Davtyan H, Fote GM, Lau L, Weinger JG, Lane TE, Inlay MA, Poon WW and Blurton-Jones M. 2016. The adaptive immune system restrains Alzheimer's disease pathogenesis by modulating microglial function. Proc Natl Acad Sci USA. doi: 10.1073/pnas.1525466113.

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Benck, CJ, Martinov, T, Fife, BT, and Chatterjea, D. 2016. Isolation of infiltrating leukocytes from mouse skin using enzymatic digest and gradient separation. J Vis Exp. (107) e53638, doi: 10.3791/53638 (2016)

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Barwick BG, Scharer CD, Bally APR and Boss JM. 2016. Plasma Cell Differentiation is Coupled to Division-Dependent DNA Hypomethylation and Gene Regulation. Nat Immunol. 17(10):1216-25

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Shiyang Li, John W. Bostick, Jian Ye, Joseph F. Urban, Jr., Dorina Avram, Liang Zhou. Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function. Immunity. 2018 Nov 20;49(5):915-928.e5. doi: 10.1016/j.immuni.2018.09.015

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Nicholas N. Jarjour, Elizabeth A. Schwarzkopf, Tara R. Bradstreet, Irina Shchukina, Chih-Chung Lin, Stanley Ching-Cheng Huang, Chin-Wen Lai, Melissa E. Cook, Reshma Taneja, Thaddeus S. Stappenbeck, Gwendalyn J. Randolph, Maxim N. Artyomov, Joseph F. Urban Jr., and Brian T. Edelson. Bhlhe40 mediates tissue-specific control of macrophage proliferation in homeostasis and type 2 immunity. Nat Immunol. 2019 Jun;20(6):687-700. doi: 10.1038/s41590-019-0382-5

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Jordy Saravia, Hu Zeng1, Yogesh Dhungana, Daniel Bastardo Blanco, Thanh-Long M. Nguyen, Nicole M. Chapman, Yanyan Wang, Apurva Kanneganti, Shaofeng Liu, Jana L. Raynor, Peter Vogel, Geoffrey Neale, Peter Carmeliet, Hongbo Chi. Homeostasis and transitional activation of regulatory T cells require c-Myc. Sci Adv. 2020 Jan 1;6(1):eaaw6443. doi: 10.1126/sciadv.aaw6443

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Hao Shi, Nicole M. Chapman, Jing Wen, Cliff Guy, Lingyun Long, Yogesh Dhungana, Sherri Rankin, Stephane Pelletier, Peter Vogel, Hong Wang, Junmin Peng, Kun-Liang Guan, and Hongbo Chi. Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb. Immunity. 2019 Dec 17;51(6):1012-1027.e7. doi: 10.1016/j.immuni.2019.10.001

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Oguro H, McDonald JG, Zhao Z, Umetani M, Shaul PW and Morrison SJ. 2017. 27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy. J Clin Invest. doi: 10.1172/JCI94027.

» View on PubMed

CD45.2 (104)

 

Rahim T, Levinson MA, Carufe KEW, Burak M, Meas R, Maher S, Bothwell ALM, Gades N, Sweasy JB. The hematopoietic compartment is sufficient for lupus development resulting from the POLB-Y265C mutation. PLoS One. 2022 Apr 29;17(4):e0267913. doi: 10.1371/journal.pone.0267913. PMID: 35486639; PMCID: PMC9053796.

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Sánchez-Navarro A, Martínez-Rojas MÁ, Albarrán-Godinez A, Pérez-Villalva R, Auwerx J, de la Cruz A, Noriega LG, Rosetti F, Bobadilla NA. Sirtuin 7 Deficiency Reduces Inflammation and Tubular Damage Induced by an Episode of Acute Kidney Injury. Int J Mol Sci. 2022 Feb 25;23(5):2573. doi: 10.3390/ijms23052573. PMID: 35269715.

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Stephens WZ, Kubinak JL, Ghazaryan A, Bauer KM, Bell R, Buhrke K, Chiaro TR, Weis AM, Tang WW, Monts JK, Soto R, Ekiz HA, O'Connell RM, Round JL. Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition. Cell Rep. 2021 Nov 2;37(5):109916. doi: 10.1016/j.celrep.2021.109916. PMID: 34731608.

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Burbach BJ, O'Flanagan SD, Shao Q, et al. Irreversible electroporation augments checkpoint immunotherapy in prostate cancer and promotes tumor antigen-specific tissue-resident memory CD8+ T cells. Nat Commun. 2021 Jun 23;12(1):3862. doi: 10.1038/s41467-021-24132-6. PMID: 34162858.

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Trott DW, Islam MT, Buckley DJ, Donato AJ, Dutson T, Sorensen ES, Cai J, Gogulamudi VR, Phuong TTT, Lesniewski LA. T lymphocyte depletion ameliorates age-related metabolic impairments in mice. Geroscience. 2021 Apr 24. doi: 10.1007/s11357-021-00368-4. PMID: 33893902.

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Dikiy S, Li J, Bai L, Jiang M, Janke L, Zong X, Hao X, Hoyos B, Wang ZM, Xu B, Fan Y, Rudensky AY, Feng Y. A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance. Immunity. 2021 May 11;54(5):931-946.e11. doi: 10.1016/j.immuni.2021.03.020. Epub 2021 Apr 9. PMID: 33838102; PMCID: PMC8317508.

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Lee W, Kingstad-Bakke B, Kedl RM, Kawaoka Y, Suresh M. CCR2 Regulates Vaccine-Induced Mucosal T-Cell Memory to Influenza A Virus. bioRxiv. 2021 Mar 25:2021.03.24.436901. doi: 10.1101/2021.03.24.436901. PMID: 33791695; PMCID: PMC8010722.

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Nishina T, Deguchi Y, Ohshima D, et a. Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer. Nat Commun. 2021 Apr 16;12(1):2281. doi: 10.1038/s41467-021-22450-3. PMID: 33863879.

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Baba T, Yoshida T, Tanabe Y, et al. Cytoplasmic DNA accumulation preferentially triggers cell death of myeloid leukemia cells by interacting with intracellular DNA sensing pathway. Cell Death Dis. 2021 Mar 26;12(4):322. doi: 10.1038/s41419-021-03587-x. PMID: 33771977.  

» View on Nature

Mishra S, Liao W, Liu Y, Yang M, Ma C, Wu H, Zhao M, Zhang X, Qiu Y, Lu Q, Zhang N. TGF-β and Eomes control the homeostasis of CD8+ regulatory T cells. J Exp Med. 2021 Jan 4;218(1):e20200030. doi: 10.1084/jem.20200030. PMID: 32991667; PMCID: PMC7527976.

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He T, Yang D, Li XQ, Jiang M, Islam MS, Chen S, Chen Y, Yang Y, Chou CK, Trivett AL, Oppenheim JJ, Chen X. Inhibition of two-pore channels in antigen-presenting cells promotes the expansion of TNFR2-expressing CD4+Foxp3+ regulatory T cells. Sci Adv. 2020 Sep 30;6(40):eaba6584. doi: 10.1126/sciadv.aba6584. PMID: 32998896. 

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Forte D, García-Fernández M, Sánchez-Aguilera A, Stavropoulou V, Fielding C, Martín-Pérez D, López JA, Costa ASH, Tronci L, Nikitopoulou E, Barber M, Gallipoli P, Marando L, Fernández de Castillejo CL, Tzankov A, Dietmann S, Cavo M, Catani L, Curti A, Vázquez J, Frezza C, Huntly BJ, Schwaller J, Méndez-Ferrer S. Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy. Cell Metab. 2020 Sep 16:S1550-4131(20)30479-4. doi: 10.1016/j.cmet.2020.09.001. PMID: 32966766.   

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Scharer CD, Patterson DG, Mi T, Price MJ, Hicks SL, Boss JM. Antibody-secreting cell destiny emerges during the initial stages of B-cell activation. Nat Commun. 2020;11(1):3989. Published 2020 Aug 10. doi:10.1038/s41467-020-17798-x.

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Karki R, Sharma BR, Lee E, et al. Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer. JCI Insight. 2020;5(12):136720. Published 2020 Jun 18. doi:10.1172/jci.insight.136720.

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Dolina JS, Lee J, Griswold RQ, Labarta-Bajo L, Kannan S, Greenbaum JA, Bahia El Idrissi N, Pont MJ, Croft M, Schoenberger SP. TLR9 Sensing of Self-DNA Controls Cell-Mediated Immunity to Listeria Infection via Rapid Conversion of Conventional CD4+ T Cells to Treg. Cell Rep. 2020 Apr 7;31(1):107249. doi: 10.1016/j.celrep.2020.01.040.

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Markman, J.L., Porritt, R.A., Wakita, D. et al. Loss of testosterone impairs anti-tumor neutrophil function. Nat Commun 11, 1613 (2020). https://doi.org/10.1038/s41467-020-153.

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Guo M, Price MJ, Patterson DG, et al. EZH2 Represses the B Cell Transcriptional Program and Regulates Antibody-Secreting Cell Metabolism and Antibody Production. J Immunol. 2018;200(3):1039-1052. doi:10.4049/jimmunol.1701470.

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Sato Y, Kato H, Ebina-Shibuya R, Itoh-Nakadai A, Okuyama R and Igarashi K. 2017. Bach2 Controls Homeostasis of Eosinophils by Restricting the Type-2 Helper Function of T Cells. Tohoku J Exp Med. doi: 10.1620/tjem.241.175

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Mgbemena VE, Signer RA, Wijayatunge R, Laxson T, Morrison SJ, Ross TS. 2017. Distinct Brca1 Mutations Differentially Reduce Hematopoietic Stem Cell Function. Cell Rep. DOI: 10.1016/j.celrep.2016.12.075

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Trott DW, Henson GD, Ho MHT, Allison SA, Lesniewski LA and Donato AJ. 2016. Age-related arterial immune cell infiltration in mice is attenuated by caloric restriction or voluntary exercise. Exp. Gerontol. DOI: 10.1016/j.exger.2016.12.016

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Guthmiller JJ, Graham AC, Zander RA, Pope RL and Butler NS. 2017. Cutting Edge: IL-10 Is Essential for the Generation of Germinal Center B Cell Responses and Anti-Plasmodium Humoral Immunity. DOI:10.4049/jimmunol.1601762

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Kamimura Y and Lanier LL. 2015. Homeostatic Control of Memory Cell Progenitors in the Natural Killer Cell Lineage. Cell Rep. 10(2): 280-291.

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Martinez-Lopez M, Iborra S, Conde-Garrosa R and Sancho D. 2014. Batf3-dependent CD103+ dendritic cells are major producers of IL-12 that drive local Th1 immunity against Leishmania major infection in mice. Eur J Immunol. 45(1): 119-129.

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Fiege JK, Burback Bj and Shimizu Y. 2015. Negative Regulation of Memory Phenotype CD8 T Cell Conversion by Adhesion and Degranulation-Promoting Adapter Protein. J Immunol. 195(7): 3119-3128.

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Lin CC, Bradstreet TR, Schwarzkopf EA, Jarjour NN, Chou C, Archambault AS, Sim J, Zinselmeyer BH, Carrero JA, Wu GF, Taneja R, Artyomov MN, Russell JH and Edelson BT. IL-1 induced Bhlhe40 identifies pathogenic T helper cells in a model of autoimmune neuroinflammation. J Exp Med. 213(2): 251-271.

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Rios D, Wood MB, Li J, Chassaing B, Gewirtz AT and Williams IR. 2015. Antigen sampling by intestinal M cells is the principal pathway initiating mucosal IgA production to commensal enteric bacteria. Mucosal Immunol. doi: 10.1038/mi.2015.121.

