CD3 (OKT3)
Poudel B, Yorek MS, Mazgaeen L, Brown SA, Kanneganti TD, Gurung P. Acute IL-4 Governs Pathogenic T Cell Responses during Leishmania major Infection. Immunohorizons. 2020 Sep 18;4(9):546-560. doi: 10.4049/immunohorizons.2000076. PMID: 32948646.
Kamakura D, Asano R, Kawai H, Yasunaga M. Mechanism of action of a T cell-dependent bispecific antibody as a breakthrough immunotherapy against refractory colorectal cancer with an oncogenic mutation. Cancer Immunol Immunother. 2020;10.1007/s00262-020-02667-9. doi:10.1007/s00262-020-02667-9.
Brincks E. L., Adams J., Wang L., Turner B., Marcinowicz A., Ke J., Essmann M., Mautino L. M., Allen C. Van, Kumar S., Vahanian N., Link C., Mautino M. R. et al Indoximod opposes the immunosuppressive effects mediated by IDO and TDO via modulation of AhR function and activation of mTORC1. Oncotarget. 2020; 11: 2438-2461.
The Tat Protein of HIV-1 Prevents the Loss of HSV-Specific Memory Adaptive Responses and Favors the Control of Viral Reactivation. Francesco Nicoli, Eleonora Gallerani, Mariaconcetta Sicurella, Salvatore Pacifico, Aurelio Cafaro, Barbara Ensoli, Peggy Marconi, Antonella Caputo, and Riccardo Gavioli. Vaccines (Basel). 2020 Jun 4;8(2):E274. doi: 10.3390/vaccines8020274.
Sánchez-Villanueva JA, Rodríguez-Jorge O, Ramírez-Pliego O, et al. Contribution of ROS and metabolic status to neonatal and adult CD8+ T cell activation. PLoS One. 2019;14(12):e0226388. Published 2019 Dec 16. doi:10.1371/journal.pone.0226388.
Morimoto S, Fujiki F, Kondo K, et al. Establishment of a novel platform cell line for efficient and precise evaluation of T cell receptor functional avidity. Oncotarget. 2018;9(75):34132-34141. Published 2018 Sep 25. doi:10.18632/oncotarget.26139.
Sun CW, Wu LC, Knopick PL, Bradley DS, Townes T and Terman DS. 2017. Sickle Cells Produce Functional Immune Modulators and Cytotoxics. Am J Hematol. doi: 10.1002/ajh.24836.
Poujol F, Monneret G, Friggeri A, Rimmele T, Malcus C, Poitevin-Later F, Pachot A, Lepape A, Textoris J and Venet F. 2014. Flow cytometric evaluation of lymphocyte transformation test based on 5-ethynyl-2'deoxyuridine incorporation as a clinical alternative to tritiated thymidine uptake measurement. J Immunol Methods. 415: 71-79.
He Q, Zhang H, Wang Y, Ting HH, Yu W, Cao X and Ge W. 2014. Purified anti-CD3 x anti-HER2 bispecific antibody potentiates cytokine-induced killer cells of poor spontaneous cytotoxicity against breast cancer cells. Cell Biosci. 4(1): 70.
Khan SQ, Guo L, Cimbaluk D, Elshabrawy H, Faridi MH, Jolly M, George JF, Agarwal A and Gupta V. 2014. A Small Molecule β2 Integrin Agonist Improves Chronic Kidney Allograft Survival by Reducing Leukocyte Recruitment and Accompanying Vasculopathy. Front Med (Lausanne). 1:45.
Bachanova V, Frankel AE, Cao Q, Lewis D, Grzywacz B, Verneris MR, Ustun C, Lazaryan A, McClune B, Warlick ED, Kantarjian H, Weisdorf DJ, Miller JS, Vallera DA. 2015. Phase I Study of a Bispecific Ligand-Directed Toxin Targeting CD22 and CD19 (DT2219) for Refractory B-cell Malignancies. Clin Cancer Res. 21(6): 1267-1272.
Miles B, Miller SM, Folkvord JM, Kimball A, Chamanian M, Meditz AL, Arends T, McCarter MD, Levy DN, Rakasz EG, Skinner PJ and Connick E. 2015. Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection. Nat Commun. doi: 10.1038/ncomms9608.
Chen KH, Wada M, Firor AE, Pinz KG, Jares A, Liu H, Salman H, Golightly M, Lan F, Jiang X and Ma Y. 2016. Novel anti-CD3 chimeric antigen receptor targeting of aggressive. DOI:10.18632/oncotarget.11019
Galindo-Albarran AO, Lopez-Portales OH, Gutierrez-Reyna DY, Rodriguez-Jorge O, Sanchez-Villanueva JA, Ramirez-Pliego O, Bergon A, Loriod B, Holota H, Imbert J, Hernandez-mendoza A, Ferrier P, Carrillo-de Santa Pau E, Valencia A, Spicuglia S and Santana MA. 2016. CD8+ T Cells from Human Neonates Are Biased toward an Innate Immune Response. Cell Rep. doi: 10.1016/j.celrep.2016.10.056
CD11c (3.9)
He T, Yang D, Li XQ, Jiang M, Islam MS, Chen S, Chen Y, Yang Y, Chou CK, Trivett AL, Oppenheim JJ, Chen X. Inhibition of two-pore channels in antigen-presenting cells promotes the expansion of TNFR2-expressing CD4+Foxp3+ regulatory T cells. Sci Adv. 2020 Sep 30;6(40):eaba6584. doi: 10.1126/sciadv.aba6584. PMID: 32998896.
Johnson LE, Olson BM and McNeel DG. 2017. Pretreatment antigen-specific immunity and regulation - association with subsequent immune response to anti-tumor DNA vaccination. J Immunother Cancer. doi: 10.1186/s40425-017-0260-3.
Visvabharathy L and Freitag NE. 2017. Propofol sedation exacerbates kidney pathology and dissemination of bacteria during Staphylococcus aureus bloodstream infections.Infect Immun. doi: 10.1128/IAI.00097-17
CD3ɛ (Hit3a)
Yamamura K, Uruno T, Shiraishi A, Tanaka Y, Ushijima M, Nakahara T, Watanabe M, Kido-Nakahara M, Tsuge I, Furue M and Fukui Y. 2017. The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction. Nat. Commun. doi:10.1038/ncomms13946
CD3 (SK7)
Chaganty BKR, Lu Y, Qiu S, Somanchi SS, Lee DA and Fan Z. 2015. Trastuzumab upregulates expression of HLA-ABC and T cell costimulatory molecules through engagement of natural killer cells and stimulation of IFN-γ secretion. OncoImmunology. DOI: 10.1080/2162402X.2015.1100790
CD3 (UCHT1)
Konduri V, Joseph SK, Byrd TT, et al. A subset of cytotoxic effector memory T cells enhances CAR T cell efficacy in a model of pancreatic ductal adenocarcinoma. Sci Transl Med. 2021 May 5;13(592):eabc3196. doi: 10.1126/scitranslmed.abc3196. PMID: 33952672.
Roth TL, Li PJ, Blaeschke F, Nies JF, Apathy R, Mowery C, Yu R, Nguyen MLT, Lee Y, Truong A, Hiatt J, Wu D, Nguyen DN, Goodman D, Bluestone JA, Ye CJ, Roybal K, Shifrut E, Marson A. Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies. Cell. 2020 Apr 15. pii: S0092-8674(20)30332-9. doi: 10.1016/j.cell.2020.03.039.
Molly OhainleI, Kyusik Kim, Sevnur Komurlu Keceli, Abby Felton, Ed Campbell, Jeremy LubanI, Michael. Emerman. TRIM34 restricts HIV-1 and SIV capsids in a TRIM5α-dependent manner. PLoS Pathog. 2020 Apr 13;16(4):e1008507. doi: 10.1371/journal.ppat.1008507.
Hultquist JF, Hiatt J, Schumann K, et al. CRISPR-Cas9 genome engineering of primary CD4+ T cells for the interrogation of HIV-host factor interactions. Nat Protoc. 2019;14(1):1-27. doi:10.1038/s41596-018-0069-7.
Rupp LJ, Schumann K, Roybal KT, Gate RE, Ye CJ, Lim WA and Marson A. 2017. CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells. Sci Rep. doi: 10.1038/s41598-017-00462-8
Miles B, Miller SM, Folkvord JM, Kimball A, Chamanian M, Meditz AL, Arends T, McCarter MD, Levy DN, Rakasz EG, Skinner PJ and Connick E. 2015. Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection. Nat Commun. doi: 10.1038/ncomms9608.
Chi S, Weiss A and Wang H. 2015. A CRISPR-based Toolbox For Studying T Cell Signal Transduction. BioMed Res Int. DOI:10.1155/2016/5052369
Locci M, Wu JE, Arumemi F, Mikulski Z, Dahlberg C, Miller AT and Crotty S. 2016. Activin A Programs the Differentiation of Human TFH Cells. Nature Immunology. doi:10.1038/ni.3494
Hultquist JF, Schumann K, Woo JM, Manganaro L, McGregor MJ, Doudna J, Simon V, Krogan NJ and Marson A. 2016. A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells. Cell Rep. doi: 10.1016/j.celrep.2016.09.080.
Chen D, Ireland SJ, Remington G, Alvarez E, Racke MK, Greenberg B, Frohman EM and Monson NL. 2016. CD40 Mediated NF-kB Activation in B Cells Is Increased in Multiple Sclerosis and Modulated by Therapeutics. J. Immunol. doi:10.4049/jimmunol.1600782
CD4 (RPA-T4)
Poudel B, Yorek MS, Mazgaeen L, Brown SA, Kanneganti TD, Gurung P. Acute IL-4 Governs Pathogenic T Cell Responses during Leishmania major Infection. Immunohorizons. 2020 Sep 18;4(9):546-560. doi: 10.4049/immunohorizons.2000076. PMID: 32948646.
Zhang AH, Yoon J, Kim YC, Scott DW. Targeting Antigen-Specific B Cells Using Antigen-Expressing Transduced Regulatory T Cells. J Immunol. 2018;201(5):1434-1441. doi:10.4049/jimmunol.1701800.
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Ryotokuji K, Nakajima T, Ishimaru K, Ozaki-Shimada A, Kihara K, Namiki Y and Otani S. 2015. Effect of Stress-Free Therapy on immune system: Induction of Interleukin 10 expression in lymphocytes through activation of CD19(+) CD24(hi) CD38(hi) regulatory B Cells. Laser Therapy. 24(3): 179-188.
Dillon, SM, Lee EJ, Donovan AM, Guo K, Harper MS, Frank DN, McCarter MD, Santiago ML, and Wilson CC. 2016. Enhancement of HIV-1 infection and intestinal CD4+ T cell depletion ex vivo by gut microbes altered during chronic HIV-1 infection. Retrovirology. DOI 10.1186/s12977-016-0237-1
Arnold N, Girke T, Sureshchandra S and Messaoudi I. 2016. Acute simian varicella infection causes robust and sustained changes in gene expression in the sensory ganglia. J. Virol. doi: 10.1128/JVI.01272-16
Viisanen T, Ihantola E, Nanto-Salonen K, Hyoty H, Nurminen N, Selvenius J, Juutilainen A, Moilanen L, Pihlajamaki J, Veijola R, Toppari J, Knip M, Ilonen J and Kinnunen T. 2016. Circulating CXCR5+PD-1+ICOS+ Follicular T Helper Cells Are Increased Close to the Diagnosis of Type 1 Diabetes in Children with Multiple Autoantibodies. Diabetes. DOI: 10.2337/db16-0714
Chen D, Ireland SJ, Remington G, Alvarez E, Racke MK, Greenberg B, Frohman EM and Monson NL. 2016. CD40 Mediated NF-kB Activation in B Cells Is Increased in Multiple Sclerosis and Modulated by Therapeutics. J. Immunol. doi:10.4049/jimmunol.1600782
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Rudloff I, Cho SX, Lao JC, Ngo D, McKenzie M, Nold-Petry CA and Nold MF. 2016. Monocytes and dendritic cells are the primary sources of interleukin 37 in human immune cells. J. Leukoc. Biol. doi:10.1189/jlb.3MA0616-287R
CD4 (OKT4)
Diana R. Dou, Yang Zhao, Brian Abe, Rui Li, Lisa C. Zaba, Kathleen Aren, Mary Carns, Lorinda S. Chung, Monique Hinchcliff, Howard Y. Chang. Distinct T cell chromatin landscapes in scleroderma subtype. bioRxiv 2021.01.10.426131; doi: https://doi.org/10.1101/2021.01.10.426131.
Woolsey C, Jankeel A, Matassov D, et al. Immune correlates of postexposure vaccine protection against Marburg virus. Sci Rep. 2020;10(1):3071. Published 2020 Feb 20. doi:10.1038/s41598-020-59976-3.
Scharer CD, Bally AP, Gandham B and Boss JM. 2017. Cutting Edge: Chromatin Accessibility Programs CD8 T Cell Memory. J Immunol. doi: 10.4049/jimmunol.1602086
Visvabharathy L and Freitag NE. 2017. Propofol sedation exacerbates kidney pathology and dissemination of bacteria during Staphylococcus aureus bloodstream infections.Infect Immun. doi: 10.1128/IAI.00097-17
Versteeg K, Menicucci AR, Woolsey C, Mire CE, Geisbert JB, Cross RW, Agans KN, Jeske D, Messaoudi I and Geisbert TW. 2017. Infection with the Makona variant results in a delayed and distinct host immune response compared to previous Ebola virus variants. Sci Rep. doi: 10.1038/s41598-017-09963-y.
CD19 (SJ25C1)
Dhariwala MO, Karthikeyan D, Vasquez KS, et al. Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature. Cell Rep Med. 2020 Nov 3;1(8):100132. doi: 10.1016/j.xcrm.2020.100132. PMID: 33294857; PMCID: PMC7691438.
Sato Y, Kato H, Ebina-Shibuya R, Itoh-Nakadai A, Okuyama R and Igarashi K. 2017. Bach2 Controls Homeostasis of Eosinophils by Restricting the Type-2 Helper Function of T Cells. Tohoku J Exp Med. doi: 10.1620/tjem.241.175
Dhariwala MO, Karthikeyan D, Vasquez KS, et al. Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature. Cell Rep Med. 2020 Nov 3;1(8):100132. doi: 10.1016/j.xcrm.2020.100132. PMID: 33294857; PMCID: PMC7691438.
IL-4 (MP4-25D2)
Poudel B, Yorek MS, Mazgaeen L, Brown SA, Kanneganti TD, Gurung P. Acute IL-4 Governs Pathogenic T Cell Responses during Leishmania major Infection. Immunohorizons. 2020 Sep 18;4(9):546-560. doi: 10.4049/immunohorizons.2000076. PMID: 32948646.
Visvabharathy L and Freitag NE. 2017. Propofol sedation exacerbates kidney pathology and dissemination of bacteria during Staphylococcus aureus bloodstream infections.Infect Immun. doi: 10.1128/IAI.00097-17
CD14 (61D3)
Pomicter AD, Clair PM, Yan D, Heaton WL, Eiring AM, Anderson MB, Richards SM, Gililland J, O'Hare T, Deininger MW. Femoral Heads from Total Hip Arthroplasty as a Source of Adult Hematopoietic Cells. Acta Haematol. 2021 Jan 7:1-7. doi: 10.1159/000511953. Epub ahead of print. PMID: 33412552; PMCID: PMC8260615.