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Khan TN, Mooster JL, Kilgore AM, Osborn JF, and Nolz JC. 2016. Local Antigen in Nonlymphoid Tissue Promotes Resident Memory CD8+ T Cell Formation During Viral Infection. The Journal of Experimental Medicine. doi: 10.1084/jem.20151855

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Paul D, Baena V, Ge S, Jiang X, Jellison ER, Kiprono T, Agalliu D and Pachter JS. 2016. Appearance of claudin-5+ leukocytes in the central nervous system during neuroinflammation: a novel role for endothelial-derived extracellular vesicles. J. Neuroinflammation DOI: 10.1186/s12974-016-0755-8

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Tedesco D, Thapa M, Gumber S, Elrod EJ, Rahman K, Ibegbu CC, Magliocca JF, Adams AB, anania F and Grakoui A. 2016. CD4+ Foxp3+ T cells promote aberrant immunoglobulin G production and maintain CD8+ T-cell suppression during chronic liver disease. Hepatology. doi:10.1002/hep.28894

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Erola Ainsua-Enrich, Ibrahim Hatipoglu, Sapana Kadel, Sean Turner, Jinny Paul, Simar Singh, Harini Bagavant, and Susan Kovats. IRF4-dependent dendritic cells regulate CD8+ T cell differentiation and memory responses in influenza infection. Mucosal Immunol. 2019 Jul;12(4):1025-1037. doi: 10.1038/s41385-019-0173-1

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Nicholas N. Jarjour, Elizabeth A. Schwarzkopf, Tara R. Bradstreet, Irina Shchukina, Chih-Chung Lin, Stanley Ching-Cheng Huang, Chin-Wen Lai, Melissa E. Cook, Reshma Taneja, Thaddeus S. Stappenbeck, Gwendalyn J. Randolph, Maxim N. Artyomov, Joseph F. Urban Jr., and Brian T. Edelson. Bhlhe40 mediates tissue-specific control of macrophage proliferation in homeostasis and type 2 immunity. Nat Immunol. 2019 Jun;20(6):687-700. doi: 10.1038/s41590-019-0382-5

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Matthew A. Huggins, Frances V. Sjaastad, Mark Pierson, Tamara A. Kucaba, Whitney Swanson, Christopher Staley, Alexa R. Weingarden, Isaac J. Jensen, Derek B. Danahy, Vladimir P. Badovinac, Stephen C. Jameson, Vaiva Vezys, David Masopust, Alexander Khoruts, Thomas S. Griffith, and Sara E. Hamilton. Microbial Exposure Enhances Immunity to Pathogens Recognized by TLR2 but Increases Susceptibility to Cytokine Storm through TLR4 Sensitization. Cell Rep. 2019 Aug 13;28(7):1729-1743.e5. doi: 10.1016/j.celrep.2019.07.028

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Jordy Saravia, Hu Zeng1, Yogesh Dhungana, Daniel Bastardo Blanco, Thanh-Long M. Nguyen, Nicole M. Chapman, Yanyan Wang, Apurva Kanneganti, Shaofeng Liu, Jana L. Raynor, Peter Vogel, Geoffrey Neale, Peter Carmeliet, Hongbo Chi. Homeostasis and transitional activation of regulatory T cells require c-Myc. Sci Adv. 2020 Jan 1;6(1):eaaw6443. doi: 10.1126/sciadv.aaw6443

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Hao Shi, Nicole M. Chapman, Jing Wen, Cliff Guy, Lingyun Long, Yogesh Dhungana, Sherri Rankin, Stephane Pelletier, Peter Vogel, Hong Wang, Junmin Peng, Kun-Liang Guan, and Hongbo Chi. Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb. Immunity. 2019 Dec 17;51(6):1012-1027.e7. doi: 10.1016/j.immuni.2019.10.001

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Oguro H, McDonald JG, Zhao Z, Umetani M, Shaul PW and Morrison SJ. 2017. 27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy. J Clin Invest. doi: 10.1172/JCI94027.

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CD62L (L-Selectin) (MEL-14)

 

Avalos A, Tietsort JT, Suwankitwat N, Woods JD, Jackson SW, Christodoulou A, Morrill C, Liggitt HD, Zhu C, Li QZ, Bui KK, Park H, Iritani BM. Hem-1 regulates protective humoral immunity and limits autoantibody production in a B cell-specific manner. JCI Insight. 2022 May 9;7(9):e153597. doi: 10.1172/jci.insight.153597. PMID: 35531955; PMCID: PMC9090261.

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Sin JH, Kashyap S, Acenas D, Cortez JT, Lee J, Marson A, Matloubian M, Waterfield MR. ATF7ip Targets Transposable Elements for H3K9me3 Deposition to Modify CD8+ T Cell Effector and Memory Responses. J Immunol. 2022 Feb 2:ji2100996. doi: 10.4049/jimmunol.2100996. Epub ahead of print. PMID: 35110421

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Mergaert AM, Denny MF, Kingstad-Bakke B, Bawadekar M, Bashar SJ, Warner TF, Suresh M, Shelef MA. Peptidylarginine Deiminase 2 in Murine Antiviral and Autoimmune Antibody Responses. J Immunol Res. 2022 Jan 17;2022:5258221. doi: 10.1155/2022/5258221. PMID: 35083342; PMCID: PMC8786467.

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Wilfahrt D, Philips RL, Lama J, Kizerwetter M, Shapiro MJ, McCue SA, Kennedy MM, Rajcula MJ, Zeng H, Shapiro VS. Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation. Elife. 2021 Dec 2;10:e70978. doi: 10.7554/eLife.70978. PMID: 34854376; PMCID: PMC8639145. 

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Trott DW, Islam MT, Buckley DJ, Donato AJ, Dutson T, Sorensen ES, Cai J, Gogulamudi VR, Phuong TTT, Lesniewski LA. T lymphocyte depletion ameliorates age-related metabolic impairments in mice. Geroscience. 2021 Apr 24. doi: 10.1007/s11357-021-00368-4. PMID: 33893902.

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Sumiyoshi M, Kotani Y, Ikuta Y, et al. Arf1 and Arf6 Synergistically Maintain Survival of T Cells during Activation. J Immunol. 2020 Dec 11:ji2000971. doi: 10.4049/jimmunol.2000971. PMID: 33310872. 

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Zhan X, Zhong X, Choi JH, et al. Adenosine monophosphate deaminase 3 null mutation causes reduction of naive T cells in mouse peripheral blood. Blood Adv. 2020;4(15):3594-3605. doi:10.1182/bloodadvances.2020001762.

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Toriyama K, Kuwahara M, Kondoh H, et al. T cell-specific deletion of Pgam1 reveals a critical role for glycolysis in T cell responses. Commun Biol. 2020;3(1):394. Published 2020 Jul 24. doi:10.1038/s42003-020-01122-w.

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Govindarajan S, Gaublomme D, Van der Cruyssen R, et al. Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha. Nat Commun. 2018;9(1):5340. Published 2018 Dec 17. doi:10.1038/s41467-018-07758-x.

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Pannu J, Belle JI, Forster M, Duerr CU, Shen S, Kane L, Harcourt K, Fritz JH, Clare S and Nijnik A. 2015. Ubiquitin Specific Protease 21 Is Dispensable for Normal Development, Hematopoiesis and Lymphocyte Differentiation. PloS one.10(2):e0117304.

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Fenutría R, Martinez VG, Simões I, Postigo J, Gil V, Martínez-Florensa M, Sintes J, Naves R, Cashman KS, et al. 2014. Transgenic Expression of Soluble Human CD5 Enhances Experimentally-Induced Autoimmune and Anti-Tumoral Immune Responses. PloS one. 9(1): e84895.

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Bapat SP, Nyoung Suh J, Fang S, Liu S, Zhang Y, Cheng A, Zhou C, Liang Y, LeBlanc M, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM and Zheng Y. 2015. Depletion of fat-resident Treg cells prevents age-associated insulin resistance. Nature. 528: 137-141.

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Watson AM, Matthew Lam LK, Klimstra WB and Ryman KD. 2016. The 17D-204 Vaccine Strain-Induced Protection Against Virulent Yellow Fever Virus is Mediated by Humoral Immunity and CD4+ But Not CD8+ T Cells. PLoS Pathog. doi:10.1371/journal.ppat.1005786

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Anstadt EJ, Fujiwara M, Wasko N, Nichols F and Clark RB. 2016. TLR Tolerance as a Treatment for Central Nervous System Autoimmunity. J. Immunol. doi: 10.4049/​jimmunol.1600876

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Avery L, Filderman J, Szymczak-Workman AL, Kane LP4. Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2455-2460. doi: 10.1073/pnas.1712107115

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Erola Ainsua-Enrich, Ibrahim Hatipoglu, Sapana Kadel, Sean Turner, Jinny Paul, Simar Singh, Harini Bagavant, and Susan Kovats. IRF4-dependent dendritic cells regulate CD8+ T cell differentiation and memory responses in influenza infection. Mucosal Immunol. 2019 Jul;12(4):1025-1037. doi: 10.1038/s41385-019-0173-1

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Jordy Saravia, Hu Zeng1, Yogesh Dhungana, Daniel Bastardo Blanco, Thanh-Long M. Nguyen, Nicole M. Chapman, Yanyan Wang, Apurva Kanneganti, Shaofeng Liu, Jana L. Raynor, Peter Vogel, Geoffrey Neale, Peter Carmeliet, Hongbo Chi. Homeostasis and transitional activation of regulatory T cells require c-Myc. Sci Adv. 2020 Jan 1;6(1):eaaw6443. doi: 10.1126/sciadv.aaw6443

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Jun Wei, Lingyun Long, Wenting Zheng, Yogesh Dhungana, Seon Ah Lim, Cliff Guy, Yanyan Wang, Yong Dong Wang, Chenxi Qian, Beisi Xu, Anil KC, Jordy Saravia, Hongling Huang, Jiyang Yu, John G. Doench, Terrence L. Geiger, & Hongbo Chi. Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy. Nature. 2019 Dec;576(7787):471-476. doi: 10.1038/s41586-019-1821-z

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Hao Shi, Nicole M. Chapman, Jing Wen, Cliff Guy, Lingyun Long, Yogesh Dhungana, Sherri Rankin, Stephane Pelletier, Peter Vogel, Hong Wang, Junmin Peng, Kun-Liang Guan, and Hongbo Chi. Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb. Immunity. 2019 Dec 17;51(6):1012-1027.e7. doi: 10.1016/j.immuni.2019.10.001

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Grinberg-Bleyer Y, Oh H, Desrichard A, Bhatt DM, Caron R, Chan TA, Schmid RM, Klein U, Hayden MS and Ghosh S. 2017. NF-κB c-Rel Is Crucial for the Regulatory T Cell Immune Checkpoint in Cancer. Cell. doi: 10.1016/j.cell.2017.08.004. 

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CD69 (H1.2F3)

 

Brian BF 4th, Sauer ML, Greene JT, Senevirathne SE, Lindstedt AJ, Funk OL, Ruis BL, Ramirez LA, Auger JL, Swanson WL, Nunez MG, Moriarity BS, Lowell CA, Binstadt BA, Freedman TS. A dominant function of LynB kinase in preventing autoimmunity. Sci Adv. 2022 Apr 22;8(16):eabj5227. doi: 10.1126/sciadv.abj5227. Epub 2022 Apr 22. PMID: 35452291.

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Kumar D, Sehrawat S. Divergent Effects of a Transient Corticosteroid Therapy on Virus-Specific Quiescent and Effector CD8+ T Cells. Front Immunol. 2019;10:1521. Published 2019 Jul 12. doi:10.3389/fimmu.2019.01521.

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Noviski M, Mueller JL, Satterthwaite A, Garrett-Sinha LA, Brombacher F, Zikherman J. IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate. Elife. 2018;7:e35074. Published 2018 Mar 9. doi:10.7554/eLife.35074.

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CD80 (B7-1) (16-10A1)

 

Brian BF 4th, Sauer ML, Greene JT, Senevirathne SE, Lindstedt AJ, Funk OL, Ruis BL, Ramirez LA, Auger JL, Swanson WL, Nunez MG, Moriarity BS, Lowell CA, Binstadt BA, Freedman TS. A dominant function of LynB kinase in preventing autoimmunity. Sci Adv. 2022 Apr 22;8(16):eabj5227. doi: 10.1126/sciadv.abj5227. Epub 2022 Apr 22. PMID: 35452291.

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Xu L, Su B, Mo L, Zhao C, Zhao Z, Li H, Hu Z, Li J. Norcantharidin Induces Immunogenic Cell Death of Bladder Cancer Cells through Promoting Autophagy in Acidic Culture. Int J Mol Sci. 2022 Apr 1;23(7):3944. doi: 10.3390/ijms23073944. PMID: 35409302; PMCID: PMC8999362. 

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Nagaoka M, Yashiro T, Uchida Y, Ando T, Hara M, Arai H, Ogawa H, Okumura K, Kasakura K and Nishiyama C. 2017. The Orphan Nuclear Receptor NR4A3 Is Involved in the Function of Dendritic Cells. J Immunol. doi: 10.4049/jimmunol.1601911.

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Chaganty BKR, Lu Y, Qiu S, Somanchi SS, Lee DA and Fan Z. 2015. Trastuzumab upregulates expression of HLA-ABC and T cell costimulatory molecules through engagement of natural killer cells and stimulation of IFN-γ secretion. OncoImmunology. DOI: 10.1080/2162402X.2015.1100790

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CD86 (GL-1)

 

Brian BF 4th, Sauer ML, Greene JT, Senevirathne SE, Lindstedt AJ, Funk OL, Ruis BL, Ramirez LA, Auger JL, Swanson WL, Nunez MG, Moriarity BS, Lowell CA, Binstadt BA, Freedman TS. A dominant function of LynB kinase in preventing autoimmunity. Sci Adv. 2022 Apr 22;8(16):eabj5227. doi: 10.1126/sciadv.abj5227. Epub 2022 Apr 22. PMID: 35452291.

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Kotake K, Kumazawa T, Adachi T. Long-term administration of Tetragenococcus halophilus No. 1 over generations affects the immune system of mice. PLoS One. 2022 Apr 26;17(4):e0267473. doi: 10.1371/journal.pone.0267473. PMID: 35472068; PMCID: PMC9041805.

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Xu L, Su B, Mo L, Zhao C, Zhao Z, Li H, Hu Z, Li J. Norcantharidin Induces Immunogenic Cell Death of Bladder Cancer Cells through Promoting Autophagy in Acidic Culture. Int J Mol Sci. 2022 Apr 1;23(7):3944. doi: 10.3390/ijms23073944. PMID: 35409302; PMCID: PMC8999362. 

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Chaganty BKR, Lu Y, Qiu S, Somanchi SS, Lee DA and Fan Z. 2015. Trastuzumab upregulates expression of HLA-ABC and T cell costimulatory molecules through engagement of natural killer cells and stimulation of IFN-γ secretion. OncoImmunology. DOI: 10.1080/2162402X.2015.1100790

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Olguin-Alor R, de la Fuente-Granada M, Bonifaz LC, Antonio-Herrara L, Garcia-Zepada EA and Soldevilla G. 2016. A Key Role for Inhibins in Dendritic Cell Maturation and Function. PLOS one. doi:10.1371/journal.pone.0167813

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Ito A, Hong C, Oka K, Salazar JV, Diehl C, Witztum JL, Diaz M, Castrillo A, Bensinger SJ, Chan L and Tontonoz P. 2016. Cholesterol Accumulation in CD11c+ Immune Cells Is a Causal and Targetable Factor in Autoimmune Disease. Immunity. doi: 10.1016/j.immuni.2016.11.008

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CD90.2 (30-H12)

 

Nishina T, Deguchi Y, Ohshima D, et a. Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer. Nat Commun. 2021 Apr 16;12(1):2281. doi: 10.1038/s41467-021-22450-3. PMID: 33863879.