Martín-Nalda A, Fortuny C, Rey L, et al. Severe Autoinflammatory Manifestations and Antibody Deficiency Due to Novel Hypermorphic PLCG2 Mutations. J Clin Immunol. 2020;10.1007/s10875-020-00794-7. doi:10.1007/s10875-020-00794-7.
Roa, J.A., Sarkar, D., Zanaty, M. et al. Preliminary results in the analysis of the immune response after aneurysmal subarachnoid hemorrhage. Sci Rep 10, 11809 (2020). https://doi.org/10.1038/s41598-020-68861-y.
Malhotra S, Costa C, Eixarch H, Keller CW, Amman L, Martínez-Banaclocha H, Midaglia L, Sarró E, Machín-Díaz I, Villar LM, Triviño JC, Oliver-Martos B, Parladé LN, Calvo-Barreiro L, Matesanz F, Vandenbroeck K, Urcelay E, Martínez-Ginés ML, Tejeda-Velarde A, Fissolo N, Castilló J, Sanchez A, Robertson AAB, Clemente D, Prinz M, Pelegrin P, Lünemann JD, Espejo C, Montalban X, Comabella M. NLRP3 inflammasome as prognostic factor and therapeutic target in primary progressive multiple sclerosis patients. Brain. 2020 Apr 13. pii: awaa084. doi: 10.1093/brain/awaa084.
Burel JG, Pomaznoy M, Lindestam Arlehamn CS, et al. Circulating T cell-monocyte complexes are markers of immune perturbations. Elife. 2019;8:e46045. Published 2019 Jun 25.
Sato Y, Kato H, Ebina-Shibuya R, Itoh-Nakadai A, Okuyama R and Igarashi K. 2017. Bach2 Controls Homeostasis of Eosinophils by Restricting the Type-2 Helper Function of T Cells. Tohoku J Exp Med. doi: 10.1620/tjem.241.175
Moghaddas F, Llamas R, De Nardo D, Martinez-Banaclocha H, Martinez-Garcia JJ, Mesa-Del-Castillo P, Baker PJ, Gargallo V, Mensa-Vilaro A, Canna S, Wicks IP, Pelegrin P, Arostegui JI and Masters SL. 2017. A novel Pyrin-Associated Autoinflammation with Neutrophilic Dermatosis mutation further defines 14-3-3 binding of pyrin and distinction to Familial Mediterranean Fever. Ann Rheum Dis. 2. doi: 10.1136/annrheumdis-2017-211473.
CD8 (SK1)
Shen M, Song Y, Ichinose T, et al. In vivo immune activation of splenocytes following exposure to tar from Asian sand dust. J Toxicol Environ Health A. 2020;1-10. doi:10.1080/15287394.2020.1806160.
Muneyoshi FutamiI, Keisuke Suzuki, Satomi Kato, Saori Ohmae, Yoshio Tahara, Masanori Nojima, Yoichi Imai, Takayuki Mimura, Yoshihiro Watanabe, Arinobu Tojo. The novel multi-cytokine inhibitor TO-207 specifically inhibits pro-inflammatory cytokine secretion in monocytes without affecting the killing ability of CAR T cells. PLoS One. 2020 Apr 22;15(4):e0231896. doi: 10.1371/journal.pone.0231896.
Scharer CD, Bally AP, Gandham B and Boss JM. 2017. Cutting Edge: Chromatin Accessibility Programs CD8 T Cell Memory. J Immunol. doi: 10.4049/jimmunol.1602086
Sato Y, Kato H, Ebina-Shibuya R, Itoh-Nakadai A, Okuyama R and Igarashi K. 2017. Bach2 Controls Homeostasis of Eosinophils by Restricting the Type-2 Helper Function of T Cells. Tohoku J Exp Med. doi: 10.1620/tjem.241.175
CD56 (NCAM) (MY31)
Bennit HF, Gonda A, Oppegard L, Chi D, Khan S and Wall N. 2017. Uptake of lymphoma-derived exosomes by peripheral blood leukocytes. Blood and Lymphatic Cancer: Targets and Therapy 7:9-23.
Chen KH, Wada M, Firor AE, Pinz KG, Jares A, Liu H, Salman H, Golightly M, Lan F, Jiang X and Ma Y. 2016. Novel anti-CD3 chimeric antigen receptor targeting of aggressive. DOI:10.18632/oncotarget.11019
CD5 (UCHT2)
Chen KH, Wada M, Firor AE, Pinz KG, Jares A, Liu H, Salman H, Golightly M, Lan F, Jiang X and Ma Y. 2016. Novel anti-CD3 chimeric antigen receptor targeting of aggressive T cell malignancies. Oncotarget. DOI: 10.18632/oncotarget.11019
CD11b (M1/70)
Pingili AK, Chaib M, Sipe LM, et al. Immune checkpoint blockade reprograms systemic immune landscape and tumor microenvironment in obesity-associated breast cancer. Cell Rep. 2021 Jun 22;35(12):109285. doi: 10.1016/j.celrep.2021.109285. PMID: 34161764.
Velasco-de Andrés M, Català C, Casadó-Llombart S, Martínez-Florensa M, Simões I, García-Luna J, Mourglia-Ettlin G, Zaragoza Ó, Carreras E, Lozano F. The lymphocytic scavenger receptor CD5 shows therapeutic potential in mouse models of fungal infection. Antimicrob Agents Chemother. 2020 Oct 12:AAC.01103-20. doi: 10.1128/AAC.01103-20. PMID: 33046489.
Racine JJ, Chapman HD, Doty R, Cairns BM, Hines TJ, Tadenev ALD, Anderson LC, Green T, Dyer ME, Wotton JM, Bichler Z, White JK, Ettinger R, Burgess RW, Serreze DV. T Cells from NOD-PerIg Mice Target Both Pancreatic and Neuronal Tissue. J Immunol. 2020 Sep 16:ji2000114. doi: 10.4049/jimmunol.2000114. PMID: 32938729.
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Ito T, Kometani K, Minato N, Hamazaki Y. Bone Marrow Endothelial Cells Take Up Blood-Borne Immune Complexes via Fcγ Receptor IIb2 in an Erythropoietin-Dependent Manner. J Immunol. 2020;ji1901101. doi:10.4049/jimmunol.1901101
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Roa, J.A., Sarkar, D., Zanaty, M. et al. Preliminary results in the analysis of the immune response after aneurysmal subarachnoid hemorrhage. Sci Rep 10, 11809 (2020). https://doi.org/10.1038/s41598-020-68861-y.
Kamata T, So TY, Ahmed Q, et al. Fibroblast-Derived STC-1 Modulates Tumor-Associated Macrophages and Lung Adenocarcinoma Development. Cell Rep. 2020;31(12):107802. doi:10.1016/j.celrep.2020.107802.
Komura N, Mabuchi S, Shimura K, et al. The role of myeloid-derived suppressor cells in increasing cancer stem-like cells and promoting PD-L1 expression in epithelial ovarian cancer. 2020 Jun 19. Cancer Immunol Immunother. 2020;10.1007/s00262-020-02628-2. doi:10.1007/s00262-020-02628-2.
Julie E. Stark, Amy M. OpokaID, Lin Fei, Huaiyu Zang, Stella M. Davies, Hector R. Wong, Matthew N. Alder. Longitudinal characterization of olfactomedin-4 expressing neutrophils in pediatric patients undergoing bone marrow transplantation. PLoS One. 2020 May 29;15(5):e0233738. doi: 10.1371/journal.pone.0233738. eCollection 2020.
Markman, J.L., Porritt, R.A., Wakita, D. et al. Loss of testosterone impairs anti-tumor neutrophil function. Nat Commun 11, 1613 (2020). https://doi.org/10.1038/s41467-020-15397-4.
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Shindo R, Katagiri T, Komazawa-Sakon S, et al. Regenerating islet-derived protein (Reg)3β plays a crucial role in attenuation of ileitis and colitis in mice. Biochem Biophys Rep. 2020;21:100738. Published 2020 Feb 7. doi:10.1016/j.bbrep.2020.100738.
Udden SN, Kwak YT, Godfrey V, et al. NLRP12 suppresses hepatocellular carcinoma via downregulation of cJun N-terminal kinase activation in the hepatocyte. Elife. 2019;8:e40396. Published 2019 Apr 16. doi:10.7554/eLife.40396.
Andersen TK, Huszthy PC, Gopalakrishnan RP, et al. Enhanced germinal center reaction by targeting vaccine antigen to major histocompatibility complex class II molecules. NPJ Vaccines. 2019;4:9. Published 2019 Feb 11. doi:10.1038/s41541-019-0101-0.
Kim IS, Gao Y, Welte T, et al. Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms. Nat Cell Biol. 2019;21(9):1113-1126. doi:10.1038/s41556-019-0373-7.
Guo M, Price MJ, Patterson DG, et al. EZH2 Represses the B Cell Transcriptional Program and Regulates Antibody-Secreting Cell Metabolism and Antibody Production. J Immunol. 2018;200(3):1039-1052. doi:10.4049/jimmunol.1701470.
Bahnan W, Boucher JC, Gayle P, et al. The eIF2α Kinase Heme-Regulated Inhibitor Protects the Host from Infection by Regulating Intracellular Pathogen Trafficking. Infect Immun. 2018;86(3):e00707-17. Published 2018 Feb 20. doi:10.1128/IAI.00707-17.
Kuroda H, Mabuchi S, Kozasa K, Yokoi E, Matsumoto Y, Komura N, Kawano M, Hashimoto K, Sawada K and Kimura T. 2017. PM01183 inhibits myeloid-derived suppressor cells in vitro and in vivo. Immunotherapy. doi: 10.2217/imt-2017-0046.
Frederick DR, Goggins JA, Sabbagh LM, Freytag LC, Clements JD and McLachlan JB. 2017. Adjuvant selection regulates gut migration and phenotypic diversity of antigen-specific CD4+ T cells following parenteral immunization. Mucosal Immunol. doi: 10.1038/mi.2017.70.
Johnson LE, Olson BM and McNeel DG. 2017. Pretreatment antigen-specific immunity and regulation - association with subsequent immune response to anti-tumor DNA vaccination. J Immunother Cancer. doi: 10.1186/s40425-017-0260-3.
Shiokawa A, Kotaki R, Takano T, Nakajima-Adachi H and Hachimura S. 2017. Mesenteric lymph node CD11b- CD103+ PD-L1High dendritic cells highly induce regulatory T cells. Immunology. doi: 10.1111/imm.12747
Kishimoto Y, Asakawa S, Sato T, Takano T, Nakajyo T, Mizuno N, Segawa R, Yoshikawa T, Hiratsuka M, Yanai K, Ohtsu H and Hirasawa N. 2017. Induced histamine regulates Ni elution from an implanted Ni wire in mice by downregulating neutrophil migration. Exp Dermatol. doi: 10.1111/exd.13315.
Mgbemena VE, Signer RA, Wijayatunge R, Laxson T, Morrison SJ, Ross TS. 2017. Distinct Brca1 Mutations Differentially Reduce Hematopoietic Stem Cell Function. Cell Rep. DOI: 10.1016/j.celrep.2016.12.075
Trott DW, Henson GD, Ho MHT, Allison SA, Lesniewski LA and Donato AJ. 2016. Age-related arterial immune cell infiltration in mice is attenuated by caloric restriction or voluntary exercise. Exp. Gerontol. DOI: 10.1016/j.exger.2016.12.016
Hastings AK, Erickson JJ, Schuster JE, Boyd KL, Tollefson SJ, Johnson M, Gilchuk P, Joyce S and Williams JV. 2015. Role of type I interferon signaling in human metapneumovirus pathogenesis and control of viral replication. J Virol. 89(8): 4405-4420.
Kawano M, Mabuchi S, Matsumoto Y, Sasano T, Takahashi R, Kuroda H, Kozasa K, Hashimoto K, Isobe A, Sawada K, Hamasaki T, Morii E and Kimura T. 2015. The significance of G-CSF expression and myeloid-derived suppressor cells in the chemoresistance of uterine cervical cancer. Sci Rep. 5:18217 doi:10.1038/srep18217.
Molina-Sanchez P, Chevre R, Rius C, Fuster JJ and Andres V. 2015. Loss of p27 phosphorylation at Ser10 accelerates early atherogenesis by promoting leukocyte recruitment via RhoA/ROCK. J Mol Cell Cardiol. 84: 84-94.
O'Sullivan TE, Johnson LR, Kang HH, Sun JC. 2015. BNIP3- and BNIP3L-Mediated Mitophagy Promotes the Generation of Natural Killer Cell Memory. Immunity. 43: 331-342.
Manz BN, Tan YX, Courtney A, Rutaganira F, Palmer E, Shokat KM and Weiss A. 2015. Small molecule inhibition of Csk alters affinity recognition by T cells. Elife. doi: 10.7554/eLife.08088.
Come C, Cvrljevic A, Khan MM, Treise I, Adler T, Aguilar-Pimental JA, Au-Yeung B, Sittig E, Laajala TD, Chen Y, Oeder S, Calzada-Wack J, Horsch M, Aittokallio T, Busch DH, Ollert MW, Neff F, Beckers J, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Chen Z, Lahesmaa R, and Westermarck J. 2016. CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection. PLoS ONE 11(4):e0152996. doi:10.1371/journal.pone.0152996
Spanier JA, Frederick DR, Taylor JJ, Heffernan JR, Kotov DI, Martinox T, Osum KC, Ruggiero JL, Rust BJ, Landry SJ, Jenkins MK, McLachlan JB, and Fife BT. 2016. Efficient Generation of Monoclonal Antibodies Against Peptide in the Context of MHCII Using Magnetic Enrichment. Nature Communications. doi:10.1038/ncomms11804
Sato T, Kishimoto Y, Asakawa S, Mizuno N, Hiratsuka M and Hirasawa N. 2016. Involvement of COX-2 in nickel elution from a wire implanted subcutaneously in mice. Toxicology. Volumes 363–364, 1 July 2016, Pages 37–45
Gilchuk P, Hill TM, Guy C, McMaster SR, Boyd KL, Rabacal WA, Lu P, Shyr Y, Kohlmeier JE, Sebzda E, Green DR and Joyce S.2016. A Distinct Lung-Interstitium-Resident Memory CD8+ T Cell Subset Confers Enhanced Protection to Lower Respiratory Tract Infection. Cell Reports. DOI: 10.1016/j.celrep.2016.07.037
Barwick BG, Scharer CD, Bally APR and Boss JM. 2016. Plasma Cell Differentiation is Coupled to Division-Dependent DNA Hypomethylation and Gene Regulation. Nat Immunol. 17(10):1216-25
Taylor RA, Chang CF, Goods BA, Hammond MD, Mac Grory B, Ai Y, Steinschneider AF, Renfroe SC, Askenase MH, McCullough LD, Kasner SE, Mullen MT, Hafler DA, Love JC, Sansing LH. 2016. TGF-β1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage. J. Clin. Invest. doi:10.1172/JCI88647
Dill R and Walker AM. 2016. Role of Prolactin in Promotion of Immune Cell Migration into the Mammary Gland. J. Mammary Gland Biol. Neoplasia. doi: 10.1007/s10911-016-9369-0
Huo M, Huang Y, Qu D, Zhang H, Wong WT, Chawla A, Huang Y and Tian XY. 2016. Myeloid Bmal1 deletion increases monocyte recruitment and worsens atherosclerosis. FASEB J. doi:10.1096/fj.201601030R
CD19 (HIB19)
Moroney JB, Vasudev A, Pertsemlidis A, Zan H, Casali P. Integrative transcriptome and chromatin landscape analysis reveals distinct epigenetic regulations in human memory B cells. Nat Commun. 2020 Oct 28;11(1):5435. doi: 10.1038/s41467-020-19242-6. PMID: 33116135.