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Acharya TK, Tiwari A, Majhi RK, Goswami C. TRPM8 channel augments T cell activation and proliferation. Cell Biol Int. 2020 Oct 14. doi: 10.1002/cbin.11483. PMID: 33090595.   

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Majhi RK, Sahoo SS, Yadav M, Pratheek BM, Chattopadhyay S and Goswami C. 2015. Functional Expression of TRPV Channels in T cells And Their Implications in Immune Regulation. FEBS J. doi: 10.1111/febs.13306.

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CD115 (c-fms) (AFS98)

Nicholas N. Jarjour, Elizabeth A. Schwarzkopf, Tara R. Bradstreet, Irina Shchukina, Chih-Chung Lin, Stanley Ching-Cheng Huang, Chin-Wen Lai, Melissa E. Cook, Reshma Taneja, Thaddeus S. Stappenbeck, Gwendalyn J. Randolph, Maxim N. Artyomov, Joseph F. Urban Jr., and Brian T. Edelson. Bhlhe40 mediates tissue-specific control of macrophage proliferation in homeostasis and type 2 immunity. Nat Immunol. 2019 Jun;20(6):687-700. doi: 10.1038/s41590-019-0382-5

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CD117 (c-Kit) (ACK2)
CD127 (IL-7Ra) (A7R34)

 

Rivera-Torruco G, Martínez-Mendiola CA, Angeles-Floriano T, Jaimes-Ortega GA, Maravillas-Montero JL, García-Contreras R, González Y, Juárez E, Nava P, Ortiz-Navarrete V, Medina-Contreras O, Licona-Limón P, Valle-Rios R. Isthmin 1 is Expressed by Progenitor-Like Cells in the Lung: Phenotypical Analysis of Isthmin 1+ Hematopoietic Stem-Like Cells in Homeostasis and during Infection. J Immunol Res. 2022 Apr 1;2022:2909487. doi: 10.1155/2022/2909487. PMID: 35402623; PMCID: PMC8993550.

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Dikiy S, Li J, Bai L, Jiang M, Janke L, Zong X, Hao X, Hoyos B, Wang ZM, Xu B, Fan Y, Rudensky AY, Feng Y. A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance. Immunity. 2021 May 11;54(5):931-946.e11. doi: 10.1016/j.immuni.2021.03.020. Epub 2021 Apr 9. PMID: 33838102; PMCID: PMC8317508.

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Kumar D, Sehrawat S. Divergent Effects of a Transient Corticosteroid Therapy on Virus-Specific Quiescent and Effector CD8+ T Cells. Front Immunol. 2019;10:1521. Published 2019 Jul 12. doi:10.3389/fimmu.2019.01521.

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Uzodinma U. Uche, Ann R. Piccirillo, Shunsuke Kataoka, Stephanie J. Grebinoski, Louise M. D’Cruz, and Lawrence P. Kane. PIK3IP1/TrIP restricts activation of T cells through inhibition of PI3K/Akt. J Exp Med. 2018 Dec 3;215(12):3165-3179. doi: 10.1084/jem.20172018

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Shiyang Li, John W. Bostick, Jian Ye, Joseph F. Urban, Jr., Dorina Avram, Liang Zhou. Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function. Immunity. 2018 Nov 20;49(5):915-928.e5. doi: 10.1016/j.immuni.2018.09.015

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Avery L, Filderman J, Szymczak-Workman AL, Kane LP4. Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2455-2460. doi: 10.1073/pnas.1712107115

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Iraolagoitia XL, Spallanzani RG, Torres NI, Araya RA, Ziblat A, Domaica CI, Sierra JM, Nunex SY, Secchiari F, Gajewski TF, Zwirner NW and Fuertes MB. 2016 NK Cells Restrain Spontaneous Antitumor CD8+ T Cell Priming Through PD-1/PD-L1 Interactions with Dendritic Cells. J. Immunol. 197:953-961

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Karmaus PWF, Herrada AA, Guy C, Neale G, Dhungana Y, Long L, Vogel P, Avila J, Clish CB and Chi H. 2017. Critical roles of mTORC1 signaling and metabolic reprogramming for M-CSF-mediated myelopoiesis. J Exp Med. doi: 10.1084/jem.20161855.

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Watson AM, Matthew Lam LK, Klimstra WB and Ryman KD. 2016. The 17D-204 Vaccine Strain-Induced Protection Against Virulent Yellow Fever Virus is Mediated by Humoral Immunity and CD4+ But Not CD8+ T Cells. PLoS Pathog. doi:10.1371/journal.ppat.1005786

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CD152 (CTLA-4) (UC10-4F10-11)

 

Kotake K, Kumazawa T, Adachi T. Long-term administration of Tetragenococcus halophilus No. 1 over generations affects the immune system of mice. PLoS One. 2022 Apr 26;17(4):e0267473. doi: 10.1371/journal.pone.0267473. PMID: 35472068; PMCID: PMC9041805.

» View on PubMed

Yang BH, Wang K, Wan S, et al. TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases. Cell Rep. 2019;27(12):3629-3645.e6. doi:10.1016/j.celrep.2019.05.061.

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Yoshida Y, Mikami N, Matsushima Y, Otani F, Miyawaki M, Takatsuji M, Banno R, Tsuji T, Fujita T, Tsujikawa K and Kohno T. 2015. Functional Mechanism(s) of the Inhibition of Disease Progression by Combination Treatment with Fingolimod plus Pathogenic Antigen in a Glucose-6-phosphate Isomerase Peptide-Induced Arthritis Mouse Model. Biol Pharm Bull. DOI:10.1248/bpb.b14-00873.

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Gilchuk P, Hill TM, Guy C, McMaster SR, Boyd KL, Rabacal WA, Lu P, Shyr Y, Kohlmeier JE, Sebzda E, Green DR and Joyce S.2016. A Distinct Lung-Interstitium-Resident Memory CD8+ T Cell Subset Confers Enhanced Protection to Lower Respiratory Tract Infection. Cell Reports. DOI: 10.1016/j.celrep.2016.07.037

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CD274 (PD-L1, B7-H1) (10F.9G2)

Iraolagoitia XL, Spallanzani RG, Torres NI, Araya RA, Ziblat A, Domaica CI, Sierra JM, Nunex SY, Secchiari F, Gajewski TF, Zwirner NW and Fuertes MB. 2016 NK Cells Restrain Spontaneous Antitumor CD8+ T Cell Priming Through PD-1/PD-L1 Interactions with Dendritic Cells. J. Immunol. 197:953-961

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CD279 (PD-1) (J43.1)

 

Kotake K, Kumazawa T, Adachi T. Long-term administration of Tetragenococcus halophilus No. 1 over generations affects the immune system of mice. PLoS One. 2022 Apr 26;17(4):e0267473. doi: 10.1371/journal.pone.0267473. PMID: 35472068; PMCID: PMC9041805.

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Jordy Saravia, Hu Zeng1, Yogesh Dhungana, Daniel Bastardo Blanco, Thanh-Long M. Nguyen, Nicole M. Chapman, Yanyan Wang, Apurva Kanneganti, Shaofeng Liu, Jana L. Raynor, Peter Vogel, Geoffrey Neale, Peter Carmeliet, Hongbo Chi. Homeostasis and transitional activation of regulatory T cells require c-Myc. Sci Adv. 2020 Jan 1;6(1):eaaw6443. doi: 10.1126/sciadv.aaw6443

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Kumar D, Sehrawat S. Divergent Effects of a Transient Corticosteroid Therapy on Virus-Specific Quiescent and Effector CD8+ T Cells. Front Immunol. 2019;10:1521. Published 2019 Jul 12. doi:10.3389/fimmu.2019.01521.

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Grinberg-Bleyer Y, Oh H, Desrichard A, Bhatt DM, Caron R, Chan TA, Schmid RM, Klein U, Hayden MS and Ghosh S. 2017. NF-κB c-Rel Is Crucial for the Regulatory T Cell Immune Checkpoint in Cancer. Cell. doi: 10.1016/j.cell.2017.08.004. 

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F4/80 (BM8.1)

 

Brian BF 4th, Sauer ML, Greene JT, Senevirathne SE, Lindstedt AJ, Funk OL, Ruis BL, Ramirez LA, Auger JL, Swanson WL, Nunez MG, Moriarity BS, Lowell CA, Binstadt BA, Freedman TS. A dominant function of LynB kinase in preventing autoimmunity. Sci Adv. 2022 Apr 22;8(16):eabj5227. doi: 10.1126/sciadv.abj5227. Epub 2022 Apr 22. PMID: 35452291.

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Burrack AL, Schmiechen ZC, Patterson MT, Miller EA, Spartz EJ, Rollins MR, Raynor JF, Mitchell JS, Kaisho T, Fife BT, Stromnes IM. Distinct myeloid antigen-presenting cells dictate differential fates of tumor-specific CD8+ T cells in pancreatic cancer. JCI Insight. 2022 Apr 8;7(7):e151593. doi: 10.1172/jci.insight.151593. PMID: 35393950. 

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Sánchez-Navarro A, Martínez-Rojas MÁ, Albarrán-Godinez A, Pérez-Villalva R, Auwerx J, de la Cruz A, Noriega LG, Rosetti F, Bobadilla NA. Sirtuin 7 Deficiency Reduces Inflammation and Tubular Damage Induced by an Episode of Acute Kidney Injury. Int J Mol Sci. 2022 Feb 25;23(5):2573. doi: 10.3390/ijms23052573. PMID: 35269715.

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Pingili AK, Chaib M, Sipe LM, et al. Immune checkpoint blockade reprograms systemic immune landscape and tumor microenvironment in obesity-associated breast cancer. Cell Rep. 2021 Jun 22;35(12):109285. doi: 10.1016/j.celrep.2021.109285. PMID: 34161764.

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Tan X, Banerjee P, Shi L, Xiao GY, Rodriguez BL, Grzeskowiak CL, Liu X, Yu J, Gibbons DL, Russell WK, Creighton CJ, Kurie JM. p53 loss activates prometastatic secretory vesicle biogenesis in the Golgi. Sci Adv. 2021 Jun 18;7(25):eabf4885. doi: 10.1126/sciadv.abf4885. PMID: 34144984.

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Saeki N, Imai Y. Reprogramming of synovial macrophage metabolism by synovial fibroblasts under inflammatory conditions. Cell Commun Signal. 2020 Nov 30;18(1):188. doi: 10.1186/s12964-020-00678-8. PMID: 33256735; PMCID: PMC7708128. 

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Ishida Y, Kuninaka Y, Nosaka M, Kimura A, Taruya A, Furuta M, Mukaida N, Kondo T. Prevention of CaCl2-induced aortic inflammation and subsequent aneurysm formation by the CCL3-CCR5 axis. Nat Commun. 2020 Nov 25;11(1):5994. doi: 10.1038/s41467-020-19763-0. PMID: 33239616.

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Wang H, Najibi AJ, Sobral MC, Seo BR, Lee JY, Wu D, Li AW, Verbeke CS, Mooney DJ. Biomaterial-based scaffold for in situ chemo-immunotherapy to treat poorly immunogenic tumors. Nat Commun. 2020 Nov 10;11(1):5696. doi: 10.1038/s41467-020-19540-z. PMID: 33173046; PMCID: PMC7655953.

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Yonebayashi S, Tajiri K, Murakoshi N, Xu D, et al. MAIR-II deficiency ameliorates cardiac remodelling post-myocardial infarction by suppressing TLR9-mediated macrophage activation. J Cell Mol Med. 2020 Nov 2. doi: 10.1111/jcmm.16070. PMID: 33140535.   

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Sardari M, Skuljec J, Yin D, et al. Lipopolysaccharide-induced sepsis-like state compromises post-ischemic neurological recovery, brain tissue survival and remodeling via mechanisms involving microvascular thrombosis and brain T cell infiltration. Brain Behav Immun. 2020 Oct 22:S0889-1591(20)32365-5. doi: 10.1016/j.bbi.2020.10.015. PMID: 33122024. 

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Bapat, Sagar P., Zheng, YE, Evans, Ronald, Downes, Michael, Atkins, Annette R., YU, Ruth T. COMPOSITIONS AND METHODS FOR TREATING AGE-RELATED DIABETES AND RELATED DISORDERS. 2020 May.

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Markman, J.L., Porritt, R.A., Wakita, D. et al. Loss of testosterone impairs anti-tumor neutrophil function. Nat Commun 11, 1613 (2020). https://doi.org/10.1038/s41467-020-15397-4.

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Udden SN, Kwak YT, Godfrey V, et al. NLRP12 suppresses hepatocellular carcinoma via downregulation of cJun N-terminal kinase activation in the hepatocyte. Elife. 2019;8:e40396. Published 2019 Apr 16. doi:10.7554/eLife.40396.

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Lam LKM, Watson AM, Ryman KD, Klimstra WB. Gamma-interferon exerts a critical early restriction on replication and dissemination of yellow fever virus vaccine strain 17D-204. NPJ Vaccines. 2018;3:5. Published 2018 Jan 23. doi:10.1038/s41541-017-0039-z.

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Palacios M, Miner TA, Frederick DR, et al. Identification of Two Regulators of Virulence That Are Conserved in Klebsiella pneumoniae Classical and Hypervirulent Strains. mBio. 2018;9(4):e01443-18. Published 2018 Aug 7. doi:10.1128/mBio.01443-18.

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Kanemaru H, Yamane F, Fukushima K, Matsuki T, Kawasaki T, Ebina I, Kuniyoshi K, Tanaka H, Maruyama K, Maeda K, Satoh T and Akira S. 2017. Antitumor effect of Batf2 through IL-12 p40 up-regulation in tumor-associated macrophages. Proc Natl Acad Sci U S A. doi: 10.1073/pnas.1708598114.

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Visvabharathy L and Freitag NE. 2017. Propofol sedation exacerbates kidney pathology and dissemination of bacteria during Staphylococcus aureus bloodstream infections.Infect Immun. doi: 10.1128/IAI.00097-17

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Trott DW, Henson GD, Ho MHT, Allison SA, Lesniewski LA and Donato AJ. 2016. Age-related arterial immune cell infiltration in mice is attenuated by caloric restriction or voluntary exercise. Exp. Gerontol. DOI: 10.1016/j.exger.2016.12.016

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Bracken SJ, Adami AJ, Szczepanek SM, Ehsan M, Natarajan P, Guernsey LA, Shahriari N, Rafti E, Matson AP, Schramm CM and Thrall RS. 2015. Long-Term Exposure to House Dust Mite Leads to the Suppression of Allergic Airway Disease Despite Persistent Lung Inflammation. Int Arch Allergy Immunol. 166(4): 243-258.

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Singh V, Holla S, Ramachandra SG and Balaji KN. 2015. WNT-Inflammasome Signaling Mediates NOD2-Induced Development of Acute Arthritis in Mice. J. Immunol. 194(7): 3351-3360.

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Skeldon AM, Morizot A, Douglas T, Santoro N, Kursawe R, Kozlitina J, Caprio S, Mehal WZ and Saleh M. 2015. Caspase-12, but Not Caspase-11, Inhibits Obesity and Insulin Resistance. J Immunol. doi: 10.4049 jimmunol.1501529

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Bapat SP, Nyoung Suh J, Fang S, Liu S, Zhang Y, Cheng A, Zhou C, Liang Y, LeBlanc M, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM and Zheng Y. 2015. Depletion of fat-resident Treg cells prevents age-associated insulin resistance. Nature. 528: 137-141.

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Spanier JA, Frederick DR, Taylor JJ, Heffernan JR, Kotov DI, Martinox T, Osum KC, Ruggiero JL, Rust BJ, Landry SJ, Jenkins MK, McLachlan JB, and Fife BT. 2016. Efficient Generation of Monoclonal Antibodies Against Peptide in the Context of MHCII Using Magnetic Enrichment. Nature Communications. doi:10.1038/ncomms11804

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Rezvani M, Español-Suñer R, Malato Y, Dumont L, Grimm AA, Kienle E, Bindman JG, Wiedtke E, Hsu BY, Naqvi SJ, Derderian SC, Schwabe RF, Corvera CU, Grimm D and Willenbring H. 2016. In vivo reprogramming of myofibroblasts into hepatocytes as a therapeutic strategy for liver fibrosis. Cell Stem Cell. 18(6):809-16.

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Daniels MJK, Rivers-Auty J, Schilling T, Spencer NG, Watremez W, Fasolino V, Booth SJ, White CS, Baldwin AG, Freeman S, Wong R, Latta C, Yu S, Jackson J, Fischer N, Koziel V, Pillot T, Bagnall J, Allan SM, Paszek P, Galea J, Harte MK, Eder C, Lawrence CB and Brough D. 2016. Fenamate NSAIDs Inhibit the NLRP3 Inflammasome and Protect Against Alzheimer's Disease in Rodent Models. Nat. Commun. doi:10.1038/ncomms12504

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Ganatra HA, Varisco BM, Harmon K, Lahni P, Opoka A and Wong HR. 2016. Zinc supplementation leads to immune modulation and improved survival in a juvenile model of murine sepsis. Innate Immun. doi: 10.1177/1753425916677073

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Boro M, Singh V and Balaji N. 2016. Mycobacterium tuberculosis-triggered Hippo pathway orchestrates CXCL1/2 expression to modulate host immune responses. Sci. Rep. doi:10.1038/srep37695

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Adam L. Burrack, Ellen J. Spartz, Jackson F. Raynor, Iris Wang, Margaret Olson, Ingunn M. Stromnes. Combination PD-1 and PD-L1 Blockade Promotes Durable Neoantigen-Specific T Cell-Mediated Immunity in Pancreatic Ductal Adenocarcinoma. Cell Rep. 2019 Aug 20;28(8):2140-2155.e6. doi: 10.1016/j.celrep.2019.07.059

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Jessica K. Fiege, Ian A. Stone, Rebekah E. Dumm, Barbara M. Waring, Brian T. FifeI, Judith Agudo, Brian D. Brown, Nicholas S. Heaton, Ryan A. Langlois. Long-term surviving influenza infected cells evade CD8+ T cell mediated clearance. PLoS Pathog. 2019 Sep 26;15(9):e1008077. doi: 10.1371/journal.ppat.1008077

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Fc epsilon Receptor I alpha (FceR1) (MAR-1)

Shiyang Li, John W. Bostick, Jian Ye, Joseph F. Urban, Jr., Dorina Avram, Liang Zhou. Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function. Immunity. 2018 Nov 20;49(5):915-928.e5. doi: 10.1016/j.immuni.2018.09.015

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IFN-g (XMG1.2)

 

Ishikura N, Sugimoto M, Yorozu K, Kurasawa M, Kondoh O. Anti‑VEGF antibody triggers the effect of anti‑PD‑L1 antibody in PD‑L1low and immune desert‑like mouse tumors. Oncol Rep. 2022 Feb;47(2):36. doi: 10.3892/or.2021.8247. Epub 2021 Dec 27. PMID: 34958105.

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Burbach BJ, O'Flanagan SD, Shao Q, et al. Irreversible electroporation augments checkpoint immunotherapy in prostate cancer and promotes tumor antigen-specific tissue-resident memory CD8+ T cells. Nat Commun. 2021 Jun 23;12(1):3862. doi: 10.1038/s41467-021-24132-6. PMID: 34162858.

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Sheppard S, Santosa EK, Lau CM, Violante S, Giovanelli P, Kim H, Cross JR, Li MO, Sun JC. Lactate dehydrogenase A-dependent aerobic glycolysis promotes natural killer cell anti-viral and anti-tumor function. Cell Rep. 2021 Jun 1;35(9):109210. doi: 10.1016/j.celrep.2021.109210. PMID: 34077737.

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Davenport BJ, Morrison TE, Kedl RM, Klarquist J. Conserved and Novel Mouse CD8 T Cell Epitopes within SARS-CoV-2 Spike Receptor Binding Domain Protein Identified following Subunit Vaccination. J Immunol. 2021 May 10:ji2100195. doi: 10.4049/jimmunol.2100195. PMID: 33972373.

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Trott DW, Islam MT, Buckley DJ, Donato AJ, Dutson T, Sorensen ES, Cai J, Gogulamudi VR, Phuong TTT, Lesniewski LA. T lymphocyte depletion ameliorates age-related metabolic impairments in mice. Geroscience. 2021 Apr 24. doi: 10.1007/s11357-021-00368-4. PMID: 33893902.

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Dikiy S, Li J, Bai L, Jiang M, Janke L, Zong X, Hao X, Hoyos B, Wang ZM, Xu B, Fan Y, Rudensky AY, Feng Y. A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance. Immunity. 2021 May 11;54(5):931-946.e11. doi: 10.1016/j.immuni.2021.03.020. Epub 2021 Apr 9. PMID: 33838102; PMCID: PMC8317508.

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Wiedemann GM, Grassmann S, Lau CM, Rapp M, Villarino AV, Friedrich C, Gasteiger G, O'Shea JJ, Sun JC. Divergent Role for STAT5 in the Adaptive Responses of Natural Killer Cells. Cell Rep. 2020 Dec 15;33(11):108498. doi: 10.1016/j.celrep.2020.108498. PMID: 33326784. 

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Diaz-Salazar C, Sun JC. Coordinated Viral Control by Cytotoxic Lymphocytes Ensures Optimal Adaptive NK Cell Responses. Cell Rep. 2020 Sep 22;32(12):108186. doi: 10.1016/j.celrep.2020.108186. PMID: 32966792. 

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Chen D, Duan Z, Zhou W, et al. Japanese encephalitis virus-primed CD8+ T cells prevent antibody-dependent enhancement of Zika virus pathogenesis. J Exp Med. 2020;217(9):e20192152. doi:10.1084/jem.20192152.

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Atkin-Smith GK, Duan M, Zanker DJ, Loh L, Nguyen THO, Koutsakos M, Nguyen T, Jiang X, Carrera J, Phan TK, Liu C, Paone S, Oveissi S, Hodge AL, Baxter AA, Kedzierska K, Mackenzie JM, Hulett MD, Bilsel P, Chen W, Poon IKH. Monocyte apoptotic bodies are vehicles for influenza A virus propagation. Commun Biol. 2020 May 8;3(1):223. doi: 10.1038/s42003-020-0955-8.

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Blagih J, Zani F, Chakravarty P, et al. Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses. Cell Rep. 2020;30(2):481-496.e6. doi:10.1016/j.celrep.2019.12.028.

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Kotov JA, Kotov DI, Linehan JL, Bardwell VJ, Gearhart MD, Jenkins MK. BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors. J Exp Med. 2019;216(6):1450-1464. doi:10.1084/jem.20182376.

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Elong Ngono A, Young MP, Bunz M, et al. CD4+ T cells promote humoral immunity and viral control during Zika virus infection [published correction appears in PLoS Pathog. 2019 May 28;15(5):e1007821]. PLoS Pathog. 2019;15(1):e1007474. Published 2019 Jan 24. doi:10.1371/journal.ppat.1007474.

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Kumar D, Sehrawat S. Divergent Effects of a Transient Corticosteroid Therapy on Virus-Specific Quiescent and Effector CD8+ T Cells. Front Immunol. 2019;10:1521. Published 2019 Jul 12. doi:10.3389/fimmu.2019.01521.

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Shimada K, Porritt RA, Markman JL, et al. T-Cell-Intrinsic Receptor Interacting Protein 2 Regulates Pathogenic T Helper 17 Cell Differentiation. Immunity. 2018;49(5):873-885.e7. doi:10.1016/j.immuni.2018.08.022.

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Lam LKM, Watson AM, Ryman KD, Klimstra WB. Gamma-interferon exerts a critical early restriction on replication and dissemination of yellow fever virus vaccine strain 17D-204. NPJ Vaccines. 2018;3:5. Published 2018 Jan 23. doi:10.1038/s41541-017-0039-z.

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Oyler-Yaniv J, Oyler-Yaniv A, Shakiba M, Min NK, Chen YH, Cheng SY, Krichevsky O, Altan-Bonnet N and Altan-Bonnet G. 2017. Catch and Release of Cytokines Mediated by Tumor Phosphatidylserine Converts Transient Exposure into Long-Lived Inflammation. Mol Cell. doi: 10.1016/j.molcel.2017.05.011.

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Rydyznski C, Daniels KA, Karmele EP, Brooks TR, Mahl SE, Moran MT, Li C, Sutiwisesak R, Welsh RM and Waggoner SN. 2015. Generation of cellular immune memory and B-cell immunity is impaired by natural killer cells. Nat Commun. doi: 10.1038/ncomms7375.

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Zellweger RM, Tang WW, Eddy WE, King K, Sanchez MC and Shresta S. 2015. CD8+ T Cells Can Mediate Short-Term Protection against Heterotypic Dengue Virus Reinfection in Mice. J Virol. 89(12): 6494-6505.

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Gao Y, Min K, Zhang Y, Su J, Greenwood M and Gronert K. 2015. Female-Specific Downregulation of Tissue Polymorphonuclear Neutrophils Drives Impaired Regulatory T Cell and Amplified Effector T Cell Responses in Autoimmune Dry Eye Disease. J Immunol. Doi: 10.4049 jimmunol.1500610.

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Carey AJ, Gracias DT, Thayer JL, Boesteanu AC, Kumova OK, Mueller YM, Hope JL, Fraietta JA, van Zessen DB and Katsikis PD. 2016. Rapid Evolution of the CD8+ TCR Repertoire in Neonatal Mice. J Immunol. doi: 10.4049/jimmunol.1502126.