Roa, J.A., Sarkar, D., Zanaty, M. et al. Preliminary results in the analysis of the immune response after aneurysmal subarachnoid hemorrhage. Sci Rep 10, 11809 (2020). https://doi.org/10.1038/s41598-020-68861-y.
Diaz-Flores E, Comeaux EQ, Kim KL, et al. Bcl-2 Is a Therapeutic Target for Hypodiploid B-Lineage Acute Lymphoblastic Leukemia. Cancer Res. 2019;79(9):2339-2351. doi:10.1158/0008-5472.CAN-18-0236.
Bustos-Moran E, Blas-Rus N, Martin-Cofreces N and Sanchez-Madrid F. 2017. Microtubule associated protein-4 (MAP4) controls nanovesicle dynamics and T cell activation. J Cell Sci. doi: 10.1242/jcs.199042
Yoshia Y, Ogata A, Kang S, Ebina K, Shi K, Nojima S, Kimura T, Ito D, et al. 2015. Semaphorin 4D contributes to rheumatoid arthritis by inducing inflammatory cytokine production: Pathogenic and therapeutic implications. Arthritis Rheumatol. 67(6): 1481-1490.
Ryotokuji K, Nakajima T, Ishimaru K, Ozaki-Shimada A, Kihara K, Namiki Y and Otani S. 2015. Effect of Stress-Free Therapy on immune system: Induction of Interleukin 10 expression in lymphocytes through activation of CD19(+) CD24(hi) CD38(hi) regulatory B Cells. Laser Therapy. 24(3): 179-188.
Price AA, Tedesco D, Prasad MR, Workowski KA, Walker CM, Suthar MS, Honegger JR and Grakoui A. 2016. Prolonged Activation of Innate Antiviral Gene Signature After Childbirth is Determined by IFNL3 Genotype. Proc Natl Acad Sci USA doi: 10.1073/pnas.1602319113
CD20 (2H7)
Kevin C. Osum, Adam L. Burrack, Tijana Martinov, Nathanael L. Sahli, Jason S. Mitchell, Christopher G. Tucker, Kristen E. Pauken, Klearchos Papas, Balamurugan Appakalai, Justin A. Spanier, & Brian T. Fife. Interferon-gamma drives programmed death-ligand 1 expression on islet β cells to limit T cell function during autoimmune diabetes. Sci Rep. 2018 May 29;8(1):8295. doi: 10.1038/s41598-018-26471-9
CD27 (O323)
Versteeg K, Menicucci AR, Woolsey C, Mire CE, Geisbert JB, Cross RW, Agans KN, Jeske D, Messaoudi I and Geisbert TW. 2017. Infection with the Makona variant results in a delayed and distinct host immune response compared to previous Ebola virus variants. Sci Rep. doi: 10.1038/s41598-017-09963-y.
Wilson RM, Marshall NE, Jeske DR, Purnell JQ, Thornburg K and Messaoudi I. 2015. Maternal Obesity alters immune cell frequencies and responses in umbilical cord blood samples. Pediatr Allergy Immunol. 26(4): 344-351.
Cantisan S, Paez-Vega A, Perez-Romero P, Montejo M, Cordero E, Gracia-Ahufinger I, Martin-Gandul C, Maruri N, Aguado R, Solana R and Torre-Cisneros J. 2016. Prevention Strategies Differentially Modulate the Impact of Cytomegalovirus Replication on CD8+ T-cell Differentiation in High-Risk Solid Organ Transplant Patients. Antiviral Research. doi:10.1016/j.antiviral.2016.06.012
CD44 (IM7)
Wilfahrt D, Philips RL, Lama J, Kizerwetter M, Shapiro MJ, McCue SA, Kennedy MM, Rajcula MJ, Zeng H, Shapiro VS. Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation. Elife. 2021 Dec 2;10:e70978. doi: 10.7554/eLife.70978. PMID: 34854376; PMCID: PMC8639145.
Ortega-Molina A, Lebrero-Fernández C, Sanz A, et al. Inhibition of Rag GTPase signaling in mice suppresses B cell responses and lymphomagenesis with minimal detrimental trade-offs. Cell Rep. 2021 Jul 13;36(2):109372. doi: 10.1016/j.celrep.2021.109372. PMID: 34260908.
Burbach BJ, O'Flanagan SD, Shao Q, et al. Irreversible electroporation augments checkpoint immunotherapy in prostate cancer and promotes tumor antigen-specific tissue-resident memory CD8+ T cells. Nat Commun. 2021 Jun 23;12(1):3862. doi: 10.1038/s41467-021-24132-6. PMID: 34162858.
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Li K, Yuan Z, Lyu J, Ahn E, Davis SJ, Ahmed R, Zhu C. PD-1 suppresses TCR-CD8 cooperativity during T-cell antigen recognition. Nat Commun. 2021 May 12;12(1):2746. doi: 10.1038/s41467-021-22965-9. PMID: 33980853; PMCID: PMC8115078.
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Feola M, Zamperone A, Moskop D, et al. Pleckstrin-2 is essential for erythropoiesis in β-thalassemic mice, reducing apoptosis and enhancing enucleation. Commun Biol. 2021 May 3;4(1):517. doi: 10.1038/s42003-021-02046-9. PMID: 33941818; PMCID: PMC8093212.
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Trott DW, Islam MT, Buckley DJ, Donato AJ, Dutson T, Sorensen ES, Cai J, Gogulamudi VR, Phuong TTT, Lesniewski LA. T lymphocyte depletion ameliorates age-related metabolic impairments in mice. Geroscience. 2021 Apr 24. doi: 10.1007/s11357-021-00368-4. PMID: 33893902.
Iida Y, Yoshikawa R, Murata A, et al. Local injection of CCL19-expressing mesenchymal stem cells augments the therapeutic efficacy of anti-PD-L1 antibody by promoting infiltration of immune cells. J Immunother Cancer. 2020;8(2):e000582. doi:10.1136/jitc-2020-000582.
Kiatpakdee B, Sato K, Otsuka Y, Arashiki N, Chen Y, Tsumita T, Otsu W, Yamamoto A, Kawata R, Yamazaki J, Sugimoto Y, Takada K, Mohandas N, Inaba M. Cholesterol-binding protein TSPO2 coordinates maturation and proliferation of terminally differentiating erythroblasts. J Biol Chem. 2020 May 1. pii: jbc.RA119.011679. doi: 10.1074/jbc.RA119.011679.
Atif SM, Mack DG, McKee AS, et al. Protective role of B cells in sterile particulate-induced lung injury. JCI Insight. 2019;5(12):e125494. Published 2019 May 16. doi:10.1172/jci.insight.125494.
Govindarajan S, Gaublomme D, Van der Cruyssen R, et al. Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha. Nat Commun. 2018;9(1):5340. Published 2018 Dec 17. doi:10.1038/s41467-018-07758-x.
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Scharer CD, Bally AP, Gandham B and Boss JM. 2017. Cutting Edge: Chromatin Accessibility Programs CD8 T Cell Memory. J Immunol. doi: 10.4049/jimmunol.1602086
Zander RA, Guthmiller JJ, Graham AC, Pope RL, Burke BE, Carr DJ and Butler NS. 2016. Type I Interferons Induce T Regulatory 1 Responses and Restrict Humoral Immunity during Experimental Malaria. PLOS Pathogens. DOI:10.1371/journal.ppat.1005945
Nakamachi T, Sugiyama K, Watanabe J, Imai N, Kagami N, Hori M, Arata S and Shioda S. 2014. Comparison of Expression and Proliferative Effect of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) and its Receptors on Human Astrocytoma Cell Lines J Mol Neurosci. 54(3): 388-394.