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Khan TN, Mooster JL, Kilgore AM, Osborn JF, and Nolz JC. 2016. Local Antigen in Nonlymphoid Tissue Promotes Resident Memory CD8+ T Cell Formation During Viral Infection. The Journal of Experimental Medicine. doi: 10.1084/jem.20151855

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Watson AM, Matthew Lam LK, Klimstra WB and Ryman KD. 2016. The 17D-204 Vaccine Strain-Induced Protection Against Virulent Yellow Fever Virus is Mediated by Humoral Immunity and CD4+ But Not CD8+ T Cells. PLoS Pathog. doi:10.1371/journal.ppat.1005786

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Uzodinma U. Uche, Ann R. Piccirillo, Shunsuke Kataoka, Stephanie J. Grebinoski, Louise M. D’Cruz, and Lawrence P. Kane. PIK3IP1/TrIP restricts activation of T cells through inhibition of PI3K/Akt. J Exp Med. 2018 Dec 3;215(12):3165-3179. doi: 10.1084/jem.20172018

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Avery L, Filderman J, Szymczak-Workman AL, Kane LP4. Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2455-2460. doi: 10.1073/pnas.1712107115

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Derek W. Trobaugh, Chengqun Sun, Matthew D. Dunn, Douglas S. Reed, William B. Klimstra. Rational design of a live-attenuated eastern equine encephalitis virus vaccine through informed mutation of virulence determinants. PLoS Pathog. 2019 Feb 11;15(2):e1007584. doi: 10.1371/journal.ppat.1007584

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Kristina S. Burrack, Matthew A. Huggins, Emily Taras, Aaron J. Johnson, Stephen C. Jameson, Sara E. Hamilton. Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells. Immunity. 2018 Apr 17;48(4):760-772.e4. doi: 10.1016/j.immuni.2018.03.012

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Matthew A. Huggins, Frances V. Sjaastad, Mark Pierson, Tamara A. Kucaba, Whitney Swanson, Christopher Staley, Alexa R. Weingarden, Isaac J. Jensen, Derek B. Danahy, Vladimir P. Badovinac, Stephen C. Jameson, Vaiva Vezys, David Masopust, Alexander Khoruts, Thomas S. Griffith, and Sara E. Hamilton. Microbial Exposure Enhances Immunity to Pathogens Recognized by TLR2 but Increases Susceptibility to Cytokine Storm through TLR4 Sensitization. Cell Rep. 2019 Aug 13;28(7):1729-1743.e5. doi: 10.1016/j.celrep.2019.07.028

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Grinberg-Bleyer Y, Oh H, Desrichard A, Bhatt DM, Caron R, Chan TA, Schmid RM, Klein U, Hayden MS and Ghosh S. 2017. NF-κB c-Rel Is Crucial for the Regulatory T Cell Immune Checkpoint in Cancer. Cell. doi: 10.1016/j.cell.2017.08.004. 

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IL-2 (JES6-5H4)

 

Toriyama K, Kuwahara M, Kondoh H, et al. T cell-specific deletion of Pgam1 reveals a critical role for glycolysis in T cell responses. Commun Biol. 2020;3(1):394. Published 2020 Jul 24. doi:10.1038/s42003-020-01122-w.

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Brincks E. L., Adams J., Wang L., Turner B., Marcinowicz A., Ke J., Essmann M., Mautino L. M., Allen C. Van, Kumar S., Vahanian N., Link C., Mautino M. R. et al Indoximod opposes the immunosuppressive effects mediated by IDO and TDO via modulation of AhR function and activation of mTORC1. Oncotarget. 2020; 11: 2438-2461.

View on Oncotarget

Brooks A, Jonkman J, Bookmyer Z and Bruns HA. 2014. Lonicera japonica alters antigen-stimulated T cell functions. Int J Herbal Med. 2(1): 13-20.

View on Flora Journal

Watson AM, Matthew Lam LK, Klimstra WB and Ryman KD. 2016. The 17D-204 Vaccine Strain-Induced Protection Against Virulent Yellow Fever Virus is Mediated by Humoral Immunity and CD4+ But Not CD8+ T Cells. PLoS Pathog. doi:10.1371/journal.ppat.1005786

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IL-4 (11B11)

 

Asakawa T, Onizawa M, Saito C, et al. Oral administration of D-serine prevents the onset and progression of colitis in mice. J Gastroenterol. 2021 Aug;56(8):732-745. doi: 10.1007/s00535-021-01792-1. Epub 2021 Jun 20. PMID: 34148144.

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Poudel B, Yorek MS, Mazgaeen L, Brown SA, Kanneganti TD, Gurung P. Acute IL-4 Governs Pathogenic T Cell Responses during Leishmania major Infection. Immunohorizons. 2020 Sep 18;4(9):546-560. doi: 10.4049/immunohorizons.2000076. PMID: 32948646.

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Kotov JA, Kotov DI, Linehan JL, Bardwell VJ, Gearhart MD, Jenkins MK. BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors. J Exp Med. 2019;216(6):1450-1464. doi:10.1084/jem.20182376.

» View on PubMed

Oyler-Yaniv J, Oyler-Yaniv A, Shakiba M, Min NK, Chen YH, Cheng SY, Krichevsky O, Altan-Bonnet N and Altan-Bonnet G. 2017. Catch and Release of Cytokines Mediated by Tumor Phosphatidylserine Converts Transient Exposure into Long-Lived Inflammation. Mol Cell. doi: 10.1016/j.molcel.2017.05.011.

» View on PubMed

Onizawa M, Oshima S, Schulze-Topphoff U, Oses-Prieto JA, Lu T, Tavares R, Produhomme T, Duong B, Whang MI, Advincula R, Agelidis A, et al. 2015. The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis. Nat Immunol. 16(6): 618-627.

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Watson AM, Matthew Lam LK, Klimstra WB and Ryman KD. 2016. The 17D-204 Vaccine Strain-Induced Protection Against Virulent Yellow Fever Virus is Mediated by Humoral Immunity and CD4+ But Not CD8+ T Cells. PLoS Pathog. doi:10.1371/journal.ppat.1005786

» View on PubMed

IL-10 (JES5-2A5)

Oyler-Yaniv J, Oyler-Yaniv A, Shakiba M, Min NK, Chen YH, Cheng SY, Krichevsky O, Altan-Bonnet N and Altan-Bonnet G. 2017. Catch and Release of Cytokines Mediated by Tumor Phosphatidylserine Converts Transient Exposure into Long-Lived Inflammation. Mol Cell. doi: 10.1016/j.molcel.2017.05.011.

» View on PubMed

Ly-6G (Gr-1) (RB6-8C5)

 

Brian BF 4th, Sauer ML, Greene JT, Senevirathne SE, Lindstedt AJ, Funk OL, Ruis BL, Ramirez LA, Auger JL, Swanson WL, Nunez MG, Moriarity BS, Lowell CA, Binstadt BA, Freedman TS. A dominant function of LynB kinase in preventing autoimmunity. Sci Adv. 2022 Apr 22;8(16):eabj5227. doi: 10.1126/sciadv.abj5227. Epub 2022 Apr 22. PMID: 35452291.

» View on PubMed

Jester BW, Zhao H, Gewe M, Adame T, Perruzza L, Bolick DT, Agosti J, Khuong N, Kuestner R, Gamble C, Cruickshank K, Ferrara J, Lim R, Paddock T, Brady C, Ertel S, Zhang M, Pollock A, Lee J, Xiong J, Tasch M, Saveria T, Doughty D, Marshall J, Carrieri D, Goetsch L, Dang J, Sanjaya N, Fletcher D, Martinez A, Kaldis B, Sigmar K, Afreen E, Nguyen T, Randolph A, Taber A, Krzeszowski A, Robinett B, Volkin DB, Grassi F, Guerrant R, Takeuchi R, Finrow B, Behnke C, Roberts J. Development of spirulina for the manufacture and oral delivery of protein therapeutics. Nat Biotechnol. 2022 Mar 21. doi: 10.1038/s41587-022-01249-7. Epub ahead of print. PMID: 35314813.

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Chen DL, Sheng H, Zhang DS, Jin Y, Zhao BT, Chen N, Song K, Xu RH. The circular RNA circDLG1 promotes gastric cancer progression and anti-PD-1 resistance through the regulation of CXCL12 by sponging miR-141-3p. Mol Cancer. 2021 Dec 15;20(1):166. doi: 10.1186/s12943-021-01475-8. PMID: 34911533; PMCID: PMC8672580.

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Oda Y, Takahashi C, Harada S, Nakamura S, Sun D, Kiso K, Urata Y, Miyachi H, Fujiyoshi Y, Honigmann A, Uchida S, Ishihama Y, Toyoshima F. Discovery of anti-inflammatory physiological peptides that promote tissue repair by reinforcing epithelial barrier formation. Sci Adv. 2021 Nov 19;7(47):eabj6895. doi: 10.1126/sciadv.abj6895. Epub 2021 Nov 17. PMID: 34788088.

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Baba T, Yoshida T, Tanabe Y, et al. Cytoplasmic DNA accumulation preferentially triggers cell death of myeloid leukemia cells by interacting with intracellular DNA sensing pathway. Cell Death Dis. 2021 Mar 26;12(4):322. doi: 10.1038/s41419-021-03587-x. PMID: 33771977.  

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Ishida Y, Kuninaka Y, Nosaka M, Kimura A, Taruya A, Furuta M, Mukaida N, Kondo T. Prevention of CaCl2-induced aortic inflammation and subsequent aneurysm formation by the CCL3-CCR5 axis. Nat Commun. 2020 Nov 25;11(1):5994. doi: 10.1038/s41467-020-19763-0. PMID: 33239616.

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Yonebayashi S, Tajiri K, Murakoshi N, Xu D, et al. MAIR-II deficiency ameliorates cardiac remodelling post-myocardial infarction by suppressing TLR9-mediated macrophage activation. J Cell Mol Med. 2020 Nov 2. doi: 10.1111/jcmm.16070. PMID: 33140535.   

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Velasco-de Andrés M, Català C, Casadó-Llombart S, et al. The lymphocytic scavenger receptor CD5 shows therapeutic potential in mouse models of fungal infection. Antimicrob Agents Chemother. 2020 Oct 12:AAC.01103-20. doi: 10.1128/AAC.01103-20. PMID: 33046489. 

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Marinaik CB, Kingstad-Bakke B, Lee W, Hatta M, Sonsalla M, Larsen A, Neldner B, Gasper DJ, Kedl RM, Kawaoka Y, Suresh M. Programming Multifaceted Pulmonary T Cell Immunity by Combination Adjuvants. Cell Rep Med. 2020 Sep 22;1(6):100095. doi: 10.1016/j.xcrm.2020.100095. PMID: 32984856; PMCID: PMC7508055.

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Sugimoto Y, Endo D, Aratani Y. Mice Deficient in NOX2 Display Severe Thymic Atrophy, Lymphopenia, and Reduced Lymphopoiesis in a Zymosan-Induced Model of Systemic Inflammation. Inflammation. 2020 Sep 16. doi: 10.1007/s10753-020-01342-6. PMID: 32939668.  

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Hiroshi Kobayashi and Keiyo Takubo. Protocol for the Maintenance of Quiescent Murine Hematopoietic Stem Cells. STAR Protocols.  Published 2 August 2020. https://doi.org/10.1016/j.xpro.2020.100078. 

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Alkhani A, Levy CS, Tsui M, Rosenberg KA, Polovina K, Mattis AN, Mack M, Van Dyken S, Wang BM, Maher JJ, Nijagal A. Ly6cLo non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic inflammation. Sci Rep. 2020 Apr 28;10(1):7165. doi: 10.1038/s41598-020-64158-2.

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Kobayashi H, Morikawa T, Okinaga A, et al. Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo. Cell Rep. 2019;28(1):145-158.e9. doi:10.1016/j.celrep.2019.06.008.

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Udden SN, Kwak YT, Godfrey V, et al. NLRP12 suppresses hepatocellular carcinoma via downregulation of cJun N-terminal kinase activation in the hepatocyte. Elife. 2019;8:e40396. Published 2019 Apr 16. doi:10.7554/eLife.40396.

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Mgbemena VE, Signer RA, Wijayatunge R, Laxson T, Morrison SJ, Ross TS. 2017. Distinct Brca1 Mutations Differentially Reduce Hematopoietic Stem Cell Function. Cell Rep. DOI: 10.1016/j.celrep.2016.12.075

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Hirao H, Uchida Y, Kadono K, Tanaka H, Niki T, Yamauchi A, Hata K, Watanabe T, Terajima H and Uemoto S. 2015. The protective function of galectin-9 in liver ischemia and reperfusion injury in mice. Liver Transpl. doi: 10.1002/lt.24159.

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Bapat SP, Nyoung Suh J, Fang S, Liu S, Zhang Y, Cheng A, Zhou C, Liang Y, LeBlanc M, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM and Zheng Y. 2015. Depletion of fat-resident Treg cells prevents age-associated insulin resistance. Nature. 528: 137-141.

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Kawano M, Mabuchi S, Matsumoto Y, Sasano T, Takahashi R, Kuroda H, Kozasa K, Hashimoto K, Isobe A, Sawada K, Hamasaki T, Morii E and Kimura T. 2015. The significance of G-CSF expression and myeloid-derived suppressor cells in the chemoresistance of uterine cervical cancer. Sci Rep. 5:18217 doi:10.1038/srep18217.

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Ganatra HA, Varisco BM, Harmon K, Lahni P, Opoka A and Wong HR. 2016. Zinc supplementation leads to immune modulation and improved survival in a juvenile model of murine sepsis. Innate Immun. doi: 10.1177/1753425916677073

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Kovats. A Major Population of Functional KLRG1- ILC2s in Female Lungs Contributes to a Sex Bias in ILC2 Numbers. Immunohorizons. 2018 Feb;2(2):74-86. doi: 10.4049/immunohorizons.1800008

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Oguro H, McDonald JG, Zhao Z, Umetani M, Shaul PW and Morrison SJ. 2017. 27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy. J Clin Invest. doi: 10.1172/JCI94027.

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Suwanpradid J, Shih M, Pontius L, Yang B, Birukova A, Guttman-Yassky E, Corcoran DL, Que LG, Tighe RM and MacLeod AS. 2017. Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity. J Immunol. doi: 10.4049/jimmunol.1700739.

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Ly-6G (1A8)

 

Brian BF 4th, Sauer ML, Greene JT, Senevirathne SE, Lindstedt AJ, Funk OL, Ruis BL, Ramirez LA, Auger JL, Swanson WL, Nunez MG, Moriarity BS, Lowell CA, Binstadt BA, Freedman TS. A dominant function of LynB kinase in preventing autoimmunity. Sci Adv. 2022 Apr 22;8(16):eabj5227. doi: 10.1126/sciadv.abj5227. Epub 2022 Apr 22. PMID: 35452291.

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Chen DL, Sheng H, Zhang DS, Jin Y, Zhao BT, Chen N, Song K, Xu RH. The circular RNA circDLG1 promotes gastric cancer progression and anti-PD-1 resistance through the regulation of CXCL12 by sponging miR-141-3p. Mol Cancer. 2021 Dec 15;20(1):166. doi: 10.1186/s12943-021-01475-8. PMID: 34911533; PMCID: PMC8672580.

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Stephens WZ, Kubinak JL, Ghazaryan A, Bauer KM, Bell R, Buhrke K, Chiaro TR, Weis AM, Tang WW, Monts JK, Soto R, Ekiz HA, O'Connell RM, Round JL. Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition. Cell Rep. 2021 Nov 2;37(5):109916. doi: 10.1016/j.celrep.2021.109916. PMID: 34731608.

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Mayes-Hopfinger L, Enache A, Xie J, Huang CL, Köchl R, Tybulewicz VLJ, Fernandes-Alnemri T, Alnemri ES. Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis. Nat Commun. 2021 Jul 27;12(1):4546. doi: 10.1038/s41467-021-24784-4. PMID: 34315884.

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Ortega-Molina A, Lebrero-Fernández C, Sanz A, et al. Inhibition of Rag GTPase signaling in mice suppresses B cell responses and lymphomagenesis with minimal detrimental trade-offs. Cell Rep. 2021 Jul 13;36(2):109372. doi: 10.1016/j.celrep.2021.109372. PMID: 34260908. 

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Pingili AK, Chaib M, Sipe LM, et al. Immune checkpoint blockade reprograms systemic immune landscape and tumor microenvironment in obesity-associated breast cancer. Cell Rep. 2021 Jun 22;35(12):109285. doi: 10.1016/j.celrep.2021.109285. PMID: 34161764.

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Lei Y, Guerra Martinez C, Torres-Odio S, et al. Elevated type I interferon responses potentiate metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice. Sci Adv. 2021 May 26;7(22):eabe7548. doi: 10.1126/sciadv.abe7548. PMID: 34039599.

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Li Y, Han Y, Su R, Liu Y, Chong G, Xu D, He R, Liu Y, Dong H, Shi D, Li Y. Photosensitizer-Laden Neutrophils Are Controlled Remotely for Cancer Immunotherapy. Cell Rep. 2020 Dec 15;33(11):108499. doi: 10.1016/j.celrep.2020.108499. PMID: 33326787. 

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Kawasoe J, Uchida Y, Miyauchi T, et al. The lectin-like domain of thrombomodulin is a drug candidate for both prophylaxis and treatment of liver ischemia and reperfusion injury in mice. Am J Transplant. 2020;10.1111/ajt.16269. doi:10.1111/ajt.16269.

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Even Fossum, Demo Yemane Tesfaye, Sonja Bobic, et al. Targeting Antigens to Different Receptors on Conventional Type 1 Dendritic Cells Impacts the Immune Response. The Journal of Immunology June 26, 2020, ji1901119; DOI: 10.4049/jimmunol.1901119.

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Andersen TK, Huszthy PC, Gopalakrishnan RP, et al. Enhanced germinal center reaction by targeting vaccine antigen to major histocompatibility complex class II molecules. NPJ Vaccines. 2019;4:9. Published 2019 Feb 11. doi:10.1038/s41541-019-0101-0.

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Kim IS, Gao Y, Welte T, et al. Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms. Nat Cell Biol. 2019;21(9):1113-1126. doi:10.1038/s41556-019-0373-7.

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Kishimoto Y, Asakawa S, Sato T, Takano T, Nakajyo T, Mizuno N, Segawa R, Yoshikawa T, Hiratsuka M, Yanai K, Ohtsu H and Hirasawa N. 2017. Induced histamine regulates Ni elution from an implanted Ni wire in mice by downregulating neutrophil migration. Exp Dermatol. doi: 10.1111/exd.13315.

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Shindo R, Katagiri T, Komazawa-Sakon S, et al. Regenerating islet-derived protein (Reg)3β plays a crucial role in attenuation of ileitis and colitis in mice. Biochem Biophys Rep. 2020;21:100738. Published 2020 Feb 7. doi:10.1016/j.bbrep.2020.100738.

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Lin CC, Bradstreet TR, Schwarzkopf EA, Jarjour NN, Chou C, Archambault AS, Sim J, Zinselmeyer BH, Carrero JA, Wu GF, Taneja R, Artyomov MN, Russell JH and Edelson BT. IL-1 induced Bhlhe40 identifies pathogenic T helper cells in a model of autoimmune neuroinflammation. J Exp Med. 213(2): 251-271.

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Vogel CF, Chang WL, Kado S, McColloh K, Vogel H, Wu D, Haarmann-Stemmann T, Yang G, Leung PS, Matsumura F and Gershwin ME. 2016. Transgenic Overexpression of Aryl Hydrocarbon Receptor Repressor (AhRR) and AhR-Mediated Induction of CYP1A1, Cytokines, and Acute Toxicity. Environ Health Perspect. DOI:10.1289/ehp.1510194.

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Sato T, Kishimoto Y, Asakawa S, Mizuno N, Hiratsuka M and Hirasawa N. 2016. Involvement of COX-2 in nickel elution from a wire implanted subcutaneously in mice. Toxicology. Volumes 363–364, 1 July 2016, Pages 37–45

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Ganatra HA, Varisco BM, Harmon K, Lahni P, Opoka A and Wong HR. 2016. Zinc supplementation leads to immune modulation and improved survival in a juvenile model of murine sepsis. Innate Immun. doi: 10.1177/1753425916677073

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Tsurusaki S, Tahara-Hanaoka S, Shibagaki S, Miyake S, Imai M, Shibayama S, Kubo M and Shibuya A. 2016. Allergin-1 inhibits TLR2-mediated mast cell activation and suppresses dermatitis. Int. Immunol. doi: 10.1093/intimm/dxw046

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Sakata K, Araki K, Nakano H, Nishina T, Komazawa-Skon S, Murai S, Lee GE, Hashimoto D, Suzuki C, Uchiyama Y, Kotohara K, Gukovskaya AS, Gukovsky I, Yamamura K, Baba H and Ohmuraya M. 2016. Novel method to rescue a lethal phenotype through integration of target gene onto the X-chromosome. Sci. Rep. doi:10.1038/srep37200

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Taylor RA, Chang CF, Goods BA, Hammond MD, Mac Grory B, Ai Y, Steinschneider AF, Renfroe SC, Askenase MH, McCullough LD, Kasner SE, Mullen MT, Hafler DA, Love JC, Sansing LH. 2016. TGF-β1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage. J. Clin. Invest. doi:10.1172/JCI88647

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Lee LM, Ji M, Sinha M, Dong MB, Ren X, Wang Y, Lowell CA, Ghosh S, Locksley RM and DeFranco AL. 2016. Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9. PLOS one. doi:10.1371/journal.pone.0167693

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Shiyang Li, John W. Bostick, Jian Ye, Joseph F. Urban, Jr., Dorina Avram, Liang Zhou. Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function. Immunity. 2018 Nov 20;49(5):915-928.e5. doi: 10.1016/j.immuni.2018.09.015

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Karmaus PWF, Herrada AA, Guy C, Neale G, Dhungana Y, Long L, Vogel P, Avila J, Clish CB and Chi H. 2017. Critical roles of mTORC1 signaling and metabolic reprogramming for M-CSF-mediated myelopoiesis. J Exp Med. doi: 10.1084/jem.20161855.

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NK1.1 (PK136)

Brian BF 4th, Sauer ML, Greene JT, Senevirathne SE, Lindstedt AJ, Funk OL, Ruis BL, Ramirez LA, Auger JL, Swanson WL, Nunez MG, Moriarity BS, Lowell CA, Binstadt BA, Freedman TS. A dominant function of LynB kinase in preventing autoimmunity. Sci Adv. 2022 Apr 22;8(16):eabj5227. doi: 10.1126/sciadv.abj5227. Epub 2022 Apr 22. PMID: 35452291.

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Cascio S, Chandler C, Zhang L, Sinno S, Gao B, Onkar S, Bruno TC, Vignali DAA, Mahdi H, Osmanbeyoglu HU, Vlad AM, Coffman LG, Buckanovich RJ. Cancer-associated MSC drive tumor immune exclusion and resistance to immunotherapy, which can be overcome by Hedgehog inhibition. Sci Adv. 2021 Nov 12;7(46):eabi5790. doi: 10.1126/sciadv.abi5790. Epub 2021 Nov 12. PMID: 34767446.

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Stephens WZ, Kubinak JL, Ghazaryan A, Bauer KM, Bell R, Buhrke K, Chiaro TR, Weis AM, Tang WW, Monts JK, Soto R, Ekiz HA, O'Connell RM, Round JL. Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition. Cell Rep. 2021 Nov 2;37(5):109916. doi: 10.1016/j.celrep.2021.109916. PMID: 34731608.

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Ortega-Molina A, Lebrero-Fernández C, Sanz A, et al. Inhibition of Rag GTPase signaling in mice suppresses B cell responses and lymphomagenesis with minimal detrimental trade-offs. Cell Rep. 2021 Jul 13;36(2):109372. doi: 10.1016/j.celrep.2021.109372. PMID: 34260908. 

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Sheppard S, Santosa EK, Lau CM, Violante S, Giovanelli P, Kim H, Cross JR, Li MO, Sun JC. Lactate dehydrogenase A-dependent aerobic glycolysis promotes natural killer cell anti-viral and anti-tumor function. Cell Rep. 2021 Jun 1;35(9):109210. doi: 10.1016/j.celrep.2021.109210. PMID: 34077737.

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Wiedemann GM, Grassmann S, Lau CM, Rapp M, Villarino AV, Friedrich C, Gasteiger G, O'Shea JJ, Sun JC. Divergent Role for STAT5 in the Adaptive Responses of Natural Killer Cells. Cell Rep. 2020 Dec 15;33(11):108498. doi: 10.1016/j.celrep.2020.108498. PMID: 33326784. 

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Clark NM, Martinez LM, Murdock S, deLigio JT, Olex AL, Effi C, Dozmorov MG, Bos PD. Regulatory T Cells Support Breast Cancer Progression by Opposing IFN-γ-Dependent Functional Reprogramming of Myeloid Cells. Cell Rep. 2020 Dec 8;33(10):108482. doi: 10.1016/j.celrep.2020.108482. PMID: 33296659.

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Diaz-Salazar C, Sun JC. Coordinated Viral Control by Cytotoxic Lymphocytes Ensures Optimal Adaptive NK Cell Responses. Cell Rep. 2020 Sep 22;32(12):108186. doi: 10.1016/j.celrep.2020.108186. PMID: 32966792. 

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Karki R, Sharma BR, Lee E, et al. Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer. JCI Insight. 2020;5(12):136720. Published 2020 Jun 18. doi:10.1172/jci.insight.136720.

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Amber Troy, Sandra C.Esparza-Gonzalez, Alicia Bartek, Elizabeth Creissen, Linda Izzo, Angelo A.Izzo. Pulmonary mucosal immunity mediated through CpG provides adequate protection against pulmonary Mycobacterium tuberculosis infection in the mouse model. A role for type I interferon. Sci Rep. 2020 May 8. https://doi.org/10.1016/j.tube.2020.101949.

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Yang BH, Wang K, Wan S, et al. TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases. Cell Rep. 2019;27(12):3629-3645.e6. doi:10.1016/j.celrep.2019.05.061.

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Govindarajan S, Gaublomme D, Van der Cruyssen R, et al. Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha. Nat Commun. 2018;9(1):5340. Published 2018 Dec 17. doi:10.1038/s41467-018-07758-x.

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Lam LKM, Watson AM, Ryman KD, Klimstra WB. Gamma-interferon exerts a critical early restriction on replication and dissemination of yellow fever virus vaccine strain 17D-204. NPJ Vaccines. 2018;3:5. Published 2018 Jan 23. doi:10.1038/s41541-017-0039-z.

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Oh JE, Oh DS, Jung HE and Lee HK. 2017. A mechanism for the induction of type 2 immune responses by a protease allergen in the genital tract. Proc Natl Acad Sci U S A. doi: 10.1073/pnas.1612997114

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O'Sullivan TE, Johnson LR, Kang HH, Sun JC. 2015. BNIP3- and BNIP3L-Mediated Mitophagy Promotes the Generation of Natural Killer Cell Memory. Immunity. 43: 331-342.