Schwerk A, Altshuler J, Roch M, Gossen M, Winter C, Berg J, Kurtz A, Akyuz L and Steiner B. 2015. Adipose-derived human mesenchymal stem cells induce long-term neurogenic and anti-inflammatory effects and improve cognitive but not motor performance in a rat model of Parkinson's disease. Regen Med. 10(4): 431-445.
CD45 (HI30)
Pomicter AD, Clair PM, Yan D, Heaton WL, Eiring AM, Anderson MB, Richards SM, Gililland J, O'Hare T, Deininger MW. Femoral Heads from Total Hip Arthroplasty as a Source of Adult Hematopoietic Cells. Acta Haematol. 2021 Jan 7:1-7. doi: 10.1159/000511953. PMID: 33412552.
Boyd DF, Allen EK, Randolph AG, Guo XJ, et al. Exuberant fibroblast activity compromises lung function via ADAMTS4. Nature. 2020 Oct 28. doi: 10.1038/s41586-020-2877-5. PMID: 33116313.
A CX3CR1 Reporter hESC Line Facilitates Integrative Analysis of In-Vitro-Derived Microglia and Improved Microglia Identity Upon Neuron-Glia Co-culture. Alexandra Grubman, Teresa H Vandekolk, Jan Schröder, Guizhi Sun, Jessica Hatwell-Humble, Jonathan Chan, Minna Oksanen, Sarka Lehtonen, Cameron Hunt, Jari E Koistinaho, Susan K Nilsson, John M Haynes, Colin W Pouton, Jose M Polo. Stem Cell Reports. 2020 May 11;S2213-6711(20)30147-8. doi: 10.1016/j.stemcr.2020.04.007.
Markman, J.L., Porritt, R.A., Wakita, D. et al. Loss of testosterone impairs anti-tumor neutrophil function. Nat Commun 11, 1613 (2020). https://doi.org/10.1038/s41467-020-153.
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Burel JG, Pomaznoy M, Lindestam Arlehamn CS, et al. Circulating T cell-monocyte complexes are markers of immune perturbations. Elife. 2019;8:e46045. Published 2019 Jun 25.
Bachanova V, Frankel AE, Cao Q, Lewis D, Grzywacz B, Verneris MR, Ustun C, Lazaryan A, McClune B, Warlick ED, Kantarjian H, Weisdorf DJ, Miller JS, Vallera DA. 2015. Phase I Study of a Bispecific Ligand-Directed Toxin Targeting CD22 and CD19 (DT2219) for Refractory B-cell Malignancies. Clin Cancer Res. 21(6): 1267-1272.
Ogata Y, Mabuchi Y, Yoshida M, Suto EG, Suzuki N, Muneta T, Sekiya I and Akazawa C. 2015. Purified Human Synovium Mesenchymal Stem Cells as a Good Resource for Cartilage Regeneration. PLoS One. 10.1371/journal.pone.0129096.
Mei HE, Leipold MD and Maecker HT. 2015. Platinum-conjugated antibodies for application in mass cytometry. Cytometry A. DOI: 10.1002/cyto.a.22778.
Shen Z, Rodriguez-Garcia M, Patel MV, Barr FD and Wire CR. 2016. Menopausal Status Influences the Expression of Programmed Death (PD)-1 and its Ligand PD-L1 on Immune Cells from the Human Female Reproductive Tract. American Journal of Reproductive Immunology. DOI: 10.1111/aji.12532
Rodriguez-Garcia M, Shen Z, Barr FD, Boesch AW, Ackerman ME, Kappes JC, Ochsenbauer C and Wira CR. 2016. Dendritic cells from the human female reproductive tract rapidly capture and respond to HIV. Dartmouth. Immunol. doi:10.1038/mi.2016.72 199
CD127 (R34-34)
Kyoizumi S, Kubo Y, Kajimura J, Yoshida K, Hayashi T, Nakachi K, Young LF, Moore MA, van den Brink MR and Kusunoki Y. 2014. Linkage between Dendritic and T Cell Commitments in Human Circulating Hematopoietic Progenitors. J Immunol. 192(12): 5749-5760.
CD8a (RPA-T8)
Lee J, Sheen JH, Lim O, Lee Y, et al. Abrogation of HLA surface expression using CRISPR/Cas9 genome editing: a step toward universal T cell therapy. Sci Rep. 2020 Oct 20;10(1):17753. doi: 10.1038/s41598-020-74772-9. PMID: 33082438; PMCID: PMC7576162.
Poudel B, Yorek MS, Mazgaeen L, Brown SA, Kanneganti TD, Gurung P. Acute IL-4 Governs Pathogenic T Cell Responses during Leishmania major Infection. Immunohorizons. 2020 Sep 18;4(9):546-560. doi: 10.4049/immunohorizons.2000076. PMID: 32948646.
Zhang AH, Yoon J, Kim YC, Scott DW. Targeting Antigen-Specific B Cells Using Antigen-Expressing Transduced Regulatory T Cells. J Immunol. 2018;201(5):1434-1441. doi:10.4049/jimmunol.1701800.
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Morimoto S, Fujiki F, Kondo K, et al. Establishment of a novel platform cell line for efficient and precise evaluation of T cell receptor functional avidity. Oncotarget. 2018;9(75):34132-34141. Published 2018 Sep 25. doi:10.18632/oncotarget.26139.
Ryotokuji K, Nakajima T, Ishimaru K, Ozaki-Shimada A, Kihara K, Namiki Y and Otani S. 2015. Effect of Stress-Free Therapy on immune system: Induction of Interleukin 10 expression in lymphocytes through activation of CD19(+) CD24(hi) CD38(hi) regulatory B Cells. Laser Therapy. 24(3): 179-188.
Dillon, SM, Lee EJ, Donovan AM, Guo K, Harper MS, Frank DN, McCarter MD, Santiago ML, and Wilson CC. 2016. Enhancement of HIV-1 infection and intestinal CD4+ T cell depletion ex vivo by gut microbes altered during chronic HIV-1 infection. Retrovirology. DOI 10.1186/s12977-016-0237-1
CD28 (CD28.2)
Brincks E. L., Adams J., Wang L., Turner B., Marcinowicz A., Ke J., Essmann M., Mautino L. M., Allen C. Van, Kumar S., Vahanian N., Link C., Mautino M. R. et al Indoximod opposes the immunosuppressive effects mediated by IDO and TDO via modulation of AhR function and activation of mTORC1. Oncotarget. 2020; 11: 2438-2461.
Molly OhainleI, Kyusik Kim, Sevnur Komurlu Keceli, Abby Felton, Ed Campbell, Jeremy LubanI, Michael. Emerman. TRIM34 restricts HIV-1 and SIV capsids in a TRIM5α-dependent manner. PLoS Pathog. 2020 Apr 13;16(4):e1008507. doi: 10.1371/journal.ppat.1008507
Hultquist JF, Hiatt J, Schumann K, et al. CRISPR-Cas9 genome engineering of primary CD4+ T cells for the interrogation of HIV-host factor interactions. Nat Protoc. 2019;14(1):1-27. doi:10.1038/s41596-018-0069-7.
Nau GJ, Horzempa J, O'Dee D, et al. A predicted Francisella tularensis DXD-motif glycosyltransferase blocks immune activation. Virulence. 2019;10(1):643-656. doi:10.1080/21505594.2019.1631662.
Sánchez-Villanueva JA, Rodríguez-Jorge O, Ramírez-Pliego O, et al. Contribution of ROS and metabolic status to neonatal and adult CD8+ T cell activation. PLoS One. 2019;14(12):e0226388. Published 2019 Dec 16. doi:10.1371/journal.pone.0226388.
Versteeg K, Menicucci AR, Woolsey C, Mire CE, Geisbert JB, Cross RW, Agans KN, Jeske D, Messaoudi I and Geisbert TW. 2017. Infection with the Makona variant results in a delayed and distinct host immune response compared to previous Ebola virus variants. Sci Rep. doi: 10.1038/s41598-017-09963-y.