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Kovats. A Major Population of Functional KLRG1- ILC2s in Female Lungs Contributes to a Sex Bias in ILC2 Numbers. Immunohorizons. 2018 Feb;2(2):74-86. doi: 10.4049/immunohorizons.1800008

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Shiyang Li, John W. Bostick, Jian Ye, Joseph F. Urban, Jr., Dorina Avram, Liang Zhou. Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function. Immunity. 2018 Nov 20;49(5):915-928.e5. doi: 10.1016/j.immuni.2018.09.015

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TCR-beta (H57-597)

 

Brian BF 4th, Sauer ML, Greene JT, Senevirathne SE, Lindstedt AJ, Funk OL, Ruis BL, Ramirez LA, Auger JL, Swanson WL, Nunez MG, Moriarity BS, Lowell CA, Binstadt BA, Freedman TS. A dominant function of LynB kinase in preventing autoimmunity. Sci Adv. 2022 Apr 22;8(16):eabj5227. doi: 10.1126/sciadv.abj5227. Epub 2022 Apr 22. PMID: 35452291.

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Sánchez-Navarro A, Martínez-Rojas MÁ, Albarrán-Godinez A, Pérez-Villalva R, Auwerx J, de la Cruz A, Noriega LG, Rosetti F, Bobadilla NA. Sirtuin 7 Deficiency Reduces Inflammation and Tubular Damage Induced by an Episode of Acute Kidney Injury. Int J Mol Sci. 2022 Feb 25;23(5):2573. doi: 10.3390/ijms23052573. PMID: 35269715.

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Nakajima T, Kanno T, Yokoyama S, Sasamoto S, Asou HK, Tumes DJ, Ohara O, Nakayama T, Endo Y. ACC1-expressing pathogenic T helper 2 cell populations facilitate lung and skin inflammation in mice. J Exp Med. 2021 Dec 6;218(12):e20210639. doi: 10.1084/jem.20210639. Epub 2021 Nov 23. PMID: 34813654; PMCID: PMC8614157.

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Fu Z, Dean JW, Xiong L, et al. Mitochondrial transcription factor A in RORγt+ lymphocytes regulate small intestine homeostasis and metabolism. Nat Commun. 2021 Jul 22;12(1):4462. doi: 10.1038/s41467-021-24755-9. PMID: 34294718.

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Bescucci DM, Clarke ST, Brown CLJ, et al. The absence of murine cathelicidin-related antimicrobial peptide impacts host responses enhancing Salmonella enterica serovar Typhimurium infection. Gut Pathog. 2020 Nov 13;12(1):53. doi: 10.1186/s13099-020-00386-1. PMID: 33292444; PMCID: PMC7666523.

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Karki R, Sharma BR, Lee E, et al. Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer. JCI Insight. 2020;5(12):136720. Published 2020 Jun 18. doi:10.1172/jci.insight.136720.

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Raynor JL, Liu C, Dhungana Y, Guy C, Chapman NM, Shi H, Neale G, Sesaki H, Chi H. Hippo/Mst signaling coordinates cellular quiescence with terminal maturation in iNKT cell development and fate decisions. J Exp Med. 2020 Jun 1;217(6). pii: e20191157. doi: 10.1084/jem.20191157.

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Dolina JS, Lee J, Griswold RQ, Labarta-Bajo L, Kannan S, Greenbaum JA, Bahia El Idrissi N, Pont MJ, Croft M, Schoenberger SP. TLR9 Sensing of Self-DNA Controls Cell-Mediated Immunity to Listeria Infection via Rapid Conversion of Conventional CD4+ T Cells to Treg. Cell Rep. 2020 Apr 7;31(1):107249. doi: 10.1016/j.celrep.2020.01.040.

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Levine AG, Arvey A, Jin W and Rudensky AY. 2014. Continuous requirement for the TCR in regulatory T cell function. Nature Immunol. 15(11): 1070-1078.

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Kondo M, Tanaka Y, Kuwabara T, Naito T, Kohwi-Shigematsu T and Watanabe A. 2015. SATB1 Plays a Critical Role in Establishment of Immune Tolerance. J Immunol. doi: 10.4049 ​jimmunol.1501429.

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Finkin S, Yuan D, Stein I, Taniguchi K, Weber A, Unger K, Browning JL, Goossens N, Nakagawa S, Gunasekara G, Schwartz ME et al. 2015. Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma. Nat Immunol. doi: 10.1038/ni.3290.

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Avery L, Filderman J, Szymczak-Workman AL, Kane LP4. Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2455-2460. doi: 10.1073/pnas.1712107115

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Kovats. A Major Population of Functional KLRG1- ILC2s in Female Lungs Contributes to a Sex Bias in ILC2 Numbers. Immunohorizons. 2018 Feb;2(2):74-86. doi: 10.4049/immunohorizons.1800008

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Qiumei Du, Ashley R. Hoover, Igor Dozmorov, Ondine B. Cleaver,Joshua T. Mendell, Nicolai S.C. van Oers. MIR205HG Is a Long Noncoding RNA that Regulates Growth Hormone and Prolactin Production in the Anterior Pituitary. Dev Cell. 2019 May 20;49(4):618-631.e5. doi: 10.1016/j.devcel.2019.03.012

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Jordy Saravia, Hu Zeng1, Yogesh Dhungana, Daniel Bastardo Blanco, Thanh-Long M. Nguyen, Nicole M. Chapman, Yanyan Wang, Apurva Kanneganti, Shaofeng Liu, Jana L. Raynor, Peter Vogel, Geoffrey Neale, Peter Carmeliet, Hongbo Chi. Homeostasis and transitional activation of regulatory T cells require c-Myc. Sci Adv. 2020 Jan 1;6(1):eaaw6443. doi: 10.1126/sciadv.aaw6443

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Hao Shi, Nicole M. Chapman, Jing Wen, Cliff Guy, Lingyun Long, Yogesh Dhungana, Sherri Rankin, Stephane Pelletier, Peter Vogel, Hong Wang, Junmin Peng, Kun-Liang Guan, and Hongbo Chi. Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb. Immunity. 2019 Dec 17;51(6):1012-1027.e7. doi: 10.1016/j.immuni.2019.10.001

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Grinberg-Bleyer Y, Oh H, Desrichard A, Bhatt DM, Caron R, Chan TA, Schmid RM, Klein U, Hayden MS and Ghosh S. 2017. NF-κB c-Rel Is Crucial for the Regulatory T Cell Immune Checkpoint in Cancer. Cell. doi: 10.1016/j.cell.2017.08.004.

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TER-119 (TER-119)

 

Brian BF 4th, Sauer ML, Greene JT, Senevirathne SE, Lindstedt AJ, Funk OL, Ruis BL, Ramirez LA, Auger JL, Swanson WL, Nunez MG, Moriarity BS, Lowell CA, Binstadt BA, Freedman TS. A dominant function of LynB kinase in preventing autoimmunity. Sci Adv. 2022 Apr 22;8(16):eabj5227. doi: 10.1126/sciadv.abj5227. Epub 2022 Apr 22. PMID: 35452291.

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Solmonson A, Faubert B, Gu W, Rao A, Cowdin MA, Menendez-Montes I, Kelekar S, Rogers TJ, Pan C, Guevara G, Tarangelo A, Zacharias LG, Martin-Sandoval MS, Do D, Pachnis P, Dumesnil D, Mathews TP, Tasdogan A, Pham A, Cai L, Zhao Z, Ni M, Cleaver O, Sadek HA, Morrison SJ, DeBerardinis RJ. Compartmentalized metabolism supports midgestation mammalian development. Nature. 2022 Apr;604(7905):349-353. doi: 10.1038/s41586-022-04557-9. Epub 2022 Apr 6. PMID: 35388219.

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Baba T, Yoshida T, Tanabe Y, et al. Cytoplasmic DNA accumulation preferentially triggers cell death of myeloid leukemia cells by interacting with intracellular DNA sensing pathway. Cell Death Dis. 2021 Mar 26;12(4):322. doi: 10.1038/s41419-021-03587-x. PMID: 33771977.  

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Hiroshi Kobayashi and Keiyo Takubo. Protocol for the Maintenance of Quiescent Murine Hematopoietic Stem Cells. STAR Protocols.  Published 2 August 2020. https://doi.org/10.1016/j.xpro.2020.100078. 

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Egusquiza RJ, Ambrosio ME, Wang SG, Kay KM, Zhang C, Lehmler HJ, Blumberg B. Evaluating the Role of the Steroid and Xenobiotic Receptor (SXR/PXR) in PCB-153 Metabolism and Protection against Associated Adverse Effects during Perinatal and Chronic Exposure in Mice. Environ Health Perspect. 2020 Apr;128(4):47011. doi: 10.1289/EHP6262. Epub 2020 Apr 30.

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Kiatpakdee B, Sato K, Otsuka Y, Arashiki N, Chen Y, Tsumita T, Otsu W, Yamamoto A, Kawata R, Yamazaki J, Sugimoto Y, Takada K, Mohandas N, Inaba M. Cholesterol-binding protein TSPO2 coordinates maturation and proliferation of terminally differentiating erythroblasts. J Biol Chem. 2020 May 1. pii: jbc.RA119.011679. doi: 10.1074/jbc.RA119.011679

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Kobayashi H, Morikawa T, Okinaga A, et al. Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo. Cell Rep. 2019;28(1):145-158.e9. doi:10.1016/j.celrep.2019.06.008.

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Kudo F, Ikutani M, Seki Y, Otsubo T, Kawamura YI, Dohi T, Oshima K, Hattori M, Nakae S, Takatsu K and Takaki S. 2015. Interferon-γ Constrains Cytokine Production of Group 2 Innate Lymphoid Cells. Immunology. doi: 10.1111/imm.12537.

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Kovats. A Major Population of Functional KLRG1- ILC2s in Female Lungs Contributes to a Sex Bias in ILC2 Numbers. Immunohorizons. 2018 Feb;2(2):74-86. doi: 10.4049/immunohorizons.1800008

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Shiyang Li, John W. Bostick, Jian Ye, Joseph F. Urban, Jr., Dorina Avram, Liang Zhou. Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function. Immunity. 2018 Nov 20;49(5):915-928.e5. doi: 10.1016/j.immuni.2018.09.015

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Qiumei Du, Ashley R. Hoover, Igor Dozmorov, Ondine B. Cleaver,Joshua T. Mendell, Nicolai S.C. van Oers. MIR205HG Is a Long Noncoding RNA that Regulates Growth Hormone and Prolactin Production in the Anterior Pituitary. Dev Cell. 2019 May 20;49(4):618-631.e5. doi: 10.1016/j.devcel.2019.03.012

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Oguro H, McDonald JG, Zhao Z, Umetani M, Shaul PW and Morrison SJ. 2017. 27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy. J Clin Invest. doi: 10.1172/JCI94027.

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KLRG1 (2F1)

 

Sheppard S, Santosa EK, Lau CM, Violante S, Giovanelli P, Kim H, Cross JR, Li MO, Sun JC. Lactate dehydrogenase A-dependent aerobic glycolysis promotes natural killer cell anti-viral and anti-tumor function. Cell Rep. 2021 Jun 1;35(9):109210. doi: 10.1016/j.celrep.2021.109210. PMID: 34077737.

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Wiedemann GM, Grassmann S, Lau CM, Rapp M, Villarino AV, Friedrich C, Gasteiger G, O'Shea JJ, Sun JC. Divergent Role for STAT5 in the Adaptive Responses of Natural Killer Cells. Cell Rep. 2020 Dec 15;33(11):108498. doi: 10.1016/j.celrep.2020.108498. PMID: 33326784. 

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Diaz-Salazar C, Sun JC. Coordinated Viral Control by Cytotoxic Lymphocytes Ensures Optimal Adaptive NK Cell Responses. Cell Rep. 2020 Sep 22;32(12):108186. doi: 10.1016/j.celrep.2020.108186. PMID: 32966792. 

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Blagih J, Zani F, Chakravarty P, et al. Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses. Cell Rep. 2020;30(2):481-496.e6. doi:10.1016/j.celrep.2019.12.028.

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Jordy Saravia, Hu Zeng1, Yogesh Dhungana, Daniel Bastardo Blanco, Thanh-Long M. Nguyen, Nicole M. Chapman, Yanyan Wang, Apurva Kanneganti, Shaofeng Liu, Jana L. Raynor, Peter Vogel, Geoffrey Neale, Peter Carmeliet, Hongbo Chi. Homeostasis and transitional activation of regulatory T cells require c-Myc. Sci Adv. 2020 Jan 1;6(1):eaaw6443. doi: 10.1126/sciadv.aaw6443

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Uzodinma U. Uche, Ann R. Piccirillo, Shunsuke Kataoka, Stephanie J. Grebinoski, Louise M. D’Cruz, and Lawrence P. Kane. PIK3IP1/TrIP restricts activation of T cells through inhibition of PI3K/Akt. J Exp Med. 2018 Dec 3;215(12):3165-3179. doi: 10.1084/jem.20172018

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Kristina S. Burrack, Matthew A. Huggins, Emily Taras, Aaron J. Johnson, Stephen C. Jameson, Sara E. Hamilton. Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells. Immunity. 2018 Apr 17;48(4):760-772.e4. doi: 10.1016/j.immuni.2018.03.012

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Watson AM, Matthew Lam LK, Klimstra WB and Ryman KD. 2016. The 17D-204 Vaccine Strain-Induced Protection Against Virulent Yellow Fever Virus is Mediated by Humoral Immunity and CD4+ But Not CD8+ T Cells. PLoS Pathog. doi:10.1371/journal.ppat.1005786

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Grinberg-Bleyer Y, Oh H, Desrichard A, Bhatt DM, Caron R, Chan TA, Schmid RM, Klein U, Hayden MS and Ghosh S. 2017. NF-κB c-Rel Is Crucial for the Regulatory T Cell Immune Checkpoint in Cancer. Cell. doi: 10.1016/j.cell.2017.08.004. 

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MHC Class II (I-A/I-E) (M5/114.15.2)

 

Zhang Y, Wang Y, Zheng G, Liu Y, Li J, Huang H, Xu C, Zeng Y, Zhang X, Qin J, Dai C, Hambrock HO, Hartmann U, Feng B, Mak KK, Liu Y, Lan HY, Huang Y, Zheng ZH, Xia Y. Follistatin-like 1 (FSTL1) interacts with Wnt ligands and Frizzled receptors to enhance Wnt/β-catenin signaling in obstructed kidneys in vivo. J Biol Chem. 2022 May 4:102010. doi: 10.1016/j.jbc.2022.102010. Epub ahead of print. PMID: 35525270

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Meirow Y, Jovanovic M, Zur Y, Habib J, Colombo DF, Twaik N, Ashkenazi-Preiser H, Ben-Meir K, Mikula I Jr, Reuven O, Kariv G, Daniel L, Baraghithy S, Klein Y, Krijgsveld J, Levaot N, Baniyash M. Specific inflammatory osteoclast precursors induced during chronic inflammation give rise to highly active osteoclasts associated with inflammatory bone loss. Bone Res. 2022 Apr 8;10(1):36. doi: 10.1038/s41413-022-00206-z. PMID: 35396510.

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Vachon L, Smaani A, Tessier N, Jean G, Demers A, Milasan A, Ardo N, Jarry S, Villeneuve L, Alikashani A, Finherty V, Ruiz M, Sorci-Thomas MG, Mayer G, Martel C. Downregulation of low-density lipoprotein receptor mRNA in lymphatic endothelial cells impairs lymphatic function through changes in intracellular lipids. Theranostics. 2022 Jan 1;12(3):1440-1458. doi: 10.7150/thno.58780. PMID: 35154499; PMCID: PMC8771568.

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Ortega-Molina A, Lebrero-Fernández C, Sanz A, et al. Inhibition of Rag GTPase signaling in mice suppresses B cell responses and lymphomagenesis with minimal detrimental trade-offs. Cell Rep. 2021 Jul 13;36(2):109372. doi: 10.1016/j.celrep.2021.109372. PMID: 34260908. 

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Burbach BJ, O'Flanagan SD, Shao Q, et al. Irreversible electroporation augments checkpoint immunotherapy in prostate cancer and promotes tumor antigen-specific tissue-resident memory CD8+ T cells. Nat Commun. 2021 Jun 23;12(1):3862. doi: 10.1038/s41467-021-24132-6. PMID: 34162858.

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Clark NM, Martinez LM, Murdock S, deLigio JT, Olex AL, Effi C, Dozmorov MG, Bos PD. Regulatory T Cells Support Breast Cancer Progression by Opposing IFN-γ-Dependent Functional Reprogramming of Myeloid Cells. Cell Rep. 2020 Dec 8;33(10):108482. doi: 10.1016/j.celrep.2020.108482. PMID: 33296659.

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Noviski M, Mueller JL, Satterthwaite A, Garrett-Sinha LA, Brombacher F, Zikherman J. IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate. Elife. 2018;7:e35074. Published 2018 Mar 9. doi:10.7554/eLife.35074.

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Milasan A, Jean G, Dallaire F, Tardif JC, Merhi Y, Sorci-Thomas M and Martel C. 2017. Apolipoprotein A-I Modulates Atherosclerosis Through Lymphatic Vessel-Dependent Mechanisms in Mice. J Am Heart Assoc. doi: 10.1161/JAHA.117.006892.

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Visvabharathy L and Freitag NE. 2017. Propofol sedation exacerbates kidney pathology and dissemination of bacteria during Staphylococcus aureus bloodstream infections.Infect Immun. doi: 10.1128/IAI.00097-17

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Watkins HC, Rappazzo G, Higgins JS, Sun X, Brock N, Chau A, Misra A, Cannizzo JPB, King MR, Maines TR, Leifer CA, Whittaker GR, DeLisa MP and Putnam D. 2017. Safe recombinant outer membrane vesicles that display M2e elicit heterologous influenza protection. Mol. Ther. DOI: 10.1016/j.ymthe.2017.01.010

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Tiner BL, Sha J, Cong Y, Kirtley ML, Andersson JA and Chopra AK. 2016. Immunisation of two rodent species with new live-attenuated mutants of Yersinia pestis CO92 induces protective long-term humoral- and cell-mediated immunity against pneumonic plague. npj Vaccines. doi:10.1038/npjvaccines.2016.20

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Griffiths KL, Ahmed M, Das S, Gopal R, Horne W, Connell TD, Moynihan KD, Kolls JK, Irvine DJ, Artyomov MN, Rangel-Moreno J and Khader SA. 2016. Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy. Nat. Commun. doi:10.1038/ncomms13894

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Hyunjoon Kima, Drishti Sehgal, Tamara A. Kucaba, David M. Ferguson, Thomas S. Griffith, Jayanth Panyam. Acidic pH-responsive polymer nanoparticles as TLR7/8 agonist delivery platform for cancer immunotherapy. anoscale. 2018 Nov 15;10(44):20851-20862. doi: 10.1039/c8nr07201a

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FoxP3 (3G3)

 

Brian BF 4th, Sauer ML, Greene JT, Senevirathne SE, Lindstedt AJ, Funk OL, Ruis BL, Ramirez LA, Auger JL, Swanson WL, Nunez MG, Moriarity BS, Lowell CA, Binstadt BA, Freedman TS. A dominant function of LynB kinase in preventing autoimmunity. Sci Adv. 2022 Apr 22;8(16):eabj5227. doi: 10.1126/sciadv.abj5227. Epub 2022 Apr 22. PMID: 35452291.

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Núñez-Ruiz A, Sánchez-Brena F, López-Pacheco C, Acevedo-Domínguez NA, Soldevila G. Obesity modulates the immune macroenvironment associated with breast cancer development. PLoS One. 2022 Apr 26;17(4):e0266827. doi: 10.1371/journal.pone.0266827. PMID: 35472214; PMCID: PMC9041840.

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Arciniega-Martínez IM, Reséndiz Albor AA, Cárdenas Jaramillo LM, Gutiérrez-Meza JM, Falfán-Valencia R, Arroyo BM, Yépez-Ortega M, Pacheco-Yépez J, Abarca-Rojano E. CD4+/IL‑4+ lymphocytes of the lamina propria and substance P promote colonic protection during acute stress. Mol Med Rep. 2022 Feb;25(2):63. doi: 10.3892/mmr.2021.12579. Epub 2021 Dec 27. PMID: 34958108.

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Wilfahrt D, Philips RL, Lama J, Kizerwetter M, Shapiro MJ, McCue SA, Kennedy MM, Rajcula MJ, Zeng H, Shapiro VS. Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation. Elife. 2021 Dec 2;10:e70978. doi: 10.7554/eLife.70978. PMID: 34854376; PMCID: PMC8639145. 

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Blagih J, Zani F, Chakravarty P, et al. Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses. Cell Rep. 2020;30(2):481-496.e6. doi:10.1016/j.celrep.2019.12.028.

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Adami AJ, Bracken SJ, Guernsey LA, et al. Early-life antibiotics attenuate regulatory T cell generation and increase the severity of murine house dust mite-induced asthma. Pediatr Res. 2018;84(3):426-434. doi:10.1038/s41390-018-0031-y.

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Biagioli M, Carino A, Cipriani S, Francisci D, Marchianò S, Scarpelli P, Sorcini D, Zampella A and Fiorucci S. 2017. The Bile Acid Receptor GPBAR1 Regulates the M1/M2 Phenotype of Intestinal Macrophages and Activation of GPBAR1 Rescues Mice from Murine Colitis. J Immunol. doi: 10.4049/jimmunol.1700183.

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Okamura K, Kitamura A, Sasaki Y, Chung DH, Kagami S, Iwai K and Yasutomo K. 2016. Survival of mature T cells depends on signaling through HOIP. Sci Rep. doi:10.1038/srep36135

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 IL-12/IL-23 p40 (C17.8) 

 

Kotov JA, Kotov DI, Linehan JL, Bardwell VJ, Gearhart MD, Jenkins MK. BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors. J Exp Med. 2019;216(6):1450-1464. doi:10.1084/jem.20182376.

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Dolina JS, Lee J, Griswold RQ, Labarta-Bajo L, Kannan S, Greenbaum JA, Bahia El Idrissi N, Pont MJ, Croft M, Schoenberger SP. TLR9 Sensing of Self-DNA Controls Cell-Mediated Immunity to Listeria Infection via Rapid Conversion of Conventional CD4+ T Cells to Treg. Cell Rep. 2020 Apr 7;31(1):107249. doi: 10.1016/j.celrep.2020.01.040.

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Clones not Specified

Dishon S, Cohen SJ, Cohen IR and Nussbaum G. 2017. Inhibition of Myeloid Differentiation Factor 88 Reduces Human and Mouse T-Cell Interleukin-17 and IFNγ Production and Ameliorates Experimental Autoimmune Encephalomyelitis Induced in Mice. Front Immunol. doi: 10.3389/fimmu.2017.00615

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O'Donnell H, Pham OH, Li L, Atif SM, Lee SJ, Ravesloot MM, Stolfi JL, Nuccio SP, Broz P, Monack DM, Baumler AJ and McSorley SJ. 2014 Toll-like Receptor and Inflammasome Signals Converge to Amplify the Innate Bactericidal Capacity of T Helper 1 Cells. Immunity. 40(2): 213-224.

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Nanton MR, Lee SJ, Atif SM, Nuccio SP, Taylor JJ, Baumler AJ, Way SS and McSorley SJ. 2014. Direct visualization of endogenous Salmonella-specific B cells reveals a marked delay in clonal expansion and germinal center development. Eur J Immunol. 45(2): 428-441.

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Burger ML, Leung KK, Bennett, MJ and Winoto A. 2014. T cell-specific inhibition of multiple apoptotic pathways blocks negative selection and causes autoimmunity. eLife 2014;10.7554/eLife.03468.

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Hsu FC, Shapiro MJ, Chen MW, McWilliams DC, Seaburg LM, Tangen SN and Shapiro VS. 2014. Immature Recent Thymic Emigrants Are Eliminated by Complement. J Immunol. 193(12): 6005-6015.

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Nabekura T and Lanier LL. 2014. Antigen-specific expansion and differentiation of natural killer cells by alloantigen stimulation. J Exp Med. 211(12): 2455-2465.

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Cozza EM, Cooper TK, Budgeon LR, Christensen ND and Schell TD. 2014. Protection from tumor recurrence following adoptive immunotherapy varies with host conditioning regimen despite initial regression of autochthonous murine brain tumors. Cancer Immunol Immunother. 64(3): 324-336.

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Liu Z, Zhou H, Wang W, Tan W, Fu YX and Zhu M. 2014. A novel method for synthetic vaccine construction based on protein assembly. Sci Rep. 4: 7266.

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Han D, Walsh MC, Kim KS, Hong SW, Lee J, Yi J, Rivas G, Surh CD and Choi Y. 2015. Microbiota-Independent Ameliorative Effects of Antibiotics on Spontaneous Th2-Associated Pathology of the Small Intestine. PLoS ONE 10(2): e0118795.

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Hemmers S and Rudensky AY. 2015. The Cell-Intrinsic Circadian Clock Is Dispensable for Lymphocyte Differentiation and Function. Cell Rep. 11(9): 1339-1349.

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Doe HT, Kumura D, Miyakoda M, Kimura K, Akbari M and Yui K. 2015. Expression of PD-1/LAG-3 and cytokine production by CD4+ T cells during infection with Plasmodium parasites. Microbiol Immunol. DOI: 10.1111/1348-0421.12354.

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Takahashi K, Nagai N, Ogura K, Tsuneyama K, Saiki I, Irimura T and Hayakawa Y. 2015. Mammary tissue microenvironment determines T cell-dependent breast cancer-associated inflammation. Cancer Sci. 106(7): 867-874.

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Gordon EB, Hart GT, Tran TM, Waisberg M, Akkaya M, Kim AS, Hamilton SE, Pena M, Yazew T, Qi CF, Lee CF, Lo YC, Miller LH, Powell JD and Pierce SK. 2015. Targeting glutamine metabolism rescues mice from late-stage cerebral malaria. Proc Natl Acad Sci USA. 112(42): 13075-13080.

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Cheekatla SS, Tripathi D, Venkatasubramanian S, Nathella PK, Paidipally P, Ishibashi M, Welch E, Tvinnereim AR, Ikebe M, Valluri VL, Babu S, Kornfeld H and Vankayalapati R. 2016. NK-CD11c+ Cell Crosstalk in Diabetes Enhances IL-6-Mediated Inflammation during Mycobacterium tuberculosis Infection. PloS one. doi.org/10.1371/journal.ppat.1005972

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Caruso G, Distefano DA, Parlascino P, Fresta CG, Lazzarino G, Lunte SM and Nicoletti VG. 20136. Receptor-mediated toxicity of human amylin fragment aggregated by short- and long-term incubations with copper ions. Mol. Cell. Biochem. doi:10.1007/s11010-016-2864-1

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CD134 (OX40) (OX-136)

 

Lee W, Kingstad-Bakke B, Kedl RM, Kawaoka Y, Suresh M. CCR2 Regulates Vaccine-Induced Mucosal T-Cell Memory to Influenza A Virus. bioRxiv. 2021 Mar 25:2021.03.24.436901. doi: 10.1101/2021.03.24.436901. PMID: 33791695; PMCID: PMC8010722.

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