Rupp LJ, Schumann K, Roybal KT, Gate RE, Ye CJ, Lim WA and Marson A. 2017. CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells. Sci Rep. doi: 10.1038/s41598-017-00462-8
Chi S, Weiss A and Wang H. 2015. A CRISPR-based Toolbox For Studying T Cell Signal Transduction. BioMed Res Int. DOI:10.1155/2016/5052369
Miles B, Miller SM, Folkvord JM, Kimball A, Chamanian M, Meditz AL, Arends T, McCarter MD, Levy DN, Rakasz EG, Skinner PJ and Connick E. 2015. Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection. Nat Commun. doi: 10.1038/ncomms9608.
Hultquist JF, Schumann K, Woo JM, Manganaro L, McGregor MJ, Doudna J, Simon V, Krogan NJ and Marson A. 2016. A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells. Cell Rep. doi: 10.1016/j.celrep.2016.09.080.
Galindo-Albarran AO, Lopez-Portales OH, Gutierrez-Reyna DY, Rodriguez-Jorge O, Sanchez-Villanueva JA, Ramirez-Pliego O, Bergon A, Loriod B, Holota H, Imbert J, Hernandez-mendoza A, Ferrier P, Carrillo-de Santa Pau E, Valencia A, Spicuglia S and Santana MA. 2016. CD8+ T Cells from Human Neonates Are Biased toward an Innate Immune Response. Cell Rep. doi: 10.1016/j.celrep.2016.10.056
Park RJ, Wang T, Koundakjian D, Hultquist JF, Lamothe-Molina P, Monel B, Schumann K, Yu H,Krupzcak KM, Garcia-Beltran W, Piechocka-Trocha A, Krogan NJ, Marson A, Sabatini DM, Lander ES, Hacohen N and Walker BD. 2016. A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors. Nature Genet. doi:10.1038/ng.3741
CD45RA (HI100)
Dejene M. Tufa, Tyler Shank, Ashley M. Yingst, George Devon Trahan, Seonhui Shim, Jessica Lake, Renee Woods, Kenneth Jones & Michael R. Verneris. Prolactin Acts on Myeloid Progenitors to Modulate SMAD7 Expression and Enhance Hematopoietic Stem Cell Differentiation into the NK Cell Lineage. Sci Rep. 2020 Apr 14;10(1):6335. doi: 10.1038/s41598-020-63346-4
Tomellini E, Fares I, Lehnertz B, et al. Integrin-α3 Is a Functional Marker of Ex Vivo Expanded Human Long-Term Hematopoietic Stem Cells. Cell Rep. 2019;28(4):1063-1073.e5. doi:10.1016/j.celrep.2019.06.084.
Zhang AH, Yoon J, Kim YC, Scott DW. Targeting Antigen-Specific B Cells Using Antigen-Expressing Transduced Regulatory T Cells. J Immunol. 2018;201(5):1434-1441. doi:10.4049/jimmunol.1701800.
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Kyoizumi S, Kubo Y, Kajimura J, Yoshida K, Hayashi T, Nakachi K, Moore MA, van den Brink MRM and Kusunoki Y. 2017. Fate Decision Between Group 3 Innate Lymphoid and Conventional NK Cell Lineages by Notch Signaling in Human Circulating Hematopoietic Progenitors. J Immunol. doi: 10.4049/jimmunol.1601711.
Caër C, Rouault C, Le Roy T, Poitou C, Aron-Wisnewsky J, Torcivia A, Bichet JC, Clément K, Guerre-Millo M, and André S. 2017. Immune cell-derived cytokines contribute to obesity-related inflammation, fibrogenesis and metabolic deregulation in human adipose tissue. Sci Rep. doi: 10.1038/s41598-017-02660-w.
Ryotokuji K, Nakajima T, Ishimaru K, Ozaki-Shimada A, Kihara K, Namiki Y and Otani S. 2015. Effect of Stress-Free Therapy on immune system: Induction of Interleukin 10 expression in lymphocytes through activation of CD19(+) CD24(hi) CD38(hi) regulatory B Cells. Laser Therapy. 24(3): 179-188.
Viisanen T, Ihantola E, Nanto-Salonen K, Hyoty H, Nurminen N, Selvenius J, Juutilainen A, Moilanen L, Pihlajamaki J, Veijola R, Toppari J, Knip M, Ilonen J and Kinnunen T. 2016. Circulating CXCR5+PD-1+ICOS+ Follicular T Helper Cells Are Increased Close to the Diagnosis of Type 1 Diabetes in Children with Multiple Autoantibodies. Diabetes. DOI: 10.2337/db16-0714
CD45R (B220) (RA3-6B2)
Burbach BJ, O'Flanagan SD, Shao Q, et al. Irreversible electroporation augments checkpoint immunotherapy in prostate cancer and promotes tumor antigen-specific tissue-resident memory CD8+ T cells. Nat Commun. 2021 Jun 23;12(1):3862. doi: 10.1038/s41467-021-24132-6. PMID: 34162858.
» View on NatureCommunications
Davenport BJ, Morrison TE, Kedl RM, Klarquist J. Conserved and Novel Mouse CD8 T Cell Epitopes within SARS-CoV-2 Spike Receptor Binding Domain Protein Identified following Subunit Vaccination. J Immunol. 2021 May 10:ji2100195. doi: 10.4049/jimmunol.2100195. PMID: 33972373.
Aihara R, Kunimura K, Watanabe M, Uruno T, Yamane N, Sakurai T, Sakata D, Nishimura F, Fukui Y. DOCK8 controls survival of group 3 innate lymphoid cells in the gut through Cdc42 activation. Int Immunol. 2020 Sep 28:dxaa066. doi: 10.1093/intimm/dxaa066. PMID: 32986079.
Racine JJ, Chapman HD, Doty R, Cairns BM, Hines TJ, Tadenev ALD, Anderson LC, Green T, Dyer ME, Wotton JM, Bichler Z, White JK, Ettinger R, Burgess RW, Serreze DV. T Cells from NOD-PerIg Mice Target Both Pancreatic and Neuronal Tissue. J Immunol. 2020 Sep 16:ji2000114. doi: 10.4049/jimmunol.2000114. PMID: 32938729.
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Jonathan J Pinney, Fátima Rivera-Escalera, Charles C Chu, Hannah E Whitehead, Karl VanDerMeid, Ashley M Nelson, Michelle C Barbeau, Clive S Zent, Michael R Elliott; Macrophage hypophagia as a mechanism of innate immune exhaustion in mAb-induced cell clearance. Blood.2020005571. doi: https://doi.org/10.1182/blood.2020005571.
Simões IT, Aranda F, Casadó-Llombart S, et al. Multifaceted effects of soluble human CD6 in experimental cancer models. J Immunother Cancer. 2020 Mar;8(1):e000172. doi: 10.1136/jitc-2019-000172. PMID: 32217757; PMCID: PMC7174071.
Noviski M, Mueller JL, Satterthwaite A, Garrett-Sinha LA, Brombacher F, Zikherman J. IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate. Elife. 2018;7:e35074. Published 2018 Mar 9. doi:10.7554/eLife.35074.
Guo M, Price MJ, Patterson DG, et al. EZH2 Represses the B Cell Transcriptional Program and Regulates Antibody-Secreting Cell Metabolism and Antibody Production. J Immunol. 2018;200(3):1039-1052. doi:10.4049/jimmunol.1701470.
Scharer CD, Barwick BG, Guo M, Bally APR, Boss JM. Plasma cell differentiation is controlled by multiple cell division-coupled epigenetic programs. Nat Commun. 2018;9(1):1698. Published 2018 Apr 27. doi:10.1038/s41467-018-04125-8.
Ganuza M, Hall T, Finkelstein D, Chabot A, Kang G and McKinney-Freeman S. (2017) Lifelong haematopoiesis is established by hundreds of precursors throughout mammalian ontogeny. Nat Cell Biol. DOI: 10.1038/ncb3607
CD161 (HP-3G10)
Roa, J.A., Sarkar, D., Zanaty, M. et al. Preliminary results in the analysis of the immune response after aneurysmal subarachnoid hemorrhage. Sci Rep 10, 11809 (2020). https://doi.org/10.1038/s41598-020-68861-y.
Ryotokuji K, Nakajima T, Ishimaru K, Ozaki-Shimada A, Kihara K, Namiki Y and Otani S. 2015. Effect of Stress-Free Therapy on immune system: Induction of Interleukin 10 expression in lymphocytes through activation of CD19(+) CD24(hi) CD38(hi) regulatory B Cells. Laser Therapy. 24(3): 179-188.
CD25 (BC96)
Zhang AH, Yoon J, Kim YC, Scott DW. Targeting Antigen-Specific B Cells Using Antigen-Expressing Transduced Regulatory T Cells. J Immunol. 2018;201(5):1434-1441. doi:10.4049/jimmunol.1701800.
» View on Journal of Immunology
Kyoizumi S, Kubo Y, Kajimura J, Yoshida K, Hayashi T, Nakachi K, Moore MA, van den Brink MRM and Kusunoki Y. 2017. Fate Decision Between Group 3 Innate Lymphoid and Conventional NK Cell Lineages by Notch Signaling in Human Circulating Hematopoietic Progenitors. J Immunol. doi: 10.4049/jimmunol.1601711.
Ryotokuji K, Nakajima T, Ishimaru K, Ozaki-Shimada A, Kihara K, Namiki Y and Otani S. 2015. Effect of Stress-Free Therapy on immune system: Induction of Interleukin 10 expression in lymphocytes through activation of CD19(+) CD24(hi) CD38(hi) regulatory B Cells. Laser Therapy. 24(3): 179-188.
Miles B, Miller SM, Folkvord JM, Kimball A, Chamanian M, Meditz AL, Arends T, McCarter MD, Levy DN, Rakasz EG, Skinner PJ and Connick E. 2015. Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection. Nat Commun. doi: 10.1038/ncomms9608.
Cheng H, Gaddis DE, Wu R, McSkimming C, Haynes LD, Taylor AM, McNamara CA, Sorci-Thomas M and Hedrick CC. 2016. Loss of ABCG1 Influences Regulatory T Cell Differentiation and Atherosclerosis. J. Clin. Invest. doi:10.1172/JCI83136.
CD45RO (UCHL1)
Justin T Gibson, Katlyn E Norris, Gal Wald, Claire M Buchta Rosean, Lewis J Thomas, Shannon K Boi, Laura A Bertrand, Megan Bing, Jennifer B Gordetsky, Jessy Deshane, Peng Li , James A Brown, Kenneth G Nepple, Lyse A Norian. Obesity induces limited changes to systemic and local immune profiles in treatment-naive human clear cell renal cell carcinoma. PLoS One. 2020 May 29;15(5):e0233795. doi: 10.1371/journal.pone.0233795. eCollection 2020.
Galindo-Albarran AO, Lopez-Portales OH, Gutierrez-Reyna DY, Rodriguez-Jorge O, Sanchez-Villanueva JA, Ramirez-Pliego O, Bergon A, Loriod B, Holota H, Imbert J, Hernandez-mendoza A, Ferrier P, Carrillo-de Santa Pau E, Valencia A, Spicuglia S and Santana MA. 2016. CD8+ T Cells from Human Neonates Are Biased toward an Innate Immune Response. Cell Rep. doi: 10.1016/j.celrep.2016.10.056
CD11b (ICRF44)
Markman, J.L., Porritt, R.A., Wakita, D. et al. Loss of testosterone impairs anti-tumor neutrophil function. Nat Commun 11, 1613 (2020). https://doi.org/10.1038/s41467-020-153.
» View on Nature Communications
Kevin C. Osum, Adam L. Burrack, Tijana Martinov, Nathanael L. Sahli, Jason S. Mitchell, Christopher G. Tucker, Kristen E. Pauken, Klearchos Papas, Balamurugan Appakalai, Justin A. Spanier, & Brian T. Fife. Interferon-gamma drives programmed death-ligand 1 expression on islet β cells to limit T cell function during autoimmune diabetes. Sci Rep. 2018 May 29;8(1):8295. doi: 10.1038/s41598-018-26471-9.
Rodriguez-Garcia M, Shen Z, Barr FD, Boesch AW, Ackerman ME, Kappes JC, Ochsenbauer C and Wira CR. 2016. Dendritic cells from the human female reproductive tract rapidly capture and respond to HIV. Mucosal. Immunol. doi:10.1038/mi.2016.72 199.
HLA-DR (L243)
Stephens WZ, Kubinak JL, Ghazaryan A, Bauer KM, Bell R, Buhrke K, Chiaro TR, Weis AM, Tang WW, Monts JK, Soto R, Ekiz HA, O'Connell RM, Round JL. Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition. Cell Rep. 2021 Nov 2;37(5):109916. doi: 10.1016/j.celrep.2021.109916. PMID: 34731608.
Markman, J.L., Porritt, R.A., Wakita, D. et al. Loss of testosterone impairs anti-tumor neutrophil function. Nat Commun 11, 1613 (2020). https://doi.org/10.1038/s41467-020-15397-4.
Clones not Specified
Roa, J.A., Sarkar, D., Zanaty, M. et al. Preliminary results in the analysis of the immune response after aneurysmal subarachnoid hemorrhage. Sci Rep 10, 11809 (2020). https://doi.org/10.1038/s41598-020-68861-y.
Dishon S, Cohen SJ, Cohen IR and Nussbaum G. 2017. Inhibition of Myeloid Differentiation Factor 88 Reduces Human and Mouse T-Cell Interleukin-17 and IFNγ Production and Ameliorates Experimental Autoimmune Encephalomyelitis Induced in Mice. Front Immunol. doi: 10.3389/fimmu.2017.00615
Chu HH, Chan SW, Gosling JP, Blanchard N, Tsitsiklis A, Lythe G, Shastri N, Molina-París C and Robey EA. 2016. Continuous Effector CD8(+) T Cell Production in a Controlled Persistent Infection Is Sustained by a Proliferative Intermediate Population. Immunity. doi: 10.1016/j.immuni.2016.06.013.
Kobayashi E, Kishi H, Ozawa T, Horii M, Hamana H, Nagai T and Muraguchi A. 2014. Retroviral vectors for homologous recombination provide efficient cloning and expression in mammalian cells. Biochem Biophys Res Commun. 444(3): 319-324.
Steiner S, Daniel C, Fischer A, Atreya I, Hirschmann S, Waldner M, Neumann H, Neurath M, Atreya R and Weigmann B. 2014. Cyclosporine A Regulates Pro-Inflammatory Cytokine Production in Ulcerative Colitis. Arch Immunol Ther Exp (Warsz). 63(1): 53-63.
Abraham S, Choi JG, Ye C, Manjunath N and Shankar P. 2014. IL-10 exacerbates xenogeneic GVHD by inducing massive human T cell expansion. Clin Immunol. 156(1): 58-64.
Clarke EV, Weist BM, Walsh CM and Tenner AJ. 2015. Complement protein C1q bound to apoptotic cells suppresses human macrophage and dendritic cell-mediated Th17 and Th1 T cell subset proliferation. J Leukoc Biol. 97(1): 147-160.
Harper MS, Guo K, Gibbert K, Lee EJ, Dillon SM, Barrett BS, McCarter MD, Hasenkrug KJ, Dittmer U, Wilson CC and Santiago ML. 2015. Interferon-α Subtypes in an Ex Vivo Model of Acute HIV-1 Infection: Expression, Potency and Effector Mechanisms. PLoS Pathog. doi: 10.1371/journal.ppat.1005254